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KGIPMAPNVTAAPAELEAAHAEMIAATLPLVGAHIDEITTEFYRRMFAAHPELLRNLFNRGNQAQGAQQR ALAASIATFATHLIDPDLPHPAELLSRIGHKHASLGVTADQYPIVHEHLFAAIVEVLGADTVTADVAAAW DRVYWIMADTLIALERDLYKAAGVTDGDVYRRATVVSRVDDPSGVVLITVRPEGRPFTGSIPAQYVSVGV TLPDGARQLRQYTLVNAPGTADLTFAVKPVASVAESPAGEVSSWISANLCVGDIVDVTVPFGDLPAPDGA APLVLISAGIGITPMIGILEYLAASAPEASVQVLHADRSDRVHPLRERQHELAEALPNARLDVWYEDGVT AGAPGAHAGLMNLSAIDLPADAHVYLCGNNGFVQAVRGQLTDRGFISERVHCELFSPNDWLLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4884 | - | - | 100% (414) | 6,7-dihydropteridine reductase |
| M. gilvum PYR-GCK | Mflv_1353 | - | 4e-15 | 28.14% (199) | oxidoreductase FAD-binding subunit |
| M. gilvum PYR-GCK | Mflv_1462 | - | 9e-14 | 27.62% (210) | ferredoxin |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3602 | hmp | 3e-13 | 30.58% (206) | hemoglobine-like protein |
| M. tuberculosis H37Rv | Rv3571 | hmp | 3e-13 | 30.58% (206) | hemoglobine-like protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3133c | - | 5e-92 | 47.96% (392) | putative flavohemoprotein |
| M. marinum M | MMAR_5066 | hmp | 1e-10 | 27.76% (245) | flavodoxin reductase Hmp |
| M. avium 104 | MAV_0590 | - | 1e-12 | 27.46% (244) | oxidoreductase, electron transfer component |
| M. smegmatis MC2 155 | MSMEG_1336 | - | 1e-170 | 72.48% (407) | flavohemoprotein, putative |
| M. thermoresistible (build 8) | TH_1871 | - | 0.0 | 76.66% (407) | flavohemoprotein, putative |
| M. ulcerans Agy99 | MUL_4142 | hmp | 2e-10 | 27.76% (245) | flavodoxin reductase Hmp |
| M. vanbaalenii PYR-1 | Mvan_1541 | - | 0.0 | 82.47% (405) | 6,7-dihydropteridine reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3602|M.bovis_AF2122/97 --------MTEAIG----DEPLGDHVLELQIAEVVDETDEARSLVFAVPD
Rv3571|M.tuberculosis_H37Rv --------MTEAIG----DEPLGDHVLELQIAEVVDETDEARSLVFAVPD
MMAR_5066|M.marinum_M --------MTDAIP----DEPLGSHVLELQIAEVVAETDDARSLVFAVPD
MUL_4142|M.ulcerans_Agy99 --------MTDAIP----DEPLGSHVLELQIAEVVAETDDARSLVFAVPD
MAV_0590|M.avium_104 --------MTEADSAQALDEPLGDHVLELQIAEVIAETDDARSLVFAVPD
Mflv_4884|M.gilvum_PYR-GCK --MKGIPMAPNVTAAPAELEAAHAEMIAATLPLVGAHIDEITTEFYRRMF
Mvan_1541|M.vanbaalenii_PYR-1 ---------MTVTAAPAELEPAHAEIVTATLPLIGAHIDEITKEFYRRMF
TH_1871|M.thermoresistible__bu -MTVTTPGPRPTAVAHAELEPQHAEIVAATLPLVGAHIDEITAEFYRRMF
MSMEG_1336|M.smegmatis_MC2_155 -MTVTTP---EPADVRVDLEPEHAEIVSATLPLIGANIDAITSEFYRRLF
MAB_3133c|M.abscessus_ATCC_199 MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMF
.. :: :. : * .:
Mb3602|M.bovis_AF2122/97 GSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAV
Rv3571|M.tuberculosis_H37Rv GSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAV
MMAR_5066|M.marinum_M GSDDPRIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSPFTDDALTV
MUL_4142|M.ulcerans_Agy99 GSDDPRIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSPFTDDALTV
MAV_0590|M.avium_104 DDGDPDIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSPFTDDALTV
Mflv_4884|M.gilvum_PYR-GCK AAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLIDPDLPHPAELLSR
Mvan_1541|M.vanbaalenii_PYR-1 GAHPELLRNLFNRGNQAQGAQQRALAASIATFASHLVDPELPHPAELLSR
TH_1871|M.thermoresistible__bu GAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLVDPELPHPAELLSR
MSMEG_1336|M.smegmatis_MC2_155 TNHPELLRNLFNRGNQAQGAQQRALAASIATFAKHLVDPDLPHPAALLSR
MAB_3133c|M.abscessus_ATCC_199 AAHPELLRDLFNRGNQAAGEQPKALAASIAAFAGMVLEGNGAQYDSVLDR
: * . :. : .:.* . . *
Mb3602|M.bovis_AF2122/97 TVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSG
Rv3571|M.tuberculosis_H37Rv TVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSG
MMAR_5066|M.marinum_M TVKRTADGYASNWLCDNAHQGMRIHVLAPSGNFVPKTLDDDFLLLAAGSG
MUL_4142|M.ulcerans_Agy99 TVKRTADGYASNWLCDNAHQGMRIHVLAPSGNFVPKTLDDDFLLLAAGSG
MAV_0590|M.avium_104 TVKRTADGYASNWLCDNARPGMRIHVLAPSGNFVPKTLGDDFLLMAAGSG
Mflv_4884|M.gilvum_PYR-GCK IGHKHASLGVTADQYPIVHEHLFAAIVEVLGADTVTADVAAAWDRVYWIM
Mvan_1541|M.vanbaalenii_PYR-1 IGHKHASLGVTADQYPVVHEHLFAAIVAVLGADTVTADVAAAWDRVYWIM
TH_1871|M.thermoresistible__bu IAHKHASLGVTADQYPIVHEHLFAAIVAVLGADTVTAEVAAAWDRVYWIM
MSMEG_1336|M.smegmatis_MC2_155 IGHKHASLGVTAEQYPIVHDNLFAAIVAVLGADTVTPEVAAAWDRVFWIM
MAB_3133c|M.abscessus_ATCC_199 IAHKHASLGIVAEQYPIVYEHLFAAIAEVLGG-AVTADVAKAWSEFYWLM
:: *. . : : * . ..
Mb3602|M.bovis_AF2122/97 ITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAAKYPDRLTV
Rv3571|M.tuberculosis_H37Rv ITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAAKYPDRLTV
MMAR_5066|M.marinum_M ITPIMSICKSTLAEGSGQVTLLYANRDERSVIFADALRELSAKYPDRLTV
MUL_4142|M.ulcerans_Agy99 ITPIMSICKSALAEGGGQVTLLYANRDERSVIFADALRELSAKYPDRLTV
MAV_0590|M.avium_104 ITPIMSIAKSALSEGSGRVTLLYANRDERSVIFADALRELSAKYPDRLTV
Mflv_4884|M.gilvum_PYR-GCK ADTLIALERDLYKAAGVTDGDVYRRATVVSRVDDPSGVVLITVRPEGRPF
Mvan_1541|M.vanbaalenii_PYR-1 ADTLIALEHDLYRDAGVADGDVYRRTRVVSRVDDPSGAVLITVRPMGEPF
TH_1871|M.thermoresistible__bu ADVLIDLERSLYAEAGVPAGDVYRRARVTARVDDPSGAVLLTVRPLGERF
MSMEG_1336|M.smegmatis_MC2_155 ADTLIALERNLYDEAGVEPGDVYRRLRVVGRVDDPSGAVLVTVRAAEP--
MAB_3133c|M.abscessus_ATCC_199 ADELIAREKALYDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKL
:: : .. :: . :
Mb3602|M.bovis_AF2122/97 LHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVP
Rv3571|M.tuberculosis_H37Rv LHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVP
MMAR_5066|M.marinum_M VHWLESLQGLPSATALAQLAAPFTGRTAFICGPGPFMEAARVALQTLDVP
MUL_4142|M.ulcerans_Agy99 VHWLESLQGLPSATALAQLAAPFTGRTAFICGPGPFMEAARVALQTLDVP
MAV_0590|M.avium_104 LHWLESLQGLPSVTALAQLAAPYTDRPVYICGPGAFMDSAREALETLKVP
Mflv_4884|M.gilvum_PYR-GCK TGSIPAQYVSVGVTLPDGARQLRQYTLVNAPGTADLTFAVKPVASVAESP
Mvan_1541|M.vanbaalenii_PYR-1 ADFRPGQYVSVGVTLPDGARQLRQYSLVNVPGDDGLTFAVKPIAAGADAP
TH_1871|M.thermoresistible__bu AEFRPGQYISVGVTLPDGARQLRQYSLVNPPGADELTFAVRPVAATPDQP
MSMEG_1336|M.smegmatis_MC2_155 VNFLPGQYVSVGVTLPDGARQLRQYSLVSVAGATDLTFAVKPVEATAAQP
MAB_3133c|M.abscessus_ATCC_199 PNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVKRLNVG-DTP
. .: :.: *
Mb3602|M.bovis_AF2122/97 AQQVHIEVFKSLESD-------PFAAVKVDDSG--DEAPATAVVELD---
Rv3571|M.tuberculosis_H37Rv AQQVHIEVFKSLESD-------PFAAVKVDDSG--DEAPATAVVELD---
MMAR_5066|M.marinum_M AGQVHIEVFKSLESD-------PFAAVTVEDSA--AEPPATAVVELD---
MUL_4142|M.ulcerans_Agy99 AGQVHIEVFKSLESD-------PFAAVTVEDSA--AEPPATAVVELD---
MAV_0590|M.avium_104 AAQIHIEVFKSLDSD-------PFAAVKIEDTAEGDEPPATAVVELD---
Mflv_4884|M.gilvum_PYR-GCK AGEVSSWISANLCVGDIVDVTVPFGDLPAPDGA-APLVLISAGIGITPMI
Mvan_1541|M.vanbaalenii_PYR-1 AGEVSSWIAANVCVGDLLDVTVPFGDLPAPDGS-APVVLISAGIGVTPMI
TH_1871|M.thermoresistible__bu AGEVSTWIAANVCVGDILDITAPFGDLPTPVAG-EPLVLISAGIGITPMI
MSMEG_1336|M.smegmatis_MC2_155 AGEVSNWIRDNVCVGDLLDVTLPFGDLHTDDLSTGPVMLISAGIGITPMI
MAB_3133c|M.abscessus_ATCC_199 AGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSA-DPLVLVSAGIGCTPIM
* :: : .: . *:. . . :* :
Mb3602|M.bovis_AF2122/97 GQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRA-------
Rv3571|M.tuberculosis_H37Rv GQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRA-------
MMAR_5066|M.marinum_M GQTHTVSWPRSAKLLDVLLAAGLDAPFSCREGHCGACAATLRS-------
MUL_4142|M.ulcerans_Agy99 GQTHTVSWPRSAKLLDVLLAAGLDAPFSCREGHCGACAATLRS-------
MAV_0590|M.avium_104 GETHTVSWPRNAKLLDVLLAKGLDAPFSCREGHCGACACTLRK-------
Mflv_4884|M.gilvum_PYR-GCK GILEYLAASAPEASVQVLHADRSDRVHPLRERQHELAEALPNARLDVWYE
Mvan_1541|M.vanbaalenii_PYR-1 GILEHLAASAPDTVVRVLHADRSDQTHPLRERQLELIAAMPDARLDIWYE
TH_1871|M.thermoresistible__bu GILEYLAAEARATPVRVLHADRGDRSHPLRERQRELVAALPDATLDIWYE
MSMEG_1336|M.smegmatis_MC2_155 GILEHLAAERPDAHVRVLHADRSDTAHPLRERQRELVDALPEASLDIWYE
MAB_3133c|M.abscessus_ATCC_199 GMLQELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYE
* . : : ** * .. *.
Mb3602|M.bovis_AF2122/97 -------GKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE----
Rv3571|M.tuberculosis_H37Rv -------GKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE----
MMAR_5066|M.marinum_M -------GKVNMEVNDVLEQQDLDDGLILACQSHPESDSVEVTYDE----
MUL_4142|M.ulcerans_Agy99 -------GKVNMEVNDVLEQQDLDDGLILACQSHPESDSVEVTYDE----
MAV_0590|M.avium_104 -------GQVSMEVNDVLEQQDLDEGLILACQSHPESDSVEVTYDD----
Mflv_4884|M.gilvum_PYR-GCK DGVTAGAPGAHAGLMNLSAIDLPADAHVYLCGNNGFVQAVRGQLTDRGFI
Mvan_1541|M.vanbaalenii_PYR-1 DGLTAGTPGAHAGLMNVGTVELPKDAQIYLCGNNGFVQAVRAQLLDRGVV
TH_1871|M.thermoresistible__bu DGLTAGRPGVRPGLLDLDAVELPAGAAIYLCGGTGFVQAVRDQLMARGVP
MSMEG_1336|M.smegmatis_MC2_155 DGVTAGMPGVHAGLLDLDGIELPVEPQIYLCGGAGFVDAVRGQLAARGVP
MAB_3133c|M.abscessus_ATCC_199 R-AHVEHPADGIGRMSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIP
.: : * .::.
Mb3602|M.bovis_AF2122/97 -----------------
Rv3571|M.tuberculosis_H37Rv -----------------
MMAR_5066|M.marinum_M -----------------
MUL_4142|M.ulcerans_Agy99 -----------------
MAV_0590|M.avium_104 -----------------
Mflv_4884|M.gilvum_PYR-GCK SERVHCELFSPNDWLLG
Mvan_1541|M.vanbaalenii_PYR-1 AERVHCELFSPNDWLLG
TH_1871|M.thermoresistible__bu AERVHCELFAPNDWLV-
MSMEG_1336|M.smegmatis_MC2_155 AERVHCELFAPNDWLLD
MAB_3133c|M.abscessus_ATCC_199 QEQINHELFGPLASAVA