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DGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRDLFNRGNQAAGEQ PKALAASIAAFAGMVLEGNGAQYDSVLDRIAHKHASLGIVAEQYPIVYEHLFAAIAEVLGGAVTADVAKA WSEFYWLMADELIAREKALYDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKLPNFVPGQYISVQ VTLPDGARQIRQYSLSRGSTAGDWRIAVKRLNVGDTPAGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSA DPLVLVSAGIGCTPIMGMLQELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYERAHV EHPADGIGRMSLDRLPIDLSSTVFVCGPRPFMSAINEDLVSLGIPQEQINHELFGPLASAVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3133c | - | - | 100% (413) | putative flavohemoprotein |
| M. abscessus ATCC 19977 | MAB_0583c | - | 5e-15 | 27.10% (214) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1588c | - | 7e-15 | 27.27% (264) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3584 | fdxB | 3e-17 | 27.30% (304) | electron transfer protein FdxB |
| M. gilvum PYR-GCK | Mflv_4884 | - | 6e-92 | 47.96% (392) | 6,7-dihydropteridine reductase |
| M. tuberculosis H37Rv | Rv3554 | fdxB | 3e-17 | 27.30% (304) | electron transfer protein FdxB |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5066 | hmp | 2e-16 | 28.77% (212) | flavodoxin reductase Hmp |
| M. avium 104 | MAV_5168 | - | 7e-16 | 33.69% (187) | oxidoreductase FAD-binding subunit |
| M. smegmatis MC2 155 | MSMEG_1336 | - | 1e-89 | 47.46% (394) | flavohemoprotein, putative |
| M. thermoresistible (build 8) | TH_1871 | - | 5e-89 | 45.92% (392) | flavohemoprotein, putative |
| M. ulcerans Agy99 | MUL_4142 | hmp | 1e-16 | 28.77% (212) | flavodoxin reductase Hmp |
| M. vanbaalenii PYR-1 | Mvan_1541 | - | 3e-89 | 46.49% (385) | 6,7-dihydropteridine reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4884|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu --------------------------------------------------
MSMEG_1336|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3133c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3584|M.bovis_AF2122/97 MTDACQAEYAIAAMSTVEMDQAAPESAAHHPLPDPGESVPRLALPTIGIF
Rv3554|M.tuberculosis_H37Rv MTDACQAEYAIAAMSTVEMDQAAPESAAHHPLPDPGESVPRLALPTIGIF
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 --------------------------------------------------
Mflv_4884|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu --------------------------------------------------
MSMEG_1336|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3133c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3584|M.bovis_AF2122/97 LATLTAFVGSTTAYISGWIPFWVTIPVNAAVTFVMFTVVHDASHYAISSI
Rv3554|M.tuberculosis_H37Rv LATLTAFVGSTTAYISGWIPFWVTIPVNAAVTFVMFTVVHDASHYAISSI
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 --------------------------------------------------
Mflv_4884|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu --------------------------------------------------
MSMEG_1336|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3133c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3584|M.bovis_AF2122/97 RWVNGLFGRLAWLFVGPVVAFPAFGYIHIQHHRHSNDDEQDPDTFASHGS
Rv3554|M.tuberculosis_H37Rv RWVNGLFGRLAWLFVGPVVAFPAFGYIHIQHHRHSNDDEQDPDTFASHGS
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 --------------------------------------------------
Mflv_4884|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu --------------------------------------------------
MSMEG_1336|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3133c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3584|M.bovis_AF2122/97 LWVLPLRWSMVEYFYIKYYLPRGRSRPVIEVAETLVMMTLFLTGLIVAIV
Rv3554|M.tuberculosis_H37Rv LWVLPLRWSMVEYFYIKYYLPRGRSRPVIEVAETLVMMTLFLTGLIVAIV
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 --------------------------------------------------
Mflv_4884|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu --------------------------------------------------
MSMEG_1336|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3133c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3584|M.bovis_AF2122/97 TGNFWTLAIVFLIPQRIGLTVLAWWFDWLPHHGLEDTQRSNRYRATRNRV
Rv3554|M.tuberculosis_H37Rv TGNFWTLAIVFLIPQRIGLTVLAWWFDWLPHHGLEDTQRSNRYRATRNRV
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 --------------------------------------------------
Mflv_4884|M.gilvum_PYR-GCK -------------------------------------------MKGIPMA
Mvan_1541|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1871|M.thermoresistible__bu ------------------------------------------MTVTTPGP
MSMEG_1336|M.smegmatis_MC2_155 ---------------------------------------------MTVTT
MAB_3133c|M.abscessus_ATCC_199 -----------------------------------------MDGGRNSPS
Mb3584|M.bovis_AF2122/97 GAEWLFTPVLLSQNYHLVHHLHPSVPFYRYLRTWRRNEEAYLERNAAIST
Rv3554|M.tuberculosis_H37Rv GAEWLFTPVLLSQNYHLVHHLHPSVPFYRYLRTWRRNEEAYLERNAAIST
MMAR_5066|M.marinum_M --------------------------------------------------
MUL_4142|M.ulcerans_Agy99 --------------------------------------------------
MAV_5168|M.avium_104 ---------------------------------------MFTQTVQASGR
Mflv_4884|M.gilvum_PYR-GCK PNVTAAPAELEAAHAEMIAATLPLVGAHIDEITTEFYRRMFAAHPELLRN
Mvan_1541|M.vanbaalenii_PYR-1 MTVTAAPAELEPAHAEIVTATLPLIGAHIDEITKEFYRRMFGAHPELLRN
TH_1871|M.thermoresistible__bu RPTAVAHAELEPQHAEIVAATLPLVGAHIDEITAEFYRRMFGAHPELLRN
MSMEG_1336|M.smegmatis_MC2_155 PEPADVRVDLEPEHAEIVSATLPLIGANIDAITSEFYRRLFTNHPELLRN
MAB_3133c|M.abscessus_ATCC_199 NNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMFAAHPELLRD
Mb3584|M.bovis_AF2122/97 VFGQQLNPDEYRQWKELNGRLARLLPVRMPARSSSPHAVLHRIPVASVDP
Rv3554|M.tuberculosis_H37Rv VFGQQLNPDEYRQWKELNGRLARLLPVRMPARSSSPHAVLHRIPVASVDP
MMAR_5066|M.marinum_M --MTDAIPDEP-----LGSHVLELQIAEVVAETDDARSLVFAVPDGSDD-
MUL_4142|M.ulcerans_Agy99 --MTDAIPDEP-----LGSHVLELQIAEVVAETDDARSLVFAVPDGSDD-
MAV_5168|M.avium_104 VLARTVRQRVLGSELLDLLTGPHGVDRYTELVAPTWTLGEARAKVTDVRR
:
Mflv_4884|M.gilvum_PYR-GCK LFNRGNQAQGAQQRALAASIATFATHLIDPDLPHPAELLSRIGHKHASLG
Mvan_1541|M.vanbaalenii_PYR-1 LFNRGNQAQGAQQRALAASIATFASHLVDPELPHPAELLSRIGHKHASLG
TH_1871|M.thermoresistible__bu LFNRGNQAQGAQQRALAASIATFATHLVDPELPHPAELLSRIAHKHASLG
MSMEG_1336|M.smegmatis_MC2_155 LFNRGNQAQGAQQRALAASIATFAKHLVDPDLPHPAALLSRIGHKHASLG
MAB_3133c|M.abscessus_ATCC_199 LFNRGNQAAGEQPKALAASIAAFAGMVLEGNGAQYDSVLDRIAHKHASLG
Mb3584|M.bovis_AF2122/97 ITADATLVTFAVPEALRDAFRFEPGQHVTVRTDLGGQG-IRRNYSICA-P
Rv3554|M.tuberculosis_H37Rv ITADATLVTFAVPEALRDAFRFEPGQHVTVRTDLGGQG-IRRNYSICA-P
MMAR_5066|M.marinum_M ------------PRIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSP
MUL_4142|M.ulcerans_Agy99 ------------PRIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSP
MAV_5168|M.avium_104 TTPRSVTLTLDPNDTFLSSHTVTAGQYVNLTVEIDGRRHTRCYSPANREG
. :
Mflv_4884|M.gilvum_PYR-GCK VTADQYPIVHEHLFAAIVEVLGADTVTADVAAAWDRVYWIMADTLIALER
Mvan_1541|M.vanbaalenii_PYR-1 VTADQYPVVHEHLFAAIVAVLGADTVTADVAAAWDRVYWIMADTLIALEH
TH_1871|M.thermoresistible__bu VTADQYPIVHEHLFAAIVAVLGADTVTAEVAAAWDRVYWIMADVLIDLER
MSMEG_1336|M.smegmatis_MC2_155 VTAEQYPIVHDNLFAAIVAVLGADTVTPEVAAAWDRVFWIMADTLIALER
MAB_3133c|M.abscessus_ATCC_199 IVAEQYPIVYEHLFAAIAEVLGG-AVTADVAKAWSEFYWLMADELIAREK
Mb3584|M.bovis_AF2122/97 ATRAQLRIAVKHIPGGAFSTFVANELKAGDVLELMTPTGRFGTPLDPLHR
Rv3554|M.tuberculosis_H37Rv ATRAQLRIAVKHIPGGAFSTFVANELKAGDVLELMTPTGRFGTPLDPLHR
MMAR_5066|M.marinum_M FTDDALTVTVKRTADGYASNWLCDNAHQGMRIHVLAPSGNFVP---KTLD
MUL_4142|M.ulcerans_Agy99 FTDDALTVTVKRTADGYASNWLCDNAHQGMRIHVLAPSGNFVP---KTLD
MAV_5168|M.avium_104 AATLELTIG--RHDGGLVSNHLYDHARRGMVVGLAGVGGDFVLPDPRPRR
. : . . :
Mflv_4884|M.gilvum_PYR-GCK DLYKAAGVTDGDVYRRATVVSRVDDPSGVVLITVRPEGRPFTGSIPAQYV
Mvan_1541|M.vanbaalenii_PYR-1 DLYRDAGVADGDVYRRTRVVSRVDDPSGAVLITVRPMGEPFADFRPGQYV
TH_1871|M.thermoresistible__bu SLYAEAGVPAGDVYRRARVTARVDDPSGAVLLTVRPLGERFAEFRPGQYI
MSMEG_1336|M.smegmatis_MC2_155 NLYDEAGVEPGDVYRRLRVVGRVDDPSGAVLVTVRAAEP--VNFLPGQYV
MAB_3133c|M.abscessus_ATCC_199 ALYDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKLPNFVPGQYI
Mb3584|M.bovis_AF2122/97 KHYVGLVAGSGITPVLSILATTLEIETESRFTLIYGNRTKESTMFRAELD
Rv3554|M.tuberculosis_H37Rv KHYVGLVAGSGITPVLSILATTLEIETESRFTLIYGNRTKESTMFRAELD
MMAR_5066|M.marinum_M DDFLLLAAGSGITPIMSICKSTLAEGSG-QVTLLYANRDERSVIFADALR
MUL_4142|M.ulcerans_Agy99 DDFLLLAAGSGITPIMSICKSALAEGGG-QVTLLYANRDERSVIFADALR
MAV_5168|M.avium_104 VLFVSGGS--GITPVMAMVRTLVSQRHRGEIAFIHYAPTPAEACYRDELA
: * . :
Mflv_4884|M.gilvum_PYR-GCK SVGVTLPDGARQLRQYTLVNAPGTA----DLTFAVKPVASVAESPAGEVS
Mvan_1541|M.vanbaalenii_PYR-1 SVGVTLPDGARQLRQYSLVNVPGDD----GLTFAVKPIAAGADAPAGEVS
TH_1871|M.thermoresistible__bu SVGVTLPDGARQLRQYSLVNPPGAD----ELTFAVRPVAATPDQPAGEVS
MSMEG_1336|M.smegmatis_MC2_155 SVGVTLPDGARQLRQYSLVSVAGAT----DLTFAVKPVEATAAQPAGEVS
MAB_3133c|M.abscessus_ATCC_199 SVQVTLPDGARQIRQYSLSRGSTAG----DWRIAVKRLNVG-DTPAGEVS
Mb3584|M.bovis_AF2122/97 RLESRYADRLEILHVLSSEPLHTPELRGRIDRDKLTRWLTSTLRPAGVDE
Rv3554|M.tuberculosis_H37Rv RLESRYADRLEILHVLSSEPLHTPELRGRIDRDKLTRWLTSTLRPAGVDE
MMAR_5066|M.marinum_M ELSAKYPDRLTVVHWLES-----------LQGLPSATALAQLAAPFTGRT
MUL_4142|M.ulcerans_Agy99 ELSAKYPDRLTVVHWLES-----------LQGLPSATALAQLAAPFTGRT
MAV_5168|M.avium_104 ALPS-----VRVLHGYTRSAGGDLS-----GRFGPDHLAAAMPAPD---A
: :: *
Mflv_4884|M.gilvum_PYR-GCK SWISANLCVGDIVDVTVPFGDLPAPDGA-APLVLISAGIGITPMIG-ILE
Mvan_1541|M.vanbaalenii_PYR-1 SWIAANVCVGDLLDVTVPFGDLPAPDGS-APVVLISAGIGVTPMIG-ILE
TH_1871|M.thermoresistible__bu TWIAANVCVGDILDITAPFGDLPTPVAG-EPLVLISAGIGITPMIG-ILE
MSMEG_1336|M.smegmatis_MC2_155 NWIRDNVCVGDLLDVTLPFGDLHTDDLSTGPVMLISAGIGITPMIG-ILE
MAB_3133c|M.abscessus_ATCC_199 NFIYDNVFEGQQLRVSVPMGEFTLDDSA-DPLVLVSAGIGCTPIMG-MLQ
Mb3584|M.bovis_AF2122/97 WFICGPLAMATAVRETLIEHGVDSERIH----LELFYGFDTPPATRPSYA
Rv3554|M.tuberculosis_H37Rv WFICGPLAMATAVRETLIEHGVDSERIH----LELFYGFDTPPATRPSYA
MMAR_5066|M.marinum_M AFICGPGPFMEAARVALQTLDVPAGQVH----IEVFKSLESDPFAAVTVE
MUL_4142|M.ulcerans_Agy99 AFICGPGPFMEAARVALQTLDVPAGQVH----IEVFKSLESDPFAAVTVE
MAV_5168|M.avium_104 VFVCGPTSLVDAVREHCDNVYTESFTPP-------VLEASADPSGG----
:: *
Mflv_4884|M.gilvum_PYR-GCK YLAASAPEASVQVLHADRSDRVHPLRERQHELAEALPNARLDVWYEDGVT
Mvan_1541|M.vanbaalenii_PYR-1 HLAASAPDTVVRVLHADRSDQTHPLRERQLELIAAMPDARLDIWYEDGLT
TH_1871|M.thermoresistible__bu YLAAEARATPVRVLHADRGDRSHPLRERQRELVAALPDATLDIWYEDGLT
MSMEG_1336|M.smegmatis_MC2_155 HLAAERPDAHVRVLHADRSDTAHPLRERQRELVDALPEASLDIWYEDGVT
MAB_3133c|M.abscessus_ATCC_199 ELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYER-AH
Mb3584|M.bovis_AF2122/97 G------ATVTFTLSGQRAIFDLVPGDSILEGALGLRSDAPYACMGGACG
Rv3554|M.tuberculosis_H37Rv G------ATVTFTLSGQRAIFDLVPGDSILEGALGLRSDAPYACMGGACG
MMAR_5066|M.marinum_M DSAAEPPATAVVELDGQTHTVSWPRSAKLLDVLLAAGLDAPFSCREGHCG
MUL_4142|M.ulcerans_Agy99 DSAAEPPATAVVELDGQTHTVSWPRSAKLLDVLLAAGLDAPFSCREGHCG
MAV_5168|M.avium_104 -----------RVTFSDSGVDVVDDGRSLLEQAEAAGLSPQNGCRMGICH
.: :
Mflv_4884|M.gilvum_PYR-GCK AGAPGAHAGLMNLSAIDLPA--DAHVYLCGNNGFVQAVRGQLTDRGFISE
Mvan_1541|M.vanbaalenii_PYR-1 AGTPGAHAGLMNVGTVELPK--DAQIYLCGNNGFVQAVRAQLLDRGVVAE
TH_1871|M.thermoresistible__bu AGRPGVRPGLLDLDAVELPA--GAAIYLCGGTGFVQAVRDQLMARGVPAE
MSMEG_1336|M.smegmatis_MC2_155 AGMPGVHAGLLDLDGIELPV--EPQIYLCGGAGFVDAVRGQLAARGVPAE
MAB_3133c|M.abscessus_ATCC_199 VEHPADGIGRMSLDRLPIDL--SSTVFVCGPRPFMSAINEDLVSLGIPQE
Mb3584|M.bovis_AF2122/97 TCRAKLIEGNVEMDHNFALR--KAEL----DAGYILTCQSHPTTPFVAVD
Rv3554|M.tuberculosis_H37Rv TCRAKLIEGNVEMDHNFALR--KAEL----DAGYILTCQSHPTTPFVAVD
MMAR_5066|M.marinum_M ACAATLRSGKVNMEVNDVLE--QQDL----DDGLILACQSHPESDSVEVT
MUL_4142|M.ulcerans_Agy99 ACAATLRSGKVNMEVNDVLE--QQDL----DDGLILACQSHPESDSVEVT
MAV_5168|M.avium_104 TCTRRKTAGTVRNLVTGAVSTAPD--------------EDVQICVSVPVG
. * : . .
Mflv_4884|M.gilvum_PYR-GCK RVHCELFSPNDWLLG
Mvan_1541|M.vanbaalenii_PYR-1 RVHCELFSPNDWLLG
TH_1871|M.thermoresistible__bu RVHCELFAPNDWLV-
MSMEG_1336|M.smegmatis_MC2_155 RVHCELFAPNDWLLD
MAB_3133c|M.abscessus_ATCC_199 QINHELFGPLASAVA
Mb3584|M.bovis_AF2122/97 YDA------------
Rv3554|M.tuberculosis_H37Rv YDA------------
MMAR_5066|M.marinum_M YDE------------
MUL_4142|M.ulcerans_Agy99 YDE------------
MAV_5168|M.avium_104 DVDLSL---------