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MTVTTPEPADVRVDLEPEHAEIVSATLPLIGANIDAITSEFYRRLFTNHPELLRNLFNRGNQAQGAQQRA LAASIATFAKHLVDPDLPHPAALLSRIGHKHASLGVTAEQYPIVHDNLFAAIVAVLGADTVTPEVAAAWD RVFWIMADTLIALERNLYDEAGVEPGDVYRRLRVVGRVDDPSGAVLVTVRAAEPVNFLPGQYVSVGVTLP DGARQLRQYSLVSVAGATDLTFAVKPVEATAAQPAGEVSNWIRDNVCVGDLLDVTLPFGDLHTDDLSTGP VMLISAGIGITPMIGILEHLAAERPDAHVRVLHADRSDTAHPLRERQRELVDALPEASLDIWYEDGVTAG MPGVHAGLLDLDGIELPVEPQIYLCGGAGFVDAVRGQLAARGVPAERVHCELFAPNDWLLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1336 | - | - | 100% (411) | flavohemoprotein, putative |
| M. smegmatis MC2 155 | MSMEG_6039 | - | 4e-14 | 28.95% (228) | oxidoreductase, electron transfer component |
| M. smegmatis MC2 155 | MSMEG_0295 | - | 1e-12 | 29.07% (258) | oxidoreductase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3602 | hmp | 3e-15 | 32.23% (211) | hemoglobine-like protein |
| M. gilvum PYR-GCK | Mflv_4884 | - | 1e-170 | 72.48% (407) | 6,7-dihydropteridine reductase |
| M. tuberculosis H37Rv | Rv3571 | hmp | 4e-15 | 32.23% (211) | hemoglobine-like protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3133c | - | 9e-90 | 47.46% (394) | putative flavohemoprotein |
| M. marinum M | MMAR_0128 | - | 2e-13 | 29.46% (241) | oxidoreductase |
| M. avium 104 | MAV_0590 | - | 5e-14 | 29.82% (218) | oxidoreductase, electron transfer component |
| M. thermoresistible (build 8) | TH_1871 | - | 1e-178 | 76.39% (415) | flavohemoprotein, putative |
| M. ulcerans Agy99 | MUL_4142 | hmp | 2e-12 | 29.91% (214) | flavodoxin reductase Hmp |
| M. vanbaalenii PYR-1 | Mvan_1541 | - | 1e-176 | 76.46% (412) | 6,7-dihydropteridine reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4884|M.gilvum_PYR-GCK --MKGIPMAPNVTAAPAELEAAHAEMIAATLPLVGAHIDEITTEFYRRMF
Mvan_1541|M.vanbaalenii_PYR-1 ---------MTVTAAPAELEPAHAEIVTATLPLIGAHIDEITKEFYRRMF
TH_1871|M.thermoresistible__bu -MTVTTPGPRPTAVAHAELEPQHAEIVAATLPLVGAHIDEITAEFYRRMF
MSMEG_1336|M.smegmatis_MC2_155 -MTVTTP---EPADVRVDLEPEHAEIVSATLPLIGANIDAITSEFYRRLF
MAB_3133c|M.abscessus_ATCC_199 MDGGRNSPSNNGKEVVKVLSAESLGVIRETLPAVAGAIDEITPLFYSKMF
Mb3602|M.bovis_AF2122/97 --------MTEAIG----DEPLGDHVLELQIAEVVDETDEARSLVFAVPD
Rv3571|M.tuberculosis_H37Rv --------MTEAIG----DEPLGDHVLELQIAEVVDETDEARSLVFAVPD
MUL_4142|M.ulcerans_Agy99 --------MTDAIP----DEPLGSHVLELQIAEVVAETDDARSLVFAVPD
MAV_0590|M.avium_104 --------MTEADSAQALDEPLGDHVLELQIAEVIAETDDARSLVFAVPD
MMAR_0128|M.marinum_M --------------------------------MARVTLEPGAEEFLVGP-
: .
Mflv_4884|M.gilvum_PYR-GCK AAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLIDPDLPHPAELLSR
Mvan_1541|M.vanbaalenii_PYR-1 GAHPELLRNLFNRGNQAQGAQQRALAASIATFASHLVDPELPHPAELLSR
TH_1871|M.thermoresistible__bu GAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLVDPELPHPAELLSR
MSMEG_1336|M.smegmatis_MC2_155 TNHPELLRNLFNRGNQAQGAQQRALAASIATFAKHLVDPDLPHPAALLSR
MAB_3133c|M.abscessus_ATCC_199 AAHPELLRDLFNRGNQAAGEQPKALAASIAAFAGMVLEGNGAQYDSVLDR
Mb3602|M.bovis_AF2122/97 GSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAV
Rv3571|M.tuberculosis_H37Rv GSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAV
MUL_4142|M.ulcerans_Agy99 GSDDPRIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSPFTDDALTV
MAV_0590|M.avium_104 DDGDPDIPPERLRYAPGQFLTLRVPSERTGSVARCYSLCSSPFTDDALTV
MMAR_0128|M.marinum_M --DEDILSAALRSG---INLQYGCRHGNCSSCKHWLIDGDVDDSAASVYA
: .: . :
Mflv_4884|M.gilvum_PYR-GCK IGHKHASLGVTADQYPIVHEHLFAAIVEVLGADTVTADVAAAWDRVYWIM
Mvan_1541|M.vanbaalenii_PYR-1 IGHKHASLGVTADQYPVVHEHLFAAIVAVLGADTVTADVAAAWDRVYWIM
TH_1871|M.thermoresistible__bu IAHKHASLGVTADQYPIVHEHLFAAIVAVLGADTVTAEVAAAWDRVYWIM
MSMEG_1336|M.smegmatis_MC2_155 IGHKHASLGVTAEQYPIVHDNLFAAIVAVLGADTVTPEVAAAWDRVFWIM
MAB_3133c|M.abscessus_ATCC_199 IAHKHASLGIVAEQYPIVYEHLFAAIAEVLGG-AVTADVAKAWSEFYWLM
Mb3602|M.bovis_AF2122/97 TVKRTADG--YASNWLCDHAQVGMRIHVLAPSGNFVPTTLD--ADFLLLA
Rv3571|M.tuberculosis_H37Rv TVKRTADG--YASNWLCDHAQVGMRIHVLAPSGNFVPTTLD--ADFLLLA
MUL_4142|M.ulcerans_Agy99 TVKRTADG--YASNWLCDNAHQGMRIHVLAPSGNFVPKTLD--DDFLLLA
MAV_0590|M.avium_104 TVKRTADG--YASNWLCDNARPGMRIHVLAPSGNFVPKTLG--DDFLLMA
MMAR_0128|M.marinum_M IPRDERENGAILLCCTFARSDLVIEIHQNDGAEALPPMTPPSRRRAKVLG
: . * . . . . :
Mflv_4884|M.gilvum_PYR-GCK ADTLIALERDLYKAAGVTDGDVYRRATVVSRVDDPSGVVLITVRPEGRPF
Mvan_1541|M.vanbaalenii_PYR-1 ADTLIALEHDLYRDAGVADGDVYRRTRVVSRVDDPSGAVLITVRPMGEPF
TH_1871|M.thermoresistible__bu ADVLIDLERSLYAEAGVPAGDVYRRARVTARVDDPSGAVLLTVRPLGERF
MSMEG_1336|M.smegmatis_MC2_155 ADTLIALERNLYDEAGVEPGDVYRRLRVVGRVDDPSGAVLVTVRAAEP--
MAB_3133c|M.abscessus_ATCC_199 ADELIAREKALYDAAGVAPGDVWLQAIVVRRQLESADVAGFELRGVSGKL
Mb3602|M.bovis_AF2122/97 AGSGITPIMSICKSALAEGG--GQVTLLYANRDDRSVIFGDALR------
Rv3571|M.tuberculosis_H37Rv AGSGITPIMSICKSALAEGG--GQVTLLYANRDDRSVIFGDALR------
MUL_4142|M.ulcerans_Agy99 AGSGITPIMSICKSALAEGG--GQVTLLYANRDERSVIFADALR------
MAV_0590|M.avium_104 AGSGITPIMSIAKSALSEGS--GRVTLLYANRDERSVIFADALR------
MMAR_0128|M.marinum_M LRTRTSNLIELRVELDDPLS--FRAGQYAEFTLDSG--------------
: . : .
Mflv_4884|M.gilvum_PYR-GCK TGSIPAQYVSVGVTLPDGARQLRQYTLVNAPGTADLTFAVKPVASVAESP
Mvan_1541|M.vanbaalenii_PYR-1 ADFRPGQYVSVGVTLPDGARQLRQYSLVNVPGDDGLTFAVKPIAAGADAP
TH_1871|M.thermoresistible__bu AEFRPGQYISVGVTLPDGARQLRQYSLVNPPGADELTFAVRPVAATPDQP
MSMEG_1336|M.smegmatis_MC2_155 VNFLPGQYVSVGVTLPDGARQLRQYSLVSVAGATDLTFAVKPVEATAAQP
MAB_3133c|M.abscessus_ATCC_199 PNFVPGQYISVQVTLPDGARQIRQYSLSRGSTAGDWRIAVKRLNVG-DTP
Mb3602|M.bovis_AF2122/97 ---------ELAAKYPD--RLTVLHWLESLQGLPSASALAKLVAPYTDRP
Rv3571|M.tuberculosis_H37Rv ---------ELAAKYPD--RLTVLHWLESLQGLPSASALAKLVAPYTDRP
MUL_4142|M.ulcerans_Agy99 ---------ELSAKYPD--RLTVVHWLESLQGLPSATALAQLAAPFTGRT
MAV_0590|M.avium_104 ---------ELSAKYPD--RLTVLHWLESLQGLPSVTALAQLAAPYTDRP
MMAR_0128|M.marinum_M --------------------ERRSYSLVNPPS------SARELTFCIKRV
: * .:
Mflv_4884|M.gilvum_PYR-GCK AGEVSSWISANLCVGDIVDVTVPFGDLPAPDGA-APLVLISAGIGITPMI
Mvan_1541|M.vanbaalenii_PYR-1 AGEVSSWIAANVCVGDLLDVTVPFGDLPAPDGS-APVVLISAGIGVTPMI
TH_1871|M.thermoresistible__bu AGEVSTWIAANVCVGDILDITAPFGDLPTPVAG-EPLVLISAGIGITPMI
MSMEG_1336|M.smegmatis_MC2_155 AGEVSNWIRDNVCVGDLLDVTLPFGDLHTDDLSTGPVMLISAGIGITPMI
MAB_3133c|M.abscessus_ATCC_199 AGEVSNFIYDNVFEGQQLRVSVPMGEFTLDDSA-DPLVLVSAGIGCTPIM
Mb3602|M.bovis_AF2122/97 VFICGPGPFMQAARDALAALKVPAQQVHIEVFK---------SLESDPFA
Rv3571|M.tuberculosis_H37Rv VFICGPGPFMQAARDALAALKVPAQQVHIEVFK---------SLESDPFA
MUL_4142|M.ulcerans_Agy99 AFICGPGPFMEAARVALQTLDVPAGQVHIEVFK---------SLESDPFA
MAV_0590|M.avium_104 VYICGPGAFMDSAREALETLKVPAAQIHIEVFK---------SLDSDPFA
MMAR_0128|M.marinum_M PNGLFNKVLDRIEPGSTLHLEAPFGTMFLRDTE-HPVIAVATGSGIAPIL
: * . . *:
Mflv_4884|M.gilvum_PYR-GCK GILEYLAASAPEASVQVLHADRSDRVHPLRERQHELAEALPNARLDVWYE
Mvan_1541|M.vanbaalenii_PYR-1 GILEHLAASAPDTVVRVLHADRSDQTHPLRERQLELIAAMPDARLDIWYE
TH_1871|M.thermoresistible__bu GILEYLAAEARATPVRVLHADRGDRSHPLRERQRELVAALPDATLDIWYE
MSMEG_1336|M.smegmatis_MC2_155 GILEHLAAERPDAHVRVLHADRSDTAHPLRERQRELVDALPEASLDIWYE
MAB_3133c|M.abscessus_ATCC_199 GMLQELVATQSPREVVVLHADQSAAAHAYRHELADLVGRLPAGRLHTWYE
Mb3602|M.bovis_AF2122/97 AVKVDDSG--DEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFS
Rv3571|M.tuberculosis_H37Rv AVKVDDSG--DEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFS
MUL_4142|M.ulcerans_Agy99 AVTVEDSA--AEPPATAVVELDGQTHTVSWPRSAKLLDVLLAAGLDAPFS
MAV_0590|M.avium_104 AVKIEDTAEGDEPPATAVVELDGETHTVSWPRNAKLLDVLLAKGLDAPFS
MMAR_0128|M.marinum_M SMLTDAAEQHPDVPFRFYYGARFVRDLVYLDEIAALSTRLKDFRFIPCLS
.: . * : : .
Mflv_4884|M.gilvum_PYR-GCK DGVTAGAPGAHAGLMN---LSAIDLPADAHVYLCGNNGFVQAVRGQLTDR
Mvan_1541|M.vanbaalenii_PYR-1 DGLTAGTPGAHAGLMN---VGTVELPKDAQIYLCGNNGFVQAVRAQLLDR
TH_1871|M.thermoresistible__bu DGLTAGRPGVRPGLLD---LDAVELPAGAAIYLCGGTGFVQAVRDQLMAR
MSMEG_1336|M.smegmatis_MC2_155 DGVTAGMPGVHAGLLD---LDGIELPVEPQIYLCGGAGFVDAVRGQLAAR
MAB_3133c|M.abscessus_ATCC_199 R-AHVEHPADGIGRMS---LDRLPIDLSSTVFVCGPRPFMSAINEDLVSL
Mb3602|M.bovis_AF2122/97 C--REGHCGACACTLR---AGKVNMGVN------------DVLEQQDLDE
Rv3571|M.tuberculosis_H37Rv C--REGHCGACACTLR---AGKVNMGVN------------DVLEQQDLDE
MUL_4142|M.ulcerans_Agy99 C--REGHCGACAATLR---SGKVNMEVN------------DVLEQQDLDD
MAV_0590|M.avium_104 C--REGHCGACACTLR---KGQVSMEVN------------DVLEQQDLDE
MMAR_0128|M.marinum_M QQAPDPVPNGRSGRVTRAIATDIRDASPYAAYLCGAPEMCNDVGRLLEAK
: : . :
Mflv_4884|M.gilvum_PYR-GCK GFISERVHCELFSPNDWLLG-
Mvan_1541|M.vanbaalenii_PYR-1 GVVAERVHCELFSPNDWLLG-
TH_1871|M.thermoresistible__bu GVPAERVHCELFAPNDWLV--
MSMEG_1336|M.smegmatis_MC2_155 GVPAERVHCELFAPNDWLLD-
MAB_3133c|M.abscessus_ATCC_199 GIPQEQINHELFGPLASAVA-
Mb3602|M.bovis_AF2122/97 GLILACQSRPESDSVEVTYDE
Rv3571|M.tuberculosis_H37Rv GLILACQSRPESDSVEVTYDE
MUL_4142|M.ulcerans_Agy99 GLILACQSHPESDSVEVTYDE
MAV_0590|M.avium_104 GLILACQSHPESDSVEVTYDD
MMAR_0128|M.marinum_M GLPEARIHADRFYPAVESISV
*. .