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QVELPRHRKRIEDLGFEVLAPELGGRQQFSSSELLEYSSRLIGIIAGDDELDADFFAGAGKLKTVIRWGI GMDSVDHEAARRHGVTVRNTPGVFGYEVADSAFGYILNLARGYMAVDAAVRRGEWPKVEGITLDGSRLGI VGFGAIGREIAKRGAGFGQEVVAFDPFVKASPAGVSMVELDELLATSRFVVLACPLTPETFHLIDADRLA GMRSDSFLVNVARGPVVLEAALIDALKAGRLAGAALDVFEVEPLPLDSELRTLPNVVLGAHNGSNTREGV VRASNAAVEFLIEELAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4768 | - | - | 100% (298) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. gilvum PYR-GCK | Mflv_4234 | - | 2e-40 | 40.34% (238) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 2e-31 | 38.63% (233) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 1e-41 | 40.98% (244) | D-3-phosphoglycerate dehydrogenase |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 1e-41 | 40.98% (244) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 2e-40 | 39.34% (244) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 3e-40 | 40.76% (238) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 8e-41 | 40.34% (238) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_3847 | serA | 5e-43 | 42.02% (238) | D-3-phosphoglycerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6299 | - | 2e-44 | 44.31% (255) | glyoxylate reductase |
| M. thermoresistible (build 8) | TH_2037 | serA | 5e-42 | 41.60% (238) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 1e-40 | 40.34% (238) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 1e-40 | 40.76% (238) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 MSLPVVLIADKLAPSTVAALGDQVEVRWVDG---PDRDKLLAAVPEADAL
Rv2996c|M.tuberculosis_H37Rv MSLPVVLIADKLAPSTVAALGDQVEVRWVDG---PDRDKLLAAVPEADAL
MLBr_01692|M.leprae_Br4923 MDLPVVLIADKLAQSTVAALGDQVEVRWVDG---PDRTKLLAAVPEADAL
MMAR_1715|M.marinum_M MNLPVVLIADKLAQSTVAALGDQVEVRWVDG---PDREKLLAAVPEADAL
MUL_1952|M.ulcerans_Agy99 MNLPVVLIADKLAQSTVAALGDQVEVRWVDG---PDREKLLAAVPEADAL
MAV_3847|M.avium_104 MNLPVVLIADKLAESTVAALGDQVEVRWVDG---PDREKLLAAVPEADAL
TH_2037|M.thermoresistible__bu VSLPVVLIADKLAESTVAALGDQVEVRWVDG---PDREKLLAAVADADAL
Mvan_2128|M.vanbaalenii_PYR-1 MSLPVVLIADKLAQSTVEALGDQVEVRWVDG---PDREKLLAAVADADAL
MAB_3304c|M.abscessus_ATCC_199 -----MLIADKLAPSTVEALGDGVEVRWVDG---PDRPALLAAVPEADAL
Mflv_4768|M.gilvum_PYR-GCK MQVELPRHR-----KRIEDLGFEVLAPELGGRQQFSSSELLEYSSRLIGI
MSMEG_6299|M.smegmatis_MC2_155 MKVVVTRALPPATLSPLADVGEVWVSPHD---RPLTDDELRHAVRGAHGI
. : :* * .:
Mb3020c|M.bovis_AF2122/97 LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATARGVLVVNAPT
Rv2996c|M.tuberculosis_H37Rv LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATARGVLVVNAPT
MLBr_01692|M.leprae_Br4923 LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATARGVLVVNAPT
MMAR_1715|M.marinum_M LVRSATTVDAEVLAAAT-KLKIVARAGVGLDNVDVDAATTRGVLVVNAPT
MUL_1952|M.ulcerans_Agy99 LVRSATTVDAEVLAAAT-KLKIVARAGVGLDNVDVDAATTRGVLVVNAPT
MAV_3847|M.avium_104 LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATERGVLVVNAPT
TH_2037|M.thermoresistible__bu LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVEAATARGVLVVNAPT
Mvan_2128|M.vanbaalenii_PYR-1 LVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATARGVLVVNAPT
MAB_3304c|M.abscessus_ATCC_199 LVRSATTVDAEVLAAGT-KLKIVARAGVGLDNVDVKAATARGVLVVNAPT
Mflv_4768|M.gilvum_PYR-GCK IAG-DDELDADFFAGAG-KLKTVIRWGIGMDSVDHEAARRHGVTVRNTPG
MSMEG_6299|M.smegmatis_MC2_155 VSMLNDRIDERVLAAAGDQLRVVANTAVGYDNLDVAAIARHGATATNTPG
: :* .:*.. :*: * . .:* *.:* * :*. . *:*
Mb3020c|M.bovis_AF2122/97 SNIHSAAEHALALLLAASRQIPAADASLREHT---WKRSSFSGTEIFGKT
Rv2996c|M.tuberculosis_H37Rv SNIHSAAEHALALLLAASRQIPAADASLREHT---WKRSSFSGTEIFGKT
MLBr_01692|M.leprae_Br4923 SNIHSAAEHALALLLAASRQIAEADASLRAHI---WKRSSFSGTEIFGKT
MMAR_1715|M.marinum_M SNIHSAAEHAMALLLAAARQIPAADASLREHT---WKRSSFSGAEIFGKT
MUL_1952|M.ulcerans_Agy99 SNIHSAAEHAMALLLAAARQIPAADASLREHT---WKRSSFSGAEIFGKT
MAV_3847|M.avium_104 SNIHSAAEHALALLLAAAREIPAADASLREHT---WKRSSFSGTEIFGKT
TH_2037|M.thermoresistible__bu SNIHSAAEHAIALLLAAARQIPAADATLRQRT---WKRSEFSGVEIYDKT
Mvan_2128|M.vanbaalenii_PYR-1 SNIHSAAEHALALLLAAARQIPAADATLREHS---WKRSSFSGTEIFGKT
MAB_3304c|M.abscessus_ATCC_199 SNIHSAAEHAVTLLLATARQIPAADASLKAHT---WKRSSFNGTEIFGKT
Mflv_4768|M.gilvum_PYR-GCK VFGYEVADSAFGYILNLARGYMAVDAAVRRGE---WPK--VEGITLDGSR
MSMEG_6299|M.smegmatis_MC2_155 VLVDATADLTMALLLDVTRRVSEGDRLIRSGQPWSWDIGFMLGTGLQGKQ
.*: :. :* :* * :: * . * : ..
Mb3020c|M.bovis_AF2122/97 VGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLL
Rv2996c|M.tuberculosis_H37Rv VGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLL
MLBr_01692|M.leprae_Br4923 VGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLL
MMAR_1715|M.marinum_M VGVVGLGRIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLL
MUL_1952|M.ulcerans_Agy99 VGVVGLGRIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLL
MAV_3847|M.avium_104 VGVVGLGRIGQLVAQRLSAFGTHLIAYDPYVSPARAAQLGIELLSLDELL
TH_2037|M.thermoresistible__bu VGVVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQLGIELVDLDELL
Mvan_2128|M.vanbaalenii_PYR-1 VGVVGLGRIGQLVAQRLAAFGAHITAYDPYVSHARAAQLGIELLTLDELL
MAB_3304c|M.abscessus_ATCC_199 VGVVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLGIELLTLDELL
Mflv_4768|M.gilvum_PYR-GCK LGIVGFGAIGREIAKRGAGFGQEVVAFDPFVK---ASPAGVSMVELDELL
MSMEG_6299|M.smegmatis_MC2_155 LGIVGMGHIGRAVARRATAFGVRVVYHARRAQ---DDGIGR-RVPLDELL
:*:**:* **: .* * .** : . . * : :*:**
Mb3020c|M.bovis_AF2122/97 ARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALAD
Rv2996c|M.tuberculosis_H37Rv ARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALAD
MLBr_01692|M.leprae_Br4923 ARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALAD
MMAR_1715|M.marinum_M ARADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAE
MUL_1952|M.ulcerans_Agy99 ARADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAE
MAV_3847|M.avium_104 ARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAALAD
TH_2037|M.thermoresistible__bu GRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARGGLIDEQALAD
Mvan_2128|M.vanbaalenii_PYR-1 GRADFISVHLPKTKETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALAD
MAB_3304c|M.abscessus_ATCC_199 GRADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALAD
Mflv_4768|M.gilvum_PYR-GCK ATSRFVVLACPLTPETFHLIDADRLAGMRSDSFLVNVARGPVVLEAALID
MSMEG_6299|M.smegmatis_MC2_155 ATSDIVSLHCPLTIETRHLIDAEALGAMKPGSYLINTARGPIVDESALAD
. : :: : * * ** *:. : *. :.. ::*.*** :: * ** :
Mb3020c|M.bovis_AF2122/97 AITGGHVRAAGLDVFATEP-CTDSPLFELAQVVVTPHLGASTAEAQDRAG
Rv2996c|M.tuberculosis_H37Rv AITGGHVRAAGLDVFATEP-CTDSPLFELAQVVVTPHLGASTAEAQDRAG
MLBr_01692|M.leprae_Br4923 AVRSGHVRAAGLDVFATEP-CTDSPLFELSQVVVTPHLGASTAEAQDRAG
MMAR_1715|M.marinum_M AITSGHVRGAGLDVFATEP-CTDSPLFELPQVVVTPHLGASTAEAQDRAG
MUL_1952|M.ulcerans_Agy99 AITSGYVRGAGLDVFATEP-CTDSPLFELPQVVVTPHLGASTAEAQDRAG
MAV_3847|M.avium_104 AVRSGHVRAAGLDVFSKEP-CTDSPLFELPQVVVTPHLGASTTEAQDRAG
TH_2037|M.thermoresistible__bu AIISGRVRAAGIDVFAKEP-CTDSPLFDLPQVVVTPHLGASTVEAQDRAG
Mvan_2128|M.vanbaalenii_PYR-1 AINSGHVRGAGLDVFSTEP-CTDSPLFELPQVVVTPHLGASTVEAQDRAG
MAB_3304c|M.abscessus_ATCC_199 AIRSGHVRGAGLDVFSTEP-CTDSPLFELDQVVVTPHLGASTSEAQDRAG
Mflv_4768|M.gilvum_PYR-GCK ALKAGRLAGAALDVFEVEPLPLDSELRTLPNVVLGAHNGSNTREGVVRAS
MSMEG_6299|M.smegmatis_MC2_155 ALARGGIAGAALDVYEHEP-EVHPGLRELPNVVLAPHLGSATVETRTLMA
*: * : .*.:**: ** .. * * :**: .* *: * * .
Mb3020c|M.bovis_AF2122/97 TDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSD
Rv2996c|M.tuberculosis_H37Rv TDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSD
MLBr_01692|M.leprae_Br4923 TDVAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSD
MMAR_1715|M.marinum_M TDVAASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSD
MUL_1952|M.ulcerans_Agy99 TDVAASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSD
MAV_3847|M.avium_104 TDVAASVKLALAGEFVPDAVNVAGGTVNEEVAPWLDLVRKLGLLAATLSD
TH_2037|M.thermoresistible__bu TDVAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARKLGLLVGTLSG
Mvan_2128|M.vanbaalenii_PYR-1 TDVAASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGVLSS
MAB_3304c|M.abscessus_ATCC_199 TDVAASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVVRKLGVLIGAVSE
Mflv_4768|M.gilvum_PYR-GCK NAAVEFLIEELAR-------------------------------------
MSMEG_6299|M.smegmatis_MC2_155 ELAVKNVVQTLNDSGPVTPIAVPSG-------------------------
.. : *
Mb3020c|M.bovis_AF2122/97 ELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAE
Rv2996c|M.tuberculosis_H37Rv ELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAE
MLBr_01692|M.leprae_Br4923 ELPASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAE
MMAR_1715|M.marinum_M EPPVSLSVQARGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAE
MUL_1952|M.ulcerans_Agy99 EPPVSLSVQAGGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAE
MAV_3847|M.avium_104 GPPVSLSVQVRGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAEE
TH_2037|M.thermoresistible__bu EPTATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVTYVNAPTLAAE
Mvan_2128|M.vanbaalenii_PYR-1 EPPVSLQVQVQGELASEEVEVLKLSALRGLFSAVIEHPVTFVNAPALASE
MAB_3304c|M.abscessus_ATCC_199 QLPTSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEE
Mflv_4768|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6299|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 RGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQI
Rv2996c|M.tuberculosis_H37Rv RGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQI
MLBr_01692|M.leprae_Br4923 RGVSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQV
MMAR_1715|M.marinum_M RGVSVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQI
MUL_1952|M.ulcerans_Agy99 RGVSVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQI
MAV_3847|M.avium_104 RGVTAEISTASESPNHRSVVDVRAVSHDGTVVNVAGTLSGPQLVEKIVQI
TH_2037|M.thermoresistible__bu RGMQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSGPQQVEKIVQI
Mvan_2128|M.vanbaalenii_PYR-1 RGVEASITTATESANHRSVVDVRAVAADGSTVNVAGTLTGPQLVEKIVQI
MAB_3304c|M.abscessus_ATCC_199 RGVSAEITTATESPNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQI
Mflv_4768|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6299|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 NGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEG
Rv2996c|M.tuberculosis_H37Rv NGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEG
MLBr_01692|M.leprae_Br4923 NGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEG
MMAR_1715|M.marinum_M NGRHFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEG
MUL_1952|M.ulcerans_Agy99 NGRHFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEG
MAV_3847|M.avium_104 NGRNFDLRARGINLVINYVDQPGALGKIGTLLGSAGVNIQAAQLSEDAEG
TH_2037|M.thermoresistible__bu NGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNILAAQLSQDISG
Mvan_2128|M.vanbaalenii_PYR-1 NGRNLELRAEGVNLIINYDDQPGALGKIGTLLGGAAVNILAAQLSQDADG
MAB_3304c|M.abscessus_ATCC_199 NGRNFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQLSQDASG
Mflv_4768|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6299|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 PGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv PGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 PGATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MMAR_1715|M.marinum_M PGATVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MUL_1952|M.ulcerans_Agy99 PGATVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MAV_3847|M.avium_104 PGATILLRLDQDVPADVRSAIGAAVGANKLEVVDLS
TH_2037|M.thermoresistible__bu DGATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
Mvan_2128|M.vanbaalenii_PYR-1 IGATVMLRLDREVPGEVLAAIGRDVNAVTLEVVDLT
MAB_3304c|M.abscessus_ATCC_199 AAATIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
Mflv_4768|M.gilvum_PYR-GCK ------------------------------------
MSMEG_6299|M.smegmatis_MC2_155 ------------------------------------