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KQPDQREAEAAAADPWMTPERISLRNLAMSFTQKEIVPHLQDWEDAGELPRELHRRAAAAGLLGIGFAEE IGGSGGDLRDLVLLTEAVMEAGGSSGLLASLLTHHIAVPHMAAQGDPEQIRSFVAPTLAGEKIGSLGITE PDTGSDVAGIRTTARRDGDHYVVNGAKLFITSGVRADFVTTAVRTGGPGPSGISLLVVERGATGFLVSRA LKKMGWLCSDTAELGFTDVRVPVVNLVGPEGSGFLQIMQQFQVERAFIAVQCYATAQRCLDLTLDWVKKR ETFGRPLSTRQVVRHKIVDIATAVDVARTYTRAAVDRIVAGDTDVRMVSMAKNQAVEACALAVDTAVQLY GGMGYLRETEVERHYRDSRILGIGGGTTEIMKEIIAKQIGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4612 | - | - | 100% (392) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1884 | - | e-121 | 57.71% (376) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4558 | - | 5e-73 | 40.27% (375) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1000c | fadE13 | 1e-111 | 58.09% (346) | acyl-CoA dehydrogenase FADE13 |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 1e-124 | 59.04% (376) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-48 | 32.17% (373) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2085 | - | 1e-140 | 64.74% (380) | acyl CoA dehydrogenase |
| M. marinum M | MMAR_4532 | fadE13 | 1e-127 | 59.31% (376) | acyl-CoA dehydrogenase FadE13 |
| M. avium 104 | MAV_1091 | - | 1e-129 | 61.17% (376) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5491 | - | 1e-123 | 58.51% (376) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3610 | - | 8e-70 | 39.84% (379) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 1e-125 | 58.51% (376) | acyl-CoA dehydrogenase FadE13 |
| M. vanbaalenii PYR-1 | Mvan_4847 | - | 1e-118 | 56.32% (380) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4612|M.gilvum_PYR-GCK MKQP-------DQREAEAAAADPWMTPERISLRNLAMSFTQKEIVPHLQD
MAB_2085|M.abscessus_ATCC_1997 MTDAGTTTASEDGAARFVVAPEAWTTPERRALSQMARSFVEREIAPKLAE
MMAR_4532|M.marinum_M --------------------MSIWNTPEREELRKTVRSFAEREVLPHIDE
MUL_4704|M.ulcerans_Agy99 --------------------MSIWNTPEREELRKSVRSFAEREVLPHIDE
MAV_1091|M.avium_104 --------------------MNLWTTPEREQLRKTVRSFAEREILPHVDE
Mb1000c|M.bovis_AF2122/97 --------------------MNIWTTPERQQLRKTVRAFAEREILPHVDE
Rv0975c|M.tuberculosis_H37Rv --------------------MNIWTTPERQQLRKTVRAFAEREILPHVDE
MSMEG_5491|M.smegmatis_MC2_155 --------------------MSIWTTAEREALRKTVRAFAEREVLPHAHE
Mvan_4847|M.vanbaalenii_PYR-1 --------------------MSIWTTPERDDLRKTVRAFVEREVLPHAGE
TH_3610|M.thermoresistible__bu -------------------VRREVFTDDHEAFRELARDFIEKEVVPNYPD
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
. :: : : ::*: *: :
Mflv_4612|M.gilvum_PYR-GCK WEDAGELPRELHRRAAAAGLLGIGFAEEIGGSGGDLRDLVLLTEAVMEAG
MAB_2085|M.abscessus_ATCC_1997 WEHVGEIPRDLHLNAAEVGLLGIGFPEEVGGSGGNAIDSALVTEAILAAG
MMAR_4532|M.marinum_M WERTGELPRDLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSG
MUL_4704|M.ulcerans_Agy99 WERTGELPLDLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSG
MAV_1091|M.avium_104 WERSGELPRELHRSAGAAGLLGAGFPESVGGGGGDGADAVIICEEMHQAG
Mb1000c|M.bovis_AF2122/97 WERIGELPRGLHRLAGAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAG
Rv0975c|M.tuberculosis_H37Rv WERIGELPRGLHRLAGAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAG
MSMEG_5491|M.smegmatis_MC2_155 WERAGEIPRELHRKAAELGLLGAGFPEDAGGSGGDGADPVVICEEMHYAG
Mvan_4847|M.vanbaalenii_PYR-1 WERIGELPRELHRKAAEVGLLGAGFPESVGGGGGDGADAVVICEEMHRAG
TH_3610|M.thermoresistible__bu WEKAGRMPREAFELMGSLGMLGMAIPEQYGGAGIVDYRYNVVLQEEAAR-
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
: ..:* *: . ..* ** * :: :
Mflv_4612|M.gilvum_PYR-GCK GSSGLLASLLTHHIAVPHMAAQGDPEQIRSFVAPTLAGEKIGSLGITEPD
MAB_2085|M.abscessus_ATCC_1997 GSTGVCAALFTHGIALPHIAANGSDALIERYVRPTLAGKMIGSLGVTEPG
MMAR_4532|M.marinum_M APGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGDKIGALAITEPG
MUL_4704|M.ulcerans_Agy99 APGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALAITEPG
MAV_1091|M.avium_104 APGGVFASLFTCGIAVPHMIASGDQRLIEEFVRPTLAGEKIGSLAITEPG
Mb1000c|M.bovis_AF2122/97 APGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPG
Rv0975c|M.tuberculosis_H37Rv APGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPG
MSMEG_5491|M.smegmatis_MC2_155 SPGGVYASLFTCGIAVPHMIASGDQRLIDTYVRPTLRGEKIGALAITEPG
Mvan_4847|M.vanbaalenii_PYR-1 APGGVFASLFTSGIAVPHMIASGDEHLIDTYVRPTLRGEKIGALAITEPG
TH_3610|M.thermoresistible__bu ALVTLSTVRTQLDVILPYFLHYADEEQRARWFPGLAAGKLLTAIAMTEPG
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSERE
. : . : .. . : : .::*
Mflv_4612|M.gilvum_PYR-GCK TGSDVAGIRTTARRDGDHYVVNGAKLFITSGVRADFVTTAVRTGGPGPS-
MAB_2085|M.abscessus_ATCC_1997 AGSDVANLRTRAVREGDTYVVNGAKTFITSGVRADFVTTAVRTGGPGYG-
MMAR_4532|M.marinum_M GGSDVGHLRTSAVRDGDHFIVNGAKTYITSGVRADFVVTAVRTGGPGAG-
MUL_4704|M.ulcerans_Agy99 GGSDVGHLRTSAVREGDHFIVNGAKTYITSGVRADFVVTAVRTGGPGAG-
MAV_1091|M.avium_104 GGSDVGHLRTSAVRDGDHYIVNGAKTYITSGVRADYVVTAVRTGGPGAA-
Mb1000c|M.bovis_AF2122/97 GGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTGGPGAA-
Rv0975c|M.tuberculosis_H37Rv GGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTGGPGAA-
MSMEG_5491|M.smegmatis_MC2_155 GGSDVGHLRTRADLDGDHYVINGAKTYITSGVRADYVVTAARTGGPGAG-
Mvan_4847|M.vanbaalenii_PYR-1 GGSDVGHLTTRAVKDGDCYILNGAKTFITSGVRADYVVTAVRTGGPGAG-
TH_3610|M.thermoresistible__bu TGSDLAGVRTTAVRDGDDYILNGAKTFITGGIQADLVIVVARTSTDPDNR
MLBr_00737|M.leprae_Br4923 AGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN
*** . : * * :** :::** * :**.* :: . . *.
Mflv_4612|M.gilvum_PYR-GCK --GISLLVVERG----ATGFLVSRALKKMGWLCSDTAELGFTDVRVPVVN
MAB_2085|M.abscessus_ATCC_1997 --GVSLLVIDKN----SPGFEVSRRLDKMGWRCSDTAELSFVDVRVPADN
MMAR_4532|M.marinum_M --GVSLLVVEKG----TPGFVVSRKLDKMGWRSSDTAELSYTDARVPAAN
MUL_4704|M.ulcerans_Agy99 --GVSLLVVEKG----TPGFVVSRKLDKMGWRSSDTAELSYTDARIPAAN
MAV_1091|M.avium_104 --GVSLLVVEKG----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVSN
Mb1000c|M.bovis_AF2122/97 --GVSLLVVEKD----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATN
Rv0975c|M.tuberculosis_H37Rv --GVSLLVVEKD----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATN
MSMEG_5491|M.smegmatis_MC2_155 --GVSLIVVDKG----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVAN
Mvan_4847|M.vanbaalenii_PYR-1 --GISLIVVDKDGPGCSPGLQVTRKLDKMGWRSSDTAELSYTDARVPAGN
TH_3610|M.thermoresistible__bu RRGLTLLVVEDG----MPGFTRGRELEKMGCKVQDTAELSFTDVRVPVAN
MLBr_00737|M.leprae_Br4923 --GISAFIVHKD----DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDR
*:: :::. . *: .*:* . *:** : . :* .
Mflv_4612|M.gilvum_PYR-GCK LVGPEGSGFLQIMQQFQVERAFIAVQCYATAQRCLDLTLDWVKKRETFGR
MAB_2085|M.abscessus_ATCC_1997 LVGAENSGFLQIMQQFQAERLGIAVQAYATAGRALDLAKSWARERETFGR
MMAR_4532|M.marinum_M LVGAENSGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGR
MUL_4704|M.ulcerans_Agy99 LVGAENSGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGR
MAV_1091|M.avium_104 LVGAENTGFAQIAQAFVSERIGLAAQAYSSAQRCLDLTVQWCRDRETFGR
Mb1000c|M.bovis_AF2122/97 LVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGR
Rv0975c|M.tuberculosis_H37Rv LVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGR
MSMEG_5491|M.smegmatis_MC2_155 LVGSENTGFAQIAAAFVAERVGLATQAYAGAQRCLDLTVEWCRNRDTFGR
Mvan_4847|M.vanbaalenii_PYR-1 LVGAENTGFLQIAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRSRETFGK
TH_3610|M.thermoresistible__bu RLGEEGEAFSYLGHNLAQERMTVAVGSVAQARSAIDTTIEYVKSRKAFGT
MLBr_00737|M.leprae_Br4923 IIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGE
:* . .* : * :.. . . * .:* : : :.*. **
Mflv_4612|M.gilvum_PYR-GCK PLSTRQVVRHKIVDIATAVDVARTYTRAAVDRIVAGDT-DVRMVSMAKNQ
MAB_2085|M.abscessus_ATCC_1997 PLTGRQIIRHKLAEMARQVDVACTYTRAVMQRWLAGED-VVAEVSMAKNT
MMAR_4532|M.marinum_M PLISRQSVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNT
MUL_4704|M.ulcerans_Agy99 PLISRQSVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNT
MAV_1091|M.avium_104 PLISRQSVQNTLAEMARRIDVARVYSRNVVERQLAGETNLIPQVCFAKNT
Mb1000c|M.bovis_AF2122/97 PLISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNT
Rv0975c|M.tuberculosis_H37Rv PLISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNT
MSMEG_5491|M.smegmatis_MC2_155 PLISRQAVQNTLAGMARRIDVARVYTRHVVERQLAGETNLIAEVCFAKNT
Mvan_4847|M.vanbaalenii_PYR-1 PLITRQSVQNTLAEMARRIDVARVYTHHVVERELAGETNLIAEVCFAKNT
TH_3610|M.thermoresistible__bu PVASFQNTKFELAACSAEVEAAQAMLDRAVLDLVDGQL-SGADAARVKLF
MLBr_00737|M.leprae_Br4923 SISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCF
.: * : :. : ::.* . *: . *
Mflv_4612|M.gilvum_PYR-GCK AVEACALAVDTAVQLYGGMGYLRETEVERHYRDSRILGIGGGTTEIMKEI
MAB_2085|M.abscessus_ATCC_1997 AVYACDYVVNEAVQIFGGMGYMRESEIERHYRDCRILGIGGGTNEIMNEV
MMAR_4532|M.marinum_M AVEAGEWVANQAVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTAL
MUL_4704|M.ulcerans_Agy99 AVEAGEWVANQAVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTAL
MAV_1091|M.avium_104 AVEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTAL
Mb1000c|M.bovis_AF2122/97 AVQAGEWVANQAVQLFGGMGYMAESEAN----------ANTGTCESSVSE
Rv0975c|M.tuberculosis_H37Rv AVQAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTAL
MSMEG_5491|M.smegmatis_MC2_155 AVEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTSL
Mvan_4847|M.vanbaalenii_PYR-1 AVDAGEWVAHQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTSEILTAL
TH_3610|M.thermoresistible__bu CTEMQARVVDRCLQLFGGYGYMMEYPIARLYTDARVARIYAGTSEVMKVI
MLBr_00737|M.leprae_Br4923 ASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVV
. .. .:*::** ** : ** :
Mflv_4612|M.gilvum_PYR-GCK IAKQIGL--
MAB_2085|M.abscessus_ATCC_1997 IAKRIGL--
MMAR_4532|M.marinum_M AAKLLGYQS
MUL_4704|M.ulcerans_Agy99 AAKLLGYQS
MAV_1091|M.avium_104 SAKLLGFQS
Mb1000c|M.bovis_AF2122/97 AAPPK-Y--
Rv0975c|M.tuberculosis_H37Rv AAKTLGYQS
MSMEG_5491|M.smegmatis_MC2_155 AAKTLGFQS
Mvan_4847|M.vanbaalenii_PYR-1 AAKTLGYQS
TH_3610|M.thermoresistible__bu IAKSLGL--
MLBr_00737|M.leprae_Br4923 MSRALLR--
: