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MTSSVSTIDARPDLSVGKQIMHRRRSAESFALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHR VDAKIRSVQLPDCAAELVCANGVSADRAILYLHGGAFMTCGINTHRSLVARLSREADAAVLNVGYRMLPK YGLAEAIDDAVAGLRWLQEQGYTSDQIVIAGDSAGGYLALATALQLSSRGEVPAAGIAAISPLTDLDPAS KLEHPNARKCAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPVTVHVSADESLYSDSE LLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEGRRALRYVGDFVKQTTGTRLANVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0267 | - | - | 100% (338) | esterase |
| M. smegmatis MC2 155 | MSMEG_5271 | - | 2e-57 | 40.27% (298) | esterase |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 2e-23 | 32.43% (222) | acetyl-hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 6e-61 | 43.92% (296) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_2042 | - | 2e-56 | 38.83% (309) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 6e-61 | 43.92% (296) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 5e-57 | 40.53% (301) | putative esterase |
| M. abscessus ATCC 19977 | MAB_1194 | - | 1e-53 | 39.04% (333) | putative lipase LipU |
| M. marinum M | MMAR_4391 | lipU | 3e-60 | 43.28% (305) | lipase LipU |
| M. avium 104 | MAV_3011 | - | 8e-97 | 54.37% (320) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-62 | 44.30% (298) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_0204 | lipU | 5e-59 | 43.99% (291) | lipase LipU |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 1e-56 | 41.25% (303) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4391|M.marinum_M MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPSVAA
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00314|M.leprae_Br4923 ------------------------------MAISAGAPVEIVESGPSIAA
Mflv_2042|M.gilvum_PYR-GCK MTAPSKVPATPHVAINAARGRKQR-----RFPVSDGAPVEVVEDGPSVAG
Mvan_4675|M.vanbaalenii_PYR-1 MTAPSKVPATPHAAIAAARAGKIR-----RFPVSDGAPVEVVEDGPSIAG
TH_1370|M.thermoresistible__bu MTAPSKVPRTSPLATRAARGHYSR-----TFPVSDGTPSEYVEDGPSLAG
MAB_1194|M.abscessus_ATCC_1997 MTAPKRAPEYGPAG-SARSSLSAVNTLVRGLPLSDGAAVEVIEDAASLAG
MSMEG_0267|M.smegmatis_MC2_155 ---------------------MTSSVSTIDARPDLSVGKQIMHRRRSAES
MAV_3011|M.avium_104 ----------------------------------MATTRRVHHR-HSPQS
MMAR_4391|M.marinum_M RVATLASRLTIRPVLAVGSHVPHLPWPWGLIDHAAKALVPA-SATVRAAV
MUL_0204|M.ulcerans_Agy99 -------------MLAVGSHVPHLPWPWGLIDHAAKALVPA-SATVRAAV
Mb1105|M.bovis_AF2122/97 --------MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPA-STTVRAAV
Rv1076|M.tuberculosis_H37Rv --------MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPA-STTVRAAV
MLBr_00314|M.leprae_Br4923 RLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPV-TNAARAEV
Mflv_2042|M.gilvum_PYR-GCK RVLGLAAMATIKPFLTVGSYAPKLPWPWGLVDFAARVLKPA-PGTVRATI
Mvan_4675|M.vanbaalenii_PYR-1 RLMGLAAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPA-PGTVRATI
TH_1370|M.thermoresistible__bu RLTALAAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPV-PGTVRATI
MAB_1194|M.abscessus_ATCC_1997 RLLGFGVRMTVRTVLQIGSHAPTFPYPFGLIEELGRVLVPP-RGTVKATV
MSMEG_0267|M.smegmatis_MC2_155 FALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHR-VDAKIRSV
MAV_3011|M.avium_104 VAVSLASRLIVKNAVRAWALTPNLHWPLEYVDSFAGLVPRLGSAGTTHPV
: : * :* :: : :
MMAR_4391|M.marinum_M SLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRLVELLSK
MUL_0204|M.ulcerans_Agy99 SLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRFFELLSK
Mb1105|M.bovis_AF2122/97 SLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSK
Rv1076|M.tuberculosis_H37Rv SLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSK
MLBr_00314|M.leprae_Br4923 NLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETLSK
Mflv_2042|M.gilvum_PYR-GCK KLPHCTAQLVRAAGVLPADGNRTVILYLHGGAFLTCGVNTHGRLVTALSK
Mvan_4675|M.vanbaalenii_PYR-1 GLPHCNAQLVRAAGVLPADGHRSVILYLHGGAFLTCGVNTHGRLVTALSK
TH_1370|M.thermoresistible__bu RLPHCTAQLVRAPGVLPADGRRSVVLYLHGGAFLTCGAHTHGRLVTALSE
MAB_1194|M.abscessus_ATCC_1997 TLPNTNARLIRAKGVGPADGTGRVVLYLHGGAFIVGGPNTHSAMVSTISQ
MSMEG_0267|M.smegmatis_MC2_155 QLPDCAAELVCANGVSAD----RAILYLHGGAFMTCGINTHRSLVARLSR
MAV_3011|M.avium_104 RLEHCAAEWVRAPGVSGE----RAILYLHGGAFLTCGLNTHRPMVTRLSK
* . *. : * ** :********: * ::* :. :*.
MMAR_4391|M.marinum_M FADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGDSA
MUL_0204|M.ulcerans_Agy99 FADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGDSA
Mb1105|M.bovis_AF2122/97 FADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSA
Rv1076|M.tuberculosis_H37Rv FADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSA
MLBr_00314|M.leprae_Br4923 LADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIVLAGDSA
Mflv_2042|M.gilvum_PYR-GCK CADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQIVLAGDSA
Mvan_4675|M.vanbaalenii_PYR-1 CADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQIVLAGDSA
TH_1370|M.thermoresistible__bu FADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQIVLAGDSA
MAB_1194|M.abscessus_ATCC_1997 HADAPCLVVNYRMPPKASLDQAIDDCLDGYRWLRAQGYAAEQIVLAGDSA
MSMEG_0267|M.smegmatis_MC2_155 EADAAVLNVGYRMLPKYGLAEAIDDAVAGLRWLQEQGYTSDQIVIAGDSA
MAV_3011|M.avium_104 AADAAVLAVAYRKLPAHQITDAIDDGLDGLRWLQDRGFDGDRVVVAGDSA
**:. * * ** * : *:** . :**: *: :::*:*****
MMAR_4391|M.marinum_M GGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNIKR
MUL_0204|M.ulcerans_Agy99 GGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNIKR
Mb1105|M.bovis_AF2122/97 GGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHPNIKT
Rv1076|M.tuberculosis_H37Rv GGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHPNIKT
MLBr_00314|M.leprae_Br4923 GGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQAHPNAKT
Mflv_2042|M.gilvum_PYR-GCK GGYLALALAEKLQAEGINGYVGETPAAVVTMSPLFEIDNEARADHPNVRT
Mvan_4675|M.vanbaalenii_PYR-1 GGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARADHPNVRT
TH_1370|M.thermoresistible__bu GGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQHPNIRT
MAB_1194|M.abscessus_ATCC_1997 GGFLSVAVAERLLAED-----GEAPAALALISPLIELDPAAKVAHENART
MSMEG_0267|M.smegmatis_MC2_155 GGYLALATALQLSSRG-----EVPAAGIAAISPLTDLDPASKLEHPNARK
MAV_3011|M.avium_104 GGYLAFMTTLLAIQNE-----VMEPAGIATVSPFTDTDPARKLKHRNARK
**:*:. : .*.:. :**: : : * * :
MMAR_4391|M.marinum_M DAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGLPRTLIHV
MUL_0204|M.ulcerans_Agy99 DAMFPPKAFDALGELVASAAAKNRVDGKPEELYEPLEHIRPGLPRTLIHV
Mb1105|M.bovis_AF2122/97 DAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHV
Rv1076|M.tuberculosis_H37Rv DAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHV
MLBr_00314|M.leprae_Br4923 DAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHV
Mflv_2042|M.gilvum_PYR-GCK DSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGLPRTLIHV
Mvan_4675|M.vanbaalenii_PYR-1 DAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTLIHV
TH_1370|M.thermoresistible__bu DAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTLIHV
MAB_1194|M.abscessus_ATCC_1997 DVMLPPNCFEALEKILTKAGG-----GIPP--QEIIDKVDGRMPQTLVHC
MSMEG_0267|M.smegmatis_MC2_155 CAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPVTVHV
MAV_3011|M.avium_104 CSMFTCRAFSRFAEYLS--NAQVLEGHGDSTVASPVDADLSSLPPVTIHA
*:. .: : : . : :* . :*
MMAR_4391|M.marinum_M SGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATRSL
MUL_0204|M.ulcerans_Agy99 SGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATRSL
Mb1105|M.bovis_AF2122/97 SGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSL
Rv1076|M.tuberculosis_H37Rv SGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSL
MLBr_00314|M.leprae_Br4923 SGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSL
Mflv_2042|M.gilvum_PYR-GCK SGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMVPEASRSI
Mvan_4675|M.vanbaalenii_PYR-1 SGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEANRSI
TH_1370|M.thermoresistible__bu SGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAKRSL
MAB_1194|M.abscessus_ATCC_1997 SGSEVLLYDARLLGKRLAEQGVPVEIKIWPGQMHVFQVATKVVPEAKRSL
MSMEG_0267|M.smegmatis_MC2_155 SADESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEGRRAL
MAV_3011|M.avium_104 SSDELLVADAELMAKRLEASGIHCDLHLWDGQIHDFPLAADVLPEGRRAI
*..* * *:. . * : ::::* **:* * . :.*. ::
MMAR_4391|M.marinum_M RQIGDYIREATG-----------------
MUL_0204|M.ulcerans_Agy99 RQIGDYIREATG-----------------
Mb1105|M.bovis_AF2122/97 RQIGEYIREATG-----------------
Rv1076|M.tuberculosis_H37Rv RQIGEYIREATG-----------------
MLBr_00314|M.leprae_Br4923 RQISQYIREATASKASRDRQSL-------
Mflv_2042|M.gilvum_PYR-GCK KQIGEYIREATW-----------------
Mvan_4675|M.vanbaalenii_PYR-1 KQIGEYIREATW-----------------
TH_1370|M.thermoresistible__bu RQIGEYIREATW-----------------
MAB_1194|M.abscessus_ATCC_1997 AQIGQYIRDAVPGTFPAEFAAPAAV----
MSMEG_0267|M.smegmatis_MC2_155 RYVGDFVKQTT--GTRLANVS--------
MAV_3011|M.avium_104 KYLGDFVKDVTAAGTRFSNVRRLRTAAAG
:.:::::..