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MLVSSRPTPLVTTMLDLIDSASANDLPSLRIGVASGSAVSRAGDWFGNPVNLASRVSAAARPGAVLVGLH AGDRRRRRPPVVVRRRISSEGRQQQGQPVSGAARPGRPSKAPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4600 | - | - | 100% (113) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_2243 | - | 6e-19 | 63.24% (68) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_2823 | - | 7e-09 | 41.79% (67) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 2e-18 | 63.24% (68) | adenylyl cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 2e-18 | 63.24% (68) | adenylyl cyclase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4771 | - | 3e-08 | 46.51% (43) | putative adenylate cyclase |
| M. marinum M | MMAR_0157 | cyaA | 9e-19 | 65.67% (67) | adenylate cyclase, CyaA |
| M. avium 104 | MAV_1415 | - | 4e-18 | 60.29% (68) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 2e-17 | 58.82% (68) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 4e-18 | 61.76% (68) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4940 | cyaA | 6e-19 | 65.67% (67) | adenylate cyclase, CyaA |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 4e-19 | 64.71% (68) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
MSMEG_5018|M.smegmatis_MC2_155 -------------MVSQQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
Mb1295|M.bovis_AF2122/97 MT----------DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MT----------DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MMAR_0157|M.marinum_M --------------MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGF
MUL_4940|M.ulcerans_Agy99 --------------MAADVDIEASGLLDGLEGTARQDRAELIAWLLERGF
Mflv_4600|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 ---------------------------------------------MPESD
TH_1842|M.thermoresistible__bu SIEEIRE-SVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRA
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRG-NPAPMLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQRA
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQ-AITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRA
Mb1295|M.bovis_AF2122/97 TPDEIRA-TNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRA
Rv1264|M.tuberculosis_H37Rv TPDEIRA-TNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRA
MAV_1415|M.avium_104 TAEEIRT-TNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRA
MMAR_0157|M.marinum_M SLEHIQASAAAPVMLPAYRVLGDDGTLVSAREICAATGIELDVLQRLQRA
MUL_4940|M.ulcerans_Agy99 SFEHIQASAAAPVMLPAYRVLGDDGTLVSAREICAATGIELDVLQRLQRA
Mflv_4600|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 ELNAVVDAAVEQVLLGGPRRYTR-------SQVSQLSGVPVERARTLWVA
TH_1842|M.thermoresistible__bu LGLPRVDDPDAVVHLRADAEAAARAQRF-IEAGVDPDQMVQIAAVLSEGL
Mvan_4452|M.vanbaalenii_PYR-1 MGLPRVDDADAQVFLRADAEAAKFTRDF-LDAGIDPDELVQITRLLGDGL
MSMEG_5018|M.smegmatis_MC2_155 MGLPAVEDPDAAVLLRADAEAVTFSQQF-IDLGIDADQVVLITRVLAEGL
Mb1295|M.bovis_AF2122/97 VGLARVDDPDAVVHMRADGEAAARAQRF-VELGLNPDQVVLVVRVLAEGL
Rv1264|M.tuberculosis_H37Rv VGLARVDDPDAVVHMRADGEAAARAQRF-VELGLNPDQVVLVVRVLAEGL
MAV_1415|M.avium_104 IGLVRVDDPDAAVHMRADGEAAAFTQRF-VDVGLDPDQVVLVAQVLAEGL
MMAR_0157|M.marinum_M VGLPRIDDPDEAVLPRADAEAVRHAKVF-LDIGYDLEDAVAVMRVLVESL
MUL_4940|M.ulcerans_Agy99 VSLPRIDDPDEAVLPRADAEAVRHAKVF-LDIGYDLEDAVAVMRVLVESL
Mflv_4600|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 LGFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQIAAARTLGQAM
TH_1842|M.thermoresistible__bu AKAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLL
Mvan_4452|M.vanbaalenii_PYR-1 SRAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLL
MSMEG_5018|M.smegmatis_MC2_155 SRAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFV
Mb1295|M.bovis_AF2122/97 SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM
Rv1264|M.tuberculosis_H37Rv SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM
MAV_1415|M.avium_104 SRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFM
MMAR_0157|M.marinum_M GHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL
MUL_4940|M.ulcerans_Agy99 GHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL
Mflv_4600|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 ARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIAT-------LT
TH_1842|M.thermoresistible__bu QLRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEEL
Mvan_4452|M.vanbaalenii_PYR-1 QLRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPEDL
MSMEG_5018|M.smegmatis_MC2_155 QLRHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQL
Mb1295|M.bovis_AF2122/97 QLRHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL
Rv1264|M.tuberculosis_H37Rv QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL
MAV_1415|M.avium_104 QLRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEEL
MMAR_0157|M.marinum_M ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDL
MUL_4940|M.ulcerans_Agy99 ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDL
Mflv_4600|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 ALQNYAWQRHLAAALHRANETGSTTRQLLVGFADMVGYTRLSRHLDPDEL
TH_1842|M.thermoresistible__bu EQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAMLE
Mvan_4452|M.vanbaalenii_PYR-1 EQLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDTLLR
MSMEG_5018|M.smegmatis_MC2_155 EQLANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPEPAA----LLDAVLN
Mb1295|M.bovis_AF2122/97 GHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLK
Rv1264|M.tuberculosis_H37Rv GHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLK
MAV_1415|M.avium_104 GQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVVLK
MMAR_0157|M.marinum_M ERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPEPAP----LLRAALD
MUL_4940|M.ulcerans_Agy99 ERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPEPAP----LLRAALD
Mflv_4600|M.gilvum_PYR-GCK ------------------------------MLVSSRPTP----LVTTMLD
MAB_4771|M.abscessus_ATCC_1997 ASLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTA
*:.. . :
TH_1842|M.thermoresistible__bu LIDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSV
Mvan_4452|M.vanbaalenii_PYR-1 LVDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPGSV
MSMEG_5018|M.smegmatis_MC2_155 LVAATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTV
Mb1295|M.bovis_AF2122/97 LVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAV
Rv1264|M.tuberculosis_H37Rv LVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAV
MAV_1415|M.avium_104 LVEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTV
MMAR_0157|M.marinum_M LAAAAAN--NLPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPGTV
MUL_4940|M.ulcerans_Agy99 LAAAAAN--NLPPLRIGVASGAAVTRAGDWFGSPVNLASRVTSIAYPGTV
Mflv_4600|M.gilvum_PYR-GCK LIDSASAN-DLPSLRIGVASGSAVSRAGDWFGNPVNLASRVSAAARPGAV
MAB_4771|M.abscessus_ATCC_1997 ITEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTI
: . ::* :* *:* * .::* ** :*. **:*:*::. * **::
TH_1842|M.thermoresistible__bu LVAEATREAIGD---DERFRWSFAGSRRLKG--IKGEVKLYRARRAE---
Mvan_4452|M.vanbaalenii_PYR-1 LVAEATREAIGE---DERFTWSFAGGKHLKG--FKSDVKTFRARRTTNL-
MSMEG_5018|M.smegmatis_MC2_155 LVAESTRQAIAAA--DDRFRWSFAGARRLKG--IKGDVKMFRARMRDQ--
Mb1295|M.bovis_AF2122/97 LVADSVREALGDAPEADGFQWSFAGPRRLRG--IRGDVRLFRVRRGATRT
Rv1264|M.tuberculosis_H37Rv LVADSVREALGDAPEADGFQWSFAGPRRLRG--IRGDVRLFRVRRGATRT
MAV_1415|M.avium_104 LVADSVWDVIGDNGEFSG---SFAGARRLKG--IKNEVKLFRVRRGG---
MMAR_0157|M.marinum_M VVAESTRDAVGN---AGDFEWFSIGAQRIRG--MRAEVKLFRVEPARPAA
MUL_4940|M.ulcerans_Agy99 VVAESTRDAVGN---AGDFEWFSIGAQRIRG--MRAEVKLFRVEPARPAG
Mflv_4600|M.gilvum_PYR-GCK LVGLHAGDRRRRRPPVVVRRRISSEGRQQQGQPVSGAARPGRPSKAPV--
MAB_4771|M.abscessus_ATCC_1997 LLDDGAAAALGD---DGEFSLRHLRGVRVKG-FSRLGSHVLRARKR----
:: . : :* : *
TH_1842|M.thermoresistible__bu ----------------
Mvan_4452|M.vanbaalenii_PYR-1 ----------------
MSMEG_5018|M.smegmatis_MC2_155 ----------------
Mb1295|M.bovis_AF2122/97 GSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv GSGGAAQDDDLAGSSP
MAV_1415|M.avium_104 ----------------
MMAR_0157|M.marinum_M RG--------------
MUL_4940|M.ulcerans_Agy99 RG--------------
Mflv_4600|M.gilvum_PYR-GCK ----------------
MAB_4771|M.abscessus_ATCC_1997 ----------------