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LTRFVRTQLIIFSIAAVVGLGSMVFVYLQAPVMLGIGRMTVTLKLPNTGGLYEFSNVTYRGIEVGKVTGI EPTGDGVTVTMSLKSSPKIPTDLKAHVRSVSAVGEQYVDLEPRSDAGPYLQDGSVITGDRSSIPQAVGPM LDQMSALVDSIPTGTLSGLLDESYAALNGSGYELGSLFDSSARLAADADSTGDRMRNLITDSEPLLDGQA QKADAITTWARSLAGITRQIADDDQAVRTILQTGPGAADEASRLLTDVKPTLPVLLANLTTVGQVGVAYH PSLEQLLVLLPPYLAATQSYGSSLNNPTGMALSEFSLTLGDPPACSVGFLPPSSWRSPADLTDVDTPDGL YCKLPQDSPIGVRGTRNFPCMEQPGKRAPTVEICQSDRPFEPLAMRQHVTGPYPIDPALIAQGVPPDDRV TLDEQIYGPLEGTPMPAPAPGAAPASVPGPVPAAGGPPVAVATYNPETGQVATPDGEVFTQSNLAAPNPA AGEGKSWQDMLPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4533 | - | - | 100% (504) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2513 | - | e-167 | 53.26% (567) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4165 | - | e-163 | 55.38% (502) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 2e-92 | 38.48% (525) | MCE-family protein MCE1F |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 2e-91 | 38.29% (525) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 5e-87 | 36.74% (528) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 1e-93 | 38.90% (509) | MCE-family protein |
| M. marinum M | MMAR_4705 | - | 1e-180 | 58.09% (544) | MCE-family protein |
| M. avium 104 | MAV_0953 | - | 1e-170 | 59.88% (506) | mce-family protein mce1f |
| M. smegmatis MC2 155 | MSMEG_2860 | - | 0.0 | 75.99% (504) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4161 | - | 0.0 | 73.57% (507) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 1e-107 | 43.17% (505) | MCE-family protein Mce3F_1 |
| M. vanbaalenii PYR-1 | Mvan_4145 | - | 1e-163 | 52.21% (565) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2860|M.smegmatis_MC2_155 -MITRFIRTQLIIFTITSVVASAMMVFSYLQAPVLFGIGRITVTLELPST
TH_4161|M.thermoresistible__bu -MLTRFVRTQLVIFTIAAVVGMGAMVFGYLQVPMLLGIGRISVTMELPST
Mflv_4533|M.gilvum_PYR-GCK -MLTRFVRTQLIIFSIAAVVGLGSMVFVYLQAPVMLGIGRMTVTLKLPNT
MMAR_4705|M.marinum_M -MLTRFVRIQLAIFAIVGMVGVAVMAVWYIQAPTLLGIGKMTVTLELPAT
MAV_0953|M.avium_104 -MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPAT
Mvan_4145|M.vanbaalenii_PYR-1 -MLTRFVRNQLIIFTIASIVGVAVMLFAYMQVPTLLGVGRLVVTLELPES
MAB_4148c|M.abscessus_ATCC_199 --MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVAS
MUL_3923|M.ulcerans_Agy99 MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVPAMVGIGQYRVTVELPEA
Mb0180|M.bovis_AF2122/97 -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
Rv0174|M.tuberculosis_H37Rv -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
MLBr_02594|M.leprae_Br4923 -MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSAT
: : *: :* . : *:: * .*:*: :. .: :
MSMEG_2860|M.smegmatis_MC2_155 GGLYRFSNVTYRGIEVGKVTDVRPTRSGALATLSLQTSPRIPADLQADVR
TH_4161|M.thermoresistible__bu GGLYRFSNVTYRGVKVGKVLDVRPTRTGAVVTMSLQSRPRIPADLQADVR
Mflv_4533|M.gilvum_PYR-GCK GGLYEFSNVTYRGIEVGKVTGIEPTGDGVTVTMSLKSSPKIPTDLKAHVR
MMAR_4705|M.marinum_M GGLYRFSNVTYRGVQIGKVTALGLTSSGAKATLALDASPKIPADLKAEVR
MAV_0953|M.avium_104 GGLYRFSNVTYRGVQLGKVTAVGLTPSGVKATLSLSTSPKVPADLTAEVL
Mvan_4145|M.vanbaalenii_PYR-1 GGLYRFSNVTYRGVQVGKVTGVSLTENGAEATLSLETSPKIPADLQAEVL
MAB_4148c|M.abscessus_ATCC_199 GGLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVK
MUL_3923|M.ulcerans_Agy99 GGLYPRSNVTYRGVEVGTVKSVHLTNTGVAAVLSLNSDVKIPADVEAEVH
Mb0180|M.bovis_AF2122/97 GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
Rv0174|M.tuberculosis_H37Rv GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
MLBr_02594|M.leprae_Br4923 GGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVH
**** :***:**: :* * : * *. ..: : ::* : * *
MSMEG_2860|M.smegmatis_MC2_155 SVSAVGEQYVDLRPR-TDDAPYLQDGSVITAANTSVPQKVGPMLDQMSAL
TH_4161|M.thermoresistible__bu SVSAVGEQYVELLPR-HDGAPYLEDGSVIGIENTSVPQRVGPMLDQMSAL
Mflv_4533|M.gilvum_PYR-GCK SVSAVGEQYVDLEPR-SDAGPYLQDGSVITGDRSSIPQAVGPMLDQMSAL
MMAR_4705|M.marinum_M SISAVGEYYVDLRPR-TDSPPYLHDGSVIARDRAVIGQPIGPVLDQTSAL
MAV_0953|M.avium_104 SVSAVGEQYVDLRPR-TNSPPYLHDGSVIAMRDTKIPQPVGPMLDQVNAL
Mvan_4145|M.vanbaalenii_PYR-1 SVSAVGEQYVDLRPN-TDEGPYLEDGARIPVANTTVPQQVGPMLDQLSAL
MAB_4148c|M.abscessus_ATCC_199 SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
MUL_3923|M.ulcerans_Agy99 SVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDETNRG
Mb0180|M.bovis_AF2122/97 SVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNSNRG
Rv0174|M.tuberculosis_H37Rv SVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNSNRG
MLBr_02594|M.leprae_Br4923 SVSAVGEQYLDLVSS-GNPGKYLAPGQTIT--KSKIPIEIGPALDSVNRG
*:*::** *::* . : * * : :.. * . .
MSMEG_2860|M.smegmatis_MC2_155 VDSIPSGQLGGLLDESFRALNGSGHELGALFDSSARLASDLDATADTTRT
TH_4161|M.thermoresistible__bu IDSIPSGQLGALLDESATALGGSGYELGSAFDSAAQLAERLNGSGERARV
Mflv_4533|M.gilvum_PYR-GCK VDSIPTGTLSGLLDESYAALNGSGYELGSLFDSSARLAADADSTGDRMRN
MMAR_4705|M.marinum_M INSIPKGKLSTLLDESFNAFNGAGYDFGSLFDSSAQLSGDLNGIADRTRT
MAV_0953|M.avium_104 VQSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRA
Mvan_4145|M.vanbaalenii_PYR-1 VGSLPKDRIPDLLDETFKAFNGAGPDFGSMLDSAATLTNDVNGVSDQMRS
MAB_4148c|M.abscessus_ATCC_199 VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
MUL_3923|M.ulcerans_Agy99 LQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDELTL
Mb0180|M.bovis_AF2122/97 LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
Rv0174|M.tuberculosis_H37Rv LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
MLBr_02594|M.leprae_Br4923 LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
: ::. : :: *: ...* * : . .: :
MSMEG_2860|M.smegmatis_MC2_155 LIDDSRPLLDGQAASVDAIRTWARSLAGITRQVADDDAQIRTIVQTGSGA
TH_4161|M.thermoresistible__bu LIEDGRPLLDGQAVGAEAIRTWARSLSGITGQLAADDAQIRTILTDGPGA
Mflv_4533|M.gilvum_PYR-GCK LITDSEPLLDGQAQKADAITTWARSLAGITRQIADDDQAVRTILQTGPGA
MMAR_4705|M.marinum_M LTEDSGPFLDAQAQTTDSIRLWARSLAGVSGQLATNDPQIRTLLERGPGA
MAV_0953|M.avium_104 LTEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPET
Mvan_4145|M.vanbaalenii_PYR-1 LIDDSGPLIDSQAETADAIRTWAQSLNGISAQVVQNDPQVRALLQQGPAF
MAB_4148c|M.abscessus_ATCC_199 LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
MUL_3923|M.ulcerans_Agy99 LIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQGPGA
Mb0180|M.bovis_AF2122/97 IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
Rv0174|M.tuberculosis_H37Rv IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
MLBr_02594|M.leprae_Br4923 IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
: : *.:* * * . .: :: * . :: ..
MSMEG_2860|M.smegmatis_MC2_155 ADEASRLLDQVKPTLPVLLANLVTVGQIGVTYNPSIEQLLVLLPPYLAAT
TH_4161|M.thermoresistible__bu ADQAARLLAQVKPTVPVLLANLTTVGQIGVTYNPSLEQLLVLLPPYLAAT
Mflv_4533|M.gilvum_PYR-GCK ADEASRLLTDVKPTLPVLLANLTTVGQVGVAYHPSLEQLLVLLPPYLAAT
MMAR_4705|M.marinum_M FNEASRLLDQIKPTLPVLLANLTTVGQIAVTYHASVEQILVLLPPFTAAI
MAV_0953|M.avium_104 ANEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIE
Mvan_4145|M.vanbaalenii_PYR-1 AQEVSALLNQVKPTLPILLANLSTVGQTLLTYNPAIEQLLVLFPGIIAAQ
MAB_4148c|M.abscessus_ATCC_199 SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
MUL_3923|M.ulcerans_Agy99 ADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGTAVT
Mb0180|M.bovis_AF2122/97 ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
Rv0174|M.tuberculosis_H37Rv ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
MLBr_02594|M.leprae_Br4923 ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIA
::. :: :: :.* *.: : *: .:** **::* :
MSMEG_2860|M.smegmatis_MC2_155 QSYGSSLNNPTG---MALSEFSLTLGDPPACTVGFLPPSEWRSPA-DLTD
TH_4161|M.thermoresistible__bu QSYGSSLNNPTG---MALSEFSLTLGDPPACTVGFLPPSEWRSPA-DLSD
Mflv_4533|M.gilvum_PYR-GCK QSYGSSLNNPTG---MALSEFSLTLGDPPACSVGFLPPSSWRSPA-DLTD
MMAR_4705|M.marinum_M QSF-LGTKSPVG---LATGAFNLIISDPPACTVGFLPPSQWRNPA-DTTI
MAV_0953|M.avium_104 QAA-AAPNHPEG---TAQGDFALTIDDPPICTVGFMPPNTWRSPD-DLSD
Mvan_4145|M.vanbaalenii_PYR-1 QSFGLPQNSPTG---LPMGDFALTISDPNPCTVGFLPSTQWRSPE-DETT
MAB_4148c|M.abscessus_ATCC_199 LTVAGGAPMDEG---AKL-DFRLNLGDPPPCLTGFVPPPLMRTPA-DETL
MUL_3923|M.ulcerans_Agy99 QAVGVAKRNTIQDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTFEDYP
Mb0180|M.bovis_AF2122/97 QTVLTPTP---G---AAQLPLAPAINYPPPCLTGFLPASEWRSPA-DTSP
Rv0174|M.tuberculosis_H37Rv QTVLTPTP---G---AAQLPLAPAINYPPPCLTGFLPASEWRSPA-DTSP
MLBr_02594|M.leprae_Br4923 QTASATFP---N---MAALDLALSINQPPPCLTGFIPAAEWRSPA-DTSL
: : :. * * .**:*. * * :
MSMEG_2860|M.smegmatis_MC2_155 VDTPDGLYCKLPQDSPIG-VRGARNFPCMGQPGKRAPTVEICESDRPFEP
TH_4161|M.thermoresistible__bu IDTPDGLYCKLPQDSPIG-VRGARNFPCMGQPGKRAPTVEICESDRPFEP
Mflv_4533|M.gilvum_PYR-GCK VDTPDGLYCKLPQDSPIG-VRGTRNFPCMEQPGKRAPTVEICQSDRPFEP
MMAR_4705|M.marinum_M VDTPDGLYCKLPQDSPIG-VRGARNYPCMGQPGKRAPTVEICESDQPFEP
MAV_0953|M.avium_104 IDTPDGLYCKLPQDSPLS-VRGARNYPCMGHPGKRAPTVEICNSDQPFMP
Mvan_4145|M.vanbaalenii_PYR-1 IDTPDGLYCKLPQDSPMN-VRGARNYPCIEHPGKRAPTVELCNDPRGFVP
MAB_4148c|M.abscessus_ATCC_199 RELPRDMYCKTAQNDPSA-VRGARNYPCQEFPGKRAPTIQLCRDPRGYVP
MUL_3923|M.ulcerans_Agy99 NRAPGDLYCRVPQDAPFN-VRGARNLPCVTVPGKRAPTAKLCESNEVYVP
Mb0180|M.bovis_AF2122/97 RPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKDPYVP
Rv0174|M.tuberculosis_H37Rv RPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVLGKRAATPKECRSKDPYVP
MLBr_02594|M.leprae_Br4923 QPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVP
* . **: . : ***:** ** ****.: . *.. : *
MSMEG_2860|M.smegmatis_MC2_155 LAMRQHVTGPYPIDPNLI---------AQG--VPPDDRVTLD-EHIYGPV
TH_4161|M.thermoresistible__bu LAMRQHVTGPYPIDPNLI---------AQG--VAPDSRVTSD-DQIFGPP
Mflv_4533|M.gilvum_PYR-GCK LAMRQHVTGPYPIDPALI---------AQG--VPPDDRVTLD-EQIYGPL
MMAR_4705|M.marinum_M LAMRQHIFGTYPLDPNLI---------AQG--IPPDDRANWNRERIFGPV
MAV_0953|M.avium_104 LAMKQHVLGPYPLDPNLL---------AQG--VPPDDRVTVN-DRIFGPV
Mvan_4145|M.vanbaalenii_PYR-1 TAIRNHITGPYPFDPNLV---------SQG--VPIDSTVEGP-DRIYLPP
MAB_4148c|M.abscessus_ATCC_199 IGSNPWRGPPAPYDTPVE---------DPRNILPPNKFPNIP--PGAEPD
MUL_3923|M.ulcerans_Agy99 LNDGYNWKG----DPNST---------LSG-----------------QPI
Mb0180|M.bovis_AF2122/97 LGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQV
Rv0174|M.tuberculosis_H37Rv LGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQV
MLBr_02594|M.leprae_Br4923 LGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNPAPADRL
.
MSMEG_2860|M.smegmatis_MC2_155 EGTP-VDGD-----------------------------------------
TH_4161|M.thermoresistible__bu AGTP-PPADDTP--------------------------------------
Mflv_4533|M.gilvum_PYR-GCK EGTP-MPAP-----------------------------------------
MMAR_4705|M.marinum_M EGTP-LPPGVGP------PEETVMPPGPLG---PPSPMG-----------
MAV_0953|M.avium_104 EGTP-LPPGAVPRGAPAGPRGENPPPGSVGAAVPPVPSSGPPALAPMSRM
Mvan_4145|M.vanbaalenii_PYR-1 EGTP-LPPGAVRAG-TPPVSEPGTPPFPVGAPAPMVPGAP----------
MAB_4148c|M.abscessus_ATCC_199 PGTPTLPPPSPP--------------------------------------
MUL_3923|M.ulcerans_Agy99 PQLP----------------------------------------------
Mb0180|M.bovis_AF2122/97 QGTP--PPVSDPLQ------------------------------------
Rv0174|M.tuberculosis_H37Rv QGTP--PPVSDPLQ------------------------------------
MLBr_02594|M.leprae_Br4923 PGTP--PPVSDPLS------------------------------------
*
MSMEG_2860|M.smegmatis_MC2_155 ---------------------------------------ALPVAPS-AHT
TH_4161|M.thermoresistible__bu ------------------------------------PPGAAPASAS-AEA
Mflv_4533|M.gilvum_PYR-GCK ------------------------------------APGAAPASVPGPVP
MMAR_4705|M.marinum_M --EVSPIAPIDVPS-------TPPPAPSG-------APSAAPSGLG-RAA
MAV_0953|M.avium_104 SADLPPIAPLDVPTPTELPPPPPPPAPAAPDQVDGAAPQAAPSAFA-GKA
Mvan_4145|M.vanbaalenii_PYR-1 ---PPAQPPILPPAPLLPGQGPLLPGQAVPVAPASGAVPVAPSAFG--SN
MAB_4148c|M.abscessus_ATCC_199 ------------------------------------APEVPPAGGDVMPV
MUL_3923|M.ulcerans_Agy99 --------------------------------------PEPPLEQSAPPG
Mb0180|M.bovis_AF2122/97 ---------------------------------RPGSGTVQCNGQQPNPC
Rv0174|M.tuberculosis_H37Rv ---------------------------------RPGSGTVQCNGQQPNPC
MLBr_02594|M.leprae_Br4923 ---------------------------------QPRSGSVQCNGQQPNTC
MSMEG_2860|M.smegmatis_MC2_155 AGDGPSVAIATYDPETGRYATPDGQVHHQADLATP-----GAQNWEDLLP
TH_4161|M.thermoresistible__bu TDGGPSVAFATYNPRTGQYATPDGLVHTRTDLVAP-----PAQNWTDLLP
Mflv_4533|M.gilvum_PYR-GCK AAGGPPVAVATYNPETGQVATPDGEVFTQSNLAAPNPAAGEGKSWQDMLP
MMAR_4705|M.marinum_M ARPGPSVAFAQYDPHTGSYVAPDGQVYRQTDLIIPD-TPKAPRTWKDMLP
MAV_0953|M.avium_104 SKPAPSVVVAKYDPRTGRYVGPDGKLYQQSDLVT----PKAPKTWKDMLP
Mvan_4145|M.vanbaalenii_PYR-1 DSGVPTVGTAQYNPQTGEYIAPDGSMNRVTNVASG----ANPKSWKDLLP
MAB_4148c|M.abscessus_ATCC_199 SAQSGPMAARAYDPKNGVFLDANNQPSVYAPALDRG---TEAETWADLML
MUL_3923|M.ulcerans_Agy99 PAPPAPIAAAEYDPATGTYMGPDGHLYTQANLGQTVP---EEQTWQTMLL
Mb0180|M.bovis_AF2122/97 VYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTG-----DDGWKEMLA
Rv0174|M.tuberculosis_H37Rv VYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTG-----DDGWKEMLA
MLBr_02594|M.leprae_Br4923 VYTPSGPPSAVYSPQSGELVGPDGVAYAVENSTKTG-----DDGWKEMLA
*.* .* .:. * ::
MSMEG_2860|M.smegmatis_MC2_155 R----
TH_4161|M.thermoresistible__bu R----
Mflv_4533|M.gilvum_PYR-GCK R----
MMAR_4705|M.marinum_M T----
MAV_0953|M.avium_104 T----
Mvan_4145|M.vanbaalenii_PYR-1 M----
MAB_4148c|M.abscessus_ATCC_199 GPKPV
MUL_3923|M.ulcerans_Agy99 PPKK-
Mb0180|M.bovis_AF2122/97 PAS--
Rv0174|M.tuberculosis_H37Rv PAS--
MLBr_02594|M.leprae_Br4923 PAG--