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MLTRLVRIQLTLFAIASVVGIAVMVLQYIRVPTLLGIGRIEVTLQLPEAGGLYRFANVTYRGVQIGKVTA LDVDRDGAEATLSLSGTPRVPADLRAEVRSVSAVGEQYVDLQPRSRSGPYLESGAVIPSSAVTVPQRVAP MMQNLSDLITDIPKDKLAQLLDESFAAFDGSGYELQTLAESMTRISADMDRVAGRTSSLIEDTAPVLDGQ AASADALDTWAADLAAISAQLVDRDPEIRRILTTGTPAAQQVTQLIEQVRPTLPVLLANLTSLGQVGLTY RAGLEQLLVLLPPASAFYQSAVGSNNATGIPVGDFRISVDDPPACTVGFLPPSAWRSPADTTTIDTPDGL YCKLPQDSAIAVRGVRNLPCMDVPGKRAPTVELCRSDKAFQPLAARPHALGPYPFDPSLVAQGVPPDDRV TRDERLFAPPGGTPPPGSPPPPLAVATYDPQTGRIATDDGTAVQQTDLVAPARTWKDLIWPAAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4165 | - | - | 100% (484) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4533 | - | e-163 | 55.38% (502) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2513 | - | e-151 | 56.08% (469) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 4e-90 | 38.10% (525) | MCE-family protein MCE1F |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 6e-89 | 37.90% (525) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 4e-85 | 36.14% (523) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 5e-92 | 37.07% (518) | MCE-family protein |
| M. marinum M | MMAR_4705 | - | 1e-156 | 51.39% (541) | MCE-family protein |
| M. avium 104 | MAV_0953 | - | 1e-153 | 59.41% (441) | mce-family protein mce1f |
| M. smegmatis MC2 155 | MSMEG_2860 | - | 1e-164 | 57.40% (493) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4161 | - | 1e-158 | 56.71% (499) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 1e-96 | 40.57% (493) | MCE-family protein Mce3F_1 |
| M. vanbaalenii PYR-1 | Mvan_4145 | - | 1e-148 | 55.72% (463) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4705|M.marinum_M -MLTRFVRIQLAIFAIVGMVGVAVMAVWYIQAPTLLGIGKMTVTLELPAT
MAV_0953|M.avium_104 -MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPAT
MSMEG_2860|M.smegmatis_MC2_155 -MITRFIRTQLIIFTITSVVASAMMVFSYLQAPVLFGIGRITVTLELPST
TH_4161|M.thermoresistible__bu -MLTRFVRTQLVIFTIAAVVGMGAMVFGYLQVPMLLGIGRISVTMELPST
Mflv_4165|M.gilvum_PYR-GCK -MLTRLVRIQLTLFAIASVVGIAVMVLQYIRVPTLLGIGRIEVTLQLPEA
Mvan_4145|M.vanbaalenii_PYR-1 -MLTRFVRNQLIIFTIASIVGVAVMLFAYMQVPTLLGVGRLVVTLELPES
MAB_4148c|M.abscessus_ATCC_199 --MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVAS
MUL_3923|M.ulcerans_Agy99 MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVPAMVGIGQYRVTVELPEA
Mb0180|M.bovis_AF2122/97 -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
Rv0174|M.tuberculosis_H37Rv -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
MLBr_02594|M.leprae_Br4923 -MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSAT
: : *: :* . : *:: * .*:*: :. :: :
MMAR_4705|M.marinum_M GGLYRFSNVTYRGVQIGKVTALGLTSSGAKATLALDASPKIPADLKAEVR
MAV_0953|M.avium_104 GGLYRFSNVTYRGVQLGKVTAVGLTPSGVKATLSLSTSPKVPADLTAEVL
MSMEG_2860|M.smegmatis_MC2_155 GGLYRFSNVTYRGIEVGKVTDVRPTRSGALATLSLQTSPRIPADLQADVR
TH_4161|M.thermoresistible__bu GGLYRFSNVTYRGVKVGKVLDVRPTRTGAVVTMSLQSRPRIPADLQADVR
Mflv_4165|M.gilvum_PYR-GCK GGLYRFANVTYRGVQIGKVTALDVDRDGAEATLSLSGTPRVPADLRAEVR
Mvan_4145|M.vanbaalenii_PYR-1 GGLYRFSNVTYRGVQVGKVTGVSLTENGAEATLSLETSPKIPADLQAEVL
MAB_4148c|M.abscessus_ATCC_199 GGLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVK
MUL_3923|M.ulcerans_Agy99 GGLYPRSNVTYRGVEVGTVKSVHLTNTGVAAVLSLNSDVKIPADVEAEVH
Mb0180|M.bovis_AF2122/97 GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
Rv0174|M.tuberculosis_H37Rv GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
MLBr_02594|M.leprae_Br4923 GGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVH
**** :***:**: :* * : *. ..: : ::* : * *
MMAR_4705|M.marinum_M SISAVGEYYVDLRPR-TDSPPYLHDGSVIARDRAVIGQPIGPVLDQTSAL
MAV_0953|M.avium_104 SVSAVGEQYVDLRPR-TNSPPYLHDGSVIAMRDTKIPQPVGPMLDQVNAL
MSMEG_2860|M.smegmatis_MC2_155 SVSAVGEQYVDLRPR-TDDAPYLQDGSVITAANTSVPQKVGPMLDQMSAL
TH_4161|M.thermoresistible__bu SVSAVGEQYVELLPR-HDGAPYLEDGSVIGIENTSVPQRVGPMLDQMSAL
Mflv_4165|M.gilvum_PYR-GCK SVSAVGEQYVDLQPR-SRSGPYLESGAVIPSSAVTVPQRVAPMMQNLSDL
Mvan_4145|M.vanbaalenii_PYR-1 SVSAVGEQYVDLRPN-TDEGPYLEDGARIPVANTTVPQQVGPMLDQLSAL
MAB_4148c|M.abscessus_ATCC_199 SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
MUL_3923|M.ulcerans_Agy99 SVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDETNRG
Mb0180|M.bovis_AF2122/97 SVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNSNRG
Rv0174|M.tuberculosis_H37Rv SVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNSNRG
MLBr_02594|M.leprae_Br4923 SVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSVNRG
*:*::** *::* . : * * : : . : . .
MMAR_4705|M.marinum_M INSIPKGKLSTLLDESFNAFNGAGYDFGSLFDSSAQLSGDLNGIADRTRT
MAV_0953|M.avium_104 VQSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRA
MSMEG_2860|M.smegmatis_MC2_155 VDSIPSGQLGGLLDESFRALNGSGHELGALFDSSARLASDLDATADTTRT
TH_4161|M.thermoresistible__bu IDSIPSGQLGALLDESATALGGSGYELGSAFDSAAQLAERLNGSGERARV
Mflv_4165|M.gilvum_PYR-GCK ITDIPKDKLAQLLDESFAAFDGSGYELQTLAESMTRISADMDRVAGRTSS
Mvan_4145|M.vanbaalenii_PYR-1 VGSLPKDRIPDLLDETFKAFNGAGPDFGSMLDSAATLTNDVNGVSDQMRS
MAB_4148c|M.abscessus_ATCC_199 VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
MUL_3923|M.ulcerans_Agy99 LQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDELTL
Mb0180|M.bovis_AF2122/97 LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
Rv0174|M.tuberculosis_H37Rv LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
MLBr_02594|M.leprae_Br4923 LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
: :. .: :: *: ...* * : . :
MMAR_4705|M.marinum_M LTEDSGPFLDAQAQTTDSIRLWARSLAGVSGQLATNDPQIRTLLERGPGA
MAV_0953|M.avium_104 LTEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPET
MSMEG_2860|M.smegmatis_MC2_155 LIDDSRPLLDGQAASVDAIRTWARSLAGITRQVADDDAQIRTIVQTGSGA
TH_4161|M.thermoresistible__bu LIEDGRPLLDGQAVGAEAIRTWARSLSGITGQLAADDAQIRTILTDGPGA
Mflv_4165|M.gilvum_PYR-GCK LIEDTAPVLDGQAASADALDTWAADLAAISAQLVDRDPEIRRILTTGTPA
Mvan_4145|M.vanbaalenii_PYR-1 LIDDSGPLIDSQAETADAIRTWAQSLNGISAQVVQNDPQVRALLQQGPAF
MAB_4148c|M.abscessus_ATCC_199 LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
MUL_3923|M.ulcerans_Agy99 LIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQGPGA
Mb0180|M.bovis_AF2122/97 IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
Rv0174|M.tuberculosis_H37Rv IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
MLBr_02594|M.leprae_Br4923 IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
: :: *.:* * : . .: :: * . :: ..
MMAR_4705|M.marinum_M FNEASRLLDQIKPTLPVLLANLTTVGQIAVTYHASVEQILVLLPPFTAAI
MAV_0953|M.avium_104 ANEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIE
MSMEG_2860|M.smegmatis_MC2_155 ADEASRLLDQVKPTLPVLLANLVTVGQIGVTYNPSIEQLLVLLPPYLAAT
TH_4161|M.thermoresistible__bu ADQAARLLAQVKPTVPVLLANLTTVGQIGVTYNPSLEQLLVLLPPYLAAT
Mflv_4165|M.gilvum_PYR-GCK AQQVTQLIEQVRPTLPVLLANLTSLGQVGLTYRAGLEQLLVLLPPASAFY
Mvan_4145|M.vanbaalenii_PYR-1 AQEVSALLNQVKPTLPILLANLSTVGQTLLTYNPAIEQLLVLFPGIIAAQ
MAB_4148c|M.abscessus_ATCC_199 SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
MUL_3923|M.ulcerans_Agy99 ADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGTAVT
Mb0180|M.bovis_AF2122/97 ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
Rv0174|M.tuberculosis_H37Rv ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
MLBr_02594|M.leprae_Br4923 ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIA
::. :: :: :.* *.: : *. .:** **::* :
MMAR_4705|M.marinum_M QSF-LGTKSPVG---LATGAFNLIISDPPACTVGFLPPSQWRNPA-DTTI
MAV_0953|M.avium_104 QAA-AAPNHPEG---TAQGDFALTIDDPPICTVGFMPPNTWRSPD-DLSD
MSMEG_2860|M.smegmatis_MC2_155 QSYGSSLNNPTG---MALSEFSLTLGDPPACTVGFLPPSEWRSPA-DLTD
TH_4161|M.thermoresistible__bu QSYGSSLNNPTG---MALSEFSLTLGDPPACTVGFLPPSEWRSPA-DLSD
Mflv_4165|M.gilvum_PYR-GCK QSA-VGSNNATG---IPVGDFRISVDDPPACTVGFLPPSAWRSPA-DTTT
Mvan_4145|M.vanbaalenii_PYR-1 QSFGLPQNSPTG---LPMGDFALTISDPNPCTVGFLPSTQWRSPE-DETT
MAB_4148c|M.abscessus_ATCC_199 LTVAGGAPMDEG---AKL-DFRLNLGDPPPCLTGFVPPPLMRTPA-DETL
MUL_3923|M.ulcerans_Agy99 QAVGVAKRNTIQDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTFEDYP
Mb0180|M.bovis_AF2122/97 QTVLTPTPGAAQ------LPLAPAINYPPPCLTGFLPASEWRSPA-DTSP
Rv0174|M.tuberculosis_H37Rv QTVLTPTPGAAQ------LPLAPAINYPPPCLTGFLPASEWRSPA-DTSP
MLBr_02594|M.leprae_Br4923 QTASATFPNMAA------LDLALSINQPPPCLTGFIPAAEWRSPA-DTSL
: : :. * * .**:*. * * :
MMAR_4705|M.marinum_M VDTPDGLYCKLPQDSPIG-VRGARNYPCMGQPGKRAPTVEICESDQPFEP
MAV_0953|M.avium_104 IDTPDGLYCKLPQDSPLS-VRGARNYPCMGHPGKRAPTVEICNSDQPFMP
MSMEG_2860|M.smegmatis_MC2_155 VDTPDGLYCKLPQDSPIG-VRGARNFPCMGQPGKRAPTVEICESDRPFEP
TH_4161|M.thermoresistible__bu IDTPDGLYCKLPQDSPIG-VRGARNFPCMGQPGKRAPTVEICESDRPFEP
Mflv_4165|M.gilvum_PYR-GCK IDTPDGLYCKLPQDSAIA-VRGVRNLPCMDVPGKRAPTVELCRSDKAFQP
Mvan_4145|M.vanbaalenii_PYR-1 IDTPDGLYCKLPQDSPMN-VRGARNYPCIEHPGKRAPTVELCNDPRGFVP
MAB_4148c|M.abscessus_ATCC_199 RELPRDMYCKTAQNDPSA-VRGARNYPCQEFPGKRAPTIQLCRDPRGYVP
MUL_3923|M.ulcerans_Agy99 NRAPGDLYCRVPQDAPFN-VRGARNLPCVTVPGKRAPTAKLCESNEVYVP
Mb0180|M.bovis_AF2122/97 RPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKDPYVP
Rv0174|M.tuberculosis_H37Rv RPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVLGKRAATPKECRSKDPYVP
MLBr_02594|M.leprae_Br4923 QPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVP
* . **: . : *** ** ** ****.: . *.. : *
MMAR_4705|M.marinum_M LAMRQHIFGTYPLDPNLI---------AQG--IPPDDRANWNRERIFGPV
MAV_0953|M.avium_104 LAMKQHVLGPYPLDPNLL---------AQG--VPPDDRVTVN-DRIFGPV
MSMEG_2860|M.smegmatis_MC2_155 LAMRQHVTGPYPIDPNLI---------AQG--VPPDDRVTLD-EHIYGPV
TH_4161|M.thermoresistible__bu LAMRQHVTGPYPIDPNLI---------AQG--VAPDSRVTSD-DQIFGPP
Mflv_4165|M.gilvum_PYR-GCK LAARPHALGPYPFDPSLV---------AQG--VPPDDRVTRD-ERLFAPP
Mvan_4145|M.vanbaalenii_PYR-1 TAIRNHITGPYPFDPNLV---------SQG--VPIDSTVEGP-DRIYLPP
MAB_4148c|M.abscessus_ATCC_199 IGSNPWRGPPAPYDTPVE---------DPRNILPPNKFPNIPPGAEPDPG
MUL_3923|M.ulcerans_Agy99 LNDGYNWKG----DPNST---------LSG--QPIPQLPPEP------PL
Mb0180|M.bovis_AF2122/97 LGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQV
Rv0174|M.tuberculosis_H37Rv LGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQV
MLBr_02594|M.leprae_Br4923 LGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNPAPADRL
. .
MMAR_4705|M.marinum_M EGTPLPPGVGP------PEETVMPPGPLG---PPSPMG------------
MAV_0953|M.avium_104 EGTPLPPGAVPRGAPAGPRGENPPPGSVGAAVPPVPSSGPPALAPMSRMS
MSMEG_2860|M.smegmatis_MC2_155 EGTPVDGD------------------------------------------
TH_4161|M.thermoresistible__bu AGTPPPADDTP---------------------------------------
Mflv_4165|M.gilvum_PYR-GCK GGTPPPGS------------------------------------------
Mvan_4145|M.vanbaalenii_PYR-1 EGTPLPPGAVRAG-TPPVSEPGTPPFPVGAPAPMVPGAP-----------
MAB_4148c|M.abscessus_ATCC_199 TPTLPPPSPPAP--------------------------------------
MUL_3923|M.ulcerans_Agy99 EQSAPPGP------------------------------------------
Mb0180|M.bovis_AF2122/97 QGTPPPVSDPLQR-------------------------------------
Rv0174|M.tuberculosis_H37Rv QGTPPPVSDPLQR-------------------------------------
MLBr_02594|M.leprae_Br4923 PGTPPPVSDPLSQ-------------------------------------
:
MMAR_4705|M.marinum_M -EVSPIAPIDVPS-------TPPPAPSG-------APSAAPSGLGRAAAR
MAV_0953|M.avium_104 ADLPPIAPLDVPTPTELPPPPPPPAPAAPDQVDGAAPQAAPSAFAGKASK
MSMEG_2860|M.smegmatis_MC2_155 --------------------------------------ALPVAPSAHTAG
TH_4161|M.thermoresistible__bu -----------------------------------PPGAAPASASAEATD
Mflv_4165|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4145|M.vanbaalenii_PYR-1 ---PPAQPPILPPAPLLPGQGPLLPGQAVPVAPASGAVPVAPSAFGSNDS
MAB_4148c|M.abscessus_ATCC_199 ------------------------------------EVPPAGGDVMPVSA
MUL_3923|M.ulcerans_Agy99 -------------------------------------------------A
Mb0180|M.bovis_AF2122/97 --------------------------------PGSGTVQCNGQQPNPCVY
Rv0174|M.tuberculosis_H37Rv --------------------------------PGSGTVQCNGQQPNPCVY
MLBr_02594|M.leprae_Br4923 --------------------------------PRSGSVQCNGQQPNTCVY
MMAR_4705|M.marinum_M PGPSVAFAQYDPHTGSYVAPDGQVYRQTDLIIPDTPKAPRTWKDMLPT--
MAV_0953|M.avium_104 PAPSVVVAKYDPRTGRYVGPDGKLYQQSDLVT---PKAPKTWKDMLPT--
MSMEG_2860|M.smegmatis_MC2_155 DGPSVAIATYDPETGRYATPDGQVHHQADLATP----GAQNWEDLLPR--
TH_4161|M.thermoresistible__bu GGPSVAFATYNPRTGQYATPDGLVHTRTDLVAP----PAQNWTDLLPR--
Mflv_4165|M.gilvum_PYR-GCK PPPPLAVATYDPQTGRIATDDGTAVQQTDLVAP-----ARTWKDLIWPAA
Mvan_4145|M.vanbaalenii_PYR-1 GVPTVGTAQYNPQTGEYIAPDGSMNRVTNVASG---ANPKSWKDLLPM--
MAB_4148c|M.abscessus_ATCC_199 QSGPMAARAYDPKNGVFLDANNQPSVYAPALDRG--TEAETWADLMLGPK
MUL_3923|M.ulcerans_Agy99 PPAPIAAAEYDPATGTYMGPDGHLYTQANLGQT--VPEEQTWQTMLLPPK
Mb0180|M.bovis_AF2122/97 TPTSGPSAVYSPASGELVGPDGVKYAVANSSTT----GDDGWKEMLAPAS
Rv0174|M.tuberculosis_H37Rv TPTSGPSAVYSPASGELVGPDGVKYAVANSSTT----GDDGWKEMLAPAS
MLBr_02594|M.leprae_Br4923 TPSGPPSAVYSPQSGELVGPDGVAYAVENSTKT----GDDGWKEMLAPAG
*.* .* :. * ::
MMAR_4705|M.marinum_M --
MAV_0953|M.avium_104 --
MSMEG_2860|M.smegmatis_MC2_155 --
TH_4161|M.thermoresistible__bu --
Mflv_4165|M.gilvum_PYR-GCK P-
Mvan_4145|M.vanbaalenii_PYR-1 --
MAB_4148c|M.abscessus_ATCC_199 PV
MUL_3923|M.ulcerans_Agy99 K-
Mb0180|M.bovis_AF2122/97 --
Rv0174|M.tuberculosis_H37Rv --
MLBr_02594|M.leprae_Br4923 --