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MDFTLNDEQELLRGGLTRFLATRYDLEKSRTAAKTGAGWQPEIWRAFAEELGILGAALPEENGGIGGGPV EMMLIAEALGHALVIEPYVDTAVVAAGLLRRAGGEIADALLEEIVAGSAIVSLAATEPTSGDFWQDVRTT AVRDGDEWVLSGEKIVSSATPLAGHVLVTARTTGERADTAGISLFLLDIASAPSGVEVHHYRTVDDRRAS DIVLDGVRLPATALLGAEGDAWPSLARARDEGAAAISAEAVGCMRKVLADTVEYCKQRQQFGQPIGSFQV LQHRMVDMYMEVEQAAAAALLATLKLDEDETTRARAVSAAKATVGRAAQFVGQQAVQLHGGMGMTEELAI GHYFKRLTALQFEFGSTDHHITRYGRLTTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4380 | - | - | 100% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2286 | - | 1e-51 | 34.23% (371) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0345 | - | 2e-41 | 32.98% (376) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0997c | fadE12 | 4e-36 | 31.28% (358) | acyl-CoA dehydrogenase FADE12 |
| M. tuberculosis H37Rv | Rv0972c | fadE12 | 3e-36 | 31.28% (358) | acyl-CoA dehydrogenase FADE12 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-25 | 25.53% (329) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2496 | - | 1e-124 | 58.36% (377) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3738 | fadE18_2 | 1e-52 | 34.95% (372) | acyl-CoA dehydrogenase FadE18_2 |
| M. avium 104 | MAV_1765 | - | 5e-50 | 34.41% (372) | pimeloyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2190 | - | 1e-159 | 74.21% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_4557 | - | 1e-88 | 74.19% (217) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3682 | fadE18_2 | 1e-51 | 34.68% (372) | acyl-CoA dehydrogenase FadE18_2 |
| M. vanbaalenii PYR-1 | Mvan_1964 | - | 0.0 | 87.30% (378) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0997c|M.bovis_AF2122/97 -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEH--T
Rv0972c|M.tuberculosis_H37Rv -------MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEH--T
Mflv_4380|M.gilvum_PYR-GCK ----------MDFTLNDEQELLRGGLTRFLATRYDLEKSRTAAKTGAGWQ
Mvan_1964|M.vanbaalenii_PYR-1 ----------MDFKLNDEQELLRSGLTRFLATRYDLEKSRAAAKTGLGWQ
TH_4557|M.thermoresistible__bu --------------------------------------------------
MSMEG_2190|M.smegmatis_MC2_155 ----------MDFNLTKEQELLRDGLTKFLSSRYDLQTSRAAAKLGEGWQ
MAB_2496|M.abscessus_ATCC_1997 ----------MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQ
MMAR_3738|M.marinum_M ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MUL_3682|M.ulcerans_Agy99 ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MAV_1765|M.avium_104 ----------MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWS
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD--VDQRARFP
Mb0997c|M.bovis_AF2122/97 SELWAEAGKLG-FLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMV
Rv0972c|M.tuberculosis_H37Rv SELWAEAGKLG-FLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMV
Mflv_4380|M.gilvum_PYR-GCK PEIWRAFAEELGILGAALPEENGGIGGGPVEMMLIAEALGHA-LVIEPYV
Mvan_1964|M.vanbaalenii_PYR-1 PEIWRAFAEELGILGAALPEENGGIGGGPVEMMLIAEALGHA-LVVEPYV
TH_4557|M.thermoresistible__bu --------------------------------------------------
MSMEG_2190|M.smegmatis_MC2_155 PDIWRGFAEELGILGATLPEESGGIGGGAVEAMVIAEALGHA-LVIEPFV
MAB_2496|M.abscessus_ATCC_1997 PQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLGRH-LVVEPFI
MMAR_3738|M.marinum_M RDVWSQLADTG-ILGLGFEPAE----AGQIEIMLVMTEVGRR-LAPEPIV
MUL_3682|M.ulcerans_Agy99 RDVWSQLADTG-ILGLGFEPAE----AGQIEIMLVMTEVGRR-LAPEPIV
MAV_1765|M.avium_104 REVWSQLADTG-ILGLGFDPDE----SGQIEIMVVLTEIGRR-LAPEPVL
MLBr_00737|M.leprae_Br4923 EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
Mb0997c|M.bovis_AF2122/97 VSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKIT
Rv0972c|M.tuberculosis_H37Rv VSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKIT
Mflv_4380|M.gilvum_PYR-GCK DTAVVAAGLLRRAGG-EIADALLEEIVAGSAIVSLAATEPTSGDFWQDVR
Mvan_1964|M.vanbaalenii_PYR-1 DTAVVAAGLLLRAGG-DTATALLEEIVAGTAIVSLAATEPTSGEFWQDVT
TH_4557|M.thermoresistible__bu --------------------------------------------------
MSMEG_2190|M.smegmatis_MC2_155 DTVVVAGGLLQRAGG-DAAQNVLEDLVGGAAVVAVAATEPTSGDNWYSVE
MAB_2496|M.abscessus_ATCC_1997 GTVVLGGGLLRRSNA-EVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQ
MMAR_3738|M.marinum_M HAALAPGAIIAELGN-DAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MUL_3682|M.ulcerans_Agy99 HAALAPGAIIAELGN-DAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MAV_1765|M.avium_104 HAALGPGALIAELGS-AAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVG
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
Mb0997c|M.bovis_AF2122/97 TTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVP
Rv0972c|M.tuberculosis_H37Rv TTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVP
Mflv_4380|M.gilvum_PYR-GCK TTAVRDGDEWVLSGEKIVSSATPLAGHVLVTARTTGERADTAGISLFLL-
Mvan_1964|M.vanbaalenii_PYR-1 TSATRDGDSWVLRGQKIVSASTPLASHVLVTARTSGERADAEGISLFLV-
TH_4557|M.thermoresistible__bu -----------------------LASHLLVTARTSGNQRDAEGISLFLV-
MSMEG_2190|M.smegmatis_MC2_155 TTARRDGDEWVLDGSKIVVVNALFATHLLVTARTSGDTTDKDGISLFLV-
MAB_2496|M.abscessus_ATCC_1997 TTARRDGPDWVLDGEKIVVSDAPLATHVIVSARTSGEVADTSGLTLFVVP
MMAR_3738|M.marinum_M TRAVQQGDSWLLSGTKNPVLAGDCADTLVVSAALP-----DGGVGLFLV-
MUL_3682|M.ulcerans_Agy99 TRAVRQGDSWLLIGTKNPVLAGDCADTLVVSAALP-----DGGVGLFLV-
MAV_1765|M.avium_104 TKAARQGDPWTLSGQKNPVLAGDCADTLVVSAALP-----DGGTGLFLV-
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDK-GANGISAFIVH
: * . *::
Mb0997c|M.bovis_AF2122/97 --TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAHL
Rv0972c|M.tuberculosis_H37Rv --TDAPGFSYTPIEMEL-VSPERQFQVFLDDVRLPADALVGAEDAAIAQL
Mflv_4380|M.gilvum_PYR-GCK -DIASAPSGVEVHHYRT-VDDRRASDIVLDGVRLPATALLGAEGDAWPSL
Mvan_1964|M.vanbaalenii_PYR-1 -ELGSAATDIELHHYRT-VDDRRASDIVFDGLRLPSTALLGAEGGAWPSI
TH_4557|M.thermoresistible__bu -DMGAGHPGLALNSYRT-IDDRRAADITLEGVRLPADALLGAAGQAWASL
MSMEG_2190|M.smegmatis_MC2_155 -ETASAGSGFTAHHYRT-VDDRRASDLEFDGLRLPASALLGPEGQAGPSL
MAB_2496|M.abscessus_ATCC_1997 FDPAAPAQGIEAHHYRT-IDDHHASDLVISGLRVPDSARISEVDQAWPLI
MMAR_3738|M.marinum_M -DAGPEGGGVDKHPYPT-FDSQRGAQIDLD---QAPAAPLGDAVDASAAI
MUL_3682|M.ulcerans_Agy99 -NAGPEGGGVDKHPYPT-FDSQRGAQINLD---QAPAAPLGDAVDASAAI
MAV_1765|M.avium_104 -DAG----AVTRHPYRT-FDGQRGAQIDLD---ATPAEPLGEATDASGGI
MLBr_00737|M.leprae_Br4923 --KDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTA
.. :: :. . :. .
Mb0997c|M.bovis_AF2122/97 FAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPL
Rv0972c|M.tuberculosis_H37Rv FAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPL
Mflv_4380|M.gilvum_PYR-GCK ARARDEGAAAISAEAVGCMRKVLADTVEYCKQRQQFGQPIGSFQVLQHRM
Mvan_1964|M.vanbaalenii_PYR-1 ALARDEGAAAICAEAVGCMRKVLADTVEYCKQRQQFGQSIGSFQVLQHRM
TH_4557|M.thermoresistible__bu EQARDEGATAICAEAVGGMRKVLDDTVEYSKQRHQFGQPIGSFQVLQHRM
MSMEG_2190|M.smegmatis_MC2_155 ELARDEGAAAVCAEAVGGMRKVLADTVEYCKQRQQFGQPIGSFQALQHRM
MAB_2496|M.abscessus_ATCC_1997 EAALDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRM
MMAR_3738|M.marinum_M RNAITRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLNKFQALTQRA
MUL_3682|M.ulcerans_Agy99 RNAIIRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLSKFQALTQRA
MAV_1765|M.avium_104 EAAIIRIQSALCSEALGAMEESLRLTTDYLKTRKQFGVTLNKFQALTQRA
MLBr_00737|M.leprae_Br4923 LATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFML
:.*:* . * : * * *: :. .:. .* :
Mb0997c|M.bovis_AF2122/97 AQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQ
Rv0972c|M.tuberculosis_H37Rv AQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQ
Mflv_4380|M.gilvum_PYR-GCK VDMYMEVEQAAAAALLATLKLDEDETTRARAVS-AAKATVGRAAQFVGQQ
Mvan_1964|M.vanbaalenii_PYR-1 VDMYMEVEQSAAAVLLAVLKLDSDDVTRARAVS-AAKATVGRAAQFVGQQ
TH_4557|M.thermoresistible__bu VDMHMELQQAIAAVYLAVLNLTADAATRARAVS-AAKATVGRAARFIGQN
MSMEG_2190|M.smegmatis_MC2_155 VDMHMEVEQASAAMYLAVLNLDSDAVTRAKAVS-AAKATVGRAARFVGQN
MAB_2496|M.abscessus_ATCC_1997 VDMHIEVEQSVAASYLASLNLDG--PRRARAVS-AAKATIARAARLVGQE
MMAR_3738|M.marinum_M ADMYVSLELARSMNFYAAMSIADG-NLDPLIAS-RSKLQIGRSGRHIAQE
MUL_3682|M.ulcerans_Agy99 ADMYVSLELARSMNFYAAMSIADG-NLDPLIAS-RSKLQIGRSGRHIAQE
MAV_1765|M.avium_104 ADMYVSLELARSMSLYAAMSIADG-NIDPVIAS-RAKLQIGRSGRHIAQE
MLBr_00737|M.leprae_Br4923 ADMAMKVEAARLIVYAAAARAERG-EPDLGFISAASKCFASDIAMEVTTD
.: :.:: : * : :* . . :
Mb0997c|M.bovis_AF2122/97 AVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRS
Rv0972c|M.tuberculosis_H37Rv AVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRS
Mflv_4380|M.gilvum_PYR-GCK AVQLHGGMGMTEELAIGHYFKRLTALQFEFGSTDHHITRY--GRLTTP--
Mvan_1964|M.vanbaalenii_PYR-1 AVQLHGGMGMTEELAIGHYFKRLTALQFEFGSTDHHVTRY--ARLTNR--
TH_4557|M.thermoresistible__bu AVQLHGGMGMTEELAIGHYFKRLTAMQYEFGSTDHHLTRY--AQLTRS--
MSMEG_2190|M.smegmatis_MC2_155 AVQLHGGMGMTEELAIGHYFKRLTALQYEYGSTAAHVSRY--AELTRP--
MAB_2496|M.abscessus_ATCC_1997 AVQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG--
MMAR_3738|M.marinum_M SIQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLV
MUL_3682|M.ulcerans_Agy99 SIQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLV
MAV_1765|M.avium_104 SIQMHGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLV
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
::* ** * * : : .
Mb0997c|M.bovis_AF2122/97 Y-
Rv0972c|M.tuberculosis_H37Rv Y-
Mflv_4380|M.gilvum_PYR-GCK --
Mvan_1964|M.vanbaalenii_PYR-1 --
TH_4557|M.thermoresistible__bu --
MSMEG_2190|M.smegmatis_MC2_155 --
MAB_2496|M.abscessus_ATCC_1997 --
MMAR_3738|M.marinum_M RL
MUL_3682|M.ulcerans_Agy99 RL
MAV_1765|M.avium_104 RL
MLBr_00737|M.leprae_Br4923 --