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M. gilvum PYR-GCK Mflv_2286 (-)

annotation: acyl-CoA dehydrogenase domain-containing protein
coordinates: 2376214 - 2377320
length: 368

DFQFSEEQVLLRDTTREMLSRKYDPETRLKTIDSELGWSRDVWKQLAEVGVLGLGFDEDAGGQIEVLAVL
TEVGRRLAPEPVLHAALGPGALVAEVGSEQQRGLLDEVAAGERLLAFAHLEPGMRLPTAAVSTKAVREGD
SWTLSGSKNPVLAGGSADTLIVSAQLPDGGTGLFLVDGAAAQRTPYRTFDGQRAAQIDFDSVAAEPLGEA
ADASEAITRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRAADMYVSLELARSM
TFYAAMSVADENLDPTIAARAKLQIGRSGRHIAQESIQLHGGIGVTAEYPISHYAARLTAIDHTLGSASD
QLHVLTGQLDDYEVVSL*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. gilvum PYR-GCK Mflv_2286 - - 100% (368) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_4380 - 1e-51 34.23% (371) acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK Mflv_0345 - 2e-36 31.67% (360) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1968c fadE18 3e-26 29.33% (358) acyl-CoA dehydrogenase FADE18
M. tuberculosis H37Rv Rv1933c fadE18 3e-26 29.33% (358) acyl-CoA dehydrogenase FADE18
M. leprae Br4923 MLBr_00737 fadE25 9e-20 24.93% (361) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_2496 - 7e-46 32.97% (367) acyl-CoA dehydrogenase
M. marinum M MMAR_3738 fadE18_2 1e-153 71.77% (372) acyl-CoA dehydrogenase FadE18_2
M. avium 104 MAV_1765 - 1e-160 75.54% (368) pimeloyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_6512 - 1e-151 71.89% (370) acyl-CoA dehydrogenase domain-containing protein
M. thermoresistible (build 8) TH_3980 - 1e-138 67.48% (369) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_3682 fadE18_2 1e-152 71.51% (372) acyl-CoA dehydrogenase FadE18_2
M. vanbaalenii PYR-1 Mvan_4380 - 0.0 90.03% (371) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1968c|M.bovis_AF2122/97           ----------MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSD----
Rv1933c|M.tuberculosis_H37Rv        ----------MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSD----
Mflv_2286|M.gilvum_PYR-GCK          ----------MDFQFSEEQVLLRDTTREMLSRKYDPETRLKTIDSELGWS
Mvan_4380|M.vanbaalenii_PYR-1       ----------MDFQFSEEQVLLRDTTRDMLSRKYDPETRLKAIDSELGWS
MMAR_3738|M.marinum_M               ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MUL_3682|M.ulcerans_Agy99           ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MAV_1765|M.avium_104                ----------MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWS
MSMEG_6512|M.smegmatis_MC2_155      ----------MDFQLTEEQTLLADTTRDLLS-SYDTETRNKVIASDPGHK
TH_3980|M.thermoresistible__bu      ----------MDFDLTDEQELLRDTTRDLLAGVYDVETRNRTVDTDPGWS
MAB_2496|M.abscessus_ATCC_1997      ----------MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQ
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP--HAADVDQRARFP
                                                *  . *:  :  :   :                     

Mb1968c|M.bovis_AF2122/97           RRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAA
Rv1933c|M.tuberculosis_H37Rv        RRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAA
Mflv_2286|M.gilvum_PYR-GCK          RDVWKQLAEVG-VLGLGFDEDAGGQ----IEVLAVLTEVGRRLAPEPVLH
Mvan_4380|M.vanbaalenii_PYR-1       RDVWKQLAEVG-VLGLGFDEDAGGQ----LEVLVVLTEIGRRLAPEPVLH
MMAR_3738|M.marinum_M               RDVWSQLADTG-ILGLGFEPAEAGQ----IEIMLVMTEVGRRLAPEPIVH
MUL_3682|M.ulcerans_Agy99           RDVWSQLADTG-ILGLGFEPAEAGQ----IEIMLVMTEVGRRLAPEPIVH
MAV_1765|M.avium_104                REVWSQLADTG-ILGLGFDPDESGQ----IEIMVVLTEIGRRLAPEPVLH
MSMEG_6512|M.smegmatis_MC2_155      PEVWNQLAEIG-ILGLGFDEDSGGQ----LEIMVVLNEIGRRLAPEPVLH
TH_3980|M.thermoresistible__bu      REVWKQLADIG-ILSLGFDPAESGQ----IEVMVVMTEIGRRLAPEPVAA
MAB_2496|M.abscessus_ATCC_1997      PQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLGRHLVVEPFIG
MLBr_00737|M.leprae_Br4923          EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
                                          :     . .  .    .*              :.*  .  ..  

Mb1968c|M.bovis_AF2122/97           TVFAIE--AILRMGDDEQRKRLLAGLLTGARIGTIAVSG---HDVASATT
Rv1933c|M.tuberculosis_H37Rv        TVFAIE--AILRMGDDEQRKRLLAGLLTGARIGTIAVSG---HDVASATT
Mflv_2286|M.gilvum_PYR-GCK          AALGPG--ALVAEVGSEQQRGLLDEVAAGERLLAFAHLEPGMRLPTAAVS
Mvan_4380|M.vanbaalenii_PYR-1       AALGPG--ALIAEVGTEAQRGLLDEVAGGERLLAFAHLEPGMRLPTAKVS
MMAR_3738|M.marinum_M               AALAPG--AIIAELGNDAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MUL_3682|M.ulcerans_Agy99           AALAPG--AIIAELGNDAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MAV_1765|M.avium_104                AALGPG--ALIAELGSAAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVG
MSMEG_6512|M.smegmatis_MC2_155      GALAPG--AIIAERGTDAQRALLDEVASGQRILAFAHLEPGVRDAAATPT
TH_3980|M.thermoresistible__bu      AALVPG--TLIAELGSDDQ--LLEQVGSGDMLLALAHREPGTRGVFGSVT
MAB_2496|M.abscessus_ATCC_1997      TVVLGG--GLLRRSNAEVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQ
MLBr_00737|M.leprae_Br4923          AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
                                     .       ::   .      ::  :     :   *              

Mb1968c|M.bovis_AF2122/97           VRAVRRDGRPALTGECTPVLHGHVADLFVVPA-----VAD-GSIVLHVV-
Rv1933c|M.tuberculosis_H37Rv        VRAVRRDGRPALTGECTPVLHGHVADLFVVPA-----VAD-GSIVLHVV-
Mflv_2286|M.gilvum_PYR-GCK          TKAVREGDSWTLSGSKNPVLAGGSADTLIVSA----QLPD-GGTGLFLV-
Mvan_4380|M.vanbaalenii_PYR-1       TTAVREGDSWTLSGRKNPVLAGDCADTLVVSA----ALPD-GGTGLFLV-
MMAR_3738|M.marinum_M               TRAVQQGDSWLLSGTKNPVLAGDCADTLVVSA----ALPD-GGVGLFLV-
MUL_3682|M.ulcerans_Agy99           TRAVRQGDSWLLIGTKNPVLAGDCADTLVVSA----ALPD-GGVGLFLV-
MAV_1765|M.avium_104                TKAARQGDPWTLSGQKNPVLAGDCADTLVVSA----ALPD-GGTGLFLV-
MSMEG_6512|M.smegmatis_MC2_155      VTATRDGDAWTLNGTKNPVLAGDAANTLVVSA----ALPD-GGAGLFLV-
TH_3980|M.thermoresistible__bu      STAAQQGNSWTITGRKHPVLAGDVADTLIVSA----ALPDSGGTGLFLV-
MAB_2496|M.abscessus_ATCC_1997      TTARRDGPDWVLDGEKIVVSDAPLATHVIVSARTSGEVADTSGLTLFVVP
MLBr_00737|M.leprae_Br4923          TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTD---PDKGANGISAFI
                                      *   .    : *    :  .  :    * *      .* ..  :  . 

Mb1968c|M.bovis_AF2122/97           ---AADAPGVTVTPLPSFDITRPVATLRLAG---SPAEPLTAG--TPDDM
Rv1933c|M.tuberculosis_H37Rv        ---AADAPGVTVTPLPSFDITRPVATLRLAG---SPAEPLTAG--TPDDM
Mflv_2286|M.gilvum_PYR-GCK          -DGAAA----QRTPYRTFDGQR-AAQIDFD---SVAAEPLGEAADASEAI
Mvan_4380|M.vanbaalenii_PYR-1       -DATSSN-PVQRTPYRTFDGQR-GAQIDFD---SVAAEPLGEAADASDAI
MMAR_3738|M.marinum_M               -DAGPEGGGVDKHPYPTFDSQR-GAQIDLD---QAPAAPLGDAVDASAAI
MUL_3682|M.ulcerans_Agy99           -NAGPEGGGVDKHPYPTFDSQR-GAQINLD---QAPAAPLGDAVDASAAI
MAV_1765|M.avium_104                -DAG----AVTRHPYRTFDGQR-GAQIDLD---ATPAEPLGEATDASGGI
MSMEG_6512|M.smegmatis_MC2_155      -DAGASG--VSRKPFRTFDGAR-GAQIELS---AAPAEPLGDATDASETI
TH_3980|M.thermoresistible__bu      -DAAAAE----RQPFRTFDGQR-AAQIDFD---ATPARPLGSGGDATEHL
MAB_2496|M.abscessus_ATCC_1997      FDPAAPAQGIEAHHYRTIDDHH-ASDLVISGLRVPDSARISEVDQAWPLI
MLBr_00737|M.leprae_Br4923          VHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTA
                                                            : : :          :          

Mb1968c|M.bovis_AF2122/97           ERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHAC
Rv1933c|M.tuberculosis_H37Rv        ERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHAC
Mflv_2286|M.gilvum_PYR-GCK          TRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRA
Mvan_4380|M.vanbaalenii_PYR-1       SRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRA
MMAR_3738|M.marinum_M               RNAITRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLNKFQALTQRA
MUL_3682|M.ulcerans_Agy99           RNAIIRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLSKFQALTQRA
MAV_1765|M.avium_104                EAAIIRIQSALCSEALGAMEESLRLTTDYLKTRKQFGVTLNKFQALTQRA
MSMEG_6512|M.smegmatis_MC2_155      SRALVRISAGLAAEALGAMEEALRLTTDYLKSRKQFGVTLSKFQTLTQRA
TH_3980|M.thermoresistible__bu      QRALIRHQSALCAEAVGAMAEALRLTTEYLPSRKQFGVPLSSFQTLTQRA
MAB_2496|M.abscessus_ATCC_1997      EAALDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRM
MLBr_00737|M.leprae_Br4923          LATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFML
                                      .:        :: :*     *  :  *   * **. .:..**::    

Mb1968c|M.bovis_AF2122/97           ADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGSA
Rv1933c|M.tuberculosis_H37Rv        ADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGSA
Mflv_2286|M.gilvum_PYR-GCK          ADMYVSLELARSMTFYAAMSVADENLDP-TIAARAKLQIGRSGRHIAQES
Mvan_4380|M.vanbaalenii_PYR-1       ADMYVSLELARSMAFYANMSVADGNLDP-TIAARAKLQIGRSGRHIAQES
MMAR_3738|M.marinum_M               ADMYVSLELARSMNFYAAMSIADGNLDP-LIASRSKLQIGRSGRHIAQES
MUL_3682|M.ulcerans_Agy99           ADMYVSLELARSMNFYAAMSIADGNLDP-LIASRSKLQIGRSGRHIAQES
MAV_1765|M.avium_104                ADMYVSLELARSMSLYAAMSIADGNIDP-VIASRAKLQIGRSGRHIAQES
MSMEG_6512|M.smegmatis_MC2_155      ADMYVSLELARSMAFYASMSIADGEFDP-VKAARAKLQIGRSGRHIAQES
TH_3980|M.thermoresistible__bu      ADMYVSLELARSMNFWAAMSIADGRFDP-AVAARAKLQICRSGRHIGQEA
MAB_2496|M.abscessus_ATCC_1997      VDMHIEVEQSVAASYLASLNLDGPRRAR-AVS-AAKATIARAARLVGQEA
MLBr_00737|M.leprae_Br4923          ADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDA
                                    .** :.:: :      *              :  :*            .:

Mb1968c|M.bovis_AF2122/97           LQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA--
Rv1933c|M.tuberculosis_H37Rv        LQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA--
Mflv_2286|M.gilvum_PYR-GCK          IQLHGGIGVTAEYPISHYAARLTAIDHTLGSASDQLHVLTGQLDDYEVVS
Mvan_4380|M.vanbaalenii_PYR-1       IQLHGGIGVTAEYPISHYAARLTAIDNTLGSTQDQLHVLIGQLGDYEIVT
MMAR_3738|M.marinum_M               IQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLVR
MUL_3682|M.ulcerans_Agy99           IQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLVR
MAV_1765|M.avium_104                IQMHGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLVR
MSMEG_6512|M.smegmatis_MC2_155      IQLHGGIGITAEYPVGHYAARLTAIEHTLGSAQDQLRTLAGQLDSYEIVS
TH_3980|M.thermoresistible__bu      IQLHGGIGMTAEYPVGHYAARLTAIEQTLGSAHDQLQVLIDGLTGYDTVS
MAB_2496|M.abscessus_ATCC_1997      VQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG---
MLBr_00737|M.leprae_Br4923          VQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
                                    :*:.*. . * :  :  :    .  :   *.   :               

Mb1968c|M.bovis_AF2122/97           -
Rv1933c|M.tuberculosis_H37Rv        -
Mflv_2286|M.gilvum_PYR-GCK          L
Mvan_4380|M.vanbaalenii_PYR-1       V
MMAR_3738|M.marinum_M               L
MUL_3682|M.ulcerans_Agy99           L
MAV_1765|M.avium_104                L
MSMEG_6512|M.smegmatis_MC2_155      L
TH_3980|M.thermoresistible__bu      L
MAB_2496|M.abscessus_ATCC_1997      -
MLBr_00737|M.leprae_Br4923          -

species	id	gene	e-value	identity (len)	annotation
M. gilvum PYR-GCK	Mflv_2286	-	-	100% (368)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_4380	-	1e-51	34.23% (371)	acyl-CoA dehydrogenase domain-containing protein
M. gilvum PYR-GCK	Mflv_0345	-	2e-36	31.67% (360)	acyl-CoA dehydrogenase domain-containing protein