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M. smegmatis MC2 155 MSMEG_2234 (-)

annotation: acyl-CoA dehydrogenase middle domain-containing protein
coordinates: 2312674 - 2313864
length: 396

MDFSHVELSSEDAAFREELRAFLAQIVTEDVIRRDRETGDNFDEGVHLALGQAGYLEREFKSEQDGGFTR
VQRRIWALERRRAEVPWVTWGTTIMIARSVAKFASPEIRDDVLRGVFDGTVRMCLGYTEPEGGSDVATCK
TRAVRDGDQWVINGSKMFTTGAHNCQYVFLITNTDPDAPKHKSLTMFLVPLDTPGIEIQGIRTVDGDRTN
IVYYSDVRVDDKYRLGEVNGGWSVVREPLDAEHGAVAAAHDGLDDVAIMTHQATFMAHAADNVAALVGTR
DAAGRAAVDDGSVAYRLGRSFARLEASLSTPSIFGRVAMAQTMRDISPDFMDIAGSVSALPMGADGGADD
RSEYIYRFAPLVGIYGGTLEVFRNMIAQHVLGLGKPNYSPPKARAS

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_2234 - - 100% (396) acyl-CoA dehydrogenase middle domain-containing protein
M. smegmatis MC2 155 MSMEG_0578 - e-146 64.65% (396) acyl-CoA dehydrogenase middle domain-containing protein
M. smegmatis MC2 155 MSMEG_6511 - 6e-40 31.04% (393) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3573c fadE29 6e-33 30.54% (298) acyl-CoA dehydrogenase FADE29
M. gilvum PYR-GCK Mflv_4346 - 1e-178 76.84% (393) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv3543c fadE29 6e-33 30.54% (298) acyl-CoA dehydrogenase FADE29
M. leprae Br4923 MLBr_00660 fadE23 2e-13 31.29% (147) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0615 - 2e-41 36.10% (277) putative acyl-CoA dehydrogenase
M. marinum M MMAR_4010 - 1e-173 76.61% (389) acyl-CoA dehydrogenase
M. avium 104 MAV_1595 - 1e-178 76.57% (397) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_3716 - 0.0 77.33% (397) PUTATIVE putative acyl-CoA dehydrogenase
M. ulcerans Agy99 MUL_3874 - 1e-173 76.35% (389) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_1998 - 0.0 78.88% (393) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3573c|M.bovis_AF2122/97           ---MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHG--PAYRAVI
Rv3543c|M.tuberculosis_H37Rv        ---MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHG--PAYRAVI
MAB_0615|M.abscessus_ATCC_1997      ---MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDRHG--SSYEAVV
MMAR_4010|M.marinum_M               MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETGD--NFHEGLH
MUL_3874|M.ulcerans_Agy99           MDFSRVQISDADREFRETARSFLATHVT-EEVRRHDRETGD--NFHEGLH
MAV_1595|M.avium_104                MDFSRVTLSDEDQRFLDEAREFLRTHVT-DEVRRRDRETGD--NFDEGVH
TH_3716|M.thermoresistible__bu      MDFSRVELSDEDQAFYHEVRRFLREVVT-DEVIQRDRETGD--NFDEGVH
Mflv_4346|M.gilvum_PYR-GCK          MDFSRVQLSDDEQKFQDEVRTFLSEIVT-DEVIRRDRETGD--NFDEGVH
Mvan_1998|M.vanbaalenii_PYR-1       MDFSRVELSDEDQKFLDEVRTFLGEIVT-EDVIRRDRETGD--NFDEGVH
MSMEG_2234|M.smegmatis_MC2_155      MDFSHVELSSEDAAFREELRAFLAQIVT-EDVIRRDRETGD--NFDEGVH
MLBr_00660|M.leprae_Br4923          -MAINLELSRKLQAVIVKTHQGAAELMRPIARKYDLKEHTYPVELDTLFN
                                         : ::     .    :      :          :          . 

Mb3573c|M.bovis_AF2122/97           RRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLP-AVTLQTV
Rv3543c|M.tuberculosis_H37Rv        RRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLP-AVTLQTV
MAB_0615|M.abscessus_ATCC_1997      RRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRADVPMP-LVTLQTV
MMAR_4010|M.marinum_M               LALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPWVTWGTTAMV
MUL_3874|M.ulcerans_Agy99           LALGAAGYLAAEWKPEADG-GFSRVRRRIWELEKRRAHVPWVTWGTTAMV
MAV_1595|M.avium_104                LALGAAGYLEREWKPEAEG-GFSRVQRRIWELEKRRAHVPWVTWGTTAMV
TH_3716|M.thermoresistible__bu      LALGAAGYLEKEWKPADEG-GFSRVRRRIWELEKRRAHVPWVTWGTSALV
Mflv_4346|M.gilvum_PYR-GCK          LALGAAGYLDRDWNPATER-PFSRVERRIWELEKRRAHVPWVTSGTTAMI
Mvan_1998|M.vanbaalenii_PYR-1       LALGAAGYLERDWNPDSDR-AFTRVQRRIWELEKRRAHVPWVTSGTTAMI
MSMEG_2234|M.smegmatis_MC2_155      LALGQAGYLEREFKSEQDG-GFTRVQRRIWALERRRAEVPWVTWGTTIMI
MLBr_00660|M.leprae_Br4923          LFAGAAESFAFAGADALGDEDNKDENHNGANMAALLQTLEACWGDVAMLL
                                       *    :                .:.          :      .   :

Mb3573c|M.bovis_AF2122/97           GPTLQAHGSELQKKKFLPAILA--GEAHFAIGYTEPEAGTDLASLRTTAV
Rv3543c|M.tuberculosis_H37Rv        GPTLQAHGSELQKKKFLPAILA--GEAHFAIGYTEPEAGTDLASLRTTAV
MAB_0615|M.abscessus_ATCC_1997      GPTLQKYGTEEQKKKFLPGILA--GEIHFAIGYTEPEAGTDLASLRTTAV
MMAR_4010|M.marinum_M               ARSVAKFGSPELVEEVLPGVFS--GHVRMCLGYTEPEGGSDVATCKTRAL
MUL_3874|M.ulcerans_Agy99           ARSVAKFGSPELVEEVLPGVFS--GHVRMCLGYTEPEGGSDVATCKTRAL
MAV_1595|M.avium_104                ARSVAKFGSEELQREVLPGVFS--GHVRLCLGYTEPEGGSDVATCKTRAV
TH_3716|M.thermoresistible__bu      ARSVVRFGSPELQEEVMPGFFS--GHVRMCLGYTEPEGGSDIATCKTRAV
Mflv_4346|M.gilvum_PYR-GCK          TKSVEKFGSPELKDEVLPRVYS--GHVRLCLGYTEPEGGSDVATCKTRAV
Mvan_1998|M.vanbaalenii_PYR-1       AKSVERFGSPELKDEVMPKVYS--GHVRLCLGYTEPEGGSDVATCKTRAV
MSMEG_2234|M.smegmatis_MC2_155      ARSVAKFASPEIRDDVLRGVFD--GTVRMCLGYTEPEGGSDVATCKTRAV
MLBr_00660|M.leprae_Br4923          SIPYQGLGNAAISAVATNKQLERLGKVWAAMAITEPGFGSDSAAVSTTAT
                                      .    ..               *    .:. ***  *:* *:  * * 

Mb3573c|M.bovis_AF2122/97           RDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVDTKDP
Rv3543c|M.tuberculosis_H37Rv        RDGDHYIVNGQKVFTTGAHDADYIWLACRTDPNAAKHKGISILIVDTKDP
MAB_0615|M.abscessus_ATCC_1997      RDGDHYVVNGQKIFTTGAHQAQYIWLACRTDPSAPKHKGISILIVDTKDP
MMAR_4010|M.marinum_M               RDGDSWLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLTMFLVPLDSA
MUL_3874|M.ulcerans_Agy99           RDGDSWLINGSKMFTTGAHNCQYVFLITNTDPQARKHKSLTMFLVPLDSA
MAV_1595|M.avium_104                RDGNGWIINGSKMFTTGAHNCQYVFLITNTDPDAPKHKSLTMFLVPLDSP
TH_3716|M.thermoresistible__bu      RDGDHWVINGSKMFTTGAHNCQYVFLITNTDPDAPKHQSLTMFLVPLDTP
Mflv_4346|M.gilvum_PYR-GCK          RDGSSWVINGSKMFTTGAHNCQYVFLITNTDPSAPKHKSLTMFLVPLDTP
Mvan_1998|M.vanbaalenii_PYR-1       RDGDSWVINGSKMFTTGAHNCQYVFLITNTDPSAPKHKSLTMFLVPLDSP
MSMEG_2234|M.smegmatis_MC2_155      RDGDQWVINGSKMFTTGAHNCQYVFLITNTDPDAPKHKSLTMFLVPLDTP
MLBr_00660|M.leprae_Br4923          LDGDEYVINGEKIFVTAGSRATHIVVWATLDKSLG-HAAIKSFIVPREHP
                                     **. :::**.*:*.*..  . :: :    * .   * .:. ::*  . .

Mb3573c|M.bovis_AF2122/97           GYSWTPIILADG--AHHTNATYYNDVRVPVDMLVG----KENDGWRLITT
Rv3543c|M.tuberculosis_H37Rv        GYSWTPIILADG--AHHTNATYYNDVRVPVDMLVG----KENDGWRLITT
MAB_0615|M.abscessus_ATCC_1997      GYSWTPIITNDG--AHHTNATYYTDVRVPVEMLVG----EENAGWKLITT
MMAR_4010|M.marinum_M               GIEIQGIRTVD---GDRTNIVYYSDVRIDDKYRLG----AVNGGWTVLRE
MUL_3874|M.ulcerans_Agy99           GIEIQGIRTVD---GDRTNIVYYSDVRIDDKYRLG----AVNGGWTVLRE
MAV_1595|M.avium_104                GIDIQGIRTVD---GDRTNIVYYSDVRVDDKYRLG----DVNAGWTVLRE
TH_3716|M.thermoresistible__bu      GIEIQGIRTVD---GDRTNIVYYSDVRVPDKYRLG----EVNGGWQVLRE
Mflv_4346|M.gilvum_PYR-GCK          GVEIQGIRTVD---GDRTNIVYYSDVRVDDRYRLG----EVNGGWTVVRE
Mvan_1998|M.vanbaalenii_PYR-1       GVEIQGIRTVD---GDRTNIVYYSDVRVDDRYRLG----EVNDGWTVVRE
MSMEG_2234|M.smegmatis_MC2_155      GIEIQGIRTVD---GDRTNIVYYSDVRVDDKYRLG----EVNGGWSVVRE
MLBr_00660|M.leprae_Br4923          GVTVERLEYKLGIRGSDTAAIRFDNVRIPKDNLLGNPEIEVGKGFSGVME
                                    *     :       .  *    : :**:     :*      . *:  :  

Mb3573c|M.bovis_AF2122/97           QLNNER--------------VMLGPAGRFASIYDRVHAWASVPGGNGVTP
Rv3543c|M.tuberculosis_H37Rv        QLNNER--------------VMLGPAGRFASIYDRVHAWASVPGGNGVTP
MAB_0615|M.abscessus_ATCC_1997      QLNHER--------------VSLGPSGRIAGMYDRVYEWASKPGPDGVAP
MMAR_4010|M.marinum_M               PLNVEHGAVAAAPDGLQDTSIMMHQAGSMAEAVDRAASCVMRPDPDGRRP
MUL_3874|M.ulcerans_Agy99           PLNVEHGAVAAAPDGLQDTSIMMHQAGSMAEAVDRAASCVMRPDPDGRRP
MAV_1595|M.avium_104                PLNVEHGAVAAAPDGLQDVSIMMHQAGFMADALDKVAAKVTLPDPHGRRL
TH_3716|M.thermoresistible__bu      PLNAEHGAVAAAPDGLQDVSIMNHQAGFLATAVDRAAAAVNRADSSGRRL
Mflv_4346|M.gilvum_PYR-GCK          PLNAEHGDVAAADDGLADVSIMMHQAMFMAKAVDTAAQKSTIPDPNGRRL
Mvan_1998|M.vanbaalenii_PYR-1       PLNAEHGAVDAADDGLQDVSIMMHQAMFMAAAVDKAAQKSTIPDPNGRRL
MSMEG_2234|M.smegmatis_MC2_155      PLDAEHGAVAAAHDGLDDVAIMTHQATFMAHAADNVAALVGTRDAAGRAA
MLBr_00660|M.leprae_Br4923          TFDNTRPIVAAMAVGVGRAALEEIRKILTDAGIEICYDKPSHSQNAAAAE
                                     ::  :              :            :            .   

Mb3573c|M.bovis_AF2122/97           IDHDDVKRALGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERV
Rv3543c|M.tuberculosis_H37Rv        IDHDDVKRALGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERV
MAB_0615|M.abscessus_ATCC_1997      LSHEDVRRVLGEMKAVWRLNELLNWQVASSGDDISMADAAATKILATEWI
MMAR_4010|M.marinum_M               IDDTSVAYRLG--RSVARMEAALSAPSIFG----RVAIAQTMRDISPDLM
MUL_3874|M.ulcerans_Agy99           IDDTSVAYRLG--RSVARMEAALSAPSIFG----RVAIAQTMRDISPDLM
MAV_1595|M.avium_104                IDDSAIAYRLG--RNAARMEAALSAPSIYG----RVALAQTMRDISPDLM
TH_3716|M.thermoresistible__bu      IDDGSVAYRLG--RSVARLEMALSTPSIFG----RVAVAQTMRDISPDLM
Mflv_4346|M.gilvum_PYR-GCK          IDDGAVAYRLG--RSVARLEASLSAPSIFG----RVALAQTMRDISPDLM
Mvan_1998|M.vanbaalenii_PYR-1       IDDGSVAYRLG--RSVARLEASLSAPSIFG----RVALAQTMRDISPDLM
MSMEG_2234|M.smegmatis_MC2_155      VDDGSVAYRLG--RSFARLEASLSTPSIFG----RVAMAQTMRDISPDFM
MLBr_00660|M.leprae_Br4923          FLRMEADWEAS---YLLSLRAAWQADNNIP----NSKEASMSKAKAGRMA
                                    .         .       :.   .              *   :  .    

Mb3573c|M.bovis_AF2122/97           QRAGRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMR
Rv3543c|M.tuberculosis_H37Rv        QRAGRLAEEIVGKYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMR
MAB_0615|M.abscessus_ATCC_1997      QKLGRLSEGVVGRYGDPADANTAETLEWLDAQTKRHLVITFGGGVNEVMR
MMAR_4010|M.marinum_M               DILGSAAALPFGTDGAVDDGGAEYVYRFAP-------LVGIYGGTLEVFR
MUL_3874|M.ulcerans_Agy99           DILGSAAALPFGTDGAVDDGGAEYVYRFAP-------LVGIYGGTHEVFR
MAV_1595|M.avium_104                DILGTASALPVGTDGAADDGASEYVFRFAP-------LVGIYGGTLEVFR
TH_3716|M.thermoresistible__bu      DILGAASALPVGADGAADDGAAEYVYRFAP-------LVGIYGGTLEVFR
Mflv_4346|M.gilvum_PYR-GCK          DILGTASALPVGTDGAADDGAAEYVYRFAP-------LVGIYGGTLEVFR
Mvan_1998|M.vanbaalenii_PYR-1       DVMGAASALPVGTDGAADDGASEYIYRFAP-------LVGIYGGTLEVFR
MSMEG_2234|M.smegmatis_MC2_155      DIAGSVSALPMGADGGADD-RSEYIYRFAP-------LVGIYGGTLEVFR
MLBr_00660|M.leprae_Br4923          SDVTLKAVELAGTAGYSEKALLEKWARDSK-------ILDIFEGTQQIQQ
                                    .     :    *  *   .       .          :: :  *. :: :

Mb3573c|M.bovis_AF2122/97           EMIAASGLKVPRVPR--------
Rv3543c|M.tuberculosis_H37Rv        EMIAASGLKVPRVPR--------
MAB_0615|M.abscessus_ATCC_1997      EMVSTAGLGTPRVPR--------
MMAR_4010|M.marinum_M               NMIAQHVLGLGKPSYP---HRT-
MUL_3874|M.ulcerans_Agy99           NMIAQHVLGLGKPSYP---HRT-
MAV_1595|M.avium_104                NMIAQYMLGLGKPAYAPVAQRAS
TH_3716|M.thermoresistible__bu      NMIAQYVLGLGKPSYGQPVKKSA
Mflv_4346|M.gilvum_PYR-GCK          NMIAQYVLGLGKPNYSPPRKAS-
Mvan_1998|M.vanbaalenii_PYR-1       NMIAQYALGLGKPNYSPVKT---
MSMEG_2234|M.smegmatis_MC2_155      NMIAQHVLGLGKPNYSPPKARAS
MLBr_00660|M.leprae_Br4923          LVVARRLLGLSSSELK-------
                                     :::   *

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_2234	-	-	100% (396)	acyl-CoA dehydrogenase middle domain-containing protein
M. smegmatis MC2 155	MSMEG_0578	-	e-146	64.65% (396)	acyl-CoA dehydrogenase middle domain-containing protein
M. smegmatis MC2 155	MSMEG_6511	-	6e-40	31.04% (393)	acyl-CoA dehydrogenase domain-containing protein