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RHGPTTSHDIGSRDGLGRRDVVDGDRAGGNRRSRGSRRPRYRRRVRDHLRGADAGRTRRPDPASGRLARP GRRQGRATRRRCARRRGAEDDLPRRLLPAAQRGERGHRPRDPRARPAHRGDQRESARGSDGAGRRRVAAY RRPVEAGEQVIVQRHQDDRPADPVQLRMIETSGLTKSFGPKKVLDDVSVCFPGGTVTALLGLNGAGKTTL LRLIAGLDRPDGGTVTVDGRAPGGDPNQVGVHLGPGALDPRHTVGRHLKWLAALAGTEVRRIDDVLDETG LHAQRRERIGALSLGARQRLSIAGALLCSPRALLFDEPLNGLDVPGIVWFRGLLRKLADDGCAVVVATHL LAEVVLSADRVLMLDCGRPRVHGPLDNVIPAGDQPRDWLESALLDGARCA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4301 | - | - | 100% (401) | ABC transporter related |
| M. gilvum PYR-GCK | Mflv_0193 | - | 3e-44 | 47.85% (209) | ABC transporter related |
| M. gilvum PYR-GCK | Mflv_3361 | - | 6e-26 | 37.50% (224) | ABC transporter related |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2419c | cysA1 | 6e-26 | 37.27% (220) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. tuberculosis H37Rv | Rv2397c | cysA1 | 6e-26 | 37.27% (220) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. leprae Br4923 | MLBr_00590 | - | 5e-21 | 33.66% (205) | putative ABC transporter ATP-binding protein |
| M. abscessus ATCC 19977 | MAB_4215c | - | 6e-42 | 44.12% (204) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_3263 | - | 2e-25 | 33.48% (224) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_1785 | - | 4e-25 | 38.73% (204) | sulfate/thiosulfate import ATP-binding protein CysA |
| M. smegmatis MC2 155 | MSMEG_5312 | - | 5e-72 | 61.90% (231) | ABC-type multidrug transport system ATPase component |
| M. thermoresistible (build 8) | TH_2788 | - | 1e-46 | 50.49% (204) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_3658 | cysA1 | 3e-25 | 37.25% (204) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. vanbaalenii PYR-1 | Mvan_2047 | - | 1e-102 | 78.11% (233) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00590|M.leprae_Br4923 --------------------------------------------------
MMAR_3263|M.marinum_M --------------------------------------------------
Mflv_4301|M.gilvum_PYR-GCK MRHGPTTSHDIGSRDGLGRRDVVDGDRAGGNRRSRGSRRPRYRRRVRDHL
Mvan_2047|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5312|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4215c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2788|M.thermoresistible__bu --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1785|M.avium_104 --------------------------------------------------
MUL_3658|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00590|M.leprae_Br4923 --------------------------------------------------
MMAR_3263|M.marinum_M --------------------------------------------------
Mflv_4301|M.gilvum_PYR-GCK RGADAGRTRRPDPASGRLARPGRRQGRATRRRCARRRGAEDDLPRRLLPA
Mvan_2047|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5312|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4215c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2788|M.thermoresistible__bu --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1785|M.avium_104 --------------------------------------------------
MUL_3658|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00590|M.leprae_Br4923 --------------------------------------------------
MMAR_3263|M.marinum_M --------------------------------------------------
Mflv_4301|M.gilvum_PYR-GCK AQRGERGHRPRDPRARPAHRGDQRESARGSDGAGRRRVAAYRRPVEAGEQ
Mvan_2047|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5312|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4215c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2788|M.thermoresistible__bu --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 --------------------------------------------------
Rv2397c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1785|M.avium_104 --------------------------------------------------
MUL_3658|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00590|M.leprae_Br4923 -----MSSACTVPETPEVVIRLRGVCKHYGSILAVSNLDLDIHSAEVLAL
MMAR_3263|M.marinum_M ------------MRRSQSAVEVIDLVKRRGSVTAVDGISFAVPPGGVLGL
Mflv_4301|M.gilvum_PYR-GCK VIVQRHQDDRPADPVQLRMIETSGLTKSFGPKKVLDDVSVCFPGGTVTAL
Mvan_2047|M.vanbaalenii_PYR-1 ------------------MIETHGLTKSFGPRRALDDVTVTFPAGAVTAL
MSMEG_5312|M.smegmatis_MC2_155 ------------------MIEITRLVKRFGATVAVDDVTVSFPAGTVTGL
MAB_4215c|M.abscessus_ATCC_199 ------------------MIELRSLTKVYGQTPAVDDLSVTIESGVVTGF
TH_2788|M.thermoresistible__bu --------------MMAAMIELTALTKVFGRTRAVDDLTCTVEPGVVTGF
Mb2419c|M.bovis_AF2122/97 -------MT--------YAIVVADATKRYGDFVALDHVDFVVPTGSLTAL
Rv2397c|M.tuberculosis_H37Rv -------MT--------YAIVVADATKRYGDFVALDHVDFVVPTGSLTAL
MAV_1785|M.avium_104 -------MTDAGTDRGDIAITVRDAYKRYGDFVALDHVDFVVPTGSLTAL
MUL_3658|M.ulcerans_Agy99 -------MTGPG--TGGHAIVVRDAFKQYGDFVALDHVDFVVPAGSLTAL
: * * .:. : . . : .:
MLBr_00590|M.leprae_Br4923 LGPNGAGKTTTVEMCEGFVRPDAGTIEVLGLDPITDNARLRARIGVMLQG
MMAR_3263|M.marinum_M LGPNGAGKTTTVRMLATLTRPTSGAAWVAGHDVCAAPESVRREIGLTCQE
Mflv_4301|M.gilvum_PYR-GCK LGLNGAGKTTLLRLIAGLDRPDGGTVTVDGR--APGGDPN--QVGVHLGP
Mvan_2047|M.vanbaalenii_PYR-1 LGLNGAGKTTLLRLIAGLDRPDGGTVTVSGR--TPFGDPH--LVGAHLGP
MSMEG_5312|M.smegmatis_MC2_155 LGLNGAGKTTLLRLIAGLDHPDSGDVTLCGRPIRDHADPMR-TLGVHFDP
MAB_4215c|M.abscessus_ATCC_199 LGPNGAGKSTTLRMIVGLARPTSGTATIGGKQYHEIDHPLR-EVGALLDP
TH_2788|M.thermoresistible__bu LGPNGAGKTTTMRLILGLDRPTSGTATIDGRRYRDLRDPLR-TVGALLDA
Mb2419c|M.bovis_AF2122/97 LGPSGSGKSTLLRTIAGLDQPDTGTITINGRDVTRVPPQRR-GIGFVFQH
Rv2397c|M.tuberculosis_H37Rv LGPSGSGKSTLLRTIAGLDQPDTGTITINGRDVTRVPPQRR-GIGFVFQH
MAV_1785|M.avium_104 LGPSGSGKSTLLRTIAGLDQPDTGTVTIYGRDVTRVPPQRR-GIGFVFQH
MUL_3658|M.ulcerans_Agy99 LGPSGSGKSTLLRTIAGLDQPDSGNITINGRDVTRVPPQRR-GIGFVFQH
** .*:**:* :. : :* * : * :*
MLBr_00590|M.leprae_Br4923 GGGYPAARAGEMLNLVASYAADPLD-----PEWLLETLGLTDVARTTYRR
MMAR_3263|M.marinum_M ATLDGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFADRRVDT
Mflv_4301|M.gilvum_PYR-GCK GALDPRHTVGRHLKWLAALAGTE----VRRIDDVLDETGLHAQRRERIGA
Mvan_2047|M.vanbaalenii_PYR-1 DALDPRHTVARHLRWLAALAGVD----DGRVAQVLEETGLSAQRCNRIGG
MSMEG_5312|M.smegmatis_MC2_155 DAMDPRHTAERHLRWLAALGGID----GGRVDAVLAEVGLDELRHRRIAN
MAB_4215c|M.abscessus_ATCC_199 KQFHPNRSARNHLRWIAAANDIS----AQRVDEVLEMVGLTEVANRHAGT
TH_2788|M.thermoresistible__bu RAVHPARSARNHLRWLAAANRIP----QRRVDEVLELVGLTAVAARPAGT
Mb2419c|M.bovis_AF2122/97 YAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQ
Rv2397c|M.tuberculosis_H37Rv YAAFKHLTVRDNVAFGLKIRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQ
MAV_1785|M.avium_104 YAAFKHLTVRDNVAYGLKVRKRPKAEIKAKVDNLLEVVGLSGFQGRYPNQ
MUL_3658|M.ulcerans_Agy99 YAAFKHLTVRDNVAYGLKIRKRPKAEIRDKVDNLLEVVGLSGFHGRYPDQ
. : :* .:
MLBr_00590|M.leprae_Br4923 LSGGQQQRLALACTLVGRPELVFLDEPTAGMDTHARLLVWELIDTLRRDG
MMAR_3263|M.marinum_M YSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLRTLVDDG
Mflv_4301|M.gilvum_PYR-GCK LSLGARQRLSIAGALLCSPRALLFDEPLNGLDVPGIVWFRGLLRKLADDG
Mvan_2047|M.vanbaalenii_PYR-1 LSLGARQRLAIAGALLCRPQALLFDEPLNGLDVPGIVWFRGLLRQLADTG
MSMEG_5312|M.smegmatis_MC2_155 LSMGARQRLAIASALLGDPQVLVFDEPVNGLDVPGIVWLRELLHRLAGRG
MAB_4215c|M.abscessus_ATCC_199 FSLGMSQRLGIAVALLGDPKVLLFDEPVNGLDPEGIHWIRTLMQSLAAQG
TH_2788|M.thermoresistible__bu LSLGMSQRLGIAGALLGDPPVLLFDEPVNGLDPEGIRWVRTLMRTMAAEG
Mb2419c|M.bovis_AF2122/97 LSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRLHDEV
Rv2397c|M.tuberculosis_H37Rv LSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREELRAWLRRLHDEV
MAV_1785|M.avium_104 LSGGQRQRMALARALAVDPQVLLLDEPFGALDAKVREDLRAWLRRLHDEV
MUL_3658|M.ulcerans_Agy99 LSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREDLRAWLRRLHDEV
* * :*: :* :* * :.:*** .:* . : :
MLBr_00590|M.leprae_Br4923 -VTVVLTTHQLKEAEELADRLVIIDHGRMIAAGTP------------TEL
MMAR_3263|M.marinum_M -LTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSP------------FEL
Mflv_4301|M.gilvum_PYR-GCK -CAVVVATHLLAEVVLSADRVLMLDCG-----------------------
Mvan_2047|M.vanbaalenii_PYR-1 -CVVVVATHLLAEVVLSADRVILLEAG-----------------------
MSMEG_5312|M.smegmatis_MC2_155 -CTVVVASHLLGEVVLTADRLLVLQRG-----------------------
MAB_4215c|M.abscessus_ATCC_199 -RTVLVSSHLLSEMANTADQLVVIGRGRLIAA---------------TSM
TH_2788|M.thermoresistible__bu -RTVLVSSHLLAEMANTADRLLVIGRGRLIAS---------------TSV
Mb2419c|M.bovis_AF2122/97 HVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSF
Rv2397c|M.tuberculosis_H37Rv HVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGSPTDVYDAPANAFVMSF
MAV_1785|M.avium_104 HVTTVLVTHDQAEALDVADRIAVLNQGRIEQIGSPTEVYDAPTNAFVMSF
MUL_3658|M.ulcerans_Agy99 HVTTVLVTHDQAEALDVADRIAVLNSGRIEQVGSPTEVYDAPTNAFVMSF
. :: :: * **.: :: *
MLBr_00590|M.leprae_Br4923 MHTGAKDQLRFSAPPRLDLSLLAFALPEDYKTTELTP-GEYLVAGPIDPQ
MMAR_3263|M.marinum_M KQKAGDASIVVTVSRTEDVANVAAFLRTGAKEVRVDISARRITVATHGLL
Mflv_4301|M.gilvum_PYR-GCK ------------RPR-------------------------------VHGP
Mvan_2047|M.vanbaalenii_PYR-1 ------------QPR-------------------------------LDGA
MSMEG_5312|M.smegmatis_MC2_155 ------------KVK-------------------------------VAGA
MAB_4215c|M.abscessus_ATCC_199 HEFVSRAGADVVRVRSPQIDILRSAAEESGFSVVGGERTGEPGVLEISGA
TH_2788|M.thermoresistible__bu AEFVGSTAAERVRVRSPEMDTLRGLLADAGVEVR-LEPDG--AALTVRGA
Mb2419c|M.bovis_AF2122/97 LGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVL
Rv2397c|M.tuberculosis_H37Rv LGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVL
MAV_1785|M.avium_104 LGAVSTLNGTLVRPHDIRVGRTPEMAVAAEDGTAESTGVARAIVDRVVKL
MUL_3658|M.ulcerans_Agy99 LGAVSALNGALVRPHDIRVGRTPEMAVAAADGTGESTGVTRAVVDRIVVL
MLBr_00590|M.leprae_Br4923 VLATVTAWCAQINVLTTNMRVEQHSLEDVFLDLTGRKLR-----------
MMAR_3263|M.marinum_M DLSDVARMLHQYAAPIEDIRLTRPSLDDVFVLLTGHHGSSSEGDSA----
Mflv_4301|M.gilvum_PYR-GCK LDNVIPAGDQ-----------PRDWLESALLDGARCA-------------
Mvan_2047|M.vanbaalenii_PYR-1 LADVIPAGAD-----------PRDWLESRLLDCVACA-------------
MSMEG_5312|M.smegmatis_MC2_155 LADVTPAGAD-----------PRDHLESLLLETVDA--------------
MAB_4215c|M.abscessus_ATCC_199 LIEQVGELAARRGVTLYELSPQRVSLEDAYLSLTDDAVQYRSQVNDPLAA
TH_2788|M.thermoresistible__bu APEVVGELAARNGITLHELSVQRASLEDAYLELTDAAVEYR---------
Mb2419c|M.bovis_AF2122/97 GFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGG
Rv2397c|M.tuberculosis_H37Rv GFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGG
MAV_1785|M.avium_104 GFEVRVELTSAATGGPFTAQITRGDAEALALREGDTVYVRATRVPPITAG
MUL_3658|M.ulcerans_Agy99 GFEVRVELTSAATGGAFTAQITRGDAEALALQEGDTVYVRATRVPPIAGA
: : :
MLBr_00590|M.leprae_Br4923 --------------------------
MMAR_3263|M.marinum_M --------------------------
Mflv_4301|M.gilvum_PYR-GCK --------------------------
Mvan_2047|M.vanbaalenii_PYR-1 --------------------------
MSMEG_5312|M.smegmatis_MC2_155 --------------------------
MAB_4215c|M.abscessus_ATCC_199 RATGAVADAEGTH-------------
TH_2788|M.thermoresistible__bu ----AVPR------------------
Mb2419c|M.bovis_AF2122/97 ---VSGVDDAGVERVKVTST------
Rv2397c|M.tuberculosis_H37Rv ---VSGVDDAGVERVKVTST------
MAV_1785|M.avium_104 ATTVPAVSRDGADEATLTSA------
MUL_3658|M.ulcerans_Agy99 ---APAVPDDGAGSTPRAAQIGVGGQ