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VRPVRAARRAVAIAAAVLMTTTACSFDGVSSLPLPGTVGRGDGATAYTVALANVGTLEPNSPVMIDDVVI GSVSRIGIVDRHAEVGIRVKAGVEIPANAIATVGQTSLLGSMHLELAAPLGEPAVGVLAPGSSIGLDASS THPSTEQTLAALSTVVNGGGLGQIGDVVHSFNDVFAGHQNDIRELLGRLDRFVGILDTQTDDIIATITEL DRFSATLAQQRDVVSRALREIPPALDTLVRQRPRFTEALDALRRFSDTAGTVIDAVHTDLVTNLANLEPA LRAVADLGPDISTGLGYALTFPLNQNIIDRGVRGDYMNLFVTVDLTLGRFKRGLLAGTSFGDENAPLVPA PGDPGYETFYSKNPLGEAVAPPPGVMGPDRLPTGGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4164 | - | - | 100% (386) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4534 | - | e-111 | 55.41% (370) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2512 | - | e-111 | 54.05% (370) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3525c | lprN | 4e-59 | 37.43% (374) | MCE-family lipoprotein LprN |
| M. tuberculosis H37Rv | Rv1970 | lprM | 2e-70 | 43.88% (335) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 8e-46 | 30.71% (368) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 4e-66 | 40.29% (345) | MCE-family protein LprN |
| M. marinum M | MMAR_4706 | - | 1e-110 | 52.49% (381) | MCE family lipoprotein |
| M. avium 104 | MAV_2536 | - | 6e-69 | 40.24% (338) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4786 | - | 1e-110 | 53.62% (373) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4487 | - | 1e-114 | 57.10% (366) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_2866 | lprM | 7e-71 | 42.82% (341) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_4146 | - | 1e-113 | 54.32% (370) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1970|M.tuberculosis_H37Rv ----MRIG------------LTLVMIAAVVASCGWRGLNSLPLPGTQGNG
MUL_2866|M.ulcerans_Agy99 ----MRVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGNG
MAV_2536|M.avium_104 ----MSQSPLRR---RVMAALLAAVALATLSGCGFRGLNSFNLPGTKGGG
Mb3525c|M.bovis_AF2122/97 ------MNRIWL-----RAIIL-TASSALLAGCQFGGLNSLPLPGTAGHG
MAB_4149c|M.abscessus_ATCC_199 ------MSRNVL-----RAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGHG
MMAR_4706|M.marinum_M -MTASTATPALR-----RLFVIGCCVMLAVTGCAFNGLNSLPLPGAVGRG
Mvan_4146|M.vanbaalenii_PYR-1 ------MIRGVK-----QLTVLGCSAALSLSGCAFQGVNSLPLPGAVGRG
MSMEG_4786|M.smegmatis_MC2_155 ----MRIRKRIR-----LAVAAGTCVALTASGCAFQGVNSLPLPGAEGRG
TH_4487|M.thermoresistible__bu ---------MMR-----GVVAVGACVALTVSGCGFQGVNSLPLPGAVGRG
Mflv_4164|M.gilvum_PYR-GCK ----MRPVRAAR-----RAVAIAAAVLMTTTACSFDGVSSLPLPGTVGRG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGSG
:.* : *:... :** * *
Rv1970|M.tuberculosis_H37Rv PGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQG-----WHALVT
MUL_2866|M.ulcerans_Agy99 PGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQG-----WHALVT
MAV_2536|M.avium_104 PGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQG-----WNALVT
Mb3525c|M.bovis_AF2122/97 EGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVK
MAB_4149c|M.abscessus_ATCC_199 SRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGVK
MMAR_4706|M.marinum_M PGASVYHVEIANVGTLEANSPVMLNDVIVGSISKMTVRG-----WHADVE
Mvan_4146|M.vanbaalenii_PYR-1 PDAVSYNVQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADVE
MSMEG_4786|M.smegmatis_MC2_155 ADSVVYHVEIANVATLEPNSPVMMNDVVVGSVRRLAVRD-----WHADVE
TH_4487|M.thermoresistible__bu PGAETYTVEIENVATLEPNSPVMIGDVVVGSVRSMTVQD-----WHAKVE
Mflv_4164|M.gilvum_PYR-GCK DGATAYTVALANVGTLEPNSPVMIDDVVIGSVSRIGIVD-----RHAEVG
MLBr_02593|M.leprae_Br4923 KGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKN-----WVATLT
: . : :. : ** * : ** :* : : * :
Rv1970|M.tuberculosis_H37Rv MRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIAL
MUL_2866|M.ulcerans_Agy99 IRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIPL
MAV_2536|M.avium_104 MTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIPL
Mb3525c|M.bovis_AF2122/97 LDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITE
MAB_4149c|M.abscessus_ATCC_199 VSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIPL
MMAR_4706|M.marinum_M ISVRRGAVIPDNAVASVGQTSLLGSMHLALNSPLGQVSDQRLQPGSTIPL
Mvan_4146|M.vanbaalenii_PYR-1 ISVKPDVVIPANAVATVGQTSLLGSMHLALNPPLGDEPKGRLQPGSTLPL
MSMEG_4786|M.smegmatis_MC2_155 FSVEPGVVVPANAVATIGQTSLLGSMHLALNPPLGQEPQGRLTPGGTIPL
TH_4487|M.thermoresistible__bu ISVEPGVEVPANAVASVGQTSLLGSMHLALDPPPGERPQGRLAPGSVIRL
Mflv_4164|M.gilvum_PYR-GCK IRVKAGVEIPANAIATVGQTSLLGSMHLELAAPLGEPAVGVLAPGSSIGL
MLBr_02593|M.leprae_Br4923 LGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIPL
. : . :* *: * :. ****** *: * .* * * :
Rv1970|M.tuberculosis_H37Rv SHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGLI
MUL_2866|M.ulcerans_Agy99 SRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSLI
MAV_2536|M.avium_104 SSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNLL
Mb3525c|M.bovis_AF2122/97 ANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNLV
MAB_4149c|M.abscessus_ATCC_199 SRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQVL
MMAR_4706|M.marinum_M SRSSTYPSTEQTLSSLSVILNAGGLGQIGDIIHNFTAALSGRTSDIRDLL
Mvan_4146|M.vanbaalenii_PYR-1 NASSTYPTTEQTLASLSTVANGGGLGQIGDIVHNMNTALSGREPEVRELL
MSMEG_4786|M.smegmatis_MC2_155 NSASTYPTTEQTLSSLAAVVNGGGLGQIGEVIHNFSVALDGREADFRDLL
TH_4487|M.thermoresistible__bu DDSSTYPTTEQTLASLAAVVNGGGLGQIGDVIHNMSGALNGREQQIRDLL
Mflv_4164|M.gilvum_PYR-GCK DASSTHPSTEQTLAALSTVVNGGGLGQIGDVVHSFNDVFAGHQNDIRELL
MLBr_02593|M.leprae_Br4923 KNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFL
. .*:**..::::. : . *.: : : . . *: :. .:
Rv1970|M.tuberculosis_H37Rv GQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDALA
MUL_2866|M.ulcerans_Agy99 AQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDALA
MAV_2536|M.avium_104 NQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQALT
Mb3525c|M.bovis_AF2122/97 PRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAVR
MAB_4149c|M.abscessus_ATCC_199 PKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPALK
MMAR_4706|M.marinum_M VRLDRFVGTFDEQRDNLVASIQALNRLAGTLAGQRDVITQALQKIPPALD
Mvan_4146|M.vanbaalenii_PYR-1 TRLDNFVGVLAEQRENIIASIQQLRRVAGTFANQREVIDRALKEIPPAID
MSMEG_4786|M.smegmatis_MC2_155 TRLDNFVGTLDAQRDNIVSSIDSLNRLASTFAGQSEEITRALNKIPPAMD
TH_4487|M.thermoresistible__bu NRLDTFVGTLDAQRDNIVSSIESLNRLAARFAGERDDITRALERVPPAIE
Mflv_4164|M.gilvum_PYR-GCK GRLDRFVGILDTQTDDIIATITELDRFSATLAQQRDVVSRALREIPPALD
MLBr_02593|M.leprae_Br4923 TKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIK
:* : . : * :: : .. .. . : : : :
Rv1970|M.tuberculosis_H37Rv VLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLAN
MUL_2866|M.ulcerans_Agy99 VLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESLAN
MAV_2536|M.avium_104 VLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLAD
Mb3525c|M.bovis_AF2122/97 VLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALND
MAB_4149c|M.abscessus_ATCC_199 VLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALAE
MMAR_4706|M.marinum_M VLIRERPRITAALDKLGTFSDTATRLVNDAGSDLVQNLQNLGPTISALAD
Mvan_4146|M.vanbaalenii_PYR-1 VLIRERPNFTTALDRLGQFSNTATQLVNDAGDDLVKNLENLGPVLGALAD
MSMEG_4786|M.smegmatis_MC2_155 VLIQERPRFTTALQKLGTFGSTAHQLVNESQDDLVRNLRNLEPAIKALAD
TH_4487|M.thermoresistible__bu VLVRERPRLTAALERLGTFSDTTTRFVNDSQADLVRNLENLEPALKALAD
Mflv_4164|M.gilvum_PYR-GCK TLVRQRPRFTEALDALRRFSDTAGTVIDAVHTDLVTNLANLEPALRAVAD
MLBr_02593|M.leprae_Br4923 HFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELGR
: : : * : : . : : :* * : :
Rv1970|M.tuberculosis_H37Rv SGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLLT
MUL_2866|M.ulcerans_Agy99 AGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLLT
MAV_2536|M.avium_104 AGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFLT
Mb3525c|M.bovis_AF2122/97 DRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFT
MAB_4149c|M.abscessus_ATCC_199 NRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLFT
MMAR_4706|M.marinum_M IGPDLDAAIAYAPTFPFTQGFIDRYIRGDYVNGYFIIDLTNAGLRKSILL
Mvan_4146|M.vanbaalenii_PYR-1 IGPDLNEAVLWASAFPYGPTFADRITRGDYINLYAIFDLTYPRLKKTLLA
MSMEG_4786|M.smegmatis_MC2_155 VGPDLAGVLEYAGHFPFTQSFIDRAIRGDYWNLFATIDLTIPRLKRSLML
TH_4487|M.thermoresistible__bu VGPSLNSVLEFAVHFPFTQNFIDRAIRGDYYNLFAIVDFTIPRLKRTLFL
Mflv_4164|M.gilvum_PYR-GCK LGPDISTGLGYALTFPLNQNIIDRGVRGDYMNLFVTVDLTLGRFKRGLLA
MLBr_02593|M.leprae_Br4923 GAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVLT
: : * . **:* * .*.* : .:
Rv1970|M.tuberculosis_H37Rv GTRWECHLTQLELQWG-RTIGQFPSPCT----------------------
MUL_2866|M.ulcerans_Agy99 GTRWECHLTELELQWG-RTIGQFPSPCT----------------------
MAV_2536|M.avium_104 GTRFECNLTELELQWG-RTIGQLPSPCT----------------------
Mb3525c|M.bovis_AF2122/97 TAYFDPNMAHMDEILN-PPDFLIGELAN----------------------
MAB_4149c|M.abscessus_ATCC_199 TSFFDPNMQHFNDVVN-PPEWLIGSMAN----------------------
MMAR_4706|M.marinum_M GTHWGRLGAEGVPAPG-DPEYLQFKFG---APIPPGPPPADAPPPGD---
Mvan_4146|M.vanbaalenii_PYR-1 GTRWGDQNAKLIPAPG-DPYYLNYAYNPMMVGITPPPEEALPPPAQG---
MSMEG_4786|M.smegmatis_MC2_155 GTRWEQEGAQLVPAPG-DPYYLNYTYDPLKAGVETPGPASFPPPFAD---
TH_4487|M.thermoresistible__bu GTRWAQEGAQLVPAPG-DPQYLQYTYDPLRLGVDPP-PPQFVPPLGDEVF
Mflv_4164|M.gilvum_PYR-GCK GTSFGDENAPLVPAPG-DPGYETFYSK---------------NPLGE---
MLBr_02593|M.leprae_Br4923 GTGLSGALRALEQSFGRDPETMIPDVR-----------------------
: . .
Rv1970|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2866|M.ulcerans_Agy99 --------------------------------------------------
MAV_2536|M.avium_104 --------------------------------------------------
Mb3525c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4149c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4706|M.marinum_M -----------------PAPG---------------PPP-----------
Mvan_4146|M.vanbaalenii_PYR-1 -----------------GAPSSLTGVPAQPILPVVPPPPAAP-------W
MSMEG_4786|M.smegmatis_MC2_155 -PPVPAAPVDQTTLPLPEAPPGPPPAYAGPVLPVAPPAPMTLPGVPAPVT
TH_4487|M.thermoresistible__bu PPAVPPEPPQAATAEQEALPLPPITEDVGPLLPAAPPAVVNFPGGPVTVR
Mflv_4164|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_02593|M.leprae_Br4923 --------------------------------------------------
Rv1970|M.tuberculosis_H37Rv -----------------AGYRGTPGNPLTIAYRWDQGP--
MUL_2866|M.ulcerans_Agy99 -----------------AGYRGTPGNPLTVPYHWDQGP--
MAV_2536|M.avium_104 -----------------GGGPYNPGNPLVVPYHFDQGR--
Mb3525c|M.bovis_AF2122/97 ----------------LSGQAADPFKIPPGTAS---GQ--
MAB_4149c|M.abscessus_ATCC_199 ----------------LNGKETSPFDLPAPAAPQGGGR--
MMAR_4706|M.marinum_M -----------------DSAVPIPGATPAEAAPTDGGP--
Mvan_4146|M.vanbaalenii_PYR-1 LPQAQPMAGDQIFAGPFGAPTPPPVAPPAPSVPTPGGGG-
MSMEG_4786|M.smegmatis_MC2_155 -TPGDP---TQIFAGPYGDQPNPPTEAPAPAQPTTGGGG-
TH_4487|M.thermoresistible__bu PTPPAPDGSTPIFAG-HPAQPPSPETAPS-----SGGGG-
Mflv_4164|M.gilvum_PYR-GCK ------------------AVAPPPGVMGPDRLPTGGR---
MLBr_02593|M.leprae_Br4923 -------------------YTTNPNDAPGGPLVERADRRC
*