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MRRQRGAGLKFALFVTVMALLTGCLFAVFGQYRSGSTNVYSAVFKDVSNLRAGESVRFAGVRIGTVKDLS MQPDKTVVVTFDAERGLVLTSGTRAVVRYLNLVGDRFLELVDDEGSTRILPAGARIPVEQTAPALDLDLL LGGLKPVIKGLDAQEVNNLSAALIQIVQGQGGTLESLLSRTSSFSNALADRTEVIDRLIVNLQTTLGTLA DQRDDFSEGLTRLHRLVTELSAERQPIGAAIDSLSAGTASLSDLLTDTRPPLADTVDQLHRLAPNLESKL DRLETAISKAPENYRKLVRIGSYGSFVNYYICSLGVRVTDLAGRTAVFPVFRQDNGRCAEN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4161 | - | - | 100% (341) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2509 | - | e-108 | 55.59% (340) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4537 | - | e-106 | 58.33% (336) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3528c | mce4B | 2e-73 | 42.01% (338) | MCE-family protein MCE4B |
| M. tuberculosis H37Rv | Rv3498c | mce4B | 2e-73 | 42.01% (338) | MCE-family protein MCE4B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 6e-57 | 34.51% (339) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 1e-70 | 40.71% (339) | MCE-family protein |
| M. marinum M | MMAR_4709 | - | 1e-106 | 57.94% (340) | MCE-family protein |
| M. avium 104 | MAV_0949 | - | 1e-114 | 60.06% (338) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4793 | - | 1e-113 | 59.71% (340) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4265 | - | 1e-112 | 59.94% (332) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4061 | mce4B | 5e-74 | 41.52% (342) | MCE-family protein Mce4B |
| M. vanbaalenii PYR-1 | Mvan_4149 | - | 1e-110 | 56.76% (340) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3528c|M.bovis_AF2122/97 MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFT
Rv3498c|M.tuberculosis_H37Rv MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFT
MUL_4061|M.ulcerans_Agy99 MASGGMPSHRSMVIKVSVFGVVMLVLAAALVVVFGDFRFGPTNVYHATFT
MAB_4152c|M.abscessus_ATCC_199 -------MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGKRYHAMFS
MSMEG_4793|M.smegmatis_MC2_155 -----MRRASSTLVKFGVFAVVMAVLTAFLFMTFSEYRGGSYAGYSAVFD
TH_4265|M.thermoresistible__bu --------MTRTIVKFGVFVTVMTTLTAFLFMTFSQYRGGATSRYSAVFE
Mvan_4149|M.vanbaalenii_PYR-1 -----MTRSAATLVKFTAFGLVMALLTAFLFLVFSDTRTGAANEYTAVFK
MMAR_4709|M.marinum_M -----MTGSRAMIIKFGAFAAVMIVLTVFLFFIFGQYRTGSTNGYSALFN
MAV_0949|M.avium_104 -----MR-TRATLIKFAIFAVVMAMLTAFLFFIFGQYRTGATNGYSAVFT
Mflv_4161|M.gilvum_PYR-GCK -----MRRQRGAGLKFALFVTVMALLTGCLFAVFGQYRSGSTNVYSAVFK
MLBr_02590|M.leprae_Br4923 ------MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFT
::. * *: .: :. *.: * * * * *
Mb3528c|M.bovis_AF2122/97 DASRLKAGQKVRIAGVPVGSVKAVKLNPDHS-IDVAFAIDRSYTLYSSTR
Rv3498c|M.tuberculosis_H37Rv DASRLKAGQKVRIAGVPVGSVKAVKLNPDHS-IDVAFAIDRSYTLYSSTR
MUL_4061|M.ulcerans_Agy99 NASRLKAGQKVRIAGVPVGSVKAVDLNPDNT-IDVAFAIDRAYTMYSSTR
MAB_4152c|M.abscessus_ATCC_199 TASDLRSGQKVRIAGVPVGRVKNVSLNRDNS-VEVTFDVDSKYQLYSSSR
MSMEG_4793|M.smegmatis_MC2_155 DASRLESGDSVRVAGVRVGTVKNVSLQPDRT-VLVDFDTERNIALTTGTK
TH_4265|M.thermoresistible__bu DASRLESGDSVRVAGVRVGTVRGVALQPDKT-VLVDFDADRGIQLTEGTR
Mvan_4149|M.vanbaalenii_PYR-1 DASRLKTGDTVRIAGIRVGTVKDVELQADRS-VLVTFDADRNTVLTTGTN
MMAR_4709|M.marinum_M DVSRLKPGETVRIAGVRVGTVNSVSLRTDKK-VLVKFDADRNIVLTTGTR
MAV_0949|M.avium_104 DVSRLKPGQSVRVAGIRVGTVNSVSLQPDKK-VVVKFDADRNIVLTEGTR
Mflv_4161|M.gilvum_PYR-GCK DVSNLRAGESVRFAGVRIGTVKDLSMQPDKT-VVVTFDAERGLVLTSGTR
MLBr_02590|M.leprae_Br4923 NISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTT
* *..*: ** :*: :* *. : : . . : * * : : .:
Mb3528c|M.bovis_AF2122/97 AVIRYENLVGDRFLEITSG--PGELRKLPPGGTINVAHTQPALDLDALLG
Rv3498c|M.tuberculosis_H37Rv AVIRYENLVGDRFLEITSG--PGELRKLPPGGTINVAHTQPALDLDALLG
MUL_4061|M.ulcerans_Agy99 AVIRYENLVGDRYLEITSG--PDELRKLPPGGTINAEHTQPALDLDALLG
MAB_4152c|M.abscessus_ATCC_199 AIIRYENLVGDRYLEITAG--PGELHKLPDGGTLDKEHTQPALDLDALLG
MSMEG_4793|M.smegmatis_MC2_155 AAVRYLNLVGDRYLELIDS--PGSTRLLPAGSQIPKERTASALDLDLLLG
TH_4265|M.thermoresistible__bu AAVRYLNLTGDRYLELLDE--PGSTRLLPAGSRIPKERTAPALDLDLLLG
Mvan_4149|M.vanbaalenii_PYR-1 AAIRYLNLVGDRYLELVDT--PDSTQIVPAGGQIPEDRTTPALDLDVLLG
MMAR_4709|M.marinum_M AVVRYLNLVGDRYLELVDG--PGSTKTLPAGSQIPIERTAGALDLDLLLG
MAV_0949|M.avium_104 AAVRYLNLVGDRYLELVDG--PGSPKRLPAGGQIPVSRTAPALDLDLLLG
Mflv_4161|M.gilvum_PYR-GCK AVVRYLNLVGDRFLELVDD--EGSTRILPAGARIPVEQTAPALDLDLLLG
MLBr_02590|M.leprae_Br4923 AQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIG
* :** :* *:*:**: .. : :* *. : :* ***** *:*
Mb3528c|M.bovis_AF2122/97 GLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARD
Rv3498c|M.tuberculosis_H37Rv GLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARD
MUL_4061|M.ulcerans_Agy99 GLRPVLKGLDADKVNTVTGAVIELLQGQGGALANVLADTSAFSTALARRD
MAB_4152c|M.abscessus_ATCC_199 GLRPVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERD
MSMEG_4793|M.smegmatis_MC2_155 GLKPVIQGLDPQDVNALTSSLIQIFQGQGDTLSSLMSKTSSFSNTLADND
TH_4265|M.thermoresistible__bu GLRPVINGLNPQDVNALTSALVQIFQGQGDTLDSLMSKTSSFSTSLADSS
Mvan_4149|M.vanbaalenii_PYR-1 GLKPVIQGLNPEDVNGLTSALIQILQGQGGTLDSLFSKTSSFSNSLADNN
MMAR_4709|M.marinum_M GLKPVTQGLNPQDVNALSASLIQIFQGEGSTLESLLSKTSSFTNALADNN
MAV_0949|M.avium_104 GLKPVTQGLNARDVNALTSGLLQVFQGQGGTLDSLFTKATSFSNALADND
Mflv_4161|M.gilvum_PYR-GCK GLKPVIKGLDAQEVNNLSAALIQIVQGQGGTLESLLSRTSSFSNALADRT
MLBr_02590|M.leprae_Br4923 GFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERD
*::*: ..::. .:* :: ..: .**:*..: .:: : :: :.
Mb3528c|M.bovis_AF2122/97 QLIGEVITNLNAVLATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAIS
Rv3498c|M.tuberculosis_H37Rv QLIGEVITNLNAVLATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAIS
MUL_4061|M.ulcerans_Agy99 QLIGDTITNLNSVLATVDQRSAQFSASVDQLQQLITGLAENKDVIAGAIP
MAB_4152c|M.abscessus_ATCC_199 QLIGDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALP
MSMEG_4793|M.smegmatis_MC2_155 QVIGQLIENLDTVVDTLNRDGGKFSATVDRLEQLISGLSQDRDPIGTAVT
TH_4265|M.thermoresistible__bu QAIQQLIDNLRAVVDTLEKDGDKFSGAIDQLEQLVSGLAEDRDPIGTAIT
Mvan_4149|M.vanbaalenii_PYR-1 QVIEELIVDLRTVLDTLSKDGEEFSGAIDKLEQLVSGLSSDRDPIGTAIT
MMAR_4709|M.marinum_M ETVQALIDNLNVVVDTVNREGTKFSGAIDRLERLISALSQDRDTIGAAIT
MAV_0949|M.avium_104 QTVQQLIDNLNIVIGTISKDGKQFSGAVDRLERLVSGLSDDRNTIGSAID
Mflv_4161|M.gilvum_PYR-GCK EVIDRLIVNLQTTLGTLADQRDDFSEGLTRLHRLVTELSAERQPIGAAID
MLBr_02590|M.leprae_Br4923 QAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFA
: : : .* .: * .*. : .*. *:: * . : :. :.
Mb3528c|M.bovis_AF2122/97 PLASTTTDLTELLRNSRRPLQGILENARPLATELDNRKAEVNNDIEQLGE
Rv3498c|M.tuberculosis_H37Rv PLASTTTDLTELLRNSRRPLQGILENARPLATELDNRKAEVNNDIEQLGE
MUL_4061|M.ulcerans_Agy99 PLASTTTDLTELLKNSRRPLQGLLENARPLATELDNRKDEVNNDVEQLGE
MAB_4152c|M.abscessus_ATCC_199 PLASTASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAE
MSMEG_4793|M.smegmatis_MC2_155 QLDNGTASIATLLTQARPPLDATVDQLNRMAPLLDDHKVVLDRGLQKAPA
TH_4265|M.thermoresistible__bu ALDQGTASMADLLSQARPPLDRTVNELNRLAPLLADHQIVFDRALQRGPE
Mvan_4149|M.vanbaalenii_PYR-1 ALDNGTASIADLLGRGRAPLANTVDEMNRLAPLVDNDLDRLDATLQRLPE
MMAR_4709|M.marinum_M ALDNGTTSIADLLGRARAPLAGTVDQLNRLAPLLDKDKNLIDISLQKLPD
MAV_0949|M.avium_104 ALDRGTASLADLLAQARPPLTGTIDQLNRLAPILDNDKDRLDAAIGKAPK
Mflv_4161|M.gilvum_PYR-GCK SLSAGTASLSDLLTDTRPPLADTVDQLHRLAPNLESKLDRLETAISKAPE
MLBr_02590|M.leprae_Br4923 HISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPT
: : : :* : : :: : : . .: : .
Mb3528c|M.bovis_AF2122/97 DYLRLSA-LGSYGAFFNIYFCSVTIKINGPA--GSDILLPIGGQPDPSKG
Rv3498c|M.tuberculosis_H37Rv DYLRLSA-LGSYGAFFNIYFCSVTIKINGPA--GSDILLPIGGQPDPSKG
MUL_4061|M.ulcerans_Agy99 DYLRLAA-LGSYGAFFNIYFCTVTIKINGPA--GSDILIPMGGQPDPSKG
MAB_4152c|M.abscessus_ATCC_199 NYLRLNA-LGAYGSFFNIYYCSIRIKVNGPV--GTDWLIPFGGPPDPSKG
MSMEG_4793|M.smegmatis_MC2_155 NYRKLAR-LGSYGSWIMYYVCGISIRVTDLQ--GRTAVFPMIKQ---EGG
TH_4265|M.thermoresistible__bu NYRKLAR-LGSYGSWIMYYICGISFRVTDLE--GRTAVFPMVKQ---EGG
Mvan_4149|M.vanbaalenii_PYR-1 IYRKLAR-VGSYGAWFPYYICGISFRASDLE--GRTVVFPWIKQ---EEG
MMAR_4709|M.marinum_M NYRKLTR-LGSYGAWFPYYLCGLALRVSDLQ--YRTVEVGITHQ---VTG
MAV_0949|M.avium_104 NYRKLVR-LGANGATIPYYLCMLELRGTDLQ--GKTVRAPIFRS---DAG
Mflv_4161|M.gilvum_PYR-GCK NYRKLVR-IGSYGSFVNYYICSLGVRVTDLA--GRTAVFPVFRQ---DNG
MLBr_02590|M.leprae_Br4923 VLNQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQ---PTG
:: :*: * . * * : .: .. *
Mb3528c|M.bovis_AF2122/97 RCAFAK-
Rv3498c|M.tuberculosis_H37Rv RCAFAK-
MUL_4061|M.ulcerans_Agy99 RCAFAK-
MAB_4152c|M.abscessus_ATCC_199 RCAFKNE
MSMEG_4793|M.smegmatis_MC2_155 RCAEP--
TH_4265|M.thermoresistible__bu RCAEP--
Mvan_4149|M.vanbaalenii_PYR-1 RCVDE--
MMAR_4709|M.marinum_M RCAEPDA
MAV_0949|M.avium_104 RCTEP--
Mflv_4161|M.gilvum_PYR-GCK RCAEN--
MLBr_02590|M.leprae_Br4923 RCTPQ--
**.