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HSADKVGRDAGTLCGREPLGIAASGDADEMIALQPDCVVYAASGPDRDAAAVPDYVRLLESGINVVSTSS TALVYPPVYYSPQWREQLASAASQGGASFYVSGIFPGFASDQLALLLSTLSASISEVKVTEVALNDHYPV AEVMMDGMGFARPLDFEPLLKTPGFIEMAWKAPIALMADALGVEVTEVRGTLDRRLTDRDIEVAFGTIPA GTCGAVCTRAAGVVDGREAIIVEHIIRMARDVAPDWPASDFDATDRVDITGDPDIHCAMNLGDAQGHGAG RAAMTATAMRVVNAIPFVVAAPPGLLSSLDLPNTLPRHAFA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4159 | - | - | 100% (322) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_3282 | - | 5e-58 | 42.50% (320) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_1824 | - | 7e-55 | 37.46% (315) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 1e-52 | 37.34% (316) | hypothetical protein Mb0949c |
| M. tuberculosis H37Rv | Rv0926c | - | 1e-52 | 37.34% (316) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 9e-57 | 39.24% (316) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_4582 | - | 8e-56 | 38.41% (315) | hypothetical protein MMAR_4582 |
| M. avium 104 | MAV_1045 | dapB | 2e-59 | 40.32% (315) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. smegmatis MC2 155 | MSMEG_5586 | - | 1e-57 | 38.73% (315) | hypothetical protein MSMEG_5586 |
| M. thermoresistible (build 8) | TH_3380 | - | 1e-143 | 76.01% (321) | PUTATIVE dihydrodipicolinate reductase |
| M. ulcerans Agy99 | MUL_4353 | - | 5e-30 | 30.72% (319) | hypothetical protein MUL_4353 |
| M. vanbaalenii PYR-1 | Mvan_3001 | - | 5e-58 | 43.12% (320) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4159|M.gilvum_PYR-GCK -------------------------------------MHSADKVGRDAGT
TH_3380|M.thermoresistible__bu --LSKPIRTVVWSTGGVGSIAIDAISRRPDLELVGVWVHSEEKVGKDAGE
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MMAR_4582|M.marinum_M ----MAIPVVQLGTGNVGLHSLRALITNPEFELTGVWVSSDAKAGKDAAE
MAV_1045|M.avium_104 ----MPIPVVQLGTGNVGIHALRALITDPQFELTGVWVSSDAKAGKDAAE
MSMEG_5586|M.smegmatis_MC2_155 ----MAIRVAAIGTGNVGRHALRQLITNPAYELTAVWVSSPEKAGKDAGD
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
Mvan_3001|M.vanbaalenii_PYR-1 ----MAIRVALIGTGNCGSLALRQLIEDPRFALTGVWVSSQEKVGRDAGE
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
: . * * *..
Mflv_4159|M.gilvum_PYR-GCK LCGREP-LGIAASGDADEMIALQPDCVVYAASGPDRDAAAVPDYVRLLES
TH_3380|M.thermoresistible__bu LAGVGP-LGVSATDDAGALIALQPDCVVYAASGPERDAGAVPDYVRLLEA
Mb0949c|M.bovis_AF2122/97 LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MMAR_4582|M.marinum_M LAGFAESTGVKASTDLDAVLASGPQCAVYNAMADNRLPEALDDYRRVLAA
MAV_1045|M.avium_104 LAGLAQPTGVLASTDLDAVLATGPRCAVYNALADNRLPEALDDYRRVLAA
MSMEG_5586|M.smegmatis_MC2_155 LAGLEVTTGIKATDSLDEVLATEPECAVYTAMADNRLPDALEDYRRILAA
MAB_4633|M.abscessus_ATCC_1997 LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
Mvan_3001|M.vanbaalenii_PYR-1 LARLDVTTGVAAVDDMAAIIDAKPDCAVYCAMGDVRPKEALADVRGLLEA
MUL_4353|M.ulcerans_Agy99 IIGAAR-FGVTATNDVDELLALDADCVMYSPQVADE-----QDVKAILRS
: *: * . :: . *.:* . . * :* :
Mflv_4159|M.gilvum_PYR-GCK GINVVSTSSTALVYPPVYYSPQWREQLASAASQGGASFYVSGIFPGFASD
TH_3380|M.thermoresistible__bu GINVVSTTSTMLVYPPSYHSEEWRDQLEAAAKSGSASFYASGIFPGFGSD
Mb0949c|M.bovis_AF2122/97 GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MMAR_4582|M.marinum_M GVNIVGSGPVFLQYPWQVLPDELVKPLEDAAREGNSSLYVSGIDPGFAND
MAV_1045|M.avium_104 GINIVGSGPVFLQYPWQVIPDELIKPLEEAAQQGNSSLYVNGIDPGFAND
MSMEG_5586|M.smegmatis_MC2_155 GVNVVGSSAVFLQYPWQVLPEELVKPIEDAAHAGGASLFVNGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997 GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
Mvan_3001|M.vanbaalenii_PYR-1 GINVVGSSPGFLAYPWGVIPDRAIERVESAARQGNTSLFITGVDPGFVTD
MUL_4353|M.ulcerans_Agy99 GKNVFTP----VGWVYPDLSKPRVKAVADAAVAGGVTLHGSGIHPGGITE
* *: . : : . : ** *. ::. *: ** .:
Mflv_4159|M.gilvum_PYR-GCK QLALLLSTLSASISEVKVTEVALNDHYPVAEVMMDGMGFARPLDFEPLLK
TH_3380|M.thermoresistible__bu ELALLLTTQSKNIRRITATEIALNDHYPVADVMMDGMGFGRPLDFEPWLK
Mb0949c|M.bovis_AF2122/97 LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLL
Rv0926c|M.tuberculosis_H37Rv LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLL
MMAR_4582|M.marinum_M LLPMALAGTCQSIEQIRCMEIVDYATYDSAVVMFDVMGFGKPLDEIPMLL
MAV_1045|M.avium_104 LLPLALAGTCQSIQQIRCMEIVDYATYDSAAVMFDVMGFGKPLDDVPMLL
MSMEG_5586|M.smegmatis_MC2_155 LLPLALAGTCQQIEQIRCMEIVDYATYDSATVMLDVMGFGKSLDETPMLL
MAB_4633|M.abscessus_ATCC_1997 LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFGKPMEETPMLL
Mvan_3001|M.vanbaalenii_PYR-1 LLPLALASTCQSVSQVRTMEIADYATYDGATVMFDVMGFGNEIGDLPFLY
MUL_4353|M.ulcerans_Agy99 RFPLMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPHAQAMQGP
:.: : . : .: *. * . *: * ***.
Mflv_4159|M.gilvum_PYR-GCK TPGFIEMAWKAPIALMADALGVEVT-EVRGTLDRRLTDRDIEVAFGTIPA
TH_3380|M.thermoresistible__bu TPGFIEMAWRAPIHLIADGLGVEVE-ELRGTFDRSVTHRDIDVAFGRVEA
Mb0949c|M.bovis_AF2122/97 QPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASGHIPK
Rv0926c|M.tuberculosis_H37Rv QPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASGHIPK
MMAR_4582|M.marinum_M QPGVLSLAWGSVVRQLAAGLGLSLD-VVEEMYVREPAPHAFDIASGHIPQ
MAV_1045|M.avium_104 QPGVLSLAWGSVVRQLAAGLGVSLD-EVTQQHVRVPAPEDFDIASGHIAK
MSMEG_5586|M.smegmatis_MC2_155 QPGVLSLAWGSVVRQLAAGLGIELD-AVTEEHTRVPAPEDFDIAAGHISE
MAB_4633|M.abscessus_ATCC_1997 QPGVLSLAWGSVVRQLAAGLGVELD-EVTEVYEKLSAPEDFDISSGHIPA
Mvan_3001|M.vanbaalenii_PYR-1 QPGMLSAAWGVGVRQLAAGLGVEVD-EIRDSVEQEPAPEDFDVAVGTIKK
MUL_4353|M.ulcerans_Agy99 MAALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSDIASDVLPIAA
...:. .: : :* :*. : : : : :
Mflv_4159|M.gilvum_PYR-GCK GTCGAVCTRAAGVVDGREAIIVEHIIRM-ARDVAPDWPASDFD-ATDRVD
TH_3380|M.thermoresistible__bu GTCGAVRTRVAGIVGGREAIVIEHIIRM-ARDVAPEWLTSEFD-ATYRVD
Mb0949c|M.bovis_AF2122/97 GSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGSYRIE
Rv0926c|M.tuberculosis_H37Rv GSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGSYRIE
MMAR_4582|M.marinum_M GSAAALRFEVLGLVDGAPVVVLEHVTRL-REDLCPDWPQPAQPGGSYRIE
MAV_1045|M.avium_104 GTAAALRFEVFGMVDGRPVVVLEHVTRL-REDLCPDWPQPAQHGGSYRIE
MSMEG_5586|M.smegmatis_MC2_155 GTTAAMRFEVRGMVDGKPAVVLEHVTRL-RDDLCPEWPQPAQEGGSYRVE
MAB_4633|M.abscessus_ATCC_1997 GTMAALHFEVRGIKDGRAVTVLEHFTRL-REDLAPNWPQPAHEGGTYRVE
Mvan_3001|M.vanbaalenii_PYR-1 GTVAAVRFLIEGLVDGAPAIVVEHITRL-RGDLRPDWAQPAQEGGSYRVE
MUL_4353|M.ulcerans_Agy99 DTVAGRKFRWQTLADGKPVITAAVNWLMGQADMHPDWSFGERG-ERFEIE
.: .. : .* . : *: *:* .::
Mflv_4159|M.gilvum_PYR-GCK ITGDPDIHCAMN--LGDAQGHG-AGRAAMTATAMRVVNAIPFVVAAPPGL
TH_3380|M.thermoresistible__bu IEGDPDIHCAMN--LGAAEGHG-AGRAAMAATAMRVVNAIPYVVAAPAGL
Mb0949c|M.bovis_AF2122/97 ISGEP--CYAMD--ICLSSRHGDHNHAGLVATAMRIVNAIPAVVAAEPGI
Rv0926c|M.tuberculosis_H37Rv ISGEP--CYAMD--ICLSSRHGDHNHAGLVATAMRIVNAIPAVVAAEPGI
MMAR_4582|M.marinum_M ITGEP--SYAMD--LCLSSRRGDHNHAGLVATAMRVVNAIPAVVAAPPGI
MAV_1045|M.avium_104 VTGEP--SYAMD--ICLSSRKGDHNHAGLVATAMRVVNAIPAVVAAPPGI
MSMEG_5586|M.smegmatis_MC2_155 VTGEP--SYALD--LCLSSPYGDHNHAGLVATAARVVNAIPAVFAAPPGI
MAB_4633|M.abscessus_ATCC_1997 ITGEP--SYLLD--LGSFSARGDHNYANLIATAMRVVNAVPAVVAAEAGI
Mvan_3001|M.vanbaalenii_PYR-1 ITGEP--SYVMD--ICPTSNNGDHNYAAILAAAGRIVNAIPDVVAAEPGI
MUL_4353|M.ulcerans_Agy99 ITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCANAIPVVCAADPGI
: *:* :. * . : *:* : .**:* * ** .*:
Mflv_4159|M.gilvum_PYR-GCK LSSLDLPNTLPRHAFA------
TH_3380|M.thermoresistible__bu LSSLDLPTTLPRHAFD------
Mb0949c|M.bovis_AF2122/97 RTTLDLPLITGEGRYAAA----
Rv0926c|M.tuberculosis_H37Rv RTTLDLPLITGEGRYAAA----
MMAR_4582|M.marinum_M RTTLELPLVTGKGLYLPPAGAA
MAV_1045|M.avium_104 VTTLDLPLITGRGLYRPE----
MSMEG_5586|M.smegmatis_MC2_155 RTTLDMPLITGKGLYAAR----
MAB_4633|M.abscessus_ATCC_1997 RTTLDLPLITGKGRAV------
Mvan_3001|M.vanbaalenii_PYR-1 RSTLDLPFGTGRGTYRAP----
MUL_4353|M.ulcerans_Agy99 ATYLDLPLFAGRPARASRGLER
: *::* .