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LIDFTGQVVVVTGAGRGLGRLYALELARRGAAVVVNDIGATMHGEGHDTTVADTVVDEIRAHGGQAVASH ESVGSPEGGQAIIDTALTRFGRVDVVISNAGIFTSIPFESLTAERWRQMLEVHLDGAFYLSRPAYAAMMR QGYGRFVFVSSSAGNFGQPMEAHYGAAKTGLVGLSNVIAIEGAAHGILSNTVLPTGFSRMVTETVGDEKF LAESGFLRAIRPELVVPLVTFLASRECTVTHHNYSACAGRYARVFTALADGWLADTANEPTAEDIERRFG TVSATEPFIVPDSIVDEVLQVCDRRGISAMPDNAAVTFPKGPGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4157 | - | - | 100% (324) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1790 | - | 4e-56 | 42.21% (289) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0741 | - | 1e-51 | 40.43% (277) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0153 | - | 2e-52 | 41.16% (277) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv0148 | - | 2e-52 | 41.16% (277) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-18 | 28.03% (239) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4604c | - | 1e-54 | 42.03% (276) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0310 | - | 2e-57 | 48.06% (258) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5205 | - | 1e-58 | 44.83% (290) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5624 | - | 3e-53 | 41.20% (301) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4146 | - | 1e-62 | 47.29% (258) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4812 | - | 1e-56 | 47.29% (258) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4960 | - | 1e-58 | 48.59% (249) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0153|M.bovis_AF2122/97 --MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGTGAG
Rv0148|M.tuberculosis_H37Rv --MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGTGAG
MAB_4604c|M.abscessus_ATCC_199 --MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDGSGAG
TH_4146|M.thermoresistible__bu --MT-FDNEVAIVTGAGRGLGRCHALELARRGARVVVNDVGSDVDGTGAS
Mflv_4157|M.gilvum_PYR-GCK --MIDFTGQVVVVTGAGRGLGRLYALELARRGAAVVVNDIGATMHGEGHD
MMAR_0310|M.marinum_M MTELRFDDRVAVVTGAGRGLGRAYALLLAARGAKVVVNDTGGSLAGAGGD
MUL_4812|M.ulcerans_Agy99 MTELRFDDRVAVVTGAGRGLGRAYALLLAARGAKVAVNDTGGSLAGAGGD
MAV_5205|M.avium_104 ---------MAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVD
Mvan_4960|M.vanbaalenii_PYR-1 MADLRFDGRVAVVTGAGRGLGRAYALMLAADGAKVVVNDSGGALDGEGAD
MSMEG_5624|M.smegmatis_MC2_155 MSALRFDDRVAVVTGAGRGLGREYALLLAARGAKVVVNDAGVSLTGDGSD
MLBr_01807|M.leprae_Br4923 --MTDAAAKVSAAPGRGKPAFVSRSILVTGG-----NRGIGLAVARRLVA
: ..* * : :: .. *
Mb0153|M.bovis_AF2122/97 SAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVS
Rv0148|M.tuberculosis_H37Rv SAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVS
MAB_4604c|M.abscessus_ATCC_199 SAMADGVVDEIKAAGGRAVANYDSVATEEGAANIVKTALDEFGAIHGVVS
TH_4146|M.thermoresistible__bu ASAAQAVVDEITAAGGTAVASTDSVATPEGGAAIVKTAMEAFGRVDILVN
Mflv_4157|M.gilvum_PYR-GCK TTVADTVVDEIRAHGGQAVASHESVGSPEGGQAIIDTALTRFGRVDVVIS
MMAR_0310|M.marinum_M PAPAHQVVAEITALGGQAAASLDSVTTPAGGQAIIETALERYGRIDILIH
MUL_4812|M.ulcerans_Agy99 PAPAHQVVAEITALGGQAAASLDSVTTPAGGQAIIETALEHYGRIDILIH
MAV_5205|M.avium_104 TGPAAQVVDEITAAGGDAVACTESVATPEGGRAIIETALAHYGRLDVLVH
Mvan_4960|M.vanbaalenii_PYR-1 TGPAQAVVDEIASAGGEAVANTDSVATPEGGRAIIADAQQRFGGVDILIH
MSMEG_5624|M.smegmatis_MC2_155 EGPAHAVVEEIVAAGGRAVASTDSVATAAGGRAIVDTALEHYGRVDILIH
MLBr_01807|M.leprae_Br4923 DGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVA
*. . . . .* . . . * :. ::
Mb0153|M.bovis_AF2122/97 NAGILRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVV
Rv0148|M.tuberculosis_H37Rv NAGILRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVV
MAB_4604c|M.abscessus_ATCC_199 NAGILRDGTFHKMTYDNWHAVQQVHLYGGYNITRAAWPHFREQGYGRIVV
TH_4146|M.thermoresistible__bu NAGILRDAAFKNMTPQQVAAVLDVHLAGAFHVTRAVWPIMREANHGRIIQ
Mflv_4157|M.gilvum_PYR-GCK NAGIFTSIPFESLTAERWRQMLEVHLDGAFYLSRPAYAAMMRQGYGRFVF
MMAR_0310|M.marinum_M NAGNVRSAPLKEMSYEDFDAVIDVHLRGAFHVVRPAFGLMCDQLYGRIVL
MUL_4812|M.ulcerans_Agy99 NAGNVRSAPLKEMSYEDFDAVIDVHLRGAFHVVRPAFGLMCDQLYGRIVL
MAV_5205|M.avium_104 NAGNVRRASLKQMSYEDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVL
Mvan_4960|M.vanbaalenii_PYR-1 NAGIVRRAPLAEMTYDDFEAVLDVHLRGAFHVVRPAFPSMCDAGYGRIVL
MSMEG_5624|M.smegmatis_MC2_155 NAGNVRRGSLRELGDDDFDAVLDVHLRGAYHVVRPAFPVMCDAGYGRVVL
MLBr_01807|M.leprae_Br4923 NAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIF
*** : : : : .*:* * : : : . : .** :
Mb0153|M.bovis_AF2122/97 ATSTSGLFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAAT
Rv0148|M.tuberculosis_H37Rv ATSTSGLFGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAAT
MAB_4604c|M.abscessus_ATCC_199 ATSTSGLFGNFGQANYGAAKLGLVGLINTLALEGAKYNIHSNAIAPIAAT
TH_4146|M.thermoresistible__bu TSSGTGLFGNFGQANYGAAKMGLIGMMHVLAIEGARDNIAVNAIAPIART
Mflv_4157|M.gilvum_PYR-GCK VSSSAGNFGQPMEAHYGAAKTGLVGLSNVIAIEGAAHGILSNTVLPTGFS
MMAR_0310|M.marinum_M ASSIGGLYGNQGVANYAAAKAGLIGLSNVAAVEGAASGVLCNVIVPSAVT
MUL_4812|M.ulcerans_Agy99 ASSIGGLYGNQGVANYAAAKAGLIGLSNVAAVEGAASGVLCNVIVPSAVT
MAV_5205|M.avium_104 TSSIGGLYGNQGVANYAAAKAGVIGLSNVAALEGAAEGVRCNVIVPAALT
Mvan_4960|M.vanbaalenii_PYR-1 TSSIGGLYGNHEVANYAVAKAGVIGLSHVAAMEGAAHDVKSNVIVPAAVT
MSMEG_5624|M.smegmatis_MC2_155 TSSIGGLYGNHGVVNYAAAKAGILGLCNVVALEGAADGVTCNAIIPGAVT
MLBr_01807|M.leprae_Br4923 MGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAPGFID
* * * .:*..:* *::*: . * * . .: *.: *
Mb0153|M.bovis_AF2122/97 RMTQDILPP-------EVLEKLTPEFVAPVVAYLCTEECADNASVYVVGG
Rv0148|M.tuberculosis_H37Rv RMTQDILPP-------EVLEKLTPEFVAPVVAYLCTEECADNASVYVVGG
MAB_4604c|M.abscessus_ATCC_199 RMTADIASE-------AVLEQLPPAFVSPVVGYLCTEESTDNGSVFVVGG
TH_4146|M.thermoresistible__bu RMTEDIMG--------EAGKAMDPELVTPVVIYLAHRDCDRTAHIYSVGG
Mflv_4157|M.gilvum_PYR-GCK RMVTETVGDEKFLAESGFLRAIRPELVVPLVTFLASRECTVTHHNYSACA
MMAR_0310|M.marinum_M RMADGLDIS--------SYPPMGTELVAPVVGLLAHESCPVNGEMLIAIA
MUL_4812|M.ulcerans_Agy99 RMADGLDIS--------SYPPMGTELVAPVVGLLAHESCPVNGEMLIAIA
MAV_5205|M.avium_104 RMADGIDTS--------AYPPMGPELVAPVVGWLAHESCSVSGELFIALA
Mvan_4960|M.vanbaalenii_PYR-1 RMAAGIDTS--------AYPPMGPELVAPVVGYLAHETCAVTGEMFVALA
MSMEG_5624|M.smegmatis_MC2_155 RMAEGLDTS--------AYPPMGPDLVAPAVGWLAHETCSVTGEYLVAIA
MLBr_01807|M.leprae_Br4923 TEMTRAMDS--------KYQEAALQAIPLGRIGAVEEIAGAVSFLASEDA
: . . .
Mb0153|M.bovis_AF2122/97 GKVQRVALFGNDG--ANFDKPPSVQDVAARWAEITD--------------
Rv0148|M.tuberculosis_H37Rv GKVQRVALFGNDG--ANFDKPPSVQDVAARWAEITD--------------
MAB_4604c|M.abscessus_ATCC_199 GKVQRVALFENAG--ATFASPPTVDEVAARWGEIED--------------
TH_4146|M.thermoresistible__bu GKVSRVFIGVSEG--IAHP-ALTPESVAAAIDEIDD--------------
Mflv_4157|M.gilvum_PYR-GCK GRYARVFTALADGWLADTANEPTAEDIERRFGTVSATEPFIVPDSIVDEV
MMAR_0310|M.marinum_M GRVARAVVAESPG---VQRLSWSMEDVAEGLYAIRD---------LAAPL
MUL_4812|M.ulcerans_Agy99 GRVARAVVAESPG---VQRPSWSMEDVAEGLYAIRD---------LAAPL
MAV_5205|M.avium_104 GRVARAVIAESPG---VCRPGWTVEDVGEHLDAIRY---------VEAPL
Mvan_4960|M.vanbaalenii_PYR-1 GRVATAAVTETRG---VYRPSWTIADVAENLDAIRD---------RSESL
MSMEG_5624|M.smegmatis_MC2_155 GRIGRAALVESPG---VYQPSWTVEQVGERIDEIRD---------ISAPV
MLBr_01807|M.leprae_Br4923 GYISGAVIPVDGG-------------LGMGH-------------------
* . * :
Mb0153|M.bovis_AF2122/97 LSGAKIAG-FKL-----------------------
Rv0148|M.tuberculosis_H37Rv LSGAKIAG-FKL-----------------------
MAB_4604c|M.abscessus_ATCC_199 LATVTKAGPPSLA----------------------
TH_4146|M.thermoresistible__bu PSSFTIRGGPVRVDVSTR-----------------
Mflv_4157|M.gilvum_PYR-GCK LQVCDRRGISAMPDNAAVTFPKGPGR---------
MMAR_0310|M.marinum_M VFPVVPSGHSDHIRYSFESAAWANRGSAHHV----
MUL_4812|M.ulcerans_Agy99 VFPVVPSGHSDHIRYSFESAAWANRGSAHHV----
MAV_5205|M.avium_104 IFPVVPDGHAEHIRYSFELAQRANEQGALHG----
Mvan_4960|M.vanbaalenii_PYR-1 TFPVVPNGHGDHIRYSFAMASRAAAMSACAKSRSR
MSMEG_5624|M.smegmatis_MC2_155 TFPVVPDGHAEHIRYSFAQAAQGVGS---------
MLBr_01807|M.leprae_Br4923 -----------------------------------