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VTDLRFDGRVAAVTGGGRGLGRAYALMLASRGAKVVVNDVGGSLTGDGADPGPAQQVADEIVAAGGEAVA NTDSVATADGGAAIVATALDAYGRIDVLVHNAGNVRRGSLREMSHDDFDAVLDVHLRGAFHVVRPAFPVM CDNGYGRIVLTSSIGGLYGNHDVANYAVAKAGVIGLSNVAALEGAAHGVRSNVIVPAAVTRMAEGIDTSA YPPMDPDLVAPTVGWLAHETCSVTGEIFIALAGRVARAVIAETPGVYQPSWTIEDVATRIDEIRDFSAPV VFPVVPSGHNDHIGYSFAMADERSREERVASHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1790 | - | - | 100% (313) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0741 | - | 1e-60 | 44.85% (272) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4157 | - | 4e-56 | 42.27% (291) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0153 | - | 4e-60 | 44.65% (271) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv0148 | - | 4e-60 | 44.65% (271) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 6e-20 | 33.82% (207) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4604c | - | 3e-62 | 47.23% (271) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0310 | - | 1e-121 | 71.33% (300) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5205 | - | 1e-129 | 75.33% (304) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5624 | - | 1e-135 | 77.00% (300) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2730 | - | 3e-95 | 78.64% (206) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4812 | - | 1e-122 | 71.33% (300) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4960 | - | 1e-133 | 77.33% (300) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4604c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1790|M.gilvum_PYR-GCK --------------------------------------------------
TH_2730|M.thermoresistible__bu --------------------------------------------------
Mvan_4960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0310|M.marinum_M --------------------------------------------------
MUL_4812|M.ulcerans_Agy99 --------------------------------------------------
MAV_5205|M.avium_104 --------------------------------------------------
MSMEG_5624|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb0153|M.bovis_AF2122/97 ----------------------------------MPGVQDRVIVVTGAGG
Rv0148|M.tuberculosis_H37Rv ----------------------------------MPGVQDRVIVVTGAGG
MAB_4604c|M.abscessus_ATCC_199 ----------------------------------MPGVQDRVIVVTGAGG
Mflv_1790|M.gilvum_PYR-GCK --------------------------------MTDLRFDGRVAAVTGGGR
TH_2730|M.thermoresistible__bu --------------------------------------------------
Mvan_4960|M.vanbaalenii_PYR-1 --------------------------------MADLRFDGRVAVVTGAGR
MMAR_0310|M.marinum_M --------------------------------MTELRFDDRVAVVTGAGR
MUL_4812|M.ulcerans_Agy99 --------------------------------MTELRFDDRVAVVTGAGR
MAV_5205|M.avium_104 -----------------------------------------MAVVTGAGR
MSMEG_5624|M.smegmatis_MC2_155 --------------------------------MSALRFDDRVAVVTGAGR
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb0153|M.bovis_AF2122/97 GLGREYALTLAGEGASVVVNDLGGARDGTG-AGSAMADEVVAEIRDKGGR
Rv0148|M.tuberculosis_H37Rv GLGREYALTLAGEGASVVVNDLGGARDGTG-AGSAMADEVVAEIRDKGGR
MAB_4604c|M.abscessus_ATCC_199 GLGREYALTLAGEGASVVVNDLGGARDGSG-AGSAMADGVVDEIKAAGGR
Mflv_1790|M.gilvum_PYR-GCK GLGRAYALMLASRGAKVVVNDVGGSLTGDG-ADPGPAQQVADEIVAAGGE
TH_2730|M.thermoresistible__bu ------------------VRSAG----------P-PAEELGXXX------
Mvan_4960|M.vanbaalenii_PYR-1 GLGRAYALMLAADGAKVVVNDSGGALDGEG-ADTGPAQAVVDEIASAGGE
MMAR_0310|M.marinum_M GLGRAYALLLAARGAKVVVNDTGGSLAGAG-GDPAPAHQVVAEITALGGQ
MUL_4812|M.ulcerans_Agy99 GLGRAYALLLAARGAKVAVNDTGGSLAGAG-GDPAPAHQVVAEITALGGQ
MAV_5205|M.avium_104 GLGRAYAHLLAARGAKVVVNDVGGALDGAG-VDTGPAAQVVDEITAAGGD
MSMEG_5624|M.smegmatis_MC2_155 GLGREYALLLAARGAKVVVNDAGVSLTGDG-SDEGPAHAVVEEIVAAGGR
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
* * *
Mb0153|M.bovis_AF2122/97 AVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILRD------GTFH
Rv0148|M.tuberculosis_H37Rv AVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILRD------GTFH
MAB_4604c|M.abscessus_ATCC_199 AVANYDSVATEEGAANIVKTALDEFGAIHGVVSNAGILRD------GTFH
Mflv_1790|M.gilvum_PYR-GCK AVANTDSVATADGGAAIVATALDAYGRIDVLVHNAGNVRR------GSLR
TH_2730|M.thermoresistible__bu -------------------------------IHNAGTVRR------GSLR
Mvan_4960|M.vanbaalenii_PYR-1 AVANTDSVATPEGGRAIIADAQQRFGGVDILIHNAGIVRR------APLA
MMAR_0310|M.marinum_M AAASLDSVTTPAGGQAIIETALERYGRIDILIHNAGNVRS------APLK
MUL_4812|M.ulcerans_Agy99 AAASLDSVTTPAGGQAIIETALEHYGRIDILIHNAGNVRS------APLK
MAV_5205|M.avium_104 AVACTESVATPEGGRAIIETALAHYGRLDVLVHNAGNVRR------ASLK
MSMEG_5624|M.smegmatis_MC2_155 AVASTDSVATAAGGRAIVDTALEHYGRVDILIHNAGNVRR------GSLR
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
: . ..
Mb0153|M.bovis_AF2122/97 KMSFENWDAVLK---VHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLF
Rv0148|M.tuberculosis_H37Rv KMSFENWDAVLK---VHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLF
MAB_4604c|M.abscessus_ATCC_199 KMTYDNWHAVQQ---VHLYGGYNITRAAWPHFREQGYGRIVVATSTSGLF
Mflv_1790|M.gilvum_PYR-GCK EMSHDDFDAVLD---VHLRGAFHVVRPAFPVMCDNGYGRIVLTSSIGGLY
TH_2730|M.thermoresistible__bu DLSQDDFDAVLD---VHLRGAFHVLRPAFPVMCDAGYGRIVLTSSIGGLY
Mvan_4960|M.vanbaalenii_PYR-1 EMTYDDFEAVLD---VHLRGAFHVVRPAFPSMCDAGYGRIVLTSSIGGLY
MMAR_0310|M.marinum_M EMSYEDFDAVID---VHLRGAFHVVRPAFGLMCDQLYGRIVLASSIGGLY
MUL_4812|M.ulcerans_Agy99 EMSYEDFDAVID---VHLRGAFHVVRPAFGLMCDQLYGRIVLASSIGGLY
MAV_5205|M.avium_104 QMSYEDFDAVLD---VHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIGGLY
MSMEG_5624|M.smegmatis_MC2_155 ELGDDDFDAVLD---VHLRGAYHVVRPAFPVMCDAGYGRVVLTSSIGGLY
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
. ::. . . : *. . .* . .*:* ..
Mb0153|M.bovis_AF2122/97 GNFGQTNYGAAKLGLVGLIN----------TLALEGAKYNIHAN------
Rv0148|M.tuberculosis_H37Rv GNFGQTNYGAAKLGLVGLIN----------TLALEGAKYNIHAN------
MAB_4604c|M.abscessus_ATCC_199 GNFGQANYGAAKLGLVGLIN----------TLALEGAKYNIHSN------
Mflv_1790|M.gilvum_PYR-GCK GNHDVANYAVAKAGVIGLSN----------VAALEGAAHGVRSN------
TH_2730|M.thermoresistible__bu GNHEVANYAVAKSGVIGLSN----------VAALEGAEFGVKSN------
Mvan_4960|M.vanbaalenii_PYR-1 GNHEVANYAVAKAGVIGLSH----------VAAMEGAAHDVKSN------
MMAR_0310|M.marinum_M GNQGVANYAAAKAGLIGLSN----------VAAVEGAASGVLCN------
MUL_4812|M.ulcerans_Agy99 GNQGVANYAAAKAGLIGLSN----------VAAVEGAASGVLCN------
MAV_5205|M.avium_104 GNQGVANYAAAKAGVIGLSN----------VAALEGAAEGVRCN------
MSMEG_5624|M.smegmatis_MC2_155 GNHGVVNYAAAKAGILGLCN----------VVALEGAADGVTCN------
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
. .* .. :.: :*. .: *
Mb0153|M.bovis_AF2122/97 ----------------ALAPIAATRMTQDILPPEVLEKLTPEFVAPVVA-
Rv0148|M.tuberculosis_H37Rv ----------------ALAPIAATRMTQDILPPEVLEKLTPEFVAPVVA-
MAB_4604c|M.abscessus_ATCC_199 ----------------AIAPIAATRMTADIASEAVLEQLPPAFVSPVVG-
Mflv_1790|M.gilvum_PYR-GCK ----------------VIVPAAVTRMAEGID-TSAYPPMDPDLVAPTVG-
TH_2730|M.thermoresistible__bu ----------------VVVPAALTRMAEGID-TSAYPPMGPELVAPLVG-
Mvan_4960|M.vanbaalenii_PYR-1 ----------------VIVPAAVTRMAAGID-TSAYPPMGPELVAPVVG-
MMAR_0310|M.marinum_M ----------------VIVPSAVTRMADGLD-ISSYPPMGTELVAPVVG-
MUL_4812|M.ulcerans_Agy99 ----------------VIVPSAVTRMADGLD-ISSYPPMGTELVAPVVG-
MAV_5205|M.avium_104 ----------------VIVPAALTRMADGID-TSAYPPMGPELVAPVVG-
MSMEG_5624|M.smegmatis_MC2_155 ----------------AIIPGAVTRMAEGLD-TSAYPPMGPDLVAPAVG-
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
: * *:: .: :* . :.
Mb0153|M.bovis_AF2122/97 --------YLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQD
Rv0148|M.tuberculosis_H37Rv --------YLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQD
MAB_4604c|M.abscessus_ATCC_199 --------YLCTEESTDNGSVFVVGGGKVQRVALFENAGATFASPPTVDE
Mflv_1790|M.gilvum_PYR-GCK --------WLAHETCSVTGEIFIALAGRVARAVIAETPGVYQPS-WTIED
TH_2730|M.thermoresistible__bu --------WLAHESCSVTGEMLIGIAGRMARAAVVESPGVYRGS-WTIED
Mvan_4960|M.vanbaalenii_PYR-1 --------YLAHETCAVTGEMFVALAGRVATAAVTETRGVYRPS-WTIAD
MMAR_0310|M.marinum_M --------LLAHESCPVNGEMLIAIAGRVARAVVAESPGVQRLS-WSMED
MUL_4812|M.ulcerans_Agy99 --------LLAHESCPVNGEMLIAIAGRVARAVVAESPGVQRPS-WSMED
MAV_5205|M.avium_104 --------WLAHESCSVSGELFIALAGRVARAVIAESPGVCRPG-WTVED
MSMEG_5624|M.smegmatis_MC2_155 --------WLAHETCSVTGEYLVAIAGRIGRAALVESPGVYQPS-WTVEQ
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
. . . * .
Mb0153|M.bovis_AF2122/97 VAARWAEITDLSG-----AKIAG--------FKL----------------
Rv0148|M.tuberculosis_H37Rv VAARWAEITDLSG-----AKIAG--------FKL----------------
MAB_4604c|M.abscessus_ATCC_199 VAARWGEIEDLAT-----VTKAGP-------PSLA---------------
Mflv_1790|M.gilvum_PYR-GCK VATRIDEIRDFSAPVVFPVVPSGHNDHIGYSFAMADERSREERVASHG--
TH_2730|M.thermoresistible__bu VADQLEAIRDLGDPVVFDVVPTGHNEHIGYSFAMARQEAHSG--------
Mvan_4960|M.vanbaalenii_PYR-1 VAENLDAIRDRSESLTFPVVPNGHGDHIRYSFAMASRAAAMSACAKSRSR
MMAR_0310|M.marinum_M VAEGLYAIRDLAAPLVFPVVPSGHSDHIRYSFESAAWANRGSAHHV----
MUL_4812|M.ulcerans_Agy99 VAEGLYAIRDLAAPLVFPVVPSGHSDHIRYSFESAAWANRGSAHHV----
MAV_5205|M.avium_104 VGEHLDAIRYVEAPLIFPVVPDGHAEHIRYSFELAQRANEQGALHG----
MSMEG_5624|M.smegmatis_MC2_155 VGERIDEIRDISAPVTFPVVPDGHAEHIRYSFAQAAQGVGS---------
MLBr_02565|M.leprae_Br4923 IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQA
: : .
Mb0153|M.bovis_AF2122/97 ----
Rv0148|M.tuberculosis_H37Rv ----
MAB_4604c|M.abscessus_ATCC_199 ----
Mflv_1790|M.gilvum_PYR-GCK ----
TH_2730|M.thermoresistible__bu ----
Mvan_4960|M.vanbaalenii_PYR-1 ----
MMAR_0310|M.marinum_M ----
MUL_4812|M.ulcerans_Agy99 ----
MAV_5205|M.avium_104 ----
MSMEG_5624|M.smegmatis_MC2_155 ----
MLBr_02565|M.leprae_Br4923 MLGA