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MTELRFDDRVAVVTGAGRGLGRAYALLLAARGAKVVVNDTGGSLAGAGGDPAPAHQVVAEITALGGQAAA SLDSVTTPAGGQAIIETALERYGRIDILIHNAGNVRSAPLKEMSYEDFDAVIDVHLRGAFHVVRPAFGLM CDQLYGRIVLASSIGGLYGNQGVANYAAAKAGLIGLSNVAAVEGAASGVLCNVIVPSAVTRMADGLDISS YPPMGTELVAPVVGLLAHESCPVNGEMLIAIAGRVARAVVAESPGVQRLSWSMEDVAEGLYAIRDLAAPL VFPVVPSGHSDHIRYSFESAAWANRGSAHHV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0310 | - | - | 100% (311) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_0360 | - | 3e-56 | 45.59% (272) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_5036 | - | 1e-41 | 40.62% (288) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0153 | - | 4e-56 | 45.59% (272) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1790 | - | 1e-121 | 71.33% (300) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0148 | - | 4e-56 | 45.59% (272) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 8e-21 | 31.06% (235) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3440c | - | 9e-57 | 45.42% (284) | putative short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_5205 | - | 1e-126 | 75.75% (301) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5624 | - | 1e-121 | 70.10% (301) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2730 | - | 2e-79 | 70.79% (202) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4812 | - | 1e-173 | 99.04% (311) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4960 | - | 1e-116 | 69.48% (308) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0153|M.bovis_AF2122/97 --------------------------------------------------
Rv0148|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0310|M.marinum_M --------------------------------------------------
MUL_4812|M.ulcerans_Agy99 --------------------------------------------------
MAV_5205|M.avium_104 --------------------------------------------------
Mflv_1790|M.gilvum_PYR-GCK --------------------------------------------------
TH_2730|M.thermoresistible__bu --------------------------------------------------
Mvan_4960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5624|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3440c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb0153|M.bovis_AF2122/97 ----------------------------------MPGVQDRVIVVTGAGG
Rv0148|M.tuberculosis_H37Rv ----------------------------------MPGVQDRVIVVTGAGG
MMAR_0310|M.marinum_M --------------------------------MTELRFDDRVAVVTGAGR
MUL_4812|M.ulcerans_Agy99 --------------------------------MTELRFDDRVAVVTGAGR
MAV_5205|M.avium_104 -----------------------------------------MAVVTGAGR
Mflv_1790|M.gilvum_PYR-GCK --------------------------------MTDLRFDGRVAAVTGGGR
TH_2730|M.thermoresistible__bu --------------------------------------------------
Mvan_4960|M.vanbaalenii_PYR-1 --------------------------------MADLRFDGRVAVVTGAGR
MSMEG_5624|M.smegmatis_MC2_155 --------------------------------MSALRFDDRVAVVTGAGR
MAB_3440c|M.abscessus_ATCC_199 ------------------------------MFGTDVRFDGRVAIVTGAGG
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb0153|M.bovis_AF2122/97 GLGREYALTLAGEGASVVVNDLGGAR--DGTGAGSAMADEVVAEIRDKGG
Rv0148|M.tuberculosis_H37Rv GLGREYALTLAGEGASVVVNDLGGAR--DGTGAGSAMADEVVAEIRDKGG
MMAR_0310|M.marinum_M GLGRAYALLLAARGAKVVVNDTGGS--LAGAGGDPAPAHQVVAEITALGG
MUL_4812|M.ulcerans_Agy99 GLGRAYALLLAARGAKVAVNDTGGS--LAGAGGDPAPAHQVVAEITALGG
MAV_5205|M.avium_104 GLGRAYAHLLAARGAKVVVNDVGGA--LDGAGVDTGPAAQVVDEITAAGG
Mflv_1790|M.gilvum_PYR-GCK GLGRAYALMLASRGAKVVVNDVGGS--LTGDGADPGPAQQVADEIVAAGG
TH_2730|M.thermoresistible__bu ------------------VRSAG-----------P-PAEELGXXX-----
Mvan_4960|M.vanbaalenii_PYR-1 GLGRAYALMLAADGAKVVVNDSGGA--LDGEGADTGPAQAVVDEIASAGG
MSMEG_5624|M.smegmatis_MC2_155 GLGREYALLLAARGAKVVVNDAGVS--LTGDGSDEGPAHAVVEEIVAAGG
MAB_3440c|M.abscessus_ATCC_199 GLGREYALLLASRGAKVVVNDIGSSDELLGGGSSDAPANSVVAEIQALGG
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTP-DATTSTDERIAQRALEGFSRSLG
* * *
Mb0153|M.bovis_AF2122/97 RAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILR------DGTF
Rv0148|M.tuberculosis_H37Rv RAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGILR------DGTF
MMAR_0310|M.marinum_M QAAASLDSVTTPAGGQAIIETALERYGRIDILIHNAGNVR------SAPL
MUL_4812|M.ulcerans_Agy99 QAAASLDSVTTPAGGQAIIETALEHYGRIDILIHNAGNVR------SAPL
MAV_5205|M.avium_104 DAVACTESVATPEGGRAIIETALAHYGRLDVLVHNAGNVR------RASL
Mflv_1790|M.gilvum_PYR-GCK EAVANTDSVATADGGAAIVATALDAYGRIDVLVHNAGNVR------RGSL
TH_2730|M.thermoresistible__bu --------------------------------IHNAGTVR------RGSL
Mvan_4960|M.vanbaalenii_PYR-1 EAVANTDSVATPEGGRAIIADAQQRFGGVDILIHNAGIVR------RAPL
MSMEG_5624|M.smegmatis_MC2_155 RAVASTDSVATAAGGRAIVDTALEHYGRVDILIHNAGNVR------RGSL
MAB_3440c|M.abscessus_ATCC_199 DAIADTNTVATGAGGRAIVGTALSAWGRVDIVINNAGIVGP-----IKTF
MLBr_02565|M.leprae_Br4923 KELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAA
: . .
Mb0153|M.bovis_AF2122/97 HKMSFENWDAVLK---VHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGL
Rv0148|M.tuberculosis_H37Rv HKMSFENWDAVLK---VHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGL
MMAR_0310|M.marinum_M KEMSYEDFDAVID---VHLRGAFHVVRPAFGLMCDQLYGRIVLASSIGGL
MUL_4812|M.ulcerans_Agy99 KEMSYEDFDAVID---VHLRGAFHVVRPAFGLMCDQLYGRIVLASSIGGL
MAV_5205|M.avium_104 KQMSYEDFDAVLD---VHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIGGL
Mflv_1790|M.gilvum_PYR-GCK REMSHDDFDAVLD---VHLRGAFHVVRPAFPVMCDNGYGRIVLTSSIGGL
TH_2730|M.thermoresistible__bu RDLSQDDFDAVLD---VHLRGAFHVLRPAFPVMCDAGYGRIVLTSSIGGL
Mvan_4960|M.vanbaalenii_PYR-1 AEMTYDDFEAVLD---VHLRGAFHVVRPAFPSMCDAGYGRIVLTSSIGGL
MSMEG_5624|M.smegmatis_MC2_155 RELGDDDFDAVLD---VHLRGAYHVVRPAFPVMCDAGYGRVVLTSSIGGL
MAB_3440c|M.abscessus_ATCC_199 AELTDEDVDTVFG---VQLLGPFNVLRPAWKAMVDQGYGRILNISS-GSI
MLBr_02565|M.leprae_Br4923 DSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAA
. : : : . : * . : .* . .*:: ..
Mb0153|M.bovis_AF2122/97 FGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDIL
Rv0148|M.tuberculosis_H37Rv FGNFGQTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDIL
MMAR_0310|M.marinum_M YGNQGVANYAAAKAGLIGLSNVAAVEGAASGVLCNVIVPSAVTRMADGLD
MUL_4812|M.ulcerans_Agy99 YGNQGVANYAAAKAGLIGLSNVAAVEGAASGVLCNVIVPSAVTRMADGLD
MAV_5205|M.avium_104 YGNQGVANYAAAKAGVIGLSNVAALEGAAEGVRCNVIVPAALTRMADGID
Mflv_1790|M.gilvum_PYR-GCK YGNHDVANYAVAKAGVIGLSNVAALEGAAHGVRSNVIVPAAVTRMAEGID
TH_2730|M.thermoresistible__bu YGNHEVANYAVAKSGVIGLSNVAALEGAEFGVKSNVVVPAALTRMAEGID
Mvan_4960|M.vanbaalenii_PYR-1 YGNHEVANYAVAKAGVIGLSHVAAMEGAAHDVKSNVIVPAAVTRMAAGID
MSMEG_5624|M.smegmatis_MC2_155 YGNHGVVNYAAAKAGILGLCNVVALEGAADGVTCNAIIPGAVTRMAEGLD
MAB_3440c|M.abscessus_ATCC_199 FGQGEACTYPTAKAGMVGMTTNLGLAGPAYGIKVNALLPVGFTRMVENMP
MLBr_02565|M.leprae_Br4923 EALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGIT
. . .. :.: .: : .:
Mb0153|M.bovis_AF2122/97 PPEVL---------EKLTPEFVAP---VVAYLCTEECADNASVYVVG---
Rv0148|M.tuberculosis_H37Rv PPEVL---------EKLTPEFVAP---VVAYLCTEECADNASVYVVG---
MMAR_0310|M.marinum_M ISSY----------PPMGTELVAP---VVGLLAHESCPVNGEMLIAI---
MUL_4812|M.ulcerans_Agy99 ISSY----------PPMGTELVAP---VVGLLAHESCPVNGEMLIAI---
MAV_5205|M.avium_104 TSAY----------PPMGPELVAP---VVGWLAHESCSVSGELFIAL---
Mflv_1790|M.gilvum_PYR-GCK TSAY----------PPMDPDLVAP---TVGWLAHETCSVTGEIFIAL---
TH_2730|M.thermoresistible__bu TSAY----------PPMGPELVAP---LVGWLAHESCSVTGEMLIGI---
Mvan_4960|M.vanbaalenii_PYR-1 TSAY----------PPMGPELVAP---VVGYLAHETCAVTGEMFVAL---
MSMEG_5624|M.smegmatis_MC2_155 TSAY----------PPMGPDLVAP---AVGWLAHETCSVTGEYLVAI---
MAB_3440c|M.abscessus_ATCC_199 EPALSW------LRDTFPAALVAP---VAAYLVSEDVPCSGLSFSAG---
MLBr_02565|M.leprae_Br4923 RDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMA
: ::** . : . .
Mb0153|M.bovis_AF2122/97 ---GGKVQRVALFGNDGAN----------FDKPPSVQDVAARWAEITDLS
Rv0148|M.tuberculosis_H37Rv ---GGKVQRVALFGNDGAN----------FDKPPSVQDVAARWAEITDLS
MMAR_0310|M.marinum_M ---AGRVARAVVAESPGVQ----------RLS-WSMEDVAEGLYAIRDLA
MUL_4812|M.ulcerans_Agy99 ---AGRVARAVVAESPGVQ----------RPS-WSMEDVAEGLYAIRDLA
MAV_5205|M.avium_104 ---AGRVARAVIAESPGVC----------RPG-WTVEDVGEHLDAIRYVE
Mflv_1790|M.gilvum_PYR-GCK ---AGRVARAVIAETPGVY----------QPS-WTIEDVATRIDEIRDFS
TH_2730|M.thermoresistible__bu ---AGRMARAAVVESPGVY----------RGS-WTIEDVADQLEAIRDLG
Mvan_4960|M.vanbaalenii_PYR-1 ---AGRVATAAVTETRGVY----------RPS-WTIADVAENLDAIRDRS
MSMEG_5624|M.smegmatis_MC2_155 ---AGRIGRAALVESPGVY----------QPS-WTVEQVGERIDEIRDIS
MAB_3440c|M.abscessus_ATCC_199 ---GGRFARVFLGEARGVT----------SSQ-LTIEEVRDRFEAAMEIE
MLBr_02565|M.leprae_Br4923 GIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTA
..: *. :: *
Mb0153|M.bovis_AF2122/97 G------------------------AKIAGFKL-----------------
Rv0148|M.tuberculosis_H37Rv G------------------------AKIAGFKL-----------------
MMAR_0310|M.marinum_M AP-------------LVFPVVPSGHSDHIRYSFESAAWANRGSAHHV---
MUL_4812|M.ulcerans_Agy99 AP-------------LVFPVVPSGHSDHIRYSFESAAWANRGSAHHV---
MAV_5205|M.avium_104 AP-------------LIFPVVPDGHAEHIRYSFELAQRANEQGALHG---
Mflv_1790|M.gilvum_PYR-GCK AP-------------VVFPVVPSGHNDHIGYSFAMADERSREERVASHG-
TH_2730|M.thermoresistible__bu DP-------------VVFDVVPTGHNEHIGYSFAMARQEAHSG-------
Mvan_4960|M.vanbaalenii_PYR-1 ES-------------LTFPVVPNGHGDHIRYSFAMASRAAAMSACAKSRS
MSMEG_5624|M.smegmatis_MC2_155 AP-------------VTFPVVPDGHAEHIRYSFAQAAQGVGS--------
MAB_3440c|M.abscessus_ATCC_199 GA-------------ATMANVGD---ELRLYAAALTGR------------
MLBr_02565|M.leprae_Br4923 AIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQ
. :
Mb0153|M.bovis_AF2122/97 -----
Rv0148|M.tuberculosis_H37Rv -----
MMAR_0310|M.marinum_M -----
MUL_4812|M.ulcerans_Agy99 -----
MAV_5205|M.avium_104 -----
Mflv_1790|M.gilvum_PYR-GCK -----
TH_2730|M.thermoresistible__bu -----
Mvan_4960|M.vanbaalenii_PYR-1 R----
MSMEG_5624|M.smegmatis_MC2_155 -----
MAB_3440c|M.abscessus_ATCC_199 -----
MLBr_02565|M.leprae_Br4923 AMLGA