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TADAPHGLFDGKVVLVTGAARGQGRAHAVRFAEEGADVIAVDVCAQLDSVAYPMSTPEDLDETARLVEKT GRRVVAEQCDVRDRDRLADVVAAGVEEFGRLDFVLANAGILPIAGDQGRSITAFTDAVAVMLNGVYFTVD AALPALLRNPDGGAIVITSSAAGFTSVSTGFDTMNHGAAGYTAAKHGVIGVMRHFARSLAEKNIRVNSVH PGGVATPMVLNEALAQWAGEHPSFSQAQQALLAMPMMEPEHISDTMVYLCGPAGRYVTGVALPVDAGQTL K*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4087 | - | - | 100% (282) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3996 | - | 4e-68 | 49.08% (271) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2430 | - | 3e-63 | 47.57% (288) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2771 | - | 2e-65 | 49.63% (270) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 2e-65 | 49.63% (270) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 7e-17 | 30.69% (277) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3081 | - | 4e-67 | 48.74% (277) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1965 | fabG | 1e-66 | 46.95% (279) | short chain dehydrogenase |
| M. avium 104 | MAV_3641 | - | 2e-70 | 50.18% (275) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_2687 | - | 3e-68 | 50.18% (271) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_0123 | - | 1e-73 | 52.21% (272) | PROBABLE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_3392 | fabG | 5e-66 | 46.59% (279) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_2256 | - | 1e-133 | 85.93% (270) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4087|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2256|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0123|M.thermoresistible__bu --------------------------------------------------
MMAR_1965|M.marinum_M --------------------------------------------------
MUL_3392|M.ulcerans_Agy99 --------------------------------------------------
MAV_3641|M.avium_104 --------------------------------------------------
Mb2771|M.bovis_AF2122/97 --------------------------------------------------
Rv2750|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2687|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3081|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_4087|M.gilvum_PYR-GCK ---------------------------------------MTADAPHGLFD
Mvan_2256|M.vanbaalenii_PYR-1 -------------------------------------------MASQVLQ
TH_0123|M.thermoresistible__bu ---------------------------------------------MGRVQ
MMAR_1965|M.marinum_M ----------------------------------------MSRPLDGPLS
MUL_3392|M.ulcerans_Agy99 ----------------------------------------MSRPLDGPLS
MAV_3641|M.avium_104 ----------------------------------------MPRSSEGPLT
Mb2771|M.bovis_AF2122/97 ----------------------------------------MIDR---PLE
Rv2750|M.tuberculosis_H37Rv ----------------------------------------MIDR---PLE
MSMEG_2687|M.smegmatis_MC2_155 ----------------------------------------MSDTA--PLS
MAB_3081|M.abscessus_ATCC_1997 ---------------------------------------------MGKLD
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
.
Mflv_4087|M.gilvum_PYR-GCK GKVVLVTGAARGQGRAHAVRFA----------------------------
Mvan_2256|M.vanbaalenii_PYR-1 DKVVFVTGAARGQGRAHAVRFA----------------------------
TH_0123|M.thermoresistible__bu GKVAFITGAARGQGRSHAVRLA----------------------------
MMAR_1965|M.marinum_M GRVAFITGAARGQGRAHALRLA----------------------------
MUL_3392|M.ulcerans_Agy99 GRVAFITGAARGQGRAHALRLA----------------------------
MAV_3641|M.avium_104 GKVAFITGAARGQGRAHAVRLA----------------------------
Mb2771|M.bovis_AF2122/97 GKVAFITGAARGLGRAHAVRLA----------------------------
Rv2750|M.tuberculosis_H37Rv GKVAFITGAARGLGRAHAVRLA----------------------------
MSMEG_2687|M.smegmatis_MC2_155 GKVAFITGAARGQGRAEAVRLA----------------------------
MAB_3081|M.abscessus_ATCC_1997 GKVAFITGAARGQGRAHAIKLA----------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
. :.* *. **. : .
Mflv_4087|M.gilvum_PYR-GCK --EEGADVIAVDVCA-QLDSVA----------------------------
Mvan_2256|M.vanbaalenii_PYR-1 --EEGADVIAFDLCA-QIDSVA----------------------------
TH_0123|M.thermoresistible__bu --EEGASIIAVDSCQGSMDTLL----------------------------
MMAR_1965|M.marinum_M --RDGADVIAVDLCD-QIASVP----------------------------
MUL_3392|M.ulcerans_Agy99 --RDGADVIAVDLCD-QIASVP----------------------------
MAV_3641|M.avium_104 --ADGADIIAVDLCD-QIASVP----------------------------
Mb2771|M.bovis_AF2122/97 --ADGANIIAVDICE-QIASVP----------------------------
Rv2750|M.tuberculosis_H37Rv --ADGANIIAVDICE-QIASVP----------------------------
MSMEG_2687|M.smegmatis_MC2_155 --ADGADIIAVDLCA-QIASVP----------------------------
MAB_3081|M.abscessus_ATCC_1997 --SEGASIIAVDICA-QIPSVE----------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
** : . . :
Mflv_4087|M.gilvum_PYR-GCK --YPMSTPEDLDETARLVEKTGRRVVAEQCDVRDRD----------RLAD
Mvan_2256|M.vanbaalenii_PYR-1 --YPMATPEDLDETVRLVEKTGRRIVAERGDVRDRD----------RLAE
TH_0123|M.thermoresistible__bu --YDLPTEDDLKETCNQVEAVGGRIVATKADVRDRK----------GLRD
MMAR_1965|M.marinum_M --YPLGTAEELATTVKLVEDTGARIVASQADVRDRE----------ALAA
MUL_3392|M.ulcerans_Agy99 --YPLGTAEELATTVKLVEDTGARIVASQADVRDRE----------ALAA
MAV_3641|M.avium_104 --YPLATPEELAATVKLVEDIGSRIVARQADVRDRE----------SLSA
Mb2771|M.bovis_AF2122/97 --YPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
Rv2750|M.tuberculosis_H37Rv --YPLSTADDLAATVELVEDAGGGIVARQGDVRDRA----------SLSV
MSMEG_2687|M.smegmatis_MC2_155 --YPLATPDDLATTAELVEKAGGRIVTRQADVRDEP----------ELAA
MAB_3081|M.abscessus_ATCC_1997 --YPMATTEDLDLTVKEVDALGRAISAHETDVRDRE----------ALQA
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
* . * . : : :* .
Mflv_4087|M.gilvum_PYR-GCK VVAAGVEEFG---------------------------RLDFVLANAGILP
Mvan_2256|M.vanbaalenii_PYR-1 VVARGVAEFG---------------------------RLDFVLANAGILP
TH_0123|M.thermoresistible__bu AFEAGYAEFG---------------------------RVDIVLGNAGIMP
MMAR_1965|M.marinum_M ALQAGIDELG---------------------------QVDIVVANAGIAP
MUL_3392|M.ulcerans_Agy99 ALQAGIDELG---------------------------QVDIVVANAGIAP
MAV_3641|M.avium_104 ALQAGLDEFG---------------------------RLDIVVANAGIAP
Mb2771|M.bovis_AF2122/97 ALQAGLDEFG---------------------------RLDIVVANAGIAM
Rv2750|M.tuberculosis_H37Rv ALQAGLDEFG---------------------------RLDIVVANAGIAM
MSMEG_2687|M.smegmatis_MC2_155 ALAAGLDEFG---------------------------RLDIVVANAGIAP
MAB_3081|M.abscessus_ATCC_1997 AFDAGVHDLG---------------------------PVDIVVANAGIAT
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
.. .* *::: ****
Mflv_4087|M.gilvum_PYR-GCK IAGDQGRSITAFTDAVAVMLNGVYFTVDAALPALLRNPDGGAIVITSSAA
Mvan_2256|M.vanbaalenii_PYR-1 AAGPQGLDITAFTDAIAVMLNGVYFTIEAALPALLRNPDGGAIVITSSAA
TH_0123|M.thermoresistible__bu ALGEVSDTDEAFDDAIAVMLTGVYNTLRVATPKLVEQGQGGSIVLTSSTA
MMAR_1965|M.marinum_M MQ----SGDDGWRDVIDVNLSGAYYTVEVAIPTMIEQGRGGSIVLISSAA
MUL_3392|M.ulcerans_Agy99 MQ----SGDDGWRDVIDVNLSGAYYTVEVAIPTMIEQGRGGSIVLISSAA
MAV_3641|M.avium_104 MS----AGDDGWHDVIDVNLTGVYHTIKVAIPALVKQGTGGSIVLISSSA
Mb2771|M.bovis_AF2122/97 MQ----AGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAA
Rv2750|M.tuberculosis_H37Rv MQ----AGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAA
MSMEG_2687|M.smegmatis_MC2_155 ML----SGPEGWRDVIDVNLTGVHHTVEVAIPTLVEQGDGGAIVLISSVA
MAB_3081|M.abscessus_ATCC_1997 LTPE--CGDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVA
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGS-ISKGGRVIVLSSMA
: .: * * . ** ::: ** *
Mflv_4087|M.gilvum_PYR-GCK GFTSVSTGFDTMNHGAAGYTAAKHGVIGVMRHFARSLAEKNIRVNSVHPG
Mvan_2256|M.vanbaalenii_PYR-1 GFTSVSTEFGTMSHGAAGYTAAKHGVIGVMRHFARSLAEKNIRVNSVHPG
TH_0123|M.thermoresistible__bu GLKGQTTG----TAGCDGYVAAKHGVVGLMRAYATTYAKHNIRVNTVHPC
MMAR_1965|M.marinum_M GLVGISSA----DAGAIGYAASKHALVGLMRVYANLLAPHSIRVNSLHPS
MUL_3392|M.ulcerans_Agy99 GLVGISSA----DAGAIGYVASKHALVGLMRVYANLLAPHSIRVNSLHPS
MAV_3641|M.avium_104 GLAGVGSA----DPGSVGYVAAKHGVVGLMRVYANLLAGQMIRVNSIHPS
Mb2771|M.bovis_AF2122/97 GLVGIGSS----DPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPC
Rv2750|M.tuberculosis_H37Rv GLVGIGSS----DPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPC
MSMEG_2687|M.smegmatis_MC2_155 GLVGIGGG----DRGSLGYTAAKHGIVGLMRAYANHLAPHSIRVNSVHPT
MAB_3081|M.abscessus_ATCC_1997 GLTGMVMD----NPGGLAYTAAKHGLVGLMRSYANMLAPHNIRVNTIHPS
MLBr_02565|M.leprae_Br4923 GIAG--------NRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPG
*: . * *.::* .::*: : * * : * :*:: *
Mflv_4087|M.gilvum_PYR-GCK GVATPMVLNEALAQWAG---EHPSFSQAQQALLAMPMMEPEHISDTMVYL
Mvan_2256|M.vanbaalenii_PYR-1 GVATPMVLNQAMADWSG---EHPSFSAAQQPLLRLPMMEPEAVSDAMVYL
TH_0123|M.thermoresistible__bu GCATPMIENVAFAQYAQ---ENPETVSTWQTMLPVPQVQPMDISNAILWL
MMAR_1965|M.marinum_M GVDTPMINNEFIRRWLADLVAETGSGPGAGNALPVQILQADDIAGALAWL
MUL_3392|M.ulcerans_Agy99 GVDPPMINNEFIRHWLADLVAETGSGPGAGNALPVQILQADDIAGALAWL
MAV_3641|M.avium_104 GVETPMINNEFTREWLAKMAAATDTPGAMGNAMPVEVLAPEDVANAVAWL
Mb2771|M.bovis_AF2122/97 GVDTPMINNEFFQQWLT--TADMDAPHNLGNALPVELVQPTDIANAVAWL
Rv2750|M.tuberculosis_H37Rv GVDTPMINNEFFQQWLT--TADMDAPHNLGNALPVELVQPTDIANAVAWL
MSMEG_2687|M.smegmatis_MC2_155 GVDTPMIDNEFTRGWLAHITEETGRPVDMGNALPVQAIDADDVANAVAWL
MAB_3081|M.abscessus_ATCC_1997 GVATPMLINPVTEKLFADGSPEGMS--DTGNALPVVLMEPEDMANTVAWL
MLBr_02565|M.leprae_Br4923 FIETQMTAAIPLATREVG----------RRLNSLLQGGLPVDVAETIAYF
. * : . :: :: ::
Mflv_4087|M.gilvum_PYR-GCK CGPAGRYVTGVALPVDAGQTLK-
Mvan_2256|M.vanbaalenii_PYR-1 CGPSGRYLTGATLPLDAGQTLK-
TH_0123|M.thermoresistible__bu CSDEARYVTGVTLPVDAGAVAR-
MMAR_1965|M.marinum_M VSDEARYITGVALPVDAGCVNKR
MUL_3392|M.ulcerans_Agy99 VSDEARYITGVALPVDAGCVNKR
MAV_3641|M.avium_104 VSDQARYITGVTLPVDAGFLNK-
Mb2771|M.bovis_AF2122/97 ASEEARYVTGVTLPVDAGFVNKR
Rv2750|M.tuberculosis_H37Rv ASEEARYVTGVTLPVDAGFVNKR
MSMEG_2687|M.smegmatis_MC2_155 VSDQARYVTGVTLPVDAGIVNKR
MAB_3081|M.abscessus_ATCC_1997 VSEDARYITGVALPVDAGFTNRR
MLBr_02565|M.leprae_Br4923 AIPASNAVTGNVIRVCGQAMLGA
.. :** .: : .