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PRPDGNPILSVRSVFPAHRYPQAELSDAVAELSGLSADQRAQLGRLHAHAGVEHRHTALPLSGYAALRTV EASNDRYVDEAVDLGERALRRALSAADVDPADLDALFVTSVTGVTVPSLDARLIPRLGLRPDIRRVPILG LGCVAGAAGLARLHDYLLAWPQHHAALLAVEICSLSWPTTRITTADLVVTGLFGDGAAAVVAGGGGTRDA PRVLATRSEVYPDSTDALGWRLGDDGFRIVLTAELADVVERYLAGTVTAFLAEHDLTVEEISAWVCHPGG PKVLDAVQNSLKLPDSALALSRRSLAEVGNVSSVSVLHILEETLGQVAGERPPPGSTGLMIGLGPGISAE LVLLRW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3991 | - | - | 100% (357) | chalcone/stilbene synthase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_5140 | - | 6e-96 | 51.68% (358) | chalcone/stilbene synthase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1693 | pks11 | 3e-96 | 51.13% (354) | chalcone synthase |
| M. tuberculosis H37Rv | Rv1665 | pks11 | 3e-96 | 51.13% (354) | chalcone synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2474 | pks11_1 | 2e-97 | 51.98% (354) | chalcone synthase, Pks11_1 |
| M. avium 104 | MAV_1280 | - | 5e-93 | 50.14% (351) | transferase |
| M. smegmatis MC2 155 | MSMEG_0808 | - | 1e-90 | 50.28% (354) | chalcone synthase Pks10 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1656 | pks11 | 2e-96 | 51.41% (354) | chalcone synthase, Pks11 |
| M. vanbaalenii PYR-1 | Mvan_1196 | - | 3e-97 | 50.00% (354) | chalcone/stilbene synthase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1693|M.bovis_AF2122/97 ----------MSVIAGVFGALPPHRYSQSEITDSFVEFPGL-KEHEEIIR
Rv1665|M.tuberculosis_H37Rv ----------MSVIAGVFGALPPHRYSQSEITDSFVEFPGL-KEHEEIIR
MMAR_2474|M.marinum_M ----------MSVIAGVFGALPPHRYSQSEITEAFLEFPGL-QEHEEIVR
MUL_1656|M.ulcerans_Agy99 ----------MSVIAGVFGALPPHRYSQSEITESFLEFPGL-QEHEEIVR
Mvan_1196|M.vanbaalenii_PYR-1 ------MNDRISVIAGVQGALPPYRYSQAEITERFVAVPAF-AELEDVVR
MSMEG_0808|M.smegmatis_MC2_155 MENTAFTPSGTCTIAGVHGVLPPHRYTQAEVTEALLDLPGY-ADFEGIVR
MAV_1280|M.avium_104 -------MGESPSITGVAVKFPPNRYTQSEAIRALTDIAG------PEFR
Mflv_3991|M.gilvum_PYR-GCK -----MPRPDGNPILSVRSVFPAHRYPQAELSDAVAELSGLSADQRAQLG
* .* :*. **.*:* . ... .
Mb1693|M.bovis_AF2122/97 RLHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALD
Rv1665|M.tuberculosis_H37Rv RLHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALD
MMAR_2474|M.marinum_M RMHAAAKVNSRQFVLPIEQYPALTDFGDANEIFIEKAVDLGIEALMGALD
MUL_1656|M.ulcerans_Agy99 RMHAAAKVNSRQFVLPIEQYPALTDFGDTNEIFIEKAVDLGIEALMGALD
Mvan_1196|M.vanbaalenii_PYR-1 GLHKHAKVDARHFVLPMDRYPTLVDFGETNDLYLEHSLDLACEALTAALD
MSMEG_0808|M.smegmatis_MC2_155 SLHKSAKVNSRYLTLPLEEYAALDDFGETNGLFIEHATELGCAALTGALD
MAV_1280|M.avium_104 RFAHSSGVEFRNTALRLPRYRELSGFSEANDAYLEVALDLGEQALVAALD
Mflv_3991|M.gilvum_PYR-GCK RLHAHAGVEHRHTALPLSGYAALRTVEASNDRYVDEAVDLGERALRRALS
: : *: * .* : * * . :* ::: : :*. ** **.
Mb1693|M.bovis_AF2122/97 DANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCV
Rv1665|M.tuberculosis_H37Rv DANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCV
MMAR_2474|M.marinum_M EAGLTPQDIDLIITTTVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCV
MUL_1656|M.ulcerans_Agy99 EAGLTPQDIDLIITTTVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCV
Mvan_1196|M.vanbaalenii_PYR-1 EAGLGPRDLDMIMTTTVTGIAVPSLDARIADRLGLRPDVRRVPLFGLGCV
MSMEG_0808|M.smegmatis_MC2_155 EAGLRPEDVDLIITTTVTGAVVPSLDARIAGRVGLRPDVRRVPIFGLGCV
MAV_1280|M.avium_104 RAKVKPSEVDIVFSTTVTGLAVPTLEARLATRVGLRPDVKRVPLFGLGCV
Mflv_3991|M.gilvum_PYR-GCK AADVDPADLDALFVTSVTGVTVPSLDARLIPRLGLRPDIRRVPILGLGCV
* : * ::* : ::*** .**:*:**: *:*****::*:*::*****
Mb1693|M.bovis_AF2122/97 AGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFG
Rv1665|M.tuberculosis_H37Rv AGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFG
MMAR_2474|M.marinum_M AGAAGVARLHDYLRGAPDGVAVLIAVELCSLTYPAVKPTVSGIVGTALFG
MUL_1656|M.ulcerans_Agy99 AGAAGVARLHDYLRGAPDGVAVLIAVELCSLTYPAVKPTVSGIVGTALFG
Mvan_1196|M.vanbaalenii_PYR-1 AGAAGIARMHDYLRGAPDHIAALVSVELCSLTYPAVEPTMASLVGSALFG
MSMEG_0808|M.smegmatis_MC2_155 AGAAGVARLNDYLRGAPDKVAVLVSVELCSLTHKHT-PSMPTLVAGALFG
MAV_1280|M.avium_104 AGAAGVARMHDYLRAFPDQTAALLAVELCSLTIQRHDTSIANLVATSLFG
Mflv_3991|M.gilvum_PYR-GCK AGAAGLARLHDYLLAWPQHHAALLAVEICSLSWPTTRITTADLVVTGLFG
*****:**:.*** . *: *.*::**:***: : . :* .***
Mb1693|M.bovis_AF2122/97 DGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRL
Rv1665|M.tuberculosis_H37Rv DGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRL
MMAR_2474|M.marinum_M DGAAAVVAVGDRRAEQIRAGGPDILDSRSRLYPESLDIMGWDVGSHGLQL
MUL_1656|M.ulcerans_Agy99 DGAAAVVAVGDRRAEQIRAGGPDILDSRSRLYPESLDIMGWDVGSHGLQL
Mvan_1196|M.vanbaalenii_PYR-1 DGAAAVIAVGAERAETIGATGPEVLDTRSRMYPDSLDTMGWRVGASGFQL
MSMEG_0808|M.smegmatis_MC2_155 DGASAVVAVGAGRAEQLDPIGPDVLDSRSHLYPDSLHAMGWDIGTKGFEI
MAV_1280|M.avium_104 DGAAAVITEGARRAG-AEHTGPRILATRSRIYPDTEEVMGWKIGGDGFRI
Mflv_3991|M.gilvum_PYR-GCK DGAAAVVAGGGGTRD-----APRVLATRSEVYPDSTDALGWRLGDDGFRI
***:**:: * .* :* :** :**:: . :** :* *:.:
Mb1693|M.bovis_AF2122/97 RLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVAT
Rv1665|M.tuberculosis_H37Rv RLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVAT
MMAR_2474|M.marinum_M RLAPELTNLIEEYLPDDVDAFLAMHDLTKNDIGAWVSHPGGPKVLDAITN
MUL_1656|M.ulcerans_Agy99 RLAPELTNLIEEYLPDDVDAFLAMHDLTKNDIGAWVSHPGGPKVLDAIAN
Mvan_1196|M.vanbaalenii_PYR-1 ILSPNLPELIERYLADDMAGFLGAHDLQIGDIAAWVSHPGGPKVMEAISE
MSMEG_0808|M.smegmatis_MC2_155 VLSAEVPGFVGRYLGDDVTEFLGEHGVATDDVSAWVSHPGGPKVIEAIIE
MAV_1280|M.avium_104 VLSADVANIAEKYLGEDVRDFLADHGLAPRDVTTWVCHPGGPRVIEAVES
Mflv_3991|M.gilvum_PYR-GCK VLTAELADVVERYLAGTVTAFLAEHDLTVEEISAWVCHPGGPKVLDAVQN
*:.::. . .** : ** * : :: :**.*****:*::*:
Mb1693|M.bovis_AF2122/97 SLALPPEALELTWRSLGEIGNLSSASILHILRDTIE----KRPPSGSAGL
Rv1665|M.tuberculosis_H37Rv SLALPPEALELTWRSLGEIGNLSSASILHILRDTIE----KRPPSGSAGL
MMAR_2474|M.marinum_M SLGLPSDALELTWRSLGEIGNLSSASVLHILRDTIA----KVPPSGSPGL
MUL_1656|M.ulcerans_Agy99 SLGLPSDALELTWRSLGEIGNLSSASVLRILRDTIA----KVPPSGSPGL
Mvan_1196|M.vanbaalenii_PYR-1 TLGLPDDALDLAWRSLAEVGNLSSSSVLHVLRDTRA----KKPPAGTPGL
MSMEG_0808|M.smegmatis_MC2_155 TLDLPSDALDLTWQSLAEVGNLSSSSVLHVLRDTIR----KRPPAGTPGV
MAV_1280|M.avium_104 VLDLPADALDHTRNSLRENGNLSSVSVLDVLAANLA----DPPAPGSIGL
Mflv_3991|M.gilvum_PYR-GCK SLKLPDSALALSRRSLAEVGNVSSVSVLHILEETLGQVAGERPPPGSTGL
* ** .** : .** * **:** *:* :* . . *..*: *:
Mb1693|M.bovis_AF2122/97 MLAMGPGFCTELVLLRWR
Rv1665|M.tuberculosis_H37Rv MLAMGPGFCTELVLLRWR
MMAR_2474|M.marinum_M MLAMGPGFCAELVLLRWH
MUL_1656|M.ulcerans_Agy99 MLAMGPGFCAELVLLRWH
Mvan_1196|M.vanbaalenii_PYR-1 LMAMGPGFCSELVLLRWR
MSMEG_0808|M.smegmatis_MC2_155 LMAMGPGFCSELVLLRWR
MAV_1280|M.avium_104 MIAMGPAFCSELVLLAF-
Mflv_3991|M.gilvum_PYR-GCK MIGLGPGISAELVLLRW-
::.:**.:.:***** :