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AIVDGDSTLVSTPSGDLRGDIDGGVGVWRGVPYAEQPVGLRRFLAPAELAPWMGVRDAVEHGPLPPQTKS FVGGGRDDPKARDEACLTLTVWSPDTTGSLPVMVWIPGGAFVYGAGQFQLYNGSRLAANGDVVVVNVTYR IGVFGGFELSDLGEGFDDNLALRDQIAALRWVRDNIAAFGGDPGRVTVFGESAGATSVLALMAAPSATGL FGRAIAQSPALPLIADRHLRAANAQEFLRRLGVDAAEVKTLPQRQLRRAAGLVQLTSAATTPTLAYGLTT GTDLLPLHPLDAARQGRMSSVPLIVGTNSHEASMFAWTKPPMLPTTRESIDGFFERTAPHAKRQVLQAYP GYPRRSALVAIGADAMFGGPTWAFADAYSAHAPTRMYRFDHFGMSLRMLGLGATHGSEIVHIHHSYASFV GRKLHPLGRRIQPGVGRRMQRSWLDFARDNAEVDEGHWPLYEIGARLTRLITSTRDVMASDPDRDRREAW AQVYQPPKRSSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3787 | - | - | 100% (503) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_3125 | - | 2e-92 | 41.57% (498) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_4595 | - | 7e-88 | 41.12% (501) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 2e-83 | 37.96% (490) | carboxylesterase LipT |
| M. tuberculosis H37Rv | Rv2045c | lipT | 2e-83 | 37.96% (490) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2866c | - | 0.0 | 67.21% (488) | carboxylesterase (LipT) |
| M. marinum M | MMAR_4363 | - | 6e-82 | 37.33% (517) | carboxylesterase |
| M. avium 104 | MAV_2466 | - | 2e-82 | 37.90% (496) | LppT protein |
| M. smegmatis MC2 155 | MSMEG_3002 | - | 0.0 | 70.91% (495) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_2744 | - | 0.0 | 70.10% (495) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-82 | 37.80% (492) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_2609 | - | 0.0 | 85.39% (486) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2071c|M.bovis_AF2122/97 -----------------------MALESATVGSMHERTVRARTATGIVEG
Rv2045c|M.tuberculosis_H37Rv -----------------------MALESATVGSMHERTVRARTATGIVEG
MAV_2466|M.avium_104 ---------------------------------MHDRTVRARTATGIVEG
MUL_2261|M.ulcerans_Agy99 ---------------------------------MHERTVRARTATGVVEG
Mflv_3787|M.gilvum_PYR-GCK ------------------------------MAIVDGDSTLVSTPSGDLRG
Mvan_2609|M.vanbaalenii_PYR-1 ---------------------------------------MLSTPSGDLRG
MSMEG_3002|M.smegmatis_MC2_155 ------------------------------MSVVAEHSTIAHTSLGTLRG
TH_2744|M.thermoresistible__bu ----VVLVSMRIPSLKVMG--SASHNYHAGVTAVVERSPIADTPLGRLRG
MAB_2866c|M.abscessus_ATCC_199 MYPEKTRGNFPAPPLRLCGPVTADRTTIRYVAVDVALPTVVRTPLGALRG
MMAR_4363|M.marinum_M --------------------------MTSDIRRMASDGYVVETAYGPVRG
*. * :.*
Mb2071c|M.bovis_AF2122/97 FTR--------DGVHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTF
Rv2045c|M.tuberculosis_H37Rv FTR--------DGVHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTF
MAV_2466|M.avium_104 FTR--------DGVHRWRSIPYARPPVGDLRFRAPQPAQPWSGVRHCHGF
MUL_2261|M.ulcerans_Agy99 FTR--------DGVHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGF
Mflv_3787|M.gilvum_PYR-GCK DID--------GGVGVWRGVPYAEQPVGLRRFLAPAELAPWMGVRDAVEH
Mvan_2609|M.vanbaalenii_PYR-1 EVE--------AGIGVWRGIPYAEQPTGQRRFLAPEPMAPWPGVREAREH
MSMEG_3002|M.smegmatis_MC2_155 TLE--------AGVSVWRGVHYAQQPVGDLRFRAPQPLQPWSGVREAVEH
TH_2744|M.thermoresistible__bu SYENVPAQAA-EGVAVWRGVPYARQPVGDLRFRAPEPPRPWSGVRDAVEP
MAB_2866c|M.abscessus_ATCC_199 AIEG--------GVSVWRGVPYAQQPVEQLRFLAPVPLEPWEGVRDAIEH
MMAR_4363|M.marinum_M AEDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAF
*:.: *. * ** ** ** : ..
Mb2071c|M.bovis_AF2122/97 ANCAPQQRRYTVMGIG----RYQTRSEDCLTLNVVTPEE-PATQPLPVMV
Rv2045c|M.tuberculosis_H37Rv ANCAPQQRRYTVMGIG----RYQTRSEDCLTLNVVTPEE-PATQPLPVMV
MAV_2466|M.avium_104 ANCAPQQRRYTLLGLSGLGGRYQPMSEDCLTLNVVTPEA-PAEGPLPVMV
MUL_2261|M.ulcerans_Agy99 THCSPQQRRYTMLGLG----KYQPMSEDCLTLNVVAPEA-PTHRPLPVMV
Mflv_3787|M.gilvum_PYR-GCK GPLPPQTKSFVGGGRD----DPKARDEACLTLTVWSPD---TTGSLPVMV
Mvan_2609|M.vanbaalenii_PYR-1 GPLPPQSKSFVGGGRD----DPKVRDEACLTLTVWSPD---TAASLPVMV
MSMEG_3002|M.smegmatis_MC2_155 GPLPPQGRSFVGGGRD----DPKMRDEACLTVTVWSPD---TSGALPVMV
TH_2744|M.thermoresistible__bu APIPPQGRSFVGGGKD----DPRIRDEACLTLTVWSPD---PGGSLPVMV
MAB_2866c|M.abscessus_ATCC_199 APLPPQGKSFVGAGRD----DPKIRGEECLTVTVWSPD---VHASLPVMV
MMAR_4363|M.marinum_M GPVCPQP-VLANMPID----LGAPQDEDCLRLNIWAPANTAPGAAKPVMV
** . . .* ** :.: :* . ****
Mb2071c|M.bovis_AF2122/97 FIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLST
Rv2045c|M.tuberculosis_H37Rv FIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLST
MAV_2466|M.avium_104 FIHGGGYFLGSSATPLYDGAALARRG-CVYVSVNYRLGALGCVDFSSLST
MUL_2261|M.ulcerans_Agy99 FIHGGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLST
Mflv_3787|M.gilvum_PYR-GCK WIPGGAFVYGAGQFQLYNGSRLAANGDVVVVNVTYRIGVFGGFELSDLGE
Mvan_2609|M.vanbaalenii_PYR-1 WIPGGAFVYGAGQFQLYNGSRLAANGDVVVVNVTYRIGVFGGLELSDLGD
MSMEG_3002|M.smegmatis_MC2_155 WIPGGAFVYGAGQLQLYNGSRLAANGNVVVVNVTYRLGVFGGFELGDLAG
TH_2744|M.thermoresistible__bu WIPGGAFVYGAGHLQLYNGSRLAANGNVVVVNVTYRLGVFGGFELSGLGA
MAB_2866c|M.abscessus_ATCC_199 WIPGGAFVFGAGQLELYSGARLAANGNVVVVNVTYRLGALGGLELSALGE
MMAR_4363|M.marinum_M WLHGGAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSH
:: **.:. *:. :*.* ** * : *.*.**:*.:* .::. *.
Mb2071c|M.bovis_AF2122/97 PQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATL
Rv2045c|M.tuberculosis_H37Rv PQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATL
MAV_2466|M.avium_104 PEIPLESNLYLRDLVLALQWVRDNIAEFGGDPDNVTIFGESAGACITATL
MUL_2261|M.ulcerans_Agy99 PDIAIDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATL
Mflv_3787|M.gilvum_PYR-GCK G---FDDNLALRDQIAALRWVRDNIAAFGGDPGRVTVFGESAGATSVLAL
Mvan_2609|M.vanbaalenii_PYR-1 G---FDDNLALRDQIAALRWVRDNISAFGGDPGRVTVFGESAGATSVLAL
MSMEG_3002|M.smegmatis_MC2_155 D---FSDNLCLRDQLAALQWVRDNIAAFGGDPKRVTVFGESAGATSVLAL
TH_2744|M.thermoresistible__bu G---FDDNLALRDQVAALRWVRDNIAAFGGDPGRVTVFGESAGATSVLAL
MAB_2866c|M.abscessus_ATCC_199 G---FDDNLALRDQMAALTWVRDNIAAFGGDPDHVTIFGESAGATSVLAL
MMAR_4363|M.marinum_M AGRSFDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTL
:..*: *** : ** *:::**: ***** .:*:******* . :*
Mb2071c|M.bovis_AF2122/97 LAVPAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANA
Rv2045c|M.tuberculosis_H37Rv LAVPAAKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANA
MAV_2466|M.avium_104 LAVPAAKGLFAQAISESPASGLVRSQEVAAEFANRFANLLGVRRQDAANA
MUL_2261|M.ulcerans_Agy99 LAVPAAKGLFARAISESPAAGMVRPREIAAEFATRFARLLGARKHDAASA
Mflv_3787|M.gilvum_PYR-GCK MAAPSATGLFGRAIAQSPALPLIADRHLRAANAQEFLRRLGV-----DAA
Mvan_2609|M.vanbaalenii_PYR-1 MAAPSAQRLFHRAIAQSPALPLVADREYRAANAHEFLRRLGV-----GAG
MSMEG_3002|M.smegmatis_MC2_155 LASPSAEGLFARAIAQSPALPLIADRDVRARQAHRFLEIVGE-----DPA
TH_2744|M.thermoresistible__bu LASPAARGLFHRAIAQSPALPLIADADLRAGRAARFVERLGV-----GVD
MAB_2866c|M.abscessus_ATCC_199 LASPAAEGLFGRAIAQSPALPLIADKALRDKRAHRYLELLDVT----DPS
MMAR_4363|M.marinum_M LVTPAARGLFSRAIAQSSPATSVYDRERAQRVAVHLLDKLGVAAS--DVD
:. *:* ** :**::*.. : * . :.
Mb2071c|M.bovis_AF2122/97 LMQASPAQLVEAQHHLIRQGMRKRLG-AFPIGPVFGDDYLPMDPVEAMRS
Rv2045c|M.tuberculosis_H37Rv LMQASPAQLVEAQHHLIRQGMRKRLG-AFPIGPVFGDDYLPMDPVEAMRS
MAV_2466|M.avium_104 LMQASAAQLVKTQHRLIDEGMQDRLG-AFPIGPVVGDDILPTDPVEAMRR
MUL_2261|M.ulcerans_Agy99 LMRATAAQLVQTQHRLIDQGMQKRLG-AFPIGPTFGDDCLPLDPVEAMRA
Mflv_3787|M.gilvum_PYR-GCK EVKTLPQRQLRRAAGLVQLTSAATTP-TLAYGLTTGTDLLPLHPLDAARQ
Mvan_2609|M.vanbaalenii_PYR-1 EVKALPQRQLRRAAGILQLKSAANTP-TLAYGLTYGTELLPQHPVAAARE
MSMEG_3002|M.smegmatis_MC2_155 KLRDLPQKQLRRAAGQVQLESAQHTP-TLAYGLTHGVDLLPRHPIDAARA
TH_2744|M.thermoresistible__bu DIRELPQRALRRAAGLVQLDSIADSP-ALAYGLTHGVDLLPRHPIAAARA
MAB_2866c|M.abscessus_ATCC_199 RLKVLPQRELRRGAAKLQIESATETP-VLGYGLAHGTELLPYHPIEAARR
MMAR_4363|M.marinum_M KLTQLPTAAIVAASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQE
: . : : .: . : *. *: . :
Mb2071c|M.bovis_AF2122/97 GRVHAVPLIVGTNAEEGRLFTR-FLGMLPTNEPMVEELLSGMKPAD----
Rv2045c|M.tuberculosis_H37Rv GRVHAVPLIVGTNAEEGRLFTR-FLGMLPTNEPMVEELLSGMKPAD----
MAV_2466|M.avium_104 GEAHRVPLIVGTNAEEGRLFTR-FLAMLPTNESMVEELLADAEPAV----
MUL_2261|M.ulcerans_Agy99 GQSHKVPLIVGTNADEGRLFTR-FLKMLPTNKAMIDELLADTEPAT----
Mflv_3787|M.gilvum_PYR-GCK GRMSSVPLIVGTNSHEASMFAWTKPPMLPTTRESIDGFFERTAPHA----
Mvan_2609|M.vanbaalenii_PYR-1 GRTSGVPLIIGTNSHEASMFAWTKPPMLPTTKASIDGYFQRVAPDA----
MSMEG_3002|M.smegmatis_MC2_155 GEVLPVPLIIGTNSHEASMFAWGKPPMLPTTVAGVEHYFRRKHAGA----
TH_2744|M.thermoresistible__bu GTVHPVPLIIGTNSDEASMFAWGRPPMLPTTPDRVEHYFRRHAPHA----
MAB_2866c|M.abscessus_ATCC_199 GEVHQVPLIIGSNSHEASMFARVKPPMLPTTEPTVNGYFNRIGPEY----
MMAR_4363|M.marinum_M GRSHPVPLLIGTNKHEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQ
* ***::*:* .*. :* ::* . : : .
Mb2071c|M.bovis_AF2122/97 ---RERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYR
Rv2045c|M.tuberculosis_H37Rv ---RERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEAHGANAPTYLYR
MAV_2466|M.avium_104 ---RERITAAYPDYPDRSACIQLGGDFAFGSAAWQIAEAHCAHAPTYLYR
MUL_2261|M.ulcerans_Agy99 ---RERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYR
Mflv_3787|M.gilvum_PYR-GCK ---KRQVLQAYPGYPRRSALVAIGADAMFGGPTWAFADAYSAHAPTRMYR
Mvan_2609|M.vanbaalenii_PYR-1 ---KQRVLQAYPGYPRRSALVALGSDAMFGGPTWAFADAYSALAPTRMYR
MSMEG_3002|M.smegmatis_MC2_155 ---KDRILSAYPAFPRRRALVAFGSDVMFGAPTWAFSDAYSAHAPTHVYR
TH_2744|M.thermoresistible__bu ---RDTVLAAYPGYPRRRAAVAVGADVMFAAPTWAFADAYSAHAPTYLYR
MAB_2866c|M.abscessus_ATCC_199 ---QDAIIAAYPGYPSRQALVAVGSDAMFAAPMWAFADAYSAFVDTYMYR
MMAR_4363|M.marinum_M LPTEEEIGLAYSRLRRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYR
. : **. : .. * * . :::. . . :**
Mb2071c|M.bovis_AF2122/97 YDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSN
Rv2045c|M.tuberculosis_H37Rv YDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAALRVSN
MAV_2466|M.avium_104 YDYAPRTLRWSGFGATHATELLAVFDVYRTRFGALLTAAADRRAALRVSN
MUL_2261|M.ulcerans_Agy99 YDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRHALRVSD
Mflv_3787|M.gilvum_PYR-GCK FDHFGMSLRMLGLGATHGSEIVHIHHSYASFVGRKLHPLG-RRIQPGVGR
Mvan_2609|M.vanbaalenii_PYR-1 FDHFGWSLRMLGLGATHGSEIVHIHHSYESFVGRKLHPLG-RRIQPGVGR
MSMEG_3002|M.smegmatis_MC2_155 FDHTTWTLRALGLGATHGSEIVHIQHSYGSYLGRRLHPLG-RHVQPSVGR
TH_2744|M.thermoresistible__bu FEHAPPALRALGLGATHGSEIVHIQHTYASYPGRRLHPLG-ARRTPAVGR
MAB_2866c|M.abscessus_ATCC_199 FDHTAWGLKLLGLGATHGSEIVHVQHSYGSFVGMLLSPLG-ARMMPSVGR
MMAR_4363|M.marinum_M FDYSTPLLKLLLVRAAHATELPYVWGNLGGPQDPTLRLGG-AKTAKAVSK
::: *: . *:*.:*: : . * . : *.
Mb2071c|M.bovis_AF2122/97 EVQRRWRCFSQ-----IGVPGDDWPAYTQDDR-AVLVFDRRCRIEFDPHQ
Rv2045c|M.tuberculosis_H37Rv EVQRRWRCFSQ-----IGVPGDDWPAYTQDDR-AVLVFDRRCRIEFDPHQ
MAV_2466|M.avium_104 QVQRRWRAFSR-----TGVPGEDWPRYTAADR-AVLVFDRKSRVEFDPHP
MUL_2261|M.ulcerans_Agy99 EVIRRWRSFSQ-----TGTPGEDWPAYTHTRR-AVMVIDRKSRVEIDPHR
Mflv_3787|M.gilvum_PYR-GCK RMQRSWLDFARDN---AEVDEGHWPLYEIGARLTRLITSTRDVMASDPDR
Mvan_2609|M.vanbaalenii_PYR-1 RMQRAWLDFARGS---EDVDDEHWPLYETGERLTRLIASTRDVMASDPDR
MSMEG_3002|M.smegmatis_MC2_155 RMQRTWLDFAR-----AEIA--DWPFYDTERRLTRVIRSTRDDTVADPDA
TH_2744|M.thermoresistible__bu RMQRAWLAFAT-----DDHPGSDWPRYDTGRRRTRLIRTGEDLVADDPDV
MAB_2866c|M.abscessus_ATCC_199 RMQRAWLDFAT------GAGPEDWPTYGADGRRTRIIRSRSDVTVEDPDS
MMAR_4363|M.marinum_M RMRTRWINFATQDNPAGPAGEPDWPAYQDGDR-ACLVIDKSDRVARDIDA
.: * *: .** * * : :: * .
Mb2071c|M.bovis_AF2122/97 HRRIAWDGFSLAN-----
Rv2045c|M.tuberculosis_H37Rv HRRIAWDGFSLAN-----
MAV_2466|M.avium_104 HRRMAWDGFSLAR-----
MUL_2261|M.ulcerans_Agy99 HRRLAWDGFSLAR-----
Mflv_3787|M.gilvum_PYR-GCK DRREAWAQVYQPPKRSSV
Mvan_2609|M.vanbaalenii_PYR-1 DRRQAWAAVY--------
MSMEG_3002|M.smegmatis_MC2_155 LRRAVWEGLY--------
TH_2744|M.thermoresistible__bu VRRTAWQGVY--------
MAB_2866c|M.abscessus_ATCC_199 VRRIAWAQVH--------
MMAR_4363|M.marinum_M PIRAAWGREVVGFR----
* .*