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MPAKTVRTELTSGAIEGFTRDGVNRWRSIPYAKPPVGALRFKAPQPVEAWDGVRPCHRFRYCAPQPRRYT IVGPGKFQPMSEDCLTLNVVAPDGGSDRPLPVMFFIHGGAYFLGSSATPIYDGASLARSGCVYVSANYRL GALGAVDLSSLSTADIHIDDNLYLRDLVSALRWVRENIAAFGGDPDNVTIFGESAGAHAVTTLLAVPAAK GLFAQAISQSPAGALSRSQELAAEFAAKFASILCADEREPARLLLAARPAQLVNAFDRLLTTSASDLAGG YPVGCTFGTDYLPSEPIQAMRDGKAYRVPLIVGTNADEGRLFTRFLKLLPTNEAKIEALLAGAEPTCRER ITAAYPEYPAPDACIRLGADFTFGSTLWQLADSHSRHAPTYLYRYDFAPRTLQWAGLGATHATELLAVFD AYRTPLGRLLSAGADRRSALRVSDDMQGRWDAFARTGVPGDGWPRYTSDARPVLVFNRASRVDNDPHADR RKAWEGFQVLGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4595 | - | - | 100% (502) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_3125 | - | 0.0 | 64.67% (501) | carboxylesterase, type B |
| M. gilvum PYR-GCK | Mflv_3787 | - | 7e-88 | 41.12% (501) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 0.0 | 64.93% (499) | carboxylesterase LipT |
| M. tuberculosis H37Rv | Rv2045c | lipT | 0.0 | 64.93% (499) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3453c | - | 1e-164 | 57.06% (496) | carboxylesterase LipT |
| M. marinum M | MMAR_3020 | lipT | 0.0 | 65.13% (499) | carboxylesterase, LipT |
| M. avium 104 | MAV_2466 | - | 0.0 | 66.80% (503) | LppT protein |
| M. smegmatis MC2 155 | MSMEG_3848 | - | 0.0 | 65.34% (502) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_0737 | lipT | 0.0 | 65.45% (492) | Probable carboxylesterase LipT |
| M. ulcerans Agy99 | MUL_2261 | lipT | 0.0 | 64.93% (499) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3408 | - | 0.0 | 64.67% (501) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0737|M.thermoresistible__bu ---------VMHEHRVRVQISTGTIEGFTRDGVHRWRAIPYAKPPVGPLR
Mvan_3408|M.vanbaalenii_PYR-1 ----------MHEHTVRVRTASGTVEGFTRDGVHRWRSIPYARPPVGRLR
MSMEG_3848|M.smegmatis_MC2_155 ----------MHERTVRAEISTGIIEGFTRDGVHRWRSIPYARAPIGPLR
Mb2071c|M.bovis_AF2122/97 MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPVGSLR
Rv2045c|M.tuberculosis_H37Rv MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPVGSLR
MMAR_3020|M.marinum_M ----------MHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPIGPLR
MUL_2261|M.ulcerans_Agy99 ----------MHERTVRARTATGVVEGFTRDGVHRWRSIPYARAPIGLLR
MAV_2466|M.avium_104 ----------MHDRTVRARTATGIVEGFTRDGVHRWRSIPYARPPVGDLR
Mflv_4595|M.gilvum_PYR-GCK ----------MPAKTVRTELTSGAIEGFTRDGVNRWRSIPYAKPPVGALR
MAB_3453c|M.abscessus_ATCC_199 ------MASGSKTPTVRVTTPNGIVEGFVRGGVRRFRSIPYARPPIGLLR
**. ..* :***.*.**.*:*:****:.*:* **
TH_0737|M.thermoresistible__bu LRAPEPADPWPGVRHCHGFGNCAPQERKYTLIGLG----KYQPMGEDCLT
Mvan_3408|M.vanbaalenii_PYR-1 YRAPEPVQPWSGVRHCHGFLSCAPQHRRYTLIGVR----KYQPTSEDCLT
MSMEG_3848|M.smegmatis_MC2_155 LRAPQPAEPWPGVRYCHGFGFCAPQQRRYTLLGVG----KYQPTSEDCLT
Mb2071c|M.bovis_AF2122/97 FRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSEDCLT
Rv2045c|M.tuberculosis_H37Rv FRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSEDCLT
MMAR_3020|M.marinum_M FRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSEDCLT
MUL_2261|M.ulcerans_Agy99 FRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSEDCLT
MAV_2466|M.avium_104 FRAPQPAQPWSGVRHCHGFANCAPQQRRYTLLGLSGLGGRYQPMSEDCLT
Mflv_4595|M.gilvum_PYR-GCK FKAPQPVEAWDGVRPCHRFRYCAPQPRRYTIVGPG----KFQPMSEDCLT
MAB_3453c|M.abscessus_ATCC_199 LRAPQPALPWEGVRDCTEFGAAAPQRRRYRVLGPG----RVQRASEDCLT
:**.* .* *** * * .:** *:* ::* : * .*****
TH_0737|M.thermoresistible__bu LNVVAPEHPPDS--PMPVLVFIHGGGYLLGSSATPIYDGAALARRGCVYV
Mvan_3408|M.vanbaalenii_PYR-1 LNVVAPEGAASAGEPLPVMFFIHGGGYILGSSATPLYDGAALARRGCVYV
MSMEG_3848|M.smegmatis_MC2_155 LNVVAPEKPHDG--PLPVMFFVHGGGYVLGSSATPIYDGAALARRGCVYV
Mb2071c|M.bovis_AF2122/97 LNVVTPEEPATQ--PLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYV
Rv2045c|M.tuberculosis_H37Rv LNVVTPEEPATQ--PLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYV
MMAR_3020|M.marinum_M LNVVAPEAPSHR--PLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYV
MUL_2261|M.ulcerans_Agy99 LNVVAPEAPTHR--PLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYV
MAV_2466|M.avium_104 LNVVTPEAPAEG--PLPVMVFIHGGGYFLGSSATPLYDGAALARRGCVYV
Mflv_4595|M.gilvum_PYR-GCK LNVVAPDGGSDR--PLPVMFFIHGGAYFLGSSATPIYDGASLARSGCVYV
MAB_3453c|M.abscessus_ATCC_199 VNVVTPDRPSNE--PLPVMFFIYGGGYLLGSSATPLYDGAALARRGCVYV
:***:*: *:**:.*::**.*.*******:****:*** *****
TH_0737|M.thermoresistible__bu SVNYRLGALGCMDLSSLSTRRHPIDSNLFLRDLVLALQWVRDNISVFGGD
Mvan_3408|M.vanbaalenii_PYR-1 SVNYRLGPLGCMDLSSLSTPENPIDDNLFLRDLVMALRWVRDNVAAFGGD
MSMEG_3848|M.smegmatis_MC2_155 SVNYRLGVLGAMELSSLSTPEHPIDDNLFLRDLVLALQWVRDNIAVFGGD
Mb2071c|M.bovis_AF2122/97 SVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNIAEFGGD
Rv2045c|M.tuberculosis_H37Rv SVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNIAEFGGD
MMAR_3020|M.marinum_M SVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNIAEFGGD
MUL_2261|M.ulcerans_Agy99 SVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNIAEFGGD
MAV_2466|M.avium_104 SVNYRLGALGCVDFSSLSTPEIPLESNLYLRDLVLALQWVRDNIAEFGGD
Mflv_4595|M.gilvum_PYR-GCK SANYRLGALGAVDLSSLSTADIHIDDNLYLRDLVSALRWVRENIAAFGGD
MAB_3453c|M.abscessus_ATCC_199 SVNYRVGALGALDLSSLSDRDHTIDGNLFLRDVVLALQWVHDNIGTFGGD
*.***:* **.:::**** ::.*::***:* **:*:::*:. ****
TH_0737|M.thermoresistible__bu PGNVTIFGESAGAHAVATLMAVPAAKGLFSQAISQSPASGMVRSADVAAE
Mvan_3408|M.vanbaalenii_PYR-1 PDKVTIFGESAGAHAVATLLATPQAKGLFAQAISESPASGMVRSTEMAAK
MSMEG_3848|M.smegmatis_MC2_155 PDNVTIFGESAGAHAVATLLAVPAARGLFARVISESPASGMVSSADTAAR
Mb2071c|M.bovis_AF2122/97 PGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRSREVAAE
Rv2045c|M.tuberculosis_H37Rv PGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRSREVAAE
MMAR_3020|M.marinum_M PDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRPREIAAE
MUL_2261|M.ulcerans_Agy99 PDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRPREIAAE
MAV_2466|M.avium_104 PDNVTIFGESAGACITATLLAVPAAKGLFAQAISESPASGLVRSQEVAAE
Mflv_4595|M.gilvum_PYR-GCK PDNVTIFGESAGAHAVTTLLAVPAAKGLFAQAISQSPAGALSRSQELAAE
MAB_3453c|M.abscessus_ATCC_199 PGNVTIFGESAGAHCVETLMATPAAAGLFHRAICQSTASGMAVPADSAAM
*.:********** . **:*.* * *** :.*.:*.*..: . : **
TH_0737|M.thermoresistible__bu FARRFADLLG-AGRDPAAALMAASPADLVRALDELISRGMTDMPG-AFAV
Mvan_3408|M.vanbaalenii_PYR-1 FASRFADLVANDGGDAAAALMSASPHALIAALDDLVANGFKDMPG-AFPV
MSMEG_3848|M.smegmatis_MC2_155 LAGQYAGIIGHGGRDAAEALKTLSPAQLGRALEELINRGMTDMPG-AFPV
Mb2071c|M.bovis_AF2122/97 FAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRLG-AFPI
Rv2045c|M.tuberculosis_H37Rv FAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRLG-AFPI
MMAR_3020|M.marinum_M FATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRLG-AFPI
MUL_2261|M.ulcerans_Agy99 FATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRLG-AFPI
MAV_2466|M.avium_104 FANRFANLLGVRRQDAANALMQASAAQLVKTQHRLIDEGMQDRLG-AFPI
Mflv_4595|M.gilvum_PYR-GCK FAAKFASILCADEREPARLLLAARPAQLVNAFDRLLTTSASDLAG-GYPV
MAB_3453c|M.abscessus_ATCC_199 YAQKFAQILGATTQSAAETVLRSSPAELGAALNMLIADIVTNMPGGSFAI
* ::* :: ..* : . * : . *: . * .:.:
TH_0737|M.thermoresistible__bu GPSYGDDCLPRHPVEAMRDGRAHDVPLIVGTNAEEGRLFRRFLPLLPISE
Mvan_3408|M.vanbaalenii_PYR-1 GPTYGTEYLPKDPVEAMRDGTAHRVPLIVGTNAEEGRLFTRFLPLLPTTE
MSMEG_3848|M.smegmatis_MC2_155 GPTYGTEFLPTDPVEAMAAGSAHRVPLIVGNNAEEGRLFTRFLPLLPTNE
Mb2071c|M.bovis_AF2122/97 GPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLGMLPTNE
Rv2045c|M.tuberculosis_H37Rv GPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLGMLPTNE
MMAR_3020|M.marinum_M GPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLKMLPTNK
MUL_2261|M.ulcerans_Agy99 GPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLKMLPTNK
MAV_2466|M.avium_104 GPVVGDDILPTDPVEAMRRGEAHRVPLIVGTNAEEGRLFTRFLAMLPTNE
Mflv_4595|M.gilvum_PYR-GCK GCTFGTDYLPSEPIQAMRDGKAYRVPLIVGTNADEGRLFTRFLKLLPTNE
MAB_3453c|M.abscessus_ATCC_199 GPCIDGHYLPRHPIEAMEHGEAHRVPLIVGHNADEAKLFTRVLKMMPLSE
* . . ** .*::** * : ****** **:*.:** *.* ::* .:
TH_0737|M.thermoresistible__bu PMIEALFGDTDAEVRDRIIAAYPGYPDADACIRLGGDFAFGTAAWEISEA
Mvan_3408|M.vanbaalenii_PYR-1 QTIEIMLGDTDAEVRNRIMSAYPDYPKPDACVQIGGDFTFSTAAWQIGEA
MSMEG_3848|M.smegmatis_MC2_155 PMIEKLFADADPEHRERILSAYPGYPDRDVCVRLGGDFAFGSATWQVAEA
Mb2071c|M.bovis_AF2122/97 PMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEA
Rv2045c|M.tuberculosis_H37Rv PMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAEA
MMAR_3020|M.marinum_M AMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEA
MUL_2261|M.ulcerans_Agy99 AMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFNAAAWQIAEA
MAV_2466|M.avium_104 SMVEELLADAEPAVRERITAAYPDYPDRSACIQLGGDFAFGSAAWQIAEA
Mflv_4595|M.gilvum_PYR-GCK AKIEALLAGAEPTCRERITAAYPEYPAPDACIRLGADFTFGSTLWQLADS
MAB_3453c|M.abscessus_ATCC_199 SALEGMLARGGPGHRDRIVAAYPGYPERSARVKLAGDMNFSTAAWQMAEA
:: ::. . *:** :*** ** . :::..*: *.:: *::.::
TH_0737|M.thermoresistible__bu HSRHAPTYVYRYDYAPRMLHWSGIGATHATELLAVFGTYRTRPGRLLTLA
Mvan_3408|M.vanbaalenii_PYR-1 HSRHAPTFVYRYDYAPRPLHWSGMGATHATELLAVFDIYRTMPGALLTLA
MSMEG_3848|M.smegmatis_MC2_155 HSRHAPTYVYRYDYAPRALRWSGLGATHAMELLAVFDTYRTRYGSMLTAM
Mb2071c|M.bovis_AF2122/97 HGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAA
Rv2045c|M.tuberculosis_H37Rv HGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAA
MMAR_3020|M.marinum_M QGAHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAA
MUL_2261|M.ulcerans_Agy99 QGVHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAA
MAV_2466|M.avium_104 HCAHAPTYLYRYDYAPRTLRWSGFGATHATELLAVFDVYRTRFGALLTAA
Mflv_4595|M.gilvum_PYR-GCK HSRHAPTYLYRYDFAPRTLQWAGLGATHATELLAVFDAYRTPLGRLLSAG
MAB_3453c|M.abscessus_ATCC_199 HHRYAPVYFYRYDYAPGALRIAGMGATHATELLAVFDSYRGAMGTVMAGA
: **.:.****:** *: :*:***** **:***. ** * :::
TH_0737|M.thermoresistible__bu GDWVSAQRVSSDLQRRWLAFGRTGVPGDDWPAYTAEHRPVRVFDRNPRVE
Mvan_3408|M.vanbaalenii_PYR-1 GDWRSARRVSKDVQRRWSSFSRTGVPGADWPRYSAEDRPVMVFDRHPRLE
MSMEG_3848|M.smegmatis_MC2_155 ADRRSARRVSRDIQTRWRDFSRAGVPGDGWPAYRHDERAVYVFDTRPRVE
Mb2071c|M.bovis_AF2122/97 ADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVLVFDRRCRIE
Rv2045c|M.tuberculosis_H37Rv ADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVLVFDRRCRIE
MMAR_3020|M.marinum_M ADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVMVIDRKSRVE
MUL_2261|M.ulcerans_Agy99 ADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVMVIDRKSRVE
MAV_2466|M.avium_104 ADRRAALRVSNQVQRRWRAFSRTGVPGEDWPRYTAADRAVLVFDRKSRVE
Mflv_4595|M.gilvum_PYR-GCK ADRRSALRVSDDMQGRWDAFARTGVPGDGWPRYTSDARPVLVFNRASRVD
MAB_3453c|M.abscessus_ATCC_199 LGRRDAVRVSNDVQRRWLAFARSGVPGDGWPTYGPPDRAVMVFDHATRVE
. * *** :: ** *.: *.** .** * *.* *:: *::
TH_0737|M.thermoresistible__bu YDPDAHRRQAWQGFTLTRPDRN
Mvan_3408|M.vanbaalenii_PYR-1 YDPHAHRRQAWEGFSLA-----
MSMEG_3848|M.smegmatis_MC2_155 YDPDADRRLAWEGFSLAQR---
Mb2071c|M.bovis_AF2122/97 FDPHQHRRIAWDGFSLAN----
Rv2045c|M.tuberculosis_H37Rv FDPHQHRRIAWDGFSLAN----
MMAR_3020|M.marinum_M IDPHQHRRLAWDGFSLAR----
MUL_2261|M.ulcerans_Agy99 IDPHRHRRLAWDGFSLAR----
MAV_2466|M.avium_104 FDPHPHRRMAWDGFSLAR----
Mflv_4595|M.gilvum_PYR-GCK NDPHADRRKAWEGFQVLGR---
MAB_3453c|M.abscessus_ATCC_199 LDPEAARRAAWEGFSLTL----
**. ** **:** :