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MRFAQIPTARRGGKTARSAVLALLAVLALVLSACAGSGGPEQAESTGSGEVSADTSGTVRILMENVPDTD IVKSMVADFNAEYPGVEINIESLTFDQMRDKLVSSFQSSSPAYDLIVVDNPWMVDFANAKFLQPLDARID STPDYDAGDFFTPLTDITTVDGTRYGVPFYNYALGYLYNADDLAAANQQVPTTLDELVSTSKALKSGDRA GIAMQPQRGYKIFEEWGNWLFAAGGSIYDADGKITLNTPEAKRALEAYIDTYNTAAPANSLSWGMDEAQR SVSANQSASMINYNWQLPALNEPGSGPAAGKIKLATIPGGKQVLGSWSWAIPANSATPDAAWAFVSWITA KPNDVVRTEKGGAAIRKSTLQNPAVLQGQFGEEYYRTVEQLLADAAPLTQGPSGEEMIQAVGTALNEAVA GEKSVDDALATAQAEAEKIQG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3775 | - | - | 100% (441) | extracellular solute-binding protein |
| M. gilvum PYR-GCK | Mflv_3851 | - | 4e-13 | 26.78% (366) | extracellular solute-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2345 | uspC | 3e-08 | 25.25% (396) | periplasmic sugar-binding lipoprotein UspC |
| M. tuberculosis H37Rv | Rv2318 | uspC | 5e-08 | 24.30% (395) | periplasmic sugar-binding lipoprotein UspC |
| M. leprae Br4923 | MLBr_01086 | - | 2e-06 | 23.88% (289) | putative solute-binding transport lipoprotein |
| M. abscessus ATCC 19977 | MAB_1715c | - | 4e-06 | 21.33% (450) | sugar ABC transporter, sugar-binding protein |
| M. marinum M | MMAR_3619 | uspC | 1e-06 | 22.87% (363) | periplasmic sugar-binding lipoprotein UspC |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3111 | - | 1e-166 | 66.36% (434) | extracellular solute-binding protein, family protein 1 |
| M. thermoresistible (build 8) | TH_2011 | - | 1e-34 | 25.56% (450) | substrate binding protein |
| M. ulcerans Agy99 | MUL_1246 | uspC | 9e-07 | 22.87% (363) | periplasmic sugar-binding lipoprotein UspC |
| M. vanbaalenii PYR-1 | Mvan_2624 | - | 0.0 | 92.79% (444) | extracellular solute-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3775|M.gilvum_PYR-GCK MRFAQIPT-ARRGGK--TARSAVLALLAVLALVLSACAGSGGPEQAEST-
Mvan_2624|M.vanbaalenii_PYR-1 MRITQWPTSGRRSGRPGTAFSAVMALVAVLALVLTGCAGSGGPEQAEAT-
MSMEG_3111|M.smegmatis_MC2_155 ---MKIPQLRRRRRR--PAITAITAMSVAAGLVLSGCAGTGGPANDEATS
MMAR_3619|M.marinum_M --------------MSRPRFSTLVAVAVTLIAALLGVT--------AVAL
MUL_1246|M.ulcerans_Agy99 --------------MNRPRFSTLVAVAVTLIAALLGVT--------AVAL
Mb2345|M.bovis_AF2122/97 --------------MTRPRQSTLVATALVLVAILLGVT--------AVLL
Rv2318|M.tuberculosis_H37Rv --------------MTRPRQSTLVATALVLVAILLGVT--------AVLL
MAB_1715c|M.abscessus_ATCC_199 -----------------MKASTRAALTLALVALLLFGV--------AAWL
TH_2011|M.thermoresistible__bu --------------VRRTPIRAVLAAVAAVCLTLTGCAG-----------
MLBr_01086|M.leprae_Br4923 -----------MVSRRVHRAGTIILAALTLASVVLACG------------
: . :
Mflv_3775|M.gilvum_PYR-GCK GSGEVSADTSGTVRILMENVPDTDIVKSMVADFNAEYPGVEINIESLTFD
Mvan_2624|M.vanbaalenii_PYR-1 GTGEVSTDVSGTVRILMENVPDTDIVKSMVADFNKEYPGVEINIESLTFD
MSMEG_3111|M.smegmatis_MC2_155 GVGDVPTDTSATVRVLMENVPDTDIVQGLVGQFNEKYPDIKVDIETMTFD
MMAR_3619|M.marinum_M DRIDAPPGGKIVVTVRLWAAPIAAAYQQSFAAFSRTHPNIEVHTNLVSFS
MUL_1246|M.ulcerans_Agy99 DRIDAPPGGKIVVTVRLWAAPIAAAYQQSFAAFSRTHPNIEVHTNLVSFS
Mb2345|M.bovis_AF2122/97 GLSAEPRGGKIVVTVRLWDEPIAAAYRQSFAAFTRSHPDIEVRTNLVAYS
Rv2318|M.tuberculosis_H37Rv GLSAEPRGGKIVVTVRLWDEPIAAAYRQSFAAFTRSHPDIEVRTNLVAYS
MAB_1715c|M.abscessus_ATCC_199 GIPTTPHG-KTVVTVRVWDQQVAEAYRGSFDEFSRRNPDIQVAVTVTSYA
TH_2011|M.thermoresistible__bu --AGTLGSSGNTVTIALVSNSQMSDAQRLAPHFEAANPDIRLKFVTLSEN
MLBr_01086|M.leprae_Br4923 --AGGDQLVISFYTPASEDATFTEVARRCTEQFDGRFAIQHVSLPRSP-D
: * . .: .
Mflv_3775|M.gilvum_PYR-GCK QMRDKLVSSFQSSSPAYDLIVVDNPWMVDFANAKFLQPLDARID-STPDY
Mvan_2624|M.vanbaalenii_PYR-1 QMRDKLVSSFQSSSPTYDLIVVDNPWMVDFANAKFLQPLDARID-STPDY
MSMEG_3111|M.smegmatis_MC2_155 QMRDRLVSSFQAAQPAYDLIVVDNPWMDDFADAGFLQPLDERIA-ATTDF
MMAR_3619|M.marinum_M TYFDTLRTDVAG-GSADDIFWLSNAYLAAYADSGRLMKIDTAV-------
MUL_1246|M.ulcerans_Agy99 TYFDTLRTDVAG-GSADDIFWLSNAYLAAYADSGRLMKIDTAV-------
Mb2345|M.bovis_AF2122/97 TYFETLRTDVAG-GSADDIFWLSNAYFAAYADSGRLMKIQT---------
Rv2318|M.tuberculosis_H37Rv TYFETLRTDVAG-GSADDIFWLSNAYFAAYADSGRLMKIQT---------
MAB_1715c|M.abscessus_ATCC_199 SYFNSLRTDVAG-HGADDIFWLSNAYLSDYADTGNLVPVEP---------
TH_2011|M.thermoresistible__bu QARAKITASTAMGGGEFDVVMISNYETPQWAADGWLVNLSDYAR-QTPGY
MLBr_01086|M.leprae_Br4923 EQRLQLARRLTGKDRSLDVMAMDVVWTAEFAEAGWTLPLSEDPAGLAEPD
: *:. :. :* :.
Mflv_3775|M.gilvum_PYR-GCK DAGDFFTPLTDITTVDGTRYGVPFYNYALGYLYNADDLAA---------A
Mvan_2624|M.vanbaalenii_PYR-1 DAADFFKPLTDITTVDGARYGVPFYNYALGYLYNADDLTA---------A
MSMEG_3111|M.smegmatis_MC2_155 RPDDFFPSLTDITDVDGTTYGVPFYNYALGYIYNKDDLAA---------A
MMAR_3619|M.marinum_M DPGEWEPAVVDQFTRNGVLWGVPQLTDAGIAVFYNADLLA---------A
MUL_1246|M.ulcerans_Agy99 DPGEWEPAVVDQFTRNGVLWGVPQLTDAGIAVFYNADLLA---------A
Mb2345|M.bovis_AF2122/97 DAADWEPAVVDQFTRSGVLWGVPQLTDAGIAVFYNADLLA---------A
Rv2318|M.tuberculosis_H37Rv DAADWEPAVVDQFTRSGVLWGVPQLTDAGIAVFYNADLLA---------A
MAB_1715c|M.abscessus_ATCC_199 -RADWDPSVVAQFTRDGKLWGVPQLSDAGIALYYNKNLLD---------A
TH_2011|M.thermoresistible__bu DEDDFIPSIRESLSYEGDMYAVPFYGESSFLMYRKDLFEK---------S
MLBr_01086|M.leprae_Br4923 AIVDTLPGPLATATWKRKLYAAPVTTNTQLLWYRTDLVDQPPGDWNGMVA
: . :..* : : . :
Mflv_3775|M.gilvum_PYR-GCK NQQVPT--TLDELVSTSKALKSGDRAGIAMQ-------------------
Mvan_2624|M.vanbaalenii_PYR-1 NQQVPT--TLDELVSTSKALKSGDRAGIAMQ-------------------
MSMEG_3111|M.smegmatis_MC2_155 GASVPT--DLDALVRTSQQLKTADRAGIAMQ-------------------
MMAR_3619|M.marinum_M AGVDPA--ELDGLRWSPGPD-DTLRALLARLTVDADGHVGGTPGFDPGRV
MUL_1246|M.ulcerans_Agy99 AGVDPA--ELDGLRWSPGPD-DTLRALLARLTVDADGHVGGTPGFDPGRV
Mb2345|M.bovis_AF2122/97 AGVDPT--QVDNLRWSRGDD-DTLRPMLARLTVDADGRTANTPGFDARRV
Rv2318|M.tuberculosis_H37Rv AGVDPT--QVDNLRWSRGDD-DTLRPMLARLTVDADGRTANTPGFDARRV
MAB_1715c|M.abscessus_ATCC_199 AQVDPA--ELAELRWDPDPEVDTLRPMLHRLTAPG---------------
TH_2011|M.thermoresistible__bu GIDMPHNPTWQQVADAAAALDTPDMAGICLR-------------------
MLBr_01086|M.leprae_Br4923 EAARLHAAGEPSWIAVQANQGEGLVVWFNTLLASAGGQVLSEDGRHVTLT
:
Mflv_3775|M.gilvum_PYR-GCK PQRGYKIFEEWGNWLF---AAGGSIYD-----ADGKITLNTPEAKRALEA
Mvan_2624|M.vanbaalenii_PYR-1 PQRGYKIFEEWGNWLF---AAGGSIYD-----ADGKITLNTPEAKRALEA
MSMEG_3111|M.smegmatis_MC2_155 PQRGYKIFEEWANWLF---AAGGSIYD-----KDGNPTLDTEQAARALDA
MMAR_3619|M.marinum_M RQWGYNAANDPQAIYLNYIGSAGGVFM-----RDNEFAFDNPPAIDAFRY
MUL_1246|M.ulcerans_Agy99 RQWGYNAANDPQAIYLNYIGSAGGVFM-----RDNEFAFDNPPAIDAFRY
Mb2345|M.bovis_AF2122/97 RQWGYNAANDPQAIYLNYIGSAGGVFQ-----RDGKFAFDNPGAIEAFRY
Rv2318|M.tuberculosis_H37Rv RQWGYNAANDPQAIYLNYIGSAGGVFQ-----RDGKFAFDNPGAIEAFRY
MAB_1715c|M.abscessus_ATCC_199 -HWGYNAANDLQGIYLNYLGSAGAVFQ-----ADDKFAFAKPRAEMAFTY
TH_2011|M.thermoresistible__bu GKPGWGEVLAPLDTVIN--TFGGRWYD-----MDWNAQLDSPEVEEAVSF
MLBr_01086|M.leprae_Br4923 DTPEHRAATVRALRIIKAVATVPGADPSITRTDEATARLAVEQGKAALEV
: : : *.
Mflv_3775|M.gilvum_PYR-GCK YIDTYNTAAPANSLSWGMDEAQRSVSANQSASMINYNWQLPALN--EPG-
Mvan_2624|M.vanbaalenii_PYR-1 YIDTYNTAAPANSLSWGMDEAQRSVSANQAASMINYNWQLPALN--EPG-
MSMEG_3111|M.smegmatis_MC2_155 YIETYRTAAPANSLAWGFDEAFRSVSSGKAASMVGYNWNLPALN--DPAG
MMAR_3619|M.marinum_M LVGLINNDHVAPPASDTNDNGDFSRNQFLAGRMALFQSGTYSLA--PVAR
MUL_1246|M.ulcerans_Agy99 LVGLINNDHVAPPASDTNDNGDFSRNQFLAGRMALFQSGTYSLA--PVAR
Mb2345|M.bovis_AF2122/97 LVGLINDDHVAPPASDTNDNGDFSRNQFLAGKMALFQSGTYSLA--PVAR
Rv2318|M.tuberculosis_H37Rv LVGLINDDHVAPPASDTNDNGDFSRNQFLAGKMALFQSGTYSLA--PVAR
MAB_1715c|M.abscessus_ATCC_199 LVDLINVDRVAPSAADTNDNNDFSRNQFLQGRMALFQSGTYNLA--QIQA
TH_2011|M.thermoresistible__bu YVNLVRDHGEPGPATSGFGECATQFAQGRAAMWYDATSAVSVLE--DPAQ
MLBr_01086|M.leprae_Br4923 NWPFVLASMLENAVKGGVAFLPLDRISELAGSINNVGTFVPNDEQFRIAY
. . .
Mflv_3775|M.gilvum_PYR-GCK --SGPAAGKIKLATIPGGK--QVLG-SWSWAIPANSATPDAAWAFVSWIT
Mvan_2624|M.vanbaalenii_PYR-1 --SGPAAGKIKLATIPGGK--QVLG-SWSWAIPANSATPDAAWAFVSWIT
MSMEG_3111|M.smegmatis_MC2_155 A-SGERAGQFALAPIPGGK--SALG-LWSWAIPANSAASDAAWAFISWIT
MMAR_3619|M.marinum_M D-ATFRWGVAMLPIGPAGR--VSVTNGIAAAGNSASQHPDAVRQVLAWMG
MUL_1246|M.ulcerans_Agy99 D-ATFRWGVAMLPIGPAGR--VSVTNGIAAAGNSASQHPDAVRQVLAWMG
Mb2345|M.bovis_AF2122/97 D-ALFHWGVAMLPAGPAGR--VSVTNGIAAAGNSASKHPDAVRQVLAWMG
Rv2318|M.tuberculosis_H37Rv D-ALFHWGVAMLPAGPAGR--VSVTNGIAAAGNSASKHPDAVRQVLAWMG
MAB_1715c|M.abscessus_ATCC_199 N-ATFPWDVAMMPAGPQGR--VSVTNGIVAAANSSSPHPDAVHKVLAWMG
TH_2011|M.thermoresistible__bu SNVVGKVGYALAPTVVKAD--AGWLYTWALGIPASSDNKDSAWKFISWMT
MLBr_01086|M.leprae_Br4923 QATRNVFGFAPYPSVSRSEPAKVTIGGLNLAVASTSRHKAEAFEAVRCLR
. . . . : * . : :
Mflv_3775|M.gilvum_PYR-GCK AK------PNDVVRTEKG-GAAIRKSTLQNPAVLQGQFG----------E
Mvan_2624|M.vanbaalenii_PYR-1 AK------PNDVVRTEKG-GAAIRQSTLQDPAVLGGQFG----------E
MSMEG_3111|M.smegmatis_MC2_155 SP------EIDAERVAKG-GAVVRESSLTNEKVLKDGYG----------E
MMAR_3619|M.marinum_M SS------AGNEYLGRDGVAIPAVRSAQPSYFAFWEAKG----------V
MUL_1246|M.ulcerans_Agy99 SS------AGNEYLGRDGVAIPAVRSAQPSYFAFWEAKG----------V
Mb2345|M.bovis_AF2122/97 ST------EGNSYVGRHGAAIPAVLSAQPVYFDYWSARG----------V
Rv2318|M.tuberculosis_H37Rv ST------EGNSYLGRHGAAIPAVLSAQPVYFDYWSARG----------V
MAB_1715c|M.abscessus_ATCC_199 ST------DGNSFLGRSGSAIPAVLSARAPYFQYWADKG----------V
TH_2011|M.thermoresistible__bu DKNYIRLVGEELGWARVPPGNRLSTYQIPEYQQASEAFGQVTLESLENAD
MLBr_01086|M.leprae_Br4923 SE------QSQQYLSIEG-GLPAVRASLYSDPAFQDKYP-----------
: .
Mflv_3775|M.gilvum_PYR-GCK EYYRTVEQLLADAAPLTQGPSGEEMIQAVGTALNEAVAGEKSVDDALATA
Mvan_2624|M.vanbaalenii_PYR-1 EYYRTVEQLLANAAPLTQGPSGEEMIQAVGTELNEAVAGKKSVDDALAAA
MSMEG_3111|M.smegmatis_MC2_155 DYYRVVGEILSDAAPLTQGKGGEEMIQAVGTELNDAAAGNKSVADALRDA
MMAR_3619|M.marinum_M NVEPFFAVLSGSRIPAPGGAGFAAGNDALKPYFDEMFLGRGQVATILREA
MUL_1246|M.ulcerans_Agy99 NVNPFFAVLSGSRIPAPGGAGFAAGNDALKPYFDEMFLGRGQVATILREA
Mb2345|M.bovis_AF2122/97 DVTPFFAVLNGPRIAAPGGAGFAAGQQALEPYFDEMFLGRGDVTTTLRQA
Rv2318|M.tuberculosis_H37Rv DVTPFFAVLNGPRIAAPGGAGFAAGQQALEPYFDEMFLGRGDVTTTLRQA
MAB_1715c|M.abscessus_ATCC_199 DVSPFFEVLRGQQIAAPGGQGFGAGFAALKPYFAEMFLGRLDVREALQQA
TH_2011|M.thermoresistible__bu TQHPTVQPVPYTGVQFLAIPEFQDLGTRVSQQISAAIAGQKSVKDALAQA
MLBr_01086|M.leprae_Br4923 -MYTIIRQQLTDAAVRPVTPAYQAVSIRLSAALNPITDIDPEPMADRLAA
. : : . *
Mflv_3775|M.gilvum_PYR-GCK QAEAEKIQG------
Mvan_2624|M.vanbaalenii_PYR-1 QAEAEKIQG------
MSMEG_3111|M.smegmatis_MC2_155 QAAVERIQK------
MMAR_3619|M.marinum_M QAAANAAARR-----
MUL_1246|M.ulcerans_Agy99 QAAANAAARR-----
Mb2345|M.bovis_AF2122/97 QAAANAATQR-----
Rv2318|M.tuberculosis_H37Rv QAAANAATQR-----
MAB_1715c|M.abscessus_ATCC_199 QRAANRALER-----
TH_2011|M.thermoresistible__bu QKYAQVVGKTYQEKP
MLBr_01086|M.leprae_Br4923 QVQKAIDGKGLLP--
*