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MKRSSWHLRAGSVVLGWLVALVMAAIAHPYIALSNWLLIHLLGLGAASNAILIWSRHFADALLRRSPDPP YPGQVIRLLAFNIGAVTVITGMLGGWWPVVLAGGVLVAAVAAVHAGDLMRFLRAALPARFSITVHYYVAA AACLAVGAGLGVAMANSALPGILAERFRTAHAVLNLFGWVGLTVLGTLVTLWPTMLRTRMADGVERAARR GLPALVLSVAVAVAGAILGSSRVVGVGALSFLTAVGFVLWPHIDEVRRKRPADFPTLSVLCGVVWLAGSL GYLSVGLLTAPNSMAAATVTAAAGPALLAGFLVQVLFGSLAYLIPMVVGGRASALAATAELERGAPWRLS VANFGLLICVLPVPNLVRVAVSALVLVAYGAFLPLLVRAVWLAQRNTGVRSTPGRLDPPPLRQRLGIAAA GFGVVILTAAAGVAADPATLGIGSAPTVTAAPTGHTTEVRVRVDGMRYVPDTITVPAGDRLRITFHNTGT DRHDLVLANGARTDRVAPGVTAVLDAGVIGSDLAGWCSIAGHRQMGMTLTIKAIGTPPVSGHEHELPGHG PDPSLTATDIARSLGGRPGPGFAARDPKLSAAETAEHRVTLTVSEVEREVSPGITQRLWTFGGSAPGPTL RGRVGDVFEITLINDGTIGHSIDFHAGSLAPDRPMRTIEPGAQLVYRFTATRAGVWLYHCATMPMSVHIA NGMFGAVVIDPPDLSTVDREYLMVQSEFYLGADGGEVDADKVAADTPDLVVFNGYAQQYDHAPLTARVGE RVRIWVLAAGPNRGSAFHVVGGQFDTVWAEGAYRLRPGAGGSQTLGLFPAQGGFVELSFPEPGNYPFVSH AMVDAERGAHGVIAVGN
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3489 | - | - | 100% (857) | multicopper oxidase, type 3 |
M. gilvum PYR-GCK | Mflv_2663 | - | 2e-06 | 25.65% (421) | ComEC/Rec2-related protein |
M. gilvum PYR-GCK | Mflv_3485 | - | 2e-06 | 34.51% (113) | hypothetical protein Mflv_3485 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0980 | - | 4e-08 | 28.15% (302) | integral membrane protein |
M. tuberculosis H37Rv | Rv0955 | - | 4e-08 | 28.15% (302) | integral membrane protein |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_0463c | - | 2e-09 | 24.54% (216) | oxidase (copper-binding protein) |
M. marinum M | MMAR_4544 | - | 3e-08 | 28.86% (246) | integral membrane protein |
M. avium 104 | MAV_1079 | - | 6e-07 | 29.28% (263) | hypothetical protein MAV_1079 |
M. smegmatis MC2 155 | MSMEG_5517 | - | 5e-05 | 28.11% (249) | hypothetical protein MSMEG_5517 |
M. thermoresistible (build 8) | - | - | - | - | - |
M. ulcerans Agy99 | MUL_4714 | - | 3e-08 | 28.86% (246) | integral membrane protein |
M. vanbaalenii PYR-1 | Mvan_3626 | - | 0.0 | 44.69% (857) | multicopper oxidase, type 3 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3489|M.gilvum_PYR-GCK ------MKRSSWH----LRAGSVVLGWLVALVMAAIAHPYIALSNWLLIH Mvan_3626|M.vanbaalenii_PYR-1 MTAQAPRRRNSLRGPVFLWANVVVLGWLAVSVGLLAAHSWLGLPGWVAVH MMAR_4544|M.marinum_M -------------------------------------------------- MUL_4714|M.ulcerans_Agy99 -------------------------------------------------- MAV_1079|M.avium_104 -------------------------------------------------- Mb0980|M.bovis_AF2122/97 -------------------------------------------------- Rv0955|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_5517|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0463c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3489|M.gilvum_PYR-GCK LLGLGAASNAILIWSRHFADALLRRSPDPPYPGQVIRLLAFNIGAVTVIT Mvan_3626|M.vanbaalenii_PYR-1 ALLLGAVTNAIVIWSEHFAVAWCR-MPSPPQRRLALGLTALNLCVIAVLV MMAR_4544|M.marinum_M -----------MTRVEDSRAAGARQARDLVKVAFAPAVVALVIIAAVTLI MUL_4714|M.ulcerans_Agy99 --------------MEDSRAAGARQARDLVKVAFAPAVVALVIIAAVTLI MAV_1079|M.avium_104 --------------MEDNRAAGARQARDLVRVAFAPAVVALVIIAAVTLI Mb0980|M.bovis_AF2122/97 --------MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLL Rv0955|M.tuberculosis_H37Rv --------MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLL MSMEG_5517|M.smegmatis_MC2_155 ---------------MNNGPVGTRQARELLRVAFGPSVVALVIIAAVVLL MAB_0463c|M.abscessus_ATCC_199 ------------------MAVSRSQWGRRGFLQLGAATAAAGVLAACGTR . * : . Mflv_3489|M.gilvum_PYR-GCK GMLGGWWPVVLAGGVLVAAVAAVHAGDLMRFLR---AALPARFSITVHYY Mvan_3626|M.vanbaalenii_PYR-1 GVSTDTAALTGVGGTGITVIAVVHTVHLRRATRSTRSEAPGTFGYLIGFY MMAR_4544|M.marinum_M QLVIANSDMTGALGAIASMWLGVHQVPIS--------------------- MUL_4714|M.ulcerans_Agy99 QLVIANSDMTGALGAIASMWLGVHQVPIS--------------------- MAV_1079|M.avium_104 QLLIANSDMTGALGAIASMWLGVHQVPVS--------------------- Mb0980|M.bovis_AF2122/97 QLLIANSDMTGAWGAIASMWLGVHLVPIS--------------------- Rv0955|M.tuberculosis_H37Rv QLLIANSDMTGAWGAIASMWLGVHLVPIS--------------------- MSMEG_5517|M.smegmatis_MC2_155 QLVIANSDMTGAFGAIASMWLGVHQVPVS--------------------- MAB_0463c|M.abscessus_ATCC_199 PVRGPSGQPVGPSSPRVGALEAVRRDGGGR-------------------- : . . *: Mflv_3489|M.gilvum_PYR-GCK VAAAACLAVGAGLGVAMANSALPGILAERFRTAHAVLNLFGWVGLTVLGT Mvan_3626|M.vanbaalenii_PYR-1 GAAGIMLASGAVLGALLALGS--GQWYVRLWSAHVHLTLLGWVGLTVLGT MMAR_4544|M.marinum_M -------IGGRELG-----------------------------VMPLFPA MUL_4714|M.ulcerans_Agy99 -------IGGRELG-----------------------------VMPLFPA MAV_1079|M.avium_104 -------IGGRELG-----------------------------VLPLLPV Mb0980|M.bovis_AF2122/97 -------IGGRALG-----------------------------VMPLLPV Rv0955|M.tuberculosis_H37Rv -------IGGRALG-----------------------------VMPLLPV MSMEG_5517|M.smegmatis_MC2_155 -------IGGRELG-----------------------------VMPLLPV MAB_0463c|M.abscessus_ATCC_199 -------LVPVNLAARP-------------------------LQLDLAGT *. : : . Mflv_3489|M.gilvum_PYR-GCK LVTLWPTMLRTRMADGVERAARRGLPALVLSVAVAVAGAILGSSRVVGVG Mvan_3626|M.vanbaalenii_PYR-1 MLTLWPTTLRARIGSDTHTAARRALPVLCAGLALTAAGMLAAVVWLTAAG MMAR_4544|M.marinum_M LLMVWGTARTTALATSPYSSW----------------------------- MUL_4714|M.ulcerans_Agy99 MLMVWGTARTTALATSPYSSW----------------------------- MAV_1079|M.avium_104 LLMVWATARNTARATSPHSSW----------------------------- Mb0980|M.bovis_AF2122/97 LLMVWATARSTARATSPQSSG----------------------------- Rv0955|M.tuberculosis_H37Rv LLMVWATARSTARATSPQSSG----------------------------- MSMEG_5517|M.smegmatis_MC2_155 LAMVWGTAKTTAAATAPNSSW----------------------------- MAB_0463c|M.abscessus_ATCC_199 TVSTWGYGDQIPGPTIRARKG----------------------------- * Mflv_3489|M.gilvum_PYR-GCK ALSFLTAVGFVLWPHIDEVRRKRPADFPTLSVLCGVVWLAGSLGYLSVGL Mvan_3626|M.vanbaalenii_PYR-1 LLCYAVGVGVVAVPLVRSAVARRPQGPAAWMLGAATGWLAAAVVYEAGRL MMAR_4544|M.marinum_M -------------------------------------------------- MUL_4714|M.ulcerans_Agy99 -------------------------------------------------- MAV_1079|M.avium_104 -------------------------------------------------- Mb0980|M.bovis_AF2122/97 -------------------------------------------------- Rv0955|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_5517|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0463c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_3489|M.gilvum_PYR-GCK LTAPNSMAAATVTAAAGPALLAGFLVQVLFGSLAYLIPMVVG-GRASALA Mvan_3626|M.vanbaalenii_PYR-1 LVAGSVQALPAVTAETLPILIVGFTAQVLMGALTQLLPMLVGRGPAEHKV MMAR_4544|M.marinum_M ----LVVRWVIASALGGPLLIAAICLAVIH-------------------- MUL_4714|M.ulcerans_Agy99 ----LVVRWVIASALGGPLLIAAICLAVIH-------------------- MAV_1079|M.avium_104 ----LVIRWVVASALGGPLLMTAVALAVIH-------------------- Mb0980|M.bovis_AF2122/97 ----LVVRWVVASALGGPLLMAAIALAVIH-------------------- Rv0955|M.tuberculosis_H37Rv ----LVVRWVVASALGGPLLMAAIALAVIH-------------------- MSMEG_5517|M.smegmatis_MC2_155 ----FVTRWVVASALGGPLLIAALLLAVIH-------------------- MAB_0463c|M.abscessus_ATCC_199 ----EVLRVAVANGLPAPTTVHWHGIALRN-------------------- ... * : : Mflv_3489|M.gilvum_PYR-GCK ATAELERGAPWRLSVANFGLLICVLPVPNLVRVAVSALVLVAYGAFLPLL Mvan_3626|M.vanbaalenii_PYR-1 VAELLCAGWPARVAAINVAVPLVAGNWPDPLPLLGWVLAAAAVATFVVQA MMAR_4544|M.marinum_M ----------------DASSVITELQTPSALRAFVSVLAVHAIGAGLGVW MUL_4714|M.ulcerans_Agy99 ----------------DASSVITELQTPNALRAFVSVLAVHAIGAGLGVW MAV_1079|M.avium_104 ----------------DASSVITELQTPSALRAFLSVLVVHAIGAGIGVW Mb0980|M.bovis_AF2122/97 ----------------DASSVVTELQTPSALRAFTSVLVVHSVGAATGVW Rv0955|M.tuberculosis_H37Rv ----------------DASSVVTELQTPSALRAFTSVLVVHSVGAATGVW MSMEG_5517|M.smegmatis_MC2_155 ----------------DAASVITELQTPSALRAFGGVLAVHAIGALIGVS MAB_0463c|M.abscessus_ATCC_199 ----------------------DMDGVPDLTQPQIAAAGSFTYEFALAHA *. . : Mflv_3489|M.gilvum_PYR-GCK VRAVWLAQRNTGVRSTPGRLDPPPLRQRLGIAAAGFGVVILTAAAGVAAD Mvan_3626|M.vanbaalenii_PYR-1 LRVALPMARRGSIS-----------AQRQRIPGTGTGVVAGLAVVVLAVA MMAR_4544|M.marinum_M SRVGRRALAVSPLP------------------------------------ MUL_4714|M.ulcerans_Agy99 SRVGIRALAVSPLP------------------------------------ MAV_1079|M.avium_104 SQVGPRALAASSLP------------------------------------ Mb0980|M.bovis_AF2122/97 SRVGRRALAATALP------------------------------------ Rv0955|M.tuberculosis_H37Rv SRVGRRALAATALP------------------------------------ MSMEG_5517|M.smegmatis_MC2_155 TKIGRRTLAASPLP------------------------------------ MAB_0463c|M.abscessus_ATCC_199 GTYWFHPHVGTQLD------------------------------------ : Mflv_3489|M.gilvum_PYR-GCK PATLGIGSAPTVTAAPTGHTTEVRVRVDGMRYVPDTITVPAGDRLRITFH Mvan_3626|M.vanbaalenii_PYR-1 VAATGH-DAPTQTVT-SGPTRTVDVTLQAMRMNPDVVEVAAGARLVLRVT MMAR_4544|M.marinum_M ------------------------------NWLGDSLRAAAAGVLALLGL MUL_4714|M.ulcerans_Agy99 ------------------------------NWLGDSLRAAAAGVLALLGL MAV_1079|M.avium_104 ------------------------------YWLGDSLRAATAGVLALLGL Mb0980|M.bovis_AF2122/97 ------------------------------DWLHDSMRAAAAGVLALLGL Rv0955|M.tuberculosis_H37Rv ------------------------------DWLHDSMRAAAAGVLALLGL MSMEG_5517|M.smegmatis_MC2_155 ------------------------------KWLPDAVRAASAGVLALFAL MAB_0463c|M.abscessus_ATCC_199 ------------------------------RGLYAPLIVEDPDERADYDT : . Mflv_3489|M.gilvum_PYR-GCK NTGTDRHDLVLANGARTDRVAPGVTAVLDAGVIGSDLAGWCSIAGHRQMG Mvan_3626|M.vanbaalenii_PYR-1 NVDAMPHDLRVETGEKTPVLGQGETATLDLGVIDGPRQAWCTVAGHRAAG MMAR_4544|M.marinum_M SGLVTAGSLVVHWATMQELYG-----------ITDSAFGQFSLTVLSVLY MUL_4714|M.ulcerans_Agy99 SGLVTAGSLVVHWATMQELYG-----------ITDSAFGQFSLTVLSVLY MAV_1079|M.avium_104 SGFVTAGSLVVHWATMQELYG-----------ITDSIFGEFSLTVLSMLY Mb0980|M.bovis_AF2122/97 SGVVTAGSLVVHWATMQELYG-----------ITDSIFGQFSLTVLSVLY Rv0955|M.tuberculosis_H37Rv SGVVTAGSLVVHWATMQELYG-----------ITDSIFGQFSLTVLSVLY MSMEG_5517|M.smegmatis_MC2_155 SGIVTAGSLVVHWGTMHDLFA-----------ITDTVFGQLSLTGLSVLY MAB_0463c|M.abscessus_ATCC_199 ELVVALDDWIDGTGTDPDKVLAG---------LRDKGMPGMGHSMGDMPG . . . . : . : Mflv_3489|M.gilvum_PYR-GCK MTLTIKAIGTPPVSGHEHELPGHGPDPSLTATDIARSLGGRPGPGFAARD Mvan_3626|M.vanbaalenii_PYR-1 MTMTIRTDGGETASTHDTHSPGDMG----AAMPAALDLGADPSPGWTPRD MMAR_4544|M.marinum_M VPNVVVG-------------------------AAAIAVGASAHIGFATFS MUL_4714|M.ulcerans_Agy99 VPNVVVG-------------------------AAAIAVGASAHIGFATFS MAV_1079|M.avium_104 APNVIVG-------------------------TAAVAVGSSAHIGFATFS Mb0980|M.bovis_AF2122/97 APNVIVG-------------------------TSAIAVGSSAHIGFATFS Rv0955|M.tuberculosis_H37Rv APNVIVG-------------------------TSAIAVGSSAHIGFATFS MSMEG_5517|M.smegmatis_MC2_155 IPNVIVG-------------------------TSAIAVGSSAHIGLATFS MAB_0463c|M.abscessus_ATCC_199 MSIGSMG------------------------VSAQAPLGADGGDVTYPYY . :*. . Mflv_3489|M.gilvum_PYR-GCK PKLSAAETAEHRVTLTVSEVEREVSPGITQRLWTFGGSAPGPTLRGRVGD Mvan_3626|M.vanbaalenii_PYR-1 ARLQPVAGTVHKIELTVAERDVEVAPGRFERRWTFGGSAPGPTLHGRVGD MMAR_4544|M.marinum_M -------------AFTVFGGDIPAVP--------ILAAAPTPLLG----P MUL_4714|M.ulcerans_Agy99 -------------AFTVFGGDIPAVP--------ILAAAPTPPLG----P MAV_1079|M.avium_104 -------------SFTVFGGDIPALP--------VLAAVPRPPLG----P Mb0980|M.bovis_AF2122/97 -------------SFAVLGGDIPALP--------ILAAAPTPPLG----P Rv0955|M.tuberculosis_H37Rv -------------SFAVLGGDIPALP--------ILAAAPTPPLG----P MSMEG_5517|M.smegmatis_MC2_155 -------------SFTVFGGDIPAVP--------VLAAAPTPPLG----P MAB_0463c|M.abscessus_ATCC_199 LING---------RVAADPQSVDYRPG-TRVRLRIINAAGDSAFRVAIPG .:. . * . :. . : Mflv_3489|M.gilvum_PYR-GCK VFEITLINDGTIGHSIDFHAGSLAPDRPMRTIEPGAQLVYRFTATRAGVW Mvan_3626|M.vanbaalenii_PYR-1 QFEITLVNDGTMGHSIDFHAGMLAPDVPMRTIAPGERLTYRFTAHHAGAW MMAR_4544|M.marinum_M VWVALLIIGASSGVAVGQQC-------ARRPLPPLPAMGKLLAAALVGAL MUL_4714|M.ulcerans_Agy99 VWVALLIIGASSGVAVGQQC-------ARRPLPPLPAMGKLLAAALLGAL MAV_1079|M.avium_104 VWVALLIIGASSGVAVGQQC-------ARRPLPPVAAMVKLLAASVAGAL Mb0980|M.bovis_AF2122/97 AWVALLIVGASSGVAVGQQC-------ARRALPFVAAMAKLLVAAVAGAL Rv0955|M.tuberculosis_H37Rv AWVALLIVGASSGVAVGQQC-------ARRALPFVAAMAKLLVAAVAGAL MSMEG_5517|M.smegmatis_MC2_155 VWVALLIVGAASAVALGQQC-------AARPLTPFAALAKLIVASLISAV MAB_0463c|M.abscessus_ATCC_199 TPLTVTHTDGFPVQPRQTDALLIGMGERIDAIITVGEVSVPLLAAPYGKD .. . .. .: : : * . Mflv_3489|M.gilvum_PYR-GCK LYHCATMPMSVHIANGMFGAVVIDPPDLSTVDREYLMVQSEFYLGADGGE Mvan_3626|M.vanbaalenii_PYR-1 LYHCSTMPMALHIANGMFGAVIIDPPGLAPVDREYVLVSSQLYLGEPGSQ MMAR_4544|M.marinum_M AMALLGYGGSGKLGN--FGAVGVDEGALLVGVFFWFAVVGGATLVMAGG- MUL_4714|M.ulcerans_Agy99 AMALLGYGGSGKLGN--FGAVGVDEGALLVGVFFWFAVVGGATLVMAGG- MAV_1079|M.avium_104 VMSLLAYAGSGQLGN--FGHVGVDQGALLVGVFFWFAVVGGATVVMSGG- Mb0980|M.bovis_AF2122/97 VMAVLGYGGGGRLGN--FGDVGVDEGALVLGVLFWFTFVGWVTVVIAGG- Rv0955|M.tuberculosis_H37Rv VMAVLGYGGGGRLGN--FGDVGVDEGALVLGVLFWFTFVGWVTVVIAGG- MSMEG_5517|M.smegmatis_MC2_155 TMALLGYAGSGRLGN--FGHVGVDQSTFGPAVFLWFVGIGGLTVVMSGG- MAB_0463c|M.abscessus_ATCC_199 GYAQLVLRSSGTPVSGSAAEAAAALPKLAALDTASLSATEEVTLAVGEPD . . . . : . : Mflv_3489|M.gilvum_PYR-GCK VDADKVAADTPDLVVFNGYAQQYDHAPLTARVGERVRIWVLAAGPNRGSA Mvan_3626|M.vanbaalenii_PYR-1 TQTDNLRAGQPDGWAFNGMAAQYDHAPLTAVVGERARIWVVNAGPGDSTA MMAR_4544|M.marinum_M ---------------IRRRPRRPKPRPAPPVEADVDEPIH-EPVDEPFVP MUL_4714|M.ulcerans_Agy99 ---------------IRRRPRRPKPRPVPPAEADVDEPIH-EPVDEPFVP MAV_1079|M.avium_104 ---------------IRRPTRRLKPRPAP--AAPVAEEHD-SVFGEAVGP Mb0980|M.bovis_AF2122/97 ---------------ISRRPKR--LRPAPPVELDADE-------SSPPVD Rv0955|M.tuberculosis_H37Rv ---------------ISRRPKR--LRPAPPVELDADE-------SSPPVD MSMEG_5517|M.smegmatis_MC2_155 ---------------IVRRVRVAPAAPPPAPEPEPEPVVPGEVLGEPAEA MAB_0463c|M.abscessus_ATCC_199 ITYDLRLAGPGNKYSWTINEKTYNPAEGLPVREGQRVRLRFINNSMMFHP Mflv_3489|M.gilvum_PYR-GCK FHVVGGQFDTVWAEGAYRLRP-----GAGGSQTLGLFPAQGGFVELSFP- Mvan_3626|M.vanbaalenii_PYR-1 FHVVGGQFDTVYSEGAWLLRPSVGTEKSGAAQVLNLAPAQGGFVELTFP- MMAR_4544|M.marinum_M LFDQDAPLGDMTSREPVAP----------GGDDADVPPAAPDEADWS--- MUL_4714|M.ulcerans_Agy99 LFDQDAPLDDVTSREPVAP----------GGDDADVPPAAPDEVDWS--- MAV_1079|M.avium_104 VGDVAG-LDEIAAEGVDEV----------AAEGVDESPGDAGEREGD--- Mb0980|M.bovis_AF2122/97 MFDGAA------SEQPPAS----------VAE--DVPPSHDDIANGL--- Rv0955|M.tuberculosis_H37Rv MFDGAA------SEQPPAS----------VAE--DVPPSHDDIANGL--- MSMEG_5517|M.smegmatis_MC2_155 DEPDDEPFGDEPYEETPEEPL--------VSWHADEPPEPAETDDDAGAP MAB_0463c|M.abscessus_ATCC_199 MHLHGHTFAVRTASGAYGAR----------KDTVLVAPMQTVEVDFDAD- * : Mflv_3489|M.gilvum_PYR-GCK -----------EPGNYPFVSHAMVDAERGAHGVIAVGN Mvan_3626|M.vanbaalenii_PYR-1 -----------EAGNYPFVDHDMRHGENGAHGVIAVAG MMAR_4544|M.marinum_M -----------DGPDRPDGPDRQDGPDASHPPEHLT-- MUL_4714|M.ulcerans_Agy99 -----------DGPD------RQDGPDTSHPPEHLT-- MAV_1079|M.avium_104 -----------EGDP-----GERGSGDAGAAGERRPGE Mb0980|M.bovis_AF2122/97 -----------KAPT----ADDEALPLSDEPPPRAD-- Rv0955|M.tuberculosis_H37Rv -----------KAPT----ADDEALPLSDEPPPRAD-- MSMEG_5517|M.smegmatis_MC2_155 VAPRSPRDLLDEDPEDHFFVDEFGDEEVSGDKPRNAED MAB_0463c|M.abscessus_ATCC_199 -----------NPGQWLTHCHNIYHGEAGMMTVVSYRQ . .