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MTAQAPRRRNSLRGPVFLWANVVVLGWLAVSVGLLAAHSWLGLPGWVAVHALLLGAVTNAIVIWSEHFAV AWCRMPSPPQRRLALGLTALNLCVIAVLVGVSTDTAALTGVGGTGITVIAVVHTVHLRRATRSTRSEAPG TFGYLIGFYGAAGIMLASGAVLGALLALGSGQWYVRLWSAHVHLTLLGWVGLTVLGTMLTLWPTTLRARI GSDTHTAARRALPVLCAGLALTAAGMLAAVVWLTAAGLLCYAVGVGVVAVPLVRSAVARRPQGPAAWMLG AATGWLAAAVVYEAGRLLVAGSVQALPAVTAETLPILIVGFTAQVLMGALTQLLPMLVGRGPAEHKVVAE LLCAGWPARVAAINVAVPLVAGNWPDPLPLLGWVLAAAAVATFVVQALRVALPMARRGSISAQRQRIPGT GTGVVAGLAVVVLAVAVAATGHDAPTQTVTSGPTRTVDVTLQAMRMNPDVVEVAAGARLVLRVTNVDAMP HDLRVETGEKTPVLGQGETATLDLGVIDGPRQAWCTVAGHRAAGMTMTIRTDGGETASTHDTHSPGDMGA AMPAALDLGADPSPGWTPRDARLQPVAGTVHKIELTVAERDVEVAPGRFERRWTFGGSAPGPTLHGRVGD QFEITLVNDGTMGHSIDFHAGMLAPDVPMRTIAPGERLTYRFTAHHAGAWLYHCSTMPMALHIANGMFGA VIIDPPGLAPVDREYVLVSSQLYLGEPGSQTQTDNLRAGQPDGWAFNGMAAQYDHAPLTAVVGERARIWV VNAGPGDSTAFHVVGGQFDTVYSEGAWLLRPSVGTEKSGAAQVLNLAPAQGGFVELTFPEAGNYPFVDHD MRHGENGAHGVIAVAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3626 | - | - | 100% (856) | multicopper oxidase, type 3 |
| M. vanbaalenii PYR-1 | Mvan_3672 | - | 4e-08 | 29.71% (175) | multicopper oxidase, type 2 |
| M. vanbaalenii PYR-1 | Mvan_0249 | - | 5e-07 | 29.57% (257) | hypothetical protein Mvan_0249 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0869c | - | 5e-07 | 21.85% (357) | oxidase |
| M. gilvum PYR-GCK | Mflv_3489 | - | 0.0 | 44.69% (857) | multicopper oxidase, type 3 |
| M. tuberculosis H37Rv | Rv0846c | - | 5e-07 | 21.85% (357) | oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0463c | - | 1e-07 | 25.60% (168) | oxidase (copper-binding protein) |
| M. marinum M | MMAR_4770 | - | 9e-05 | 24.62% (130) | oxidase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_4277 | cobS | 4e-05 | 31.25% (192) | cobalamin synthase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0869c|M.bovis_AF2122/97 ------------------------------MPELATSGNAFDKRRFSRRG
Rv0846c|M.tuberculosis_H37Rv ------------------------------MPELATSGNAFDKRRFSRRG
MMAR_4770|M.marinum_M ------------------------------MPVLPTGGHPFGSAQLSRRG
MAB_0463c|M.abscessus_ATCC_199 ---------------------------------MAVSRSQWGRRGFLQ--
Mvan_3626|M.vanbaalenii_PYR-1 MTAQAPRRRNSLRGPVFLWANVVVLGWLAVSVGLLAAHSWLGLPGWVAVH
Mflv_3489|M.gilvum_PYR-GCK ------MKRSSWH----LRAGSVVLGWLVALVMAAIAHPYIALSNWLLIH
MSMEG_4277|M.smegmatis_MC2_155 --------------------------------------------------
Mb0869c|M.bovis_AF2122/97 FLGAGIASGFALAAC----ASKPTASGAAGM-------------------
Rv0846c|M.tuberculosis_H37Rv FLGAGIASGFALAAC----ASKPTASGAAGM-------------------
MMAR_4770|M.marinum_M FIGAGIAGGLALAGCG---HSQTTQTGETAM-------------------
MAB_0463c|M.abscessus_ATCC_199 -LGAATAAAGVLAACGTRPVRGPSGQPVGPS-------------------
Mvan_3626|M.vanbaalenii_PYR-1 ALLLGAVTNAIVIWSEHFAVAWCR-MPSPPQRRLALGLTALNLCVIAVLV
Mflv_3489|M.gilvum_PYR-GCK LLGLGAASNAILIWSRHFADALLRRSPDPPYPGQVIRLLAFNIGAVTVIT
MSMEG_4277|M.smegmatis_MC2_155 --------------------------------------------------
Mb0869c|M.bovis_AF2122/97 -------------TAAIDAAEAARPHSG-RTVTATLTPQPARIDLGG---
Rv0846c|M.tuberculosis_H37Rv -------------TAAIDAAEAARPHSG-RTVTATLTPQPARIDLGG---
MMAR_4770|M.marinum_M -------------ADAIAAAERARPHTG-RTVTASLTPQQAQIDLGG---
MAB_0463c|M.abscessus_ATCC_199 -------------SPRVGALEAVRRDGGGRLVPVNLAARPLQLDLAG---
Mvan_3626|M.vanbaalenii_PYR-1 GVSTDTAALTGVGGTGITVIAVVHTVHLRRATRSTRSEAPGTFGYLIGFY
Mflv_3489|M.gilvum_PYR-GCK GMLGGWWPVVLAGGVLVAAVAAVHAGDLMRFLR---AALPARFSITVHYY
MSMEG_4277|M.smegmatis_MC2_155 ------------------------------MIR-----------------
Mb0869c|M.bovis_AF2122/97 -PIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRND
Rv0846c|M.tuberculosis_H37Rv -PIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRND
MMAR_4770|M.marinum_M -PVVQTLAFGNTVPGPLIRASVGDEVVVAVSNRLDRATSVHWHGIALRND
MAB_0463c|M.abscessus_ATCC_199 -TTVSTWGYGDQIPGPTIRARKGEVLRVAVANGLPAPTTVHWHGIALRND
Mvan_3626|M.vanbaalenii_PYR-1 GAAGIMLASGAVLGALLALGS--GQWYVRLWSAHVHLTLLGWVGLTVLGT
Mflv_3489|M.gilvum_PYR-GCK VAAAACLAVGAGLGVAMANSALPGILAERFRTAHAVLNLFGWVGLTVLGT
MSMEG_4277|M.smegmatis_MC2_155 -SLAGAFAFGTVLP-----------VRASAGVGRGALTALPFVGLALG--
. * : . . : *:::
Mb0869c|M.bovis_AF2122/97 MDGT--EPATANIGPGGDFTYRFSVP------------------------
Rv0846c|M.tuberculosis_H37Rv MDGT--EPATANIGPGGDFTYRFSVP------------------------
MMAR_4770|M.marinum_M MDGA--EPATPNIGADQDFTYRFSVP------------------------
MAB_0463c|M.abscessus_ATCC_199 MDGVP-DLTQPQIAAAGSFTYEFALA------------------------
Mvan_3626|M.vanbaalenii_PYR-1 MLTLWPTTLRARIGSDTHTAARRALPVLCAGLALTAAGMLAAVVWLTAAG
Mflv_3489|M.gilvum_PYR-GCK LVTLWPTMLRTRMADGVERAARRGLPALVLSVAVAVAGAILGSSRVVGVG
MSMEG_4277|M.smegmatis_MC2_155 -------ALAAAVVWAGGWAFAAGSP------------------------
. : : . .
Mb0869c|M.bovis_AF2122/97 --------------------------------DPGTYWAHPHVGLQGDHG
Rv0846c|M.tuberculosis_H37Rv --------------------------------DPGTYWAHPHVGLQGDHG
MMAR_4770|M.marinum_M --------------------------------NAGTYWAHPHVGLEDDHG
MAB_0463c|M.abscessus_ATCC_199 --------------------------------HAGTYWFHPHVGTQLDRG
Mvan_3626|M.vanbaalenii_PYR-1 LLCYAVGVGVVAVPLVRSAVARRPQGPAAWMLGAATGWLAAAVVYEAGRL
Mflv_3489|M.gilvum_PYR-GCK ALSFLTAVGFVLWPHIDEVRRKRPADFPTLSVLCGVVWLAGSLGYLSVGL
MSMEG_4277|M.smegmatis_MC2_155 ----------------------------------LPGVLAVAVLLLATRG
:
Mb0869c|M.bovis_AF2122/97 LYLPVVVDDPTEPGHYDAEWII------------ILDDWTDGIGKSPQQL
Rv0846c|M.tuberculosis_H37Rv LYLPVVVDDPTEPGHYDAEWII------------ILDDWTDGIGKSPQQL
MMAR_4770|M.marinum_M LYLPFIVDDPTEPNRYDAEWIV------------VLDDWTDGVGKSPQQL
MAB_0463c|M.abscessus_ATCC_199 LYAPLIVEDPDERADYDTELVV------------ALDDWIDGTGTDPDKV
Mvan_3626|M.vanbaalenii_PYR-1 LVAGSVQALPAVTAETLPILIVGFTAQVLMGALTQLLPMLVGRGPAEHKV
Mflv_3489|M.gilvum_PYR-GCK LTAPNSMAAATVTAAAGPALLAGFLVQVLFGSLAYLIPMVVG-GRASALA
MSMEG_4277|M.smegmatis_MC2_155 LHIDGFCDTVDG----------------------------LGCYGPPERA
* *
Mb0869c|M.bovis_AF2122/97 YGELTDPNKPTMQNT-----------------------------------
Rv0846c|M.tuberculosis_H37Rv YGELTDPNKPTMQNT-----------------------------------
MMAR_4770|M.marinum_M FDALVDPNKPRMQELPGSSTAPSTSTSTTTTTTTPTTKTSTTTTTTGTSK
MAB_0463c|M.abscessus_ATCC_199 LAGLRDKGMPGMGHS-----------------------------------
Mvan_3626|M.vanbaalenii_PYR-1 VAELLCAGWPARVAAINVAVPLVAGNWPDPLPLLGWVLAAAAVATFVVQA
Mflv_3489|M.gilvum_PYR-GCK ATAELERGAPWRLSVANFGLLICVLPVPNLVRVAVSALVLVAYGAFLPLL
MSMEG_4277|M.smegmatis_MC2_155 LAVMRDGSAG----------------------------------------
.
Mb0869c|M.bovis_AF2122/97 ----------------------------TGMPE---GEGVDSN--LLGGD
Rv0846c|M.tuberculosis_H37Rv ----------------------------TGMPE---GEGVDSN--LLGGD
MMAR_4770|M.marinum_M TSPTTTTS-------------------ATGKPDEESGEVGSSD--LLGGD
MAB_0463c|M.abscessus_ATCC_199 ---------------------------MGDMPGMSIGSMGVSAQAPLGAD
Mvan_3626|M.vanbaalenii_PYR-1 LRVALPMARRGSIS-----------AQRQRIPGTGTGVVAGLAVVVLAVA
Mflv_3489|M.gilvum_PYR-GCK VRAVWLAQRNTGVRSTPGRLDPPPLRQRLGIAAAGFGVVILTAAAGVAAD
MSMEG_4277|M.smegmatis_MC2_155 --------------------------------------------------
Mb0869c|M.bovis_AF2122/97 GGDIAY---------------PYYLINGRIPVAATSFKAKPGQRIRIRII
Rv0846c|M.tuberculosis_H37Rv GGDIAY---------------PYYLINGRIPVAATSFKAKPGQRIRIRII
MMAR_4770|M.marinum_M AGDIAY---------------PYYLVNGRIPAAPTSFKAKPGQRIRIRII
MAB_0463c|M.abscessus_ATCC_199 GGDVTY---------------PYYLINGRVAADPQSVDYRPGTRVRLRII
Mvan_3626|M.vanbaalenii_PYR-1 VAATGH-DAPTQTVT-SGPTRTVDVTLQAMRMNPDVVEVAAGARLVLRVT
Mflv_3489|M.gilvum_PYR-GCK PATLGIGSAPTVTAAPTGHTTEVRVRVDGMRYVPDTITVPAGDRLRITFH
MSMEG_4277|M.smegmatis_MC2_155 ---------------------PFGVAAVVVVIAVQALTFAELS-------
: : .
Mb0869c|M.bovis_AF2122/97 NS---------------------------------------------AAD
Rv0846c|M.tuberculosis_H37Rv NS---------------------------------------------AAD
MMAR_4770|M.marinum_M NV---------------------------------------------ASD
MAB_0463c|M.abscessus_ATCC_199 NA---------------------------------------------AGD
Mvan_3626|M.vanbaalenii_PYR-1 NVDAMPHDLRVETGEKTPVLGQGETATLDLGVIDGPRQAWCTVAGHRAAG
Mflv_3489|M.gilvum_PYR-GCK NTGTDRHDLVLANGARTDRVAPGVTAVLDAGVIGSDLAGWCSIAGHRQMG
MSMEG_4277|M.smegmatis_MC2_155 -----------------------------------------------VLA
Mb0869c|M.bovis_AF2122/97 TAFRIALAGHSMTVTHTDGYP-----------------------------
Rv0846c|M.tuberculosis_H37Rv TAFRIALAGHSMTVTHTDGYP-----------------------------
MMAR_4770|M.marinum_M TAFRVALAGHTMTVTHTDGYP-----------------------------
MAB_0463c|M.abscessus_ATCC_199 SAFRVAIPGTPLTVTHTDGFP-----------------------------
Mvan_3626|M.vanbaalenii_PYR-1 MTMTIRTDGGETASTHDTHSPGDMG----AAMPAALDLGADPSPGWTPRD
Mflv_3489|M.gilvum_PYR-GCK MTLTIKAIGTPPVSGHEHELPGHGPDPSLTATDIARSLGGRPGPGFAARD
MSMEG_4277|M.smegmatis_MC2_155 VVTAVVAGRVAVVAACRRSVP-----------------------------
. : . *
Mb0869c|M.bovis_AF2122/97 -----------------------VIP-----------TEVDALLIG-MAE
Rv0846c|M.tuberculosis_H37Rv -----------------------VIP-----------TEVDALLIG-MAE
MMAR_4770|M.marinum_M -----------------------VIP-----------TQVDALLIG-MAE
MAB_0463c|M.abscessus_ATCC_199 -----------------------VQP-----------RQTDALLIG-MGE
Mvan_3626|M.vanbaalenii_PYR-1 ARLQPVAGTVHKIELTVAERDVEVAPGRFERRWTFGGSAPGPTLHGRVGD
Mflv_3489|M.gilvum_PYR-GCK PKLSAAETAEHRVTLTVSEVEREVSPGITQRLWTFGGSAPGPTLRGRVGD
MSMEG_4277|M.smegmatis_MC2_155 -------------------------------------AAAGSTLGAAVAG
.. * . :.
Mb0869c|M.bovis_AF2122/97 RYDVMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPD---PQFRP---
Rv0846c|M.tuberculosis_H37Rv RYDVMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPD---PQFRP---
MMAR_4770|M.marinum_M RYDVIVTAADGVFPLVASAEGKNALARALLSTGSGTAPD---PQFRP---
MAB_0463c|M.abscessus_ATCC_199 RIDAIITVGEVSVPLLAAPYGKDGYAQLVLRS-SGTPVSGSAAEAAA---
Mvan_3626|M.vanbaalenii_PYR-1 QFEITLVNDGTMGHSIDFHAGMLAPDVPMRTIAPGERLTYRFTAHHAGAW
Mflv_3489|M.gilvum_PYR-GCK VFEITLINDGTIGHSIDFHAGSLAPDRPMRTIEPGAQLVYRFTATRAGVW
MSMEG_4277|M.smegmatis_MC2_155 SQPRWVVAG-----------------------------------------
:
Mb0869c|M.bovis_AF2122/97 -----------------------DELNWRVGTVEMFTAATTANLGRPEPT
Rv0846c|M.tuberculosis_H37Rv -----------------------DELNWRVGTVEMFTAATTANLGRPEPT
MMAR_4770|M.marinum_M -----------------------AELNKRVGTVEMFTATTAVNLGRPDPQ
MAB_0463c|M.abscessus_ATCC_199 -----------------------ALPKLAALDTASLSATEEVTLAVGEPD
Mvan_3626|M.vanbaalenii_PYR-1 LYHCSTMPMALHIANGMFGAVIIDPPGLAPVDREYVLVSSQLYLGEPGSQ
Mflv_3489|M.gilvum_PYR-GCK LYHCATMPMSVHIANGMFGAVVIDPPDLSTVDREYLMVQSEFYLGADGGE
MSMEG_4277|M.smegmatis_MC2_155 ---------------------------------WIVALAALAVFACP---
. :.
Mb0869c|M.bovis_AF2122/97 HDLPVTLGGTMAKYDWTINGEPHSTTNPLHVRLGQRPTLMFDNT-TMMYH
Rv0846c|M.tuberculosis_H37Rv HDLPVTLGGTMAKYDWTINGEPYSTTNPLHVRLGQRPTLMFDNT-TMMYH
MMAR_4770|M.marinum_M MSLPITLGGTMAKYDWTINGEPYSKTHPLTVRLGERPTLMFDNP-TMMYH
MAB_0463c|M.abscessus_ATCC_199 ITYDLRLAGPGNKYSWTINEKTYNPAEGLPVREGQRVRLRFINN-SMMFH
Mvan_3626|M.vanbaalenii_PYR-1 TQTDNLRAGQPDGWAFNGMAAQYDHAP-LTAVVGERARIWVVNAGPGDST
Mflv_3489|M.gilvum_PYR-GCK VDADKVAADTPDLVVFNGYAQQYDHAP-LTARVGERVRIWVLAAGPNRGS
MSMEG_4277|M.smegmatis_MC2_155 --------------------RPWQGPLAVLVAIGCSLALVAHCVRRFGGI
. . : . * :
Mb0869c|M.bovis_AF2122/97 PIHLHGHTFQMIKADGSPGARK----------DTVIVLPKQKMRAVLVAD
Rv0846c|M.tuberculosis_H37Rv PIHLHGHTFQMIKADGSPGARK----------DTVIVLPKQKMRAVLVAD
MMAR_4770|M.marinum_M PIHLHGHTFQMIKPDGTPGARK----------DTVIVLPGQQLRAVLVAD
MAB_0463c|M.abscessus_ATCC_199 PMHLHGHTFAVRTASGAYGARK----------DTVLVAPMQTVEVDFDAD
Mvan_3626|M.vanbaalenii_PYR-1 AFHVVGGQFDTVYSEGAWLLRPSVGTEKSGAAQVLNLAPAQGGFVELTFP
Mflv_3489|M.gilvum_PYR-GCK AFHVVGGQFDTVWAEGAYRLRP-----GAGGSQTLGLFPAQGGFVELSFP
MSMEG_4277|M.smegmatis_MC2_155 TGDVLGAAVEVTTTLAALGLAIG---------------------------
. .: * . . .:
Mb0869c|M.bovis_AF2122/97 NPGVWVMHCHNNYHQVAGMATRLDYIL
Rv0846c|M.tuberculosis_H37Rv NPGVWVMHCHNNYHQVAGMATRLDYIL
MMAR_4770|M.marinum_M NPGYWVLHCHNSYHREAGMMTLLDYIF
MAB_0463c|M.abscessus_ATCC_199 NPGQWLTHCHNIYHGEAGMMTVVSYRQ
Mvan_3626|M.vanbaalenii_PYR-1 EAGNYPFVDHDMRHGENGAHGVIAVAG
Mflv_3489|M.gilvum_PYR-GCK EPGNYPFVSHAMVDAERGAHGVIAVGN
MSMEG_4277|M.smegmatis_MC2_155 ---------------------------