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MSPDQRGVRALTVQGWQYVVLAVMGLVVLVGGIAVSVLLHRTDQLSGQLINNIQPARVAAYQLQAALRDQ ETAVRGYLIAADQQFLLPYDEGRVVEQEAAANIRQLEQNRPDLLDDLDAIEQASGAWRVEYAEPVIADVR PGTPGPVDPALTEIGKNYSNTLRTLFDTQNEHLAQARNDGVAELERSRTLRNAILLAMAVTFGLTIVLLA VVLRRALVRPLDALAAACRRIAEGNFGERIVPHGPRDIRLISLDVEHMRQRIVSELEGSRAATDALDVHA EELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGDQLDERGKEYIGFAVDGAKRMQVLINDLLT FSRVGRLNATESDVDLDAALDAALGNLSASVEESGAIVDRPTGGLPTVKGDPTLLTMVWQNLIGNAVKFR REDTAPHIAIECEQIADGESQNWSITVTDNGIGIAPEFADKVFVIFQRLHGRDAYTGTGIGLALCKKIVE HHGGTIWIDTEFSEGTRFRFTLPVTADDTADKSLEESPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3269 | - | - | 100% (529) | multi-sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_4423 | - | 4e-19 | 30.42% (263) | multi-sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_1582 | - | 4e-19 | 28.27% (329) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 8e-23 | 29.28% (345) | two component system response sensor kinase membrane |
| M. tuberculosis H37Rv | Rv0758 | phoR | 5e-22 | 28.99% (345) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00774 | mtrB | 4e-20 | 27.79% (331) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 6e-20 | 28.41% (352) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_1264 | - | 0.0 | 63.72% (521) | two-component system membrane associated sensor kinase |
| M. avium 104 | MAV_4241 | - | 1e-170 | 60.50% (524) | two-component sensor protein |
| M. smegmatis MC2 155 | MSMEG_6130 | - | 0.0 | 68.06% (504) | two-component sensor protein |
| M. thermoresistible (build 8) | TH_2175 | - | 1e-178 | 62.45% (538) | two-component sensor protein |
| M. ulcerans Agy99 | MUL_2624 | - | 0.0 | 64.11% (521) | two component system membrane associated sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_2988 | - | 0.0 | 80.27% (527) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3269|M.gilvum_PYR-GCK ----------MSPDQRGVRALTVQGWQYVVLAVMGLVVLVGGIAVSVLLH
Mvan_2988|M.vanbaalenii_PYR-1 ----------MSPDQRGVRALTVQGWQYLVLSVMGFVVLTGGIMVAVLLN
MSMEG_6130|M.smegmatis_MC2_155 ------------------MRLTVQGWQNLVLSVMGVVVFTGAIAGAVLVG
TH_2175|M.thermoresistible__bu -------VTPAATGERRGSRLTVQGWQNLVLSGMGVIVLAGAITGWLLLH
MMAR_1264|M.marinum_M ----MTPEPPIRPRTRRRIALTVRGWQALVLSIMGVMVLAGTVAGAVLLN
MUL_2624|M.ulcerans_Agy99 ----MTPEPPIRPRTRRRIALTVRGWQALVLSIMGVMVLAGTVAGAVLLN
MAV_4241|M.avium_104 ----MT-----APRPLRLTQLTVRGWLALVLWIMGTTVLIGALVGAVLLH
Mb0781|M.bovis_AF2122/97 ---------------------------MARHLRGRLPLRVRLVAATLILV
Rv0758|M.tuberculosis_H37Rv ---------------------------MARHLRGRLPLRVRLVAATLILV
MAB_0674|M.abscessus_ATCC_1997 ----MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLV
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
: : . :
Mflv_3269|M.gilvum_PYR-GCK RTDQLSGQLINNIQPARVAAYQLQAALRDQETAVRGYLIAADQQFLLPYD
Mvan_2988|M.vanbaalenii_PYR-1 RTDQVSGQLIERIQPARVAALQMQAAIRDQETAVRGYLITADLRFLKPYD
MSMEG_6130|M.smegmatis_MC2_155 RTDTLSDELINEIQPARVAAYQLQAALRDQETAVRGYAIAADPQFLAPYD
TH_2175|M.thermoresistible__bu RTDDMTRELKNDIQPARVAAYQLQSALRDQETAVRSYALTGDEGFLTLYE
MMAR_1264|M.marinum_M RTDDVSRELSDNIEPARVAAFQLQSALRDQESGIRGYVISSDSQFLSPYY
MUL_2624|M.ulcerans_Agy99 RTDGVSRELSDNIEPARVAAFQLQSALRDQESGIRGYVISSDSQFLSPYY
MAV_4241|M.avium_104 RTDQVSRQVADGVGPARVAAARLQAALRDQETGLRGYLIAADRQFLAPYY
Mb0781|M.bovis_AF2122/97 ATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQ---IWAQITLPLAPDPYP
Rv0758|M.tuberculosis_H37Rv ATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQ---IWAQITLPLAPDPYP
MAB_0674|M.abscessus_ATCC_1997 ALGLVASGIAVTTTMQRTMMNRADRELIDAAN---GWANR--PPPPPPAF
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSL
:: . :
Mflv_3269|M.gilvum_PYR-GCK EGRVVEQEAAANIRQLEQNRP--------DLLDDLDAIEQASGAWRVEYA
Mvan_2988|M.vanbaalenii_PYR-1 EGRAAEQQASADIRQLEQDRP--------DLLDDLDAIEQASGSWRTNYA
MSMEG_6130|M.smegmatis_MC2_155 EGQQAEADAAASIRDDLDGRD--------ELLADLAVIEKAAAAWRAAYA
TH_2175|M.thermoresistible__bu TAQRDERAAADYLRALVGDRP--------EQMSDLADIERNAATWRTDYV
MMAR_1264|M.marinum_M DGRRTEEAAAQNIRRLLGRRG--------DLLADLDAIEKAARAWRASYA
MUL_2624|M.ulcerans_Agy99 DGRRTEEAAAQNIRRLLGRRG--------DLLADLDAIEKAARAWRASYA
MAV_4241|M.avium_104 DGQRTEQAAADEIRRLVGGNAGNT-----ELIADLDAVESAAADWRTNYA
Mb0781|M.bovis_AF2122/97 IHNPDRPPSRFYVRVISPDGQ---------------------SYTALNDN
Rv0758|M.tuberculosis_H37Rv GHNPDRPPSRFYVRVISPDGQ---------------------SYTALNDN
MAB_0674|M.abscessus_ATCC_1997 ETTRHRPPSLFFIRTTDDRGR---------------------VVIMLNDR
MLBr_00774|M.leprae_Br4923 DSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQV
:
Mflv_3269|M.gilvum_PYR-GCK EPVIADVRPGTPGPVDPALTEIG--KNYSNTLRTLFDTQNEHLAQARNDG
Mvan_2988|M.vanbaalenii_PYR-1 EPVVADVRPGDPGSVDPELTAIG--QADFDALRVLFDTQNENLAQARDAD
MSMEG_6130|M.smegmatis_MC2_155 DPMIASIQPGRPHIGNDMVAERG--KAQFDQLRGLFDVQNRHLSEARNVG
TH_2175|M.thermoresistible__bu APLLSAVRP-TAQPELTALVEGE--RVEFDRMRALFDVQNSHLTETRQAA
MMAR_1264|M.marinum_M EPLIAQVNSNAPVMLNGAATAIG--KAQFDQLRTLFEDQNRHLGAARAQA
MUL_2624|M.ulcerans_Agy99 EPLIAQVNSNAPVMLNGAATAIG--KAQFDQLRTLFEDQNRHLGAARAQA
MAV_4241|M.avium_104 EPVIASVTPRAPAVVSAPTADLG--KAKFDHLRALFETQNTHLAQAAASA
Mb0781|M.bovis_AF2122/97 T-AIPAVPANNDVGRHPTTLPSI--GGSKTLWRAVSVRASDGYLTTVAID
Rv0758|M.tuberculosis_H37Rv T-AIPAVPANNDVGRHPTTLPSI--GGSKTLWRAVSVRASDGYLTTVAID
MAB_0674|M.abscessus_ATCC_1997 ARADPDLPFDNDVGGRPVTVRSS--DGG-TEWRAVSRHDALGGYTTVARD
MLBr_00774|M.leprae_Br4923 PNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFP
.
Mflv_3269|M.gilvum_PYR-GCK VAELERSRTLRNAILLAMAVTFGLTIVLLAVVLRRALVRPLDALAAACRR
Mvan_2988|M.vanbaalenii_PYR-1 IAELERMRTLRNAVLLAMAVTFAVTVVALAVLLRRALVRPLSRLAASCRR
MSMEG_6130|M.smegmatis_MC2_155 IEDMERMRTWRNSVLIAMIVAFFAMAVVLAVLVRNAVNRPLAALAASCRR
TH_2175|M.thermoresistible__bu VDELERTRGWRNAVLIAMVTAFFVTAALLAVLVRATITRPLEELAAACRR
MMAR_1264|M.marinum_M AERLQRMDDWRDRVLAAMVLLFFATAALLGILTRRAVTIPLAALAAACRR
MUL_2624|M.ulcerans_Agy99 AERLQRMDDWRDRVLAAMVLLFFARAALLGVLTRRAVTIPLAALAAACRR
MAV_4241|M.avium_104 TAELHEINGWRDWVLGAMVLAILGTGLFLGLFSRAAITRPIAQLAASCRR
Mb0781|M.bovis_AF2122/97 LADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAA
Rv0758|M.tuberculosis_H37Rv LADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAA
MAB_0674|M.abscessus_ATCC_1997 ITDVRTTVRDLLWLQVAIGIAVLTVLGVAGYWLVHRSLRPLAEVEATAAD
MLBr_00774|M.leprae_Br4923 LKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAER
. . . *: .
Mflv_3269|M.gilvum_PYR-GCK IAEGNFGERIV-PHGPRDIRLISLDVEHMRQRIVSELEGSRAAT------
Mvan_2988|M.vanbaalenii_PYR-1 IAEGNFGERIV-PQGPRDIRLISLDVEHMRQRIVEELEASRAAT------
MSMEG_6130|M.smegmatis_MC2_155 ITEGNFTERIE-PKGPKDIRAIAIDVEDMRQRIVDELDASKQAR------
TH_2175|M.thermoresistible__bu ITEGDFGERIS-LRGPRDLRSIATDVDDMRQRIVDELRTSHRAHAKLSEQ
MMAR_1264|M.marinum_M VTEGNFGERIVAPRRPRDIRGIAIDVENMRQRMVEELDTSRCAR------
MUL_2624|M.ulcerans_Agy99 FTEGNFGERIVAPRRPRDIRGIAIDIENMRQRMVEELDTSRCAR------
MAV_4241|M.avium_104 ITEGNFAETIVAPKRPKDIRDMAIDVENMRRRMVEELDVSRSAQ------
Mb0781|M.bovis_AF2122/97 IGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASA----------
Rv0758|M.tuberculosis_H37Rv IGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASA----------
MAB_0674|M.abscessus_ATCC_1997 IAAGHLDRRVPERDPRTEVGRLSLALNGMLAQIQRAVADS----------
MLBr_00774|M.leprae_Br4923 FAEGHLSERMP-VRGEDDMARLAVSFNDMAESLS----------------
. *.: . : :: :: .: * :
Mflv_3269|M.gilvum_PYR-GCK -DALDVHAEELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGDQ
Mvan_2988|M.vanbaalenii_PYR-1 -EALDEQAEELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGDQ
MSMEG_6130|M.smegmatis_MC2_155 -LALDEQAEELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLERRYGDK
TH_2175|M.thermoresistible__bu TEALDEQAAELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGDQ
MMAR_1264|M.marinum_M -AQLDEQTEELRRSNAELEQFAYVASHDLQEPLRKVAAFCQLLERRYADQ
MUL_2624|M.ulcerans_Agy99 -AQLDEQAEELRRSNAELEQFAYVASHDLQEPLRKVAAFCQLLERRYADQ
MAV_4241|M.avium_104 -EQLDEQAAELRRSNTELEQFAYVASHDLQEPLRKVASFCQLLERRYGDQ
Mb0781|M.bovis_AF2122/97 ----ESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARD
Rv0758|M.tuberculosis_H37Rv ----ESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARD
MAB_0674|M.abscessus_ATCC_1997 ----EKSAKAARTSEERMRRFITDASHELRTPLTTIRGYAELYRQGAATD
MLBr_00774|M.leprae_Br4923 -----RQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYD-HSSD
. .:* .**:*: ** .: .:* . .
Mflv_3269|M.gilvum_PYR-GCK LDERGKEYIGFAVDGAKRMQVLINDLLTFSRVG-RLN-ATESDVDLDAAL
Mvan_2988|M.vanbaalenii_PYR-1 LDERGVEYIGFAVDGAKRMQILINDLLTFSRVG-RLN-ATETEVDLDEAL
MSMEG_6130|M.smegmatis_MC2_155 LDERGVEYIGFAVDGAKRMQVLINDLLTFSRVG-RLY-STTTEVDLNAVV
TH_2175|M.thermoresistible__bu LDERGVEYIRFAVDGAKRMQVLINDLLTFSRVG-RLN-ATEAAVSLDAAL
MMAR_1264|M.marinum_M LDERGIEYIGFAVDGAKRMQVLINDLLSFSRVG-RLG-ATSVEVELGATL
MUL_2624|M.ulcerans_Agy99 LDERGIEYIGFAVDGAKRMQVLINDLLSFSRVG-RLG-ATSVEVELGATL
MAV_4241|M.avium_104 LDERGLEYIGFAVDGAKRMQALINDLLTFSRVG-RLG-TTEAEVQLDATL
Mb0781|M.bovis_AF2122/97 VG----MLLSRIESEASRMGLLVDDLLLLARLD-AHRPLELCRVDLLALA
Rv0758|M.tuberculosis_H37Rv VG----MLLSRIESEASRMGLLVDDLLLLARLD-AHRPLELCRVDLLALA
MAB_0674|M.abscessus_ATCC_1997 TE----LVLGRIEGESTRMGQLVEDLLLLARLD-AHRPMEQRLVDLLVLA
MLBr_00774|M.leprae_Br4923 LDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMV
. *: *::*** ::* . *.*
Mflv_3269|M.gilvum_PYR-GCK DAALGNLSASVEESGAIVDRPTGG-LPTVKGDPTLLTMVWQNLIGNAVKF
Mvan_2988|M.vanbaalenii_PYR-1 DNALSNLATAVEESDAVIERPVGG-LPTVKGDPTLLTMLWQNLIGNAVKF
MSMEG_6130|M.smegmatis_MC2_155 DAALNNISTAVEESGAEIIRPQEP-LPHIDGDPTLLIMVWQNLLGNAVKF
TH_2175|M.thermoresistible__bu NTALDNLSTAIEESGTEIVRPAG--LPTVVGDPTLMAMLWQNLIGNAVKF
MMAR_1264|M.marinum_M DAAVANLGAAIEESDAEIVRLEHD-FPPVVGDPTLLTMLWQNLIGNAVKF
MUL_2624|M.ulcerans_Agy99 DAAVANLGAAIEESDAEIVRLEHG-FPPVVGDPTLLTMLWQNLIGNAVKF
MAV_4241|M.avium_104 DAGLANLAAAVEETGAEIVR-PAE-LPRIVGDPMLLTMLWQNLIGNAIKF
Mb0781|M.bovis_AF2122/97 SDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQH
Rv0758|M.tuberculosis_H37Rv SDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQH
MAB_0674|M.abscessus_ATCC_1997 TDAVHDAKATAPERDVELEVFDGPGTPEVIGDELRLRQVLGNLVSNALGH
MLBr_00774|M.leprae_Br4923 NNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRNLIANAIDH
. : : : * : : **:.**: .
Mflv_3269|M.gilvum_PYR-GCK RREDTAPHIAIECEQIADG---------ESQNWSITVTDNGIGIAPEFAD
Mvan_2988|M.vanbaalenii_PYR-1 RREGVAPRIVIDVAQSGDD---------DAQNWSFSLADNGIGIAAEFTD
MSMEG_6130|M.smegmatis_MC2_155 RRDGVAPRIVIECHAQTGG---------GVDSWLFTVSDNGIGISEEFVD
TH_2175|M.thermoresistible__bu TRPRQRPRIVIDCRRRGAGEQGDDANHGDGDEWLISVSDNGIGIADEFVD
MMAR_1264|M.marinum_M RREDLPPRVVIDCQLGTGD---------HQGLWLLSVSDNGIGIAQEFAD
MUL_2624|M.ulcerans_Agy99 RREDLPPRVVIDCQLGSGD---------HQGLWLLSVSDNGIGIAQEFAD
MAV_4241|M.avium_104 RHKDRRPRVVIECAPGEGT---------HDGEWLLSVSDNGIGIPEEFSD
Mb0781|M.bovis_AF2122/97 TPESADVTVRVGTE---------------GDDAILEVADDGPGMSQEDAL
Rv0758|M.tuberculosis_H37Rv TPESADVTVRVGTE---------------GDDAILEVADDGPGMSQEDAL
MAB_0674|M.abscessus_ATCC_1997 T--TAAVRVRVGTE---------------GDDAVLEVIDRGPGMTKTDAE
MLBr_00774|M.leprae_Br4923 S-EHKPVRIRMAAD---------------EDTVAVTVRDYGIGLRPGEEK
: : . : * * *:
Mflv_3269|M.gilvum_PYR-GCK KVFVIFQRLHGR--DAYTGTGIGLALCKKIVEHHGGTIWIDTEFSEGTRF
Mvan_2988|M.vanbaalenii_PYR-1 KVFVIFQRLHGR--DAYSGTGIGLALCKKIVEHHGGTIWIDSSYTEGTRF
MSMEG_6130|M.smegmatis_MC2_155 KVFVIFQRLHGR--DSYSGTGIGLALCKKIIEHHGGNIWIDTSYTGGTRF
TH_2175|M.thermoresistible__bu KVFVIFQRLHGR--DSYTGTGIGLALCKKIVEHHGGTIWIDTGYADGARF
MMAR_1264|M.marinum_M KVFIIFQRLHGR--DSYGGTGLGLALCRKIVEHHGGTVWIDSTYTDGTRF
MUL_2624|M.ulcerans_Agy99 KVFIIFQRLHGR--DSYGGTGLGLALCRKIVEHHGGTVWIDSSYTEGTRF
MAV_4241|M.avium_104 KVFVIFQRLHGR--EVYAGTGVGLALVKKIVEHHGGTVRIDTSYTDGTRF
Mb0781|M.bovis_AF2122/97 RVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCF
Rv0758|M.tuberculosis_H37Rv RVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCF
MAB_0674|M.abscessus_ATCC_1997 RVFERFYRADSSRTRSSGGTGLGLSIVDALTAAHGGTVTVHTAPGAGCRF
MLBr_00774|M.leprae_Br4923 LVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWGEPGQGACF
** * * . ***:**:: * * : * *
Mflv_3269|M.gilvum_PYR-GCK RFTLPVTADDT-------ADKSLEESPT----------------------
Mvan_2988|M.vanbaalenii_PYR-1 RFTLPMTLDDT-------ATPLLEGSTP----------------------
MSMEG_6130|M.smegmatis_MC2_155 CFTLPVMPTNKPGV---LTDAQLEGNNT----------------------
TH_2175|M.thermoresistible__bu CFTLPVTSTET-------ASAVLEGDQE----------------------
MMAR_1264|M.marinum_M QFTLPVAAPATADP---EHLEPAEGIAE----------------------
MUL_2624|M.ulcerans_Agy99 QFTLPVAAPATADP---EHLEPAEGIAE----------------------
MAV_4241|M.avium_104 EFSLPVPGP--VDE---TDAVALEGAQQ----------------------
Mb0781|M.bovis_AF2122/97 RVSLPRVS---------DVDQ-LSLTPVVPGPP-----------------
Rv0758|M.tuberculosis_H37Rv RVSLPRVS---------DVDQ-LSLTPVVPGPP-----------------
MAB_0674|M.abscessus_ATCC_1997 EVRLPRADMTDDDA---DVDEPESATPDAAASEPKIVRASRSESAQP---
MLBr_00774|M.leprae_Br4923 RLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAERS
. ** .
Mflv_3269|M.gilvum_PYR-GCK -
Mvan_2988|M.vanbaalenii_PYR-1 -
MSMEG_6130|M.smegmatis_MC2_155 -
TH_2175|M.thermoresistible__bu -
MMAR_1264|M.marinum_M -
MUL_2624|M.ulcerans_Agy99 -
MAV_4241|M.avium_104 -
Mb0781|M.bovis_AF2122/97 -
Rv0758|M.tuberculosis_H37Rv -
MAB_0674|M.abscessus_ATCC_1997 -
MLBr_00774|M.leprae_Br4923 R