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MSQGLDLAVIGSGGAAMAAAIRATALGKSVVMIERGIFGGTCVNTGCVPSKALIAAAEARHTAADTARFP GIATTAGPVDMAALIAGTHDLVESLRSEKYLNVAESYGWQRIQGQARFAGTPDAPVIEVGDATIEAEHYL IATGANPVIPPAFEGVAYLTSTTAMEVTEVPESLLVIGGGYVALEQAQLFARLGSTVTVLVRSTLASKEE PEVGMALLEVFADDGIRVVRRATVSEVEQADDQVTVTATITGGTQQFRAAKVLVATGRRPNTDGLNLEAV QVKTGENNEVVVSDGLQSSNPRIWAAGDVTGHREFVYVAAHHGAMVADNIFTDAGRRVDYRHLPRVTFTS PAVGAAGTTEAELLAAGTRCDCRVLPLKHVPRAVVNRDTRGFIKLVADAGTGRIHGITAVAKDAGEIAAA AVYILDAAMTVDQVAGSWAPYLTMAEGIKIAAQSFSADMSRLSCCAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3213 | - | - | 100% (467) | mercuric reductase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 1e-61 | 34.67% (450) | mercuric reductase |
| M. gilvum PYR-GCK | Mflv_0114 | - | 7e-44 | 27.57% (457) | dihydrolipoamide dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0471 | lpd | 8e-43 | 28.69% (467) | dihydrolipoamide dehydrogenase |
| M. tuberculosis H37Rv | Rv0462 | lpd | 8e-43 | 28.69% (467) | dihydrolipoamide dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 6e-43 | 27.53% (465) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 3e-60 | 32.74% (452) | mercuric reductase |
| M. marinum M | MMAR_3101 | lpd_1 | 3e-60 | 33.77% (456) | dihydrolipoamide dehydrogenase Lpd_1 |
| M. avium 104 | MAV_2396 | - | 2e-63 | 34.22% (453) | mercuric reductase |
| M. smegmatis MC2 155 | MSMEG_0903 | lpdA | 6e-44 | 27.83% (460) | dihydrolipoamide dehydrogenase |
| M. thermoresistible (build 8) | TH_3945 | - | 3e-62 | 34.09% (443) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 1e-42 | 28.29% (463) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 7e-66 | 35.53% (456) | mercuric reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3101|M.marinum_M -MTQHYDAIVVGAGQAGPPLVGRLTAAGERVAIVERKHVGGTCVNSGCIP
MAV_2396|M.avium_104 -MTKHFDAIIVGAGQAGPPLAGRLTAAGQRVAIIERKLIGGTCVNTGCIP
Mvan_3468|M.vanbaalenii_PYR-1 MSAQHFDAIIVGAGQAGPPLAGRLTAAGQTVAVIERKLVGGTCVNYGCIP
TH_3945|M.thermoresistible__bu --------MIIGAGQAGPPLAGRLADAGQRVVLIERRLIGGTCVNYGCIP
MAB_3014|M.abscessus_ATCC_1997 -MSTHFDAVVVGAGQAGPSLAARLRGAGLTVAIVERHLFGGTCVNTGCRP
Mflv_3213|M.gilvum_PYR-GCK -MSQGLDLAVIGSGGAAMAAAIRATALGKSVVMIERGIFGGTCVNTGCVP
Mb0471|M.bovis_AF2122/97 --MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIP
Rv0462|M.tuberculosis_H37Rv --MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIP
MUL_2214|M.ulcerans_Agy99 --MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIP
MSMEG_0903|M.smegmatis_MC2_155 --MTHFDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCIP
MLBr_02387|M.leprae_Br4923 --MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVGCIP
::*:* .. . * * ..::* ** *:* ** *
MMAR_3101|M.marinum_M TKTLVASAHAAQLARRGAEYGVGT-GPISVDMAKVKARKDGIMLADRKGV
MAV_2396|M.avium_104 TKTLVASAHAAHLARRGADYGVGT-GAISVDMAKVKARKDEIMLGDRKGV
Mvan_3468|M.vanbaalenii_PYR-1 TKTLVASAHAAHLARRGNDFGVAA-AGVTVDMAAVKARKDRISVGDREGL
TH_3945|M.thermoresistible__bu TKTLVASAHAAHLARRAADYGVRT-GPVTVDMARVKARKDAIMLDDRRGL
MAB_3014|M.abscessus_ATCC_1997 TKALVASAHAAHMAREAARWGVVVDGSVSMDMVRVRERKDAVILPSRNGG
Mflv_3213|M.gilvum_PYR-GCK SKALIAAAEARHTAADTARFPGIATTAGPVDMAALIAGTHDLVESLRSEK
Mb0471|M.bovis_AF2122/97 SKALLRNAELVHIFTKDAKAFGIS-GEVTFDYGIAYDRSRKVAEG-RVAG
Rv0462|M.tuberculosis_H37Rv SKALLRNAELVHIFTKDAKAFGIS-GEVTFDYGIAYDRSRKVAEG-RVAG
MUL_2214|M.ulcerans_Agy99 SKALLRNAELAHIFTKDAKAFGIS-GEATFDYGVAFDRSRKVAEG-RVAG
MSMEG_0903|M.smegmatis_MC2_155 SKALLRNAEIAHMFNKEAKTFGIS-GEATFDYGAAFDRSRKVADG-RVAG
MLBr_02387|M.leprae_Br4923 SKVLLHNAELAHIFTKEAKTFGIS-GDASFDYGIAYDRSRKVSEG-RVAG
:*.*: *. : ..* . : *
MMAR_3101|M.marinum_M EDWLDGMNGCTVFRGHARFEDP---HTLRVGDDLLSADR-------IFLN
MAV_2396|M.avium_104 EDWLAGMAGCTVVRGHARFRDP---HTLQVGEDLLRAER-------IFLN
Mvan_3468|M.vanbaalenii_PYR-1 ESWLAGMKGCTLIRGHARFENP---HTLRVDDQLLEADR-------IFLN
TH_3945|M.thermoresistible__bu ESWLQGMDGCTVVRGHARFEDP---HTVRVGERLLSADR-------IFLN
MAB_3014|M.abscessus_ATCC_1997 QTWLKDLG-CAIYHEHASFLSP---TELSVGDEIISAER-------IFLN
Mflv_3213|M.gilvum_PYR-GCK YLNVAESYGWQRIQGQARFAGTPDAPVIEVGDATIEAEH-------YLIA
Mb0471|M.bovis_AF2122/97 VHFLMKKNKITEIHGYGTFADA---NTLLVDLNDGGTES---VTFDNAII
Rv0462|M.tuberculosis_H37Rv VHFLMKKNKITEIHGYGTFADA---NTLLVDLNDGGTES---VTFDNAII
MUL_2214|M.ulcerans_Agy99 VHFLMKKNKITEIHGYGKFTDA---NTLSVDLNDGGTEK---VTFDNAII
MSMEG_0903|M.smegmatis_MC2_155 VHFLMKKNKITEIHGYGKFTGP---NSLEVALNDGGTEK---VEFSNAII
MLBr_02387|M.leprae_Br4923 VHFLMKKNKITEIHGYGRFTDA---NTLSVELSEGVPETPLKVTFNNVII
: : . * .. : * .: :
MMAR_3101|M.marinum_M VGGRAVAPNIPGLADIDFLTNVSILELDTLPEHLVIVGGSYIALEFAQMY
MAV_2396|M.avium_104 VGGRAVVPDIPGLAEVDFLTNVSILELDRLPTHLVIVGGSYIALEFAQMY
Mvan_3468|M.vanbaalenii_PYR-1 VGGRAVAPDMPGLADVDYLTNVGILDLDEVPEHLVVIGGSYIALEFAQMY
TH_3945|M.thermoresistible__bu VGGRAVVPDLPGLADVDHLTNVSMLELDTLPEHLVIVGGGYIALEFAQMY
MAB_3014|M.abscessus_ATCC_1997 VGGRAVVPDWPGVDDVPLFTNSSLIEYDGIPEHLVVIGGSYVGLEFAQIY
Mflv_3213|M.gilvum_PYR-GCK TGANPVIP--PAFEGVAYLTSTTAMEVTEVPESLLVIGGGYVALEQAQLF
Mb0471|M.bovis_AF2122/97 ATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVL
Rv0462|M.tuberculosis_H37Rv ATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVL
MUL_2214|M.ulcerans_Agy99 ATGSSTRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVL
MSMEG_0903|M.smegmatis_MC2_155 ATGSSTRLVPGTSLSENVVTYETQILSRELPGSIIIAGAGAIGMEFAYVL
MLBr_02387|M.leprae_Br4923 ATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYVL
. . . .* : :* ::: *.. :.:* . :
MMAR_3101|M.marinum_M RRFGAPVTVVERGPRLASREDEDVSATIREILEAEGINVVVGADDVRITK
MAV_2396|M.avium_104 RRFGAAVTVVERGPRLASREDEDVSAAVQEILRAEGIDIVVNADDVRIAK
Mvan_3468|M.vanbaalenii_PYR-1 RRFGAAVTVIERGPRLTAREDEDVSAAIKEILEAEGIDVVVGADAISFAK
TH_3945|M.thermoresistible__bu RRFGARVTVVQRGSRLASHEDADVSAAIHDILAGEGIDIVVDASAIRFAR
MAB_3014|M.abscessus_ATCC_1997 RRFGSQVTVVHRGPRLVEREDPDASAIIQEVLEREGITFRLNASCINLAR
Mflv_3213|M.gilvum_PYR-GCK ARLGSTVTVLVR-STLASKEEPEVGMALLEVFADDGIRVVRRATVSEVEQ
Mb0471|M.bovis_AF2122/97 KNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
Rv0462|M.tuberculosis_H37Rv KNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
MUL_2214|M.ulcerans_Agy99 KNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISD
MSMEG_0903|M.smegmatis_MC2_155 KNYGVDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEGIAD
MLBr_02387|M.leprae_Br4923 KNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESISD
. * **:: . .*: :.. : *: . : .
MMAR_3101|M.marinum_M RDSSVGGFELTPCAGAAPIAGSHLLLAVGRRPNTDDLGLEAAGVQTDARG
MAV_2396|M.avium_104 TGN---GFELTSRDGAPPIRGSHLLLAVGRRPNTDDLDLAVAGVRTDARG
Mvan_3468|M.vanbaalenii_PYR-1 QAD---GFTVTPRAGAEPIGGSHLLVAVGRRPNTDDLNLEAAGVQTDSRG
TH_3945|M.thermoresistible__bu CDG---GVAVTPADGAEPVVGSHLLIAVGRRPNTDDLALDRAGVAVDERG
MAB_3014|M.abscessus_ATCC_1997 HDEG-VAVGVDCTDGAPKVVGSHVLVAVGRRPNTDDLGLENAGVATDARG
Mflv_3213|M.gilvum_PYR-GCK ADDQ-VTVTATITGGTQQFRAAKVLVATGRRPNTDGLNLEAVQVKTGENN
Mb0471|M.bovis_AF2122/97 GGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRK
Rv0462|M.tuberculosis_H37Rv GGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRK
MUL_2214|M.ulcerans_Agy99 DGSA-VTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRK
MSMEG_0903|M.smegmatis_MC2_155 DGST-VKVTVSKDGKTEELKADKVLQAIGFAPNVEGYGLEAAGVELTDRK
MLBr_02387|M.leprae_Br4923 NGSH-VLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTADK
. . . ::* * * **.:. * . *
MMAR_3101|M.marinum_M YIVVDDQLKTSVDHIWAMGDCNGKGAFTHTSYNDFEIVAANLLDDDPRRV
MAV_2396|M.avium_104 YILVDDQLKTNVEHIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
Mvan_3468|M.vanbaalenii_PYR-1 YIVVDDQLRTSADNIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
TH_3945|M.thermoresistible__bu HIVVDDRLRTTAEHIWAMGDCNGRGAFTHTAYNDFEIVAANLLDADPRGV
MAB_3014|M.abscessus_ATCC_1997 YITVDDQLRTSTPGIWALGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
Mflv_3213|M.gilvum_PYR-GCK EVVVSDGLQSSNPRIWAAGDVTGHREFVYVAAHHGAMVADNIFTDAGRRV
Mb0471|M.bovis_AF2122/97 AIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTL
Rv0462|M.tuberculosis_H37Rv AIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTL
MUL_2214|M.ulcerans_Agy99 AIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLPL
MSMEG_0903|M.smegmatis_MC2_155 AIGIDDYMRTNVGHIYAIGDVTGKLQLAHVAEAMAVVAAETIAGAETLPL
MLBr_02387|M.leprae_Br4923 AVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLAL
: :.: :::. *:* ** .* :.:.: :.* : :
MMAR_3101|M.marinum_M SDR-ITTYALYIDPPLGRAGMSVAQAQATGRKLLVGKRPMTRVGRAVEKG
MAV_2396|M.avium_104 SDR-ITTYALYIDPPLGRAGMTVAQVRASGRRALVGKRPMTRVGRAVEKG
Mvan_3468|M.vanbaalenii_PYR-1 SDR-VTTYALYIDPPLGRAGMTVEEVRRSGRKALVGKRPMTRVGRAVEKG
TH_3945|M.thermoresistible__bu GDR-VRAYAMYIDPPLGRAGMTEDEVRASGRKALLAKRPMSRVGRAVEKG
MAB_3014|M.abscessus_ATCC_1997 TDR-LPCYALYTDPPLGRVGMTEAQARASGRSLLVGRKPMSHVGRALEKG
Mflv_3213|M.gilvum_PYR-GCK DYR-HLPRVTFTSPAVGAAGTTEAELLAAGTRCDCRVLPLKHVPRAVVNR
Mb0471|M.bovis_AF2122/97 GDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVG
Rv0462|M.tuberculosis_H37Rv GDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVG
MUL_2214|M.ulcerans_Agy99 GDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLG
MSMEG_0903|M.smegmatis_MC2_155 GDYRMMPRATFCQPQVASFGLTEEQARDEGYDVKVAKFPFTANGKAHGLA
MLBr_02387|M.leprae_Br4923 SDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMG
. : .* :. * : : * *:. :*
MMAR_3101|M.marinum_M ETQGFMKVVVDADTDEILGATIFGVGGDEAIHAILDVMSAKAPYTTLSRT
MAV_2396|M.avium_104 ETQGFMKVVVDADTREILGAAILGVGGDEAIHGILDVMSAKAPYTTLSRT
Mvan_3468|M.vanbaalenii_PYR-1 ETQGFMKVVVDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYTAISRT
TH_3945|M.thermoresistible__bu ETQGFMKVLVDADTAEILGAAILGVGGDEVVHAIVDVMAARQPYTAISRT
MAB_3014|M.abscessus_ATCC_1997 ETDGYMQVLVDADSDLILGATILGVGGDEVVHCLLDTMQYGIPARQLQRT
Mflv_3213|M.gilvum_PYR-GCK DTRGFIKLVADAGTGRIHGITAVAKDAGEIAAAAVYILDAAMTVDQVAGS
Mb0471|M.bovis_AF2122/97 DPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARN
Rv0462|M.tuberculosis_H37Rv DPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARN
MUL_2214|M.ulcerans_Agy99 DPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTATELARN
MSMEG_0903|M.smegmatis_MC2_155 DPTGFVKLIADAKYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELARN
MLBr_02387|M.leprae_Br4923 DPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRN
:. *:::::.*. : * .. . * . : .
MMAR_3101|M.marinum_M MHIHPTVSELVPTMLQEMAPLV--------
MAV_2396|M.avium_104 MHIHPTVSELIPTMLQQMSPLA--------
Mvan_3468|M.vanbaalenii_PYR-1 MHIHPTVSELIPTVLQELKPLA--------
TH_3945|M.thermoresistible__bu MHIHPTVSELLPTLLQDLQPLR--------
MAB_3014|M.abscessus_ATCC_1997 VHIHPTVAEFLPTILGELQPLI--------
Mflv_3213|M.gilvum_PYR-GCK WAPYLTMAEGIKIAAQSFSADMSRLSCCAS
Mb0471|M.bovis_AF2122/97 VHTHPTMSEALQECFHGLVGHMINF-----
Rv0462|M.tuberculosis_H37Rv VHTHPTMSEALQECFHGLVGHMINF-----
MUL_2214|M.ulcerans_Agy99 VHTHPTMSEALQECFHGLAGHMINF-----
MSMEG_0903|M.smegmatis_MC2_155 VHTHPTLSEALQECFHGLAGHMINF-----
MLBr_02387|M.leprae_Br4923 VHTHPTLSEALQECFHGLIGHMINF-----
: *::* : :