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VSETATQKFDAIIIGAGQAGPPLAARLTAAGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRG ADFGIGTSEVTVDMAAVKARKDRISGGDREGLESWLDGMDGATLIRGHARFESPNTVRVDGTLLGAERIF LNVGGRAVVPDIPGLADVDYLTNVGILDLGVVPEHLVIIGGSYIALEFAQMYRRFGAEVTVVEKGPRLTA REDEDVSAVIKDILEAEGIRVELGADAISVAKRRNGIAVTPRDGAAPIDASHLLVAVGRVPNTDDLGLEA AGVETDKRGYVVVDDQLRTSAENIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRVSDRITTYALYI DPPLGRAGMTADEVRRTGRKALVGKRPMTRVGRAVEKGETQGFMKVVVDAETEEILGASILGVGGDEVVH LILDVMTAKLPYTAISRTMHIHPTVSELVPTLLQDLHPLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3059 | - | - | 100% (460) | mercuric reductase |
| M. gilvum PYR-GCK | Mflv_3213 | - | 1e-61 | 34.67% (450) | mercuric reductase |
| M. gilvum PYR-GCK | Mflv_4054 | - | 8e-51 | 32.33% (467) | mycothione/glutathione reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0471 | lpd | 1e-50 | 30.00% (450) | dihydrolipoamide dehydrogenase |
| M. tuberculosis H37Rv | Rv0462 | lpd | 1e-50 | 30.00% (450) | dihydrolipoamide dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 2e-49 | 28.76% (452) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 1e-159 | 61.01% (454) | mercuric reductase |
| M. marinum M | MMAR_3101 | lpd_1 | 0.0 | 75.93% (457) | dihydrolipoamide dehydrogenase Lpd_1 |
| M. avium 104 | MAV_2396 | - | 0.0 | 76.87% (454) | mercuric reductase |
| M. smegmatis MC2 155 | MSMEG_0903 | lpdA | 2e-52 | 30.67% (450) | dihydrolipoamide dehydrogenase |
| M. thermoresistible (build 8) | TH_3945 | - | 0.0 | 75.45% (448) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 7e-50 | 28.64% (447) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 0.0 | 86.59% (455) | mercuric reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3059|M.gilvum_PYR-GCK MSETATQKFDAIIIGAGQAGPPLAARLTAAGQTVAVIERKLVGGTCVNYG
Mvan_3468|M.vanbaalenii_PYR-1 ---MSAQHFDAIIVGAGQAGPPLAGRLTAAGQTVAVIERKLVGGTCVNYG
MMAR_3101|M.marinum_M ----MTQHYDAIVVGAGQAGPPLVGRLTAAGERVAIVERKHVGGTCVNSG
MAV_2396|M.avium_104 ----MTKHFDAIIVGAGQAGPPLAGRLTAAGQRVAIIERKLIGGTCVNTG
TH_3945|M.thermoresistible__bu -----------MIIGAGQAGPPLAGRLADAGQRVVLIERRLIGGTCVNYG
MAB_3014|M.abscessus_ATCC_1997 ----MSTHFDAVVVGAGQAGPSLAARLRGAGLTVAIVERHLFGGTCVNTG
Mb0471|M.bovis_AF2122/97 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
Rv0462|M.tuberculosis_H37Rv -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
MUL_2214|M.ulcerans_Agy99 -----MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVG
MSMEG_0903|M.smegmatis_MC2_155 -----MTHFDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVG
MLBr_02387|M.leprae_Br4923 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVG
:::*** .* . * * ..::* : ** *:* *
Mflv_3059|M.gilvum_PYR-GCK CIPTKTLVASAHAAHLARRGADFGIGTS-EVTVDMAAVKARKDRISGGDR
Mvan_3468|M.vanbaalenii_PYR-1 CIPTKTLVASAHAAHLARRGNDFGVAAA-GVTVDMAAVKARKDRISVGDR
MMAR_3101|M.marinum_M CIPTKTLVASAHAAQLARRGAEYGVGTG-PISVDMAKVKARKDGIMLADR
MAV_2396|M.avium_104 CIPTKTLVASAHAAHLARRGADYGVGTG-AISVDMAKVKARKDEIMLGDR
TH_3945|M.thermoresistible__bu CIPTKTLVASAHAAHLARRAADYGVRTG-PVTVDMARVKARKDAIMLDDR
MAB_3014|M.abscessus_ATCC_1997 CRPTKALVASAHAAHMAREAARWGVVVDGSVSMDMVRVRERKDAVILPSR
Mb0471|M.bovis_AF2122/97 CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
Rv0462|M.tuberculosis_H37Rv CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
MUL_2214|M.ulcerans_Agy99 CIPSKALLRNAELAHIFTKDAKAFGISG-EATFDYGVAFDRSRKVAEGRV
MSMEG_0903|M.smegmatis_MC2_155 CIPSKALLRNAEIAHMFNKEAKTFGISG-EATFDYGAAFDRSRKVADGRV
MLBr_02387|M.leprae_Br4923 CIPSKVLLHNAELAHIFTKEAKTFGISG-DASFDYGIAYDRSRKVSEGRV
* *:*.*: .*. .:: . :.* . *. :
Mflv_3059|M.gilvum_PYR-GCK EGLESWLDGMDGATLIRGHARFESPNTVRVDGTLLGAER-------IFLN
Mvan_3468|M.vanbaalenii_PYR-1 EGLESWLAGMKGCTLIRGHARFENPHTLRVDDQLLEADR-------IFLN
MMAR_3101|M.marinum_M KGVEDWLDGMNGCTVFRGHARFEDPHTLRVGDDLLSADR-------IFLN
MAV_2396|M.avium_104 KGVEDWLAGMAGCTVVRGHARFRDPHTLQVGEDLLRAER-------IFLN
TH_3945|M.thermoresistible__bu RGLESWLQGMDGCTVVRGHARFEDPHTVRVGERLLSADR-------IFLN
MAB_3014|M.abscessus_ATCC_1997 NGGQTWLKDLG-CAIYHEHASFLSPTELSVGDEIISAER-------IFLN
Mb0471|M.bovis_AF2122/97 AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
Rv0462|M.tuberculosis_H37Rv AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
MUL_2214|M.ulcerans_Agy99 AG-VHFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAII
MSMEG_0903|M.smegmatis_MC2_155 AG-VHFLMKKNKITEIHGYGKFTGPNSLEVALNDGGTEK---VEFSNAII
MLBr_02387|M.leprae_Br4923 AG-VHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVII
* :* : : :. * .. : * .: :
Mflv_3059|M.gilvum_PYR-GCK VGGRAVVPDIPGLADVDYLTNVGILDLGVVPEHLVIIGGSYIALEFAQMY
Mvan_3468|M.vanbaalenii_PYR-1 VGGRAVAPDMPGLADVDYLTNVGILDLDEVPEHLVVIGGSYIALEFAQMY
MMAR_3101|M.marinum_M VGGRAVAPNIPGLADIDFLTNVSILELDTLPEHLVIVGGSYIALEFAQMY
MAV_2396|M.avium_104 VGGRAVVPDIPGLAEVDFLTNVSILELDRLPTHLVIVGGSYIALEFAQMY
TH_3945|M.thermoresistible__bu VGGRAVVPDLPGLADVDHLTNVSMLELDTLPEHLVIVGGGYIALEFAQMY
MAB_3014|M.abscessus_ATCC_1997 VGGRAVVPDWPGVDDVPLFTNSSLIEYDGIPEHLVVIGGSYVGLEFAQIY
Mb0471|M.bovis_AF2122/97 ATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVL
Rv0462|M.tuberculosis_H37Rv ATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVL
MUL_2214|M.ulcerans_Agy99 ATGSSTRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVL
MSMEG_0903|M.smegmatis_MC2_155 ATGSSTRLVPGTSLSENVVTYETQILSRELPGSIIIAGAGAIGMEFAYVL
MLBr_02387|M.leprae_Br4923 ATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYVL
. * . . .* : :* ::: *.. :.:**. :
Mflv_3059|M.gilvum_PYR-GCK RRFGAEVTVVEKGPRLTAREDEDVSAVIKDILEAEGIRVELGADAISVAK
Mvan_3468|M.vanbaalenii_PYR-1 RRFGAAVTVIERGPRLTAREDEDVSAAIKEILEAEGIDVVVGADAISFAK
MMAR_3101|M.marinum_M RRFGAPVTVVERGPRLASREDEDVSATIREILEAEGINVVVGADDVRITK
MAV_2396|M.avium_104 RRFGAAVTVVERGPRLASREDEDVSAAVQEILRAEGIDIVVNADDVRIAK
TH_3945|M.thermoresistible__bu RRFGARVTVVQRGSRLASHEDADVSAAIHDILAGEGIDIVVDASAIRFAR
MAB_3014|M.abscessus_ATCC_1997 RRFGSQVTVVHRGPRLVEREDPDASAIIQEVLEREGITFRLNASCINLAR
Mb0471|M.bovis_AF2122/97 KNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
Rv0462|M.tuberculosis_H37Rv KNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIAD
MUL_2214|M.ulcerans_Agy99 KNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISD
MSMEG_0903|M.smegmatis_MC2_155 KNYGVDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEGIAD
MLBr_02387|M.leprae_Br4923 KNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESISD
:.:* **::. .* .** :.* :. *: . :. .:
Mflv_3059|M.gilvum_PYR-GCK RRN---GIAVTPRDGAAPIDASHLLVAVGRVPNTDDLGLEAAGVETDKRG
Mvan_3468|M.vanbaalenii_PYR-1 QAD---GFTVTPRAGAEPIGGSHLLVAVGRRPNTDDLNLEAAGVQTDSRG
MMAR_3101|M.marinum_M RDSSVGGFELTPCAGAAPIAGSHLLLAVGRRPNTDDLGLEAAGVQTDARG
MAV_2396|M.avium_104 TGN---GFELTSRDGAPPIRGSHLLLAVGRRPNTDDLDLAVAGVRTDARG
TH_3945|M.thermoresistible__bu CDG---GVAVTPADGAEPVVGSHLLIAVGRRPNTDDLALDRAGVAVDERG
MAB_3014|M.abscessus_ATCC_1997 HDEG-VAVGVDCTDGAPKVVGSHVLVAVGRRPNTDDLGLENAGVATDARG
Mb0471|M.bovis_AF2122/97 GGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRK
Rv0462|M.tuberculosis_H37Rv GGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRK
MUL_2214|M.ulcerans_Agy99 DGSA-VTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRK
MSMEG_0903|M.smegmatis_MC2_155 DGST-VKVTVSKDGKTEELKADKVLQAIGFAPNVEGYGLEAAGVELTDRK
MLBr_02387|M.leprae_Br4923 NGSH-VLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTADK
. : : ..::* *:* **.:. * .**
Mflv_3059|M.gilvum_PYR-GCK YVVVDDQLRTSAENIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
Mvan_3468|M.vanbaalenii_PYR-1 YIVVDDQLRTSADNIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
MMAR_3101|M.marinum_M YIVVDDQLKTSVDHIWAMGDCNGKGAFTHTSYNDFEIVAANLLDDDPRRV
MAV_2396|M.avium_104 YILVDDQLKTNVEHIWAMGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
TH_3945|M.thermoresistible__bu HIVVDDRLRTTAEHIWAMGDCNGRGAFTHTAYNDFEIVAANLLDADPRGV
MAB_3014|M.abscessus_ATCC_1997 YITVDDQLRTSTPGIWALGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRV
Mb0471|M.bovis_AF2122/97 AIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTL
Rv0462|M.tuberculosis_H37Rv AIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTL
MUL_2214|M.ulcerans_Agy99 AIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLPL
MSMEG_0903|M.smegmatis_MC2_155 AIGIDDYMRTNVGHIYAIGDVTGKLQLAHVAEAMAVVAAETIAGAETLPL
MLBr_02387|M.leprae_Br4923 AVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLAL
: :.: ::*.. *:*:** .* ::*.: :.* : . :. :
Mflv_3059|M.gilvum_PYR-GCK SDR-ITTYALYIDPPLGRAGMTADEVRRTGRKALVGKRPMTRVGRAVEKG
Mvan_3468|M.vanbaalenii_PYR-1 SDR-VTTYALYIDPPLGRAGMTVEEVRRSGRKALVGKRPMTRVGRAVEKG
MMAR_3101|M.marinum_M SDR-ITTYALYIDPPLGRAGMSVAQAQATGRKLLVGKRPMTRVGRAVEKG
MAV_2396|M.avium_104 SDR-ITTYALYIDPPLGRAGMTVAQVRASGRRALVGKRPMTRVGRAVEKG
TH_3945|M.thermoresistible__bu GDR-VRAYAMYIDPPLGRAGMTEDEVRASGRKALLAKRPMSRVGRAVEKG
MAB_3014|M.abscessus_ATCC_1997 TDR-LPCYALYTDPPLGRVGMTEAQARASGRSLLVGRKPMSHVGRALEKG
Mb0471|M.bovis_AF2122/97 GDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVG
Rv0462|M.tuberculosis_H37Rv GDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVG
MUL_2214|M.ulcerans_Agy99 GDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLG
MSMEG_0903|M.smegmatis_MC2_155 GDYRMMPRATFCQPQVASFGLTEEQARDEGYDVKVAKFPFTANGKAHGLA
MLBr_02387|M.leprae_Br4923 SDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMG
* : * : :* :. *:: :.: * :.: *:: .:* .
Mflv_3059|M.gilvum_PYR-GCK ETQGFMKVVVDAETEEILGASILGVGGDEVVHLILDVMTAKLPYTAISRT
Mvan_3468|M.vanbaalenii_PYR-1 ETQGFMKVVVDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYTAISRT
MMAR_3101|M.marinum_M ETQGFMKVVVDADTDEILGATIFGVGGDEAIHAILDVMSAKAPYTTLSRT
MAV_2396|M.avium_104 ETQGFMKVVVDADTREILGAAILGVGGDEAIHGILDVMSAKAPYTTLSRT
TH_3945|M.thermoresistible__bu ETQGFMKVLVDADTAEILGAAILGVGGDEVVHAIVDVMAARQPYTAISRT
MAB_3014|M.abscessus_ATCC_1997 ETDGYMQVLVDADSDLILGATILGVGGDEVVHCLLDTMQYGIPARQLQRT
Mb0471|M.bovis_AF2122/97 DPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARN
Rv0462|M.tuberculosis_H37Rv DPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARN
MUL_2214|M.ulcerans_Agy99 DPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTATELARN
MSMEG_0903|M.smegmatis_MC2_155 DPTGFVKLIADAKYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELARN
MLBr_02387|M.leprae_Br4923 DPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRN
:. *:::::.*.. :**. :.* . * : : . . : *.
Mflv_3059|M.gilvum_PYR-GCK MHIHPTVSELVPTLLQDLHPLT---
Mvan_3468|M.vanbaalenii_PYR-1 MHIHPTVSELIPTVLQELKPLA---
MMAR_3101|M.marinum_M MHIHPTVSELVPTMLQEMAPLV---
MAV_2396|M.avium_104 MHIHPTVSELIPTMLQQMSPLA---
TH_3945|M.thermoresistible__bu MHIHPTVSELLPTLLQDLQPLR---
MAB_3014|M.abscessus_ATCC_1997 VHIHPTVAEFLPTILGELQPLI---
Mb0471|M.bovis_AF2122/97 VHTHPTMSEALQECFHGLVGHMINF
Rv0462|M.tuberculosis_H37Rv VHTHPTMSEALQECFHGLVGHMINF
MUL_2214|M.ulcerans_Agy99 VHTHPTMSEALQECFHGLAGHMINF
MSMEG_0903|M.smegmatis_MC2_155 VHTHPTLSEALQECFHGLAGHMINF
MLBr_02387|M.leprae_Br4923 VHTHPTLSEALQECFHGLIGHMINF
:* ***::* : : :