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THYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHVFHKDAKTFGI SGDVSFDYGAAFDRSRKVADGRVAGVHFLMKKNKITEVHGYGRFTGPNSIEVEPTGDGEEGPVKLEFDNA IIATGSSTRLVPGTSLSENVVTYEKQILTRELPGSIIIAGAGAIGMEFAYVLKNYGVDVTIVEFLPRALP NEDAEVSKEIEKQYKKLGVKILTGTKVEKIEDDGKQVTVTVSKNDKTEELKADKVMQAIGFAPNVEGFGL DKAGVELTDRKAIGIDDYMRTNVPHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGADTLPFEDYRMMPRA TFCQPQVASFGLTEQQAKDEGYDVVVAKFPFTANGKAHGLGDPTGFVKLIADKKHLELLGGHLIGPDVAE LLPELTLAQKWDLTANELARNVHTHPTLSEAMQECFHGLVGHMINF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0114 | - | - | 100% (467) | dihydrolipoamide dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 1e-49 | 28.22% (450) | mercuric reductase |
| M. gilvum PYR-GCK | Mflv_4822 | - | 3e-48 | 27.70% (473) | flavoprotein disulfide reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0471 | lpd | 0.0 | 83.08% (467) | dihydrolipoamide dehydrogenase |
| M. tuberculosis H37Rv | Rv0462 | lpd | 0.0 | 83.08% (467) | dihydrolipoamide dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 0.0 | 80.30% (467) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4127c | - | 0.0 | 83.66% (465) | dihydrolipoamide dehydrogenase |
| M. marinum M | MMAR_0785 | lpd | 0.0 | 84.80% (467) | dihydrolipoamide dehydrogenase Lpd |
| M. avium 104 | MAV_4687 | lpdA | 0.0 | 84.12% (466) | dihydrolipoamide dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0903 | lpdA | 0.0 | 88.65% (467) | dihydrolipoamide dehydrogenase |
| M. thermoresistible (build 8) | TH_4200 | - | 0.0 | 81.66% (469) | PUTATIVE dihydrolipoamide dehydrogenase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 0.0 | 84.80% (467) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0794 | - | 0.0 | 91.22% (467) | dihydrolipoamide dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0114|M.gilvum_PYR-GCK ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
Mvan_0794|M.vanbaalenii_PYR-1 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MSMEG_0903|M.smegmatis_MC2_155 ---MTHFDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
MAB_4127c|M.abscessus_ATCC_199 --MTAHYDVVVLGAGPGGYVAAIRAAQLGLKTAIVEEKYWGGVCLNVGCI
Mb0471|M.bovis_AF2122/97 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
Rv0462|M.tuberculosis_H37Rv ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MMAR_0785|M.marinum_M MGAVTHYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
MUL_2214|M.ulcerans_Agy99 ---MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
MAV_4687|M.avium_104 --MTSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MLBr_02387|M.leprae_Br4923 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVGCI
TH_4200|M.thermoresistible__bu VEAVSHYDVVVLGAGPGGYVAAIRAAQLGQKTAIIEPRYWGGVCLNVGCI
:*:*********.************ .**::* :****:*******
Mflv_0114|M.gilvum_PYR-GCK PSKALLRNAELAHVFHKDAKTFGISGDVSFDYGAAFDRSRKVADGRVAGV
Mvan_0794|M.vanbaalenii_PYR-1 PSKALLRNAELAHIFTKEAKTFGISGEASFDYGAAFDRSRKVADGRVAGV
MSMEG_0903|M.smegmatis_MC2_155 PSKALLRNAEIAHMFNKEAKTFGISGEATFDYGAAFDRSRKVADGRVAGV
MAB_4127c|M.abscessus_ATCC_199 PSKALLRNAELAHIFTKEAKTFGISGEATFDFGAAFDRSRKVAEGRVAGV
Mb0471|M.bovis_AF2122/97 PSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGV
Rv0462|M.tuberculosis_H37Rv PSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGV
MMAR_0785|M.marinum_M PSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSRKVAEGRVAGV
MUL_2214|M.ulcerans_Agy99 PSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSRKVAEGRVAGV
MAV_4687|M.avium_104 PSKALLRNAELAHIFTKEAKTFGINGEATFDYGAAFDRSRKVAEGRVAGV
MLBr_02387|M.leprae_Br4923 PSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSEGRVAGV
TH_4200|M.thermoresistible__bu PSKALLRNAELASIFTRDAKLFGIQGEVTFDYGAAFDRSRKVADGRVSGV
***.**:***:. :* ::** ***.*:.:**:* *:******::***:**
Mflv_0114|M.gilvum_PYR-GCK HFLMKKNKITEVHGYGRFTGPNSIEVEPTGDGEEGPVKLEFDNAIIATGS
Mvan_0794|M.vanbaalenii_PYR-1 HFLMKKNKITEIHGYGKFTGPNSIEVDLN-DG--GTEKLEFDNAIIATGS
MSMEG_0903|M.smegmatis_MC2_155 HFLMKKNKITEIHGYGKFTGPNSLEVALN-DG--GTEKVEFSNAIIATGS
MAB_4127c|M.abscessus_ATCC_199 HFLMKKNKITEYEGVGTFTDANTLAVKKA-DG--SHETLTFANVIIATGS
Mb0471|M.bovis_AF2122/97 HFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAIIATGS
Rv0462|M.tuberculosis_H37Rv HFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAIIATGS
MMAR_0785|M.marinum_M HFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAIIATGS
MUL_2214|M.ulcerans_Agy99 HFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAIIATGS
MAV_4687|M.avium_104 HFLMKKNKITEIHGYGRFTDPHTLAVELNDGGTET---VTFDNAIIATGS
MLBr_02387|M.leprae_Br4923 HFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVIIATGS
TH_4200|M.thermoresistible__bu HFLMKKNKITEIHGYGRFTDAHTIEVELNEGGTEQ---VTFDNAIIATGS
*********** .* * *:..::: * . : * *.******
Mflv_0114|M.gilvum_PYR-GCK STRLVPGTSLSENVVTYEKQILTRELPGSIIIAGAGAIGMEFAYVLKNYG
Mvan_0794|M.vanbaalenii_PYR-1 STRLVPGTSLSENVVTYEDQILSRELPGSIVIAGAGAIGMEFAYVMKNYG
MSMEG_0903|M.smegmatis_MC2_155 STRLVPGTSLSENVVTYETQILSRELPGSIIIAGAGAIGMEFAYVLKNYG
MAB_4127c|M.abscessus_ATCC_199 SVRLVPGTSLSENVVTYEKQILTRELPGSIIIAGAGAIGMEFAYVLKNYG
Mb0471|M.bovis_AF2122/97 STRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYG
Rv0462|M.tuberculosis_H37Rv STRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYG
MMAR_0785|M.marinum_M STRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVLKNYG
MUL_2214|M.ulcerans_Agy99 STRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVLKNYG
MAV_4687|M.avium_104 STRLVPGTSLSANVVTYEEQILSRELPESIIIAGAGAIGMEFGYVLHNYG
MLBr_02387|M.leprae_Br4923 KTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYVLKNYG
TH_4200|M.thermoresistible__bu STKLVPGTSLSENVVTYEKLIMTRELPGSIVIAGAGAIGMEFGYIMANYG
..:***** ** **:*** *::**** **:*.******:**.*:: ***
Mflv_0114|M.gilvum_PYR-GCK VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEKIEDDGK-
Mvan_0794|M.vanbaalenii_PYR-1 VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEKIQDDGS-
MSMEG_0903|M.smegmatis_MC2_155 VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEGIADDGS-
MAB_4127c|M.abscessus_ATCC_199 VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVESITDSGS-
Mb0471|M.bovis_AF2122/97 VDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGS-
Rv0462|M.tuberculosis_H37Rv VDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGS-
MMAR_0785|M.marinum_M VDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISDDGS-
MUL_2214|M.ulcerans_Agy99 VDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISDDGS-
MAV_4687|M.avium_104 VEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESISDDGS-
MLBr_02387|M.leprae_Br4923 VDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESISDNGS-
TH_4200|M.thermoresistible__bu VDVTVVEFLPRVLPNEDPEVSREIEKQFKKLGVKIHTGTKVESITDNGAG
*:**:******.:****.:**:***:*:**:*:.* *.**** * *.*
Mflv_0114|M.gilvum_PYR-GCK -QVTVTVSKNDKTEELKADKVMQAIGFAPNVEGFGLDKAGVELTDRKAIG
Mvan_0794|M.vanbaalenii_PYR-1 -TVTVTVSKDGKTDELKADKVLQAIGFAPNVEGFGLETTGVQLTDRRAIG
MSMEG_0903|M.smegmatis_MC2_155 -TVKVTVSKDGKTEELKADKVLQAIGFAPNVEGYGLEAAGVELTDRKAIG
MAB_4127c|M.abscessus_ATCC_199 -QVTVKVSKDGQESELVADKVLQAIGFAPNVEGFGLENTGVALTDRGAIA
Mb0471|M.bovis_AF2122/97 -QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
Rv0462|M.tuberculosis_H37Rv -QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MMAR_0785|M.marinum_M -AVTVVVSKDGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MUL_2214|M.ulcerans_Agy99 -AVTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MAV_4687|M.avium_104 -QVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIG
MLBr_02387|M.leprae_Br4923 -HVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTADKAVD
TH_4200|M.thermoresistible__bu GSVVVKVSKDGESSELKADKVLQAIGFAPNVDGYGLDRAGVRLDDRQAIA
* * *:*.. .** * **:*********:*:**: .** * *:
Mflv_0114|M.gilvum_PYR-GCK IDDYMRTNVPHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGADTLPFEDY
Mvan_0794|M.vanbaalenii_PYR-1 IDDYMRTNVQHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGAETLALGDY
MSMEG_0903|M.smegmatis_MC2_155 IDDYMRTNVGHIYAIGDVTGKLQLAHVAEAMAVVAAETIAGAETLPLGDY
MAB_4127c|M.abscessus_ATCC_199 IDERMRTNVPHIYAIGDVTSKLQLAHVAEAQAVVAAETIAGAETLELGDY
Mb0471|M.bovis_AF2122/97 VDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDH
Rv0462|M.tuberculosis_H37Rv VDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDH
MMAR_0785|M.marinum_M IGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLSLGDY
MUL_2214|M.ulcerans_Agy99 IGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLPLGDY
MAV_4687|M.avium_104 ITDYMRTNIEHIYAIGDVTGKLQLAHVAEAQGVVAAETIAGAETLALGDY
MLBr_02387|M.leprae_Br4923 IDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLALSDY
TH_4200|M.thermoresistible__bu IDDYMRTSVPHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGVETLPLGDY
: : *:*.: ********.. * ******* .*****:***.:** : *:
Mflv_0114|M.gilvum_PYR-GCK RMMPRATFCQPQVASFGLTEQQAKDEGYDVVVAKFPFTANGKAHGLGDPT
Mvan_0794|M.vanbaalenii_PYR-1 RMLPRATFCQPQVASFGLTEQQAKDEGYDVVVAKFPFTANGKAHGLGDPT
MSMEG_0903|M.smegmatis_MC2_155 RMMPRATFCQPQVASFGLTEEQARDEGYDVKVAKFPFTANGKAHGLADPT
MAB_4127c|M.abscessus_ATCC_199 RMMPRATFCQPQVASFGLTEEQARAEGYDVKVAKFPFTANGKAHGLADPT
Mb0471|M.bovis_AF2122/97 RMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
Rv0462|M.tuberculosis_H37Rv RMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
MMAR_0785|M.marinum_M RMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLGDPS
MUL_2214|M.ulcerans_Agy99 RMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLGDPS
MAV_4687|M.avium_104 RMMPRATFCQPNVASFGLTEQQARDEGHDVVVAKFPFTANGKAHGVGDPS
MLBr_02387|M.leprae_Br4923 RMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDPS
TH_4200|M.thermoresistible__bu RMMPRATFCQPQVASFGLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPS
**:********:********:**: *:** *********.****:. *:
Mflv_0114|M.gilvum_PYR-GCK GFVKLIADKKHLELLGGHLIGPDVAELLPELTLAQKWDLTANELARNVHT
Mvan_0794|M.vanbaalenii_PYR-1 GFVKLVADRKHLELLGGHLIGPDVSELLPELTLAQKWDLTANELARNVHT
MSMEG_0903|M.smegmatis_MC2_155 GFVKLIADAKYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELARNVHT
MAB_4127c|M.abscessus_ATCC_199 GFVKLIADAKYGELIGGHLIGPDVSELLPELTLAQKWDLTVNELTRNVHT
Mb0471|M.bovis_AF2122/97 GFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHT
Rv0462|M.tuberculosis_H37Rv GFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHT
MMAR_0785|M.marinum_M GFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTATELARNVHT
MUL_2214|M.ulcerans_Agy99 GFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTATELARNVHT
MAV_4687|M.avium_104 GFVKLIADAKYGELLGGHLVGHDVSELLPELTLAQKWDLTATELARNVHT
MLBr_02387|M.leprae_Br4923 GFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRNVHT
TH_4200|M.thermoresistible__bu GFVKLIADAKYGELLGGHMVGHDVSELLPELTLAQKWDLTAHELARNVHT
*****:** *: **:***::* :*:**********:****. **.*****
Mflv_0114|M.gilvum_PYR-GCK HPTLSEAMQECFHGLVGHMINF
Mvan_0794|M.vanbaalenii_PYR-1 HPTLSEAMQECFHGLVGHMINF
MSMEG_0903|M.smegmatis_MC2_155 HPTLSEALQECFHGLAGHMINF
MAB_4127c|M.abscessus_ATCC_199 HPTLSEALQEAFHGLAGHMINF
Mb0471|M.bovis_AF2122/97 HPTMSEALQECFHGLVGHMINF
Rv0462|M.tuberculosis_H37Rv HPTMSEALQECFHGLVGHMINF
MMAR_0785|M.marinum_M HPTMSEALQECFHGLAGHMINF
MUL_2214|M.ulcerans_Agy99 HPTMSEALQECFHGLAGHMINF
MAV_4687|M.avium_104 HPTMSEALQECFHGLTGHMINF
MLBr_02387|M.leprae_Br4923 HPTLSEALQECFHGLIGHMINF
TH_4200|M.thermoresistible__bu HPTLSEAMQECFHGLVGHMINF
***:***:**.**** ******