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TQHYDAIVVGAGQAGPPLVGRLTAAGERVAIVERKHVGGTCVNSGCIPTKTLVASAHAAQLARRGAEYGV GTGPISVDMAKVKARKDGIMLADRKGVEDWLDGMNGCTVFRGHARFEDPHTLRVGDDLLSADRIFLNVGG RAVAPNIPGLADIDFLTNVSILELDTLPEHLVIVGGSYIALEFAQMYRRFGAPVTVVERGPRLASREDED VSATIREILEAEGINVVVGADDVRITKRDSSVGGFELTPCAGAAPIAGSHLLLAVGRRPNTDDLGLEAAG VQTDARGYIVVDDQLKTSVDHIWAMGDCNGKGAFTHTSYNDFEIVAANLLDDDPRRVSDRITTYALYIDP PLGRAGMSVAQAQATGRKLLVGKRPMTRVGRAVEKGETQGFMKVVVDADTDEILGATIFGVGGDEAIHAI LDVMSAKAPYTTLSRTMHIHPTVSELVPTMLQEMAPLV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3101 | lpd_1 | - | 100% (459) | dihydrolipoamide dehydrogenase Lpd_1 |
| M. marinum M | MMAR_0785 | lpd | 5e-46 | 28.35% (462) | dihydrolipoamide dehydrogenase Lpd |
| M. marinum M | MMAR_1875 | mtr | 2e-45 | 29.96% (464) | NADPH-dependent mycothiol reductase Mtr |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0471 | lpd | 4e-47 | 29.33% (450) | dihydrolipoamide dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 0.0 | 75.93% (457) | mercuric reductase |
| M. tuberculosis H37Rv | Rv0462 | lpd | 4e-47 | 29.33% (450) | dihydrolipoamide dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 8e-48 | 29.58% (453) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 1e-166 | 62.04% (461) | mercuric reductase |
| M. avium 104 | MAV_2396 | - | 0.0 | 84.93% (458) | mercuric reductase |
| M. smegmatis MC2 155 | MSMEG_2611 | - | 3e-48 | 29.87% (472) | mycothione/glutathione reductase |
| M. thermoresistible (build 8) | TH_3945 | - | 0.0 | 73.39% (451) | PUTATIVE pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 2e-46 | 28.57% (462) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 0.0 | 78.51% (456) | mercuric reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3101|M.marinum_M ----MTQHYDAIVVGAGQAGPPLVGRLTAAGERVAIVERKHVGGTCVNSG
MAV_2396|M.avium_104 ----MTKHFDAIIVGAGQAGPPLAGRLTAAGQRVAIIERKLIGGTCVNTG
Mflv_3059|M.gilvum_PYR-GCK MSETATQKFDAIIIGAGQAGPPLAARLTAAGQTVAVIERKLVGGTCVNYG
Mvan_3468|M.vanbaalenii_PYR-1 ---MSAQHFDAIIVGAGQAGPPLAGRLTAAGQTVAVIERKLVGGTCVNYG
TH_3945|M.thermoresistible__bu -----------MIIGAGQAGPPLAGRLADAGQRVVLIERRLIGGTCVNYG
MAB_3014|M.abscessus_ATCC_1997 ----MSTHFDAVVVGAGQAGPSLAARLRGAGLTVAIVERHLFGGTCVNTG
Mb0471|M.bovis_AF2122/97 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
Rv0462|M.tuberculosis_H37Rv -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
MUL_2214|M.ulcerans_Agy99 -----MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVG
MLBr_02387|M.leprae_Br4923 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVG
MSMEG_2611|M.smegmatis_MC2_155 -----MEHYDLAIIGTGSGNSIVDDR--YAGKKVAICEQGTFGGTCLNVG
::*:* .. * * ..: * ** *:* *
MMAR_3101|M.marinum_M CIPTKTLVASAHAAQLARRGAEYGVGTG-PISVDMAKVKARKDGIMLADR
MAV_2396|M.avium_104 CIPTKTLVASAHAAHLARRGADYGVGTG-AISVDMAKVKARKDEIMLGDR
Mflv_3059|M.gilvum_PYR-GCK CIPTKTLVASAHAAHLARRGADFGIGTS-EVTVDMAAVKARKDRISGGDR
Mvan_3468|M.vanbaalenii_PYR-1 CIPTKTLVASAHAAHLARRGNDFGVAAA-GVTVDMAAVKARKDRISVGDR
TH_3945|M.thermoresistible__bu CIPTKTLVASAHAAHLARRAADYGVRTG-PVTVDMARVKARKDAIMLDDR
MAB_3014|M.abscessus_ATCC_1997 CRPTKALVASAHAAHMAREAARWGVVVDGSVSMDMVRVRERKDAVILPSR
Mb0471|M.bovis_AF2122/97 CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
Rv0462|M.tuberculosis_H37Rv CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
MUL_2214|M.ulcerans_Agy99 CIPSKALLRNAELAHIFTKDAKAFGISG-EATFDYGVAFDRSRKVAEGRV
MLBr_02387|M.leprae_Br4923 CIPSKVLLHNAELAHIFTKEAKTFGISG-DASFDYGIAYDRSRKVSEGRV
MSMEG_2611|M.smegmatis_MC2_155 CIPTKMFVYAAEVAHSVRTSARYGVDAH-IDKVRWPDIVERVFGRIDPIA
* *:* :: *. .: .. *
MMAR_3101|M.marinum_M KGVEDWLDGMNGCTVFRGHARFEDPHTLRVGDDLLSADR---IFLN---V
MAV_2396|M.avium_104 KGVEDWLAGMAGCTVVRGHARFRDPHTLQVGEDLLRAER---IFLN---V
Mflv_3059|M.gilvum_PYR-GCK EGLESWLDGMDGATLIRGHARFESPNTVRVDGTLLGAER---IFLN---V
Mvan_3468|M.vanbaalenii_PYR-1 EGLESWLAGMKGCTLIRGHARFENPHTLRVDDQLLEADR---IFLN---V
TH_3945|M.thermoresistible__bu RGLESWLQGMDGCTVVRGHARFEDPHTVRVGERLLSADR---IFLN---V
MAB_3014|M.abscessus_ATCC_1997 NGGQTWLKDLG-CAIYHEHASFLSPTELSVGDEIISAER---IFLN---V
Mb0471|M.bovis_AF2122/97 AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
Rv0462|M.tuberculosis_H37Rv AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
MUL_2214|M.ulcerans_Agy99 AG-VHFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAII
MLBr_02387|M.leprae_Br4923 AG-VHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVII
MSMEG_2611|M.smegmatis_MC2_155 AGGEDYRRSDPNITVYSSHTRFG--PKTDDGRYTLRTESGEEFTSDQVVI
* : : : * .: . : :
MMAR_3101|M.marinum_M GGRAVAPNIPG--LADIDFLTNVSILELDTLPEHLVIVGGSYIALEFAQM
MAV_2396|M.avium_104 GGRAVVPDIPG--LAEVDFLTNVSILELDRLPTHLVIVGGSYIALEFAQM
Mflv_3059|M.gilvum_PYR-GCK GGRAVVPDIPG--LADVDYLTNVGILDLGVVPEHLVIIGGSYIALEFAQM
Mvan_3468|M.vanbaalenii_PYR-1 GGRAVAPDMPG--LADVDYLTNVGILDLDEVPEHLVVIGGSYIALEFAQM
TH_3945|M.thermoresistible__bu GGRAVVPDLPG--LADVDHLTNVSMLELDTLPEHLVIVGGGYIALEFAQM
MAB_3014|M.abscessus_ATCC_1997 GGRAVVPDWPG--VDDVPLFTNSSLIEYDGIPEHLVVIGGSYVGLEFAQI
Mb0471|M.bovis_AF2122/97 ATGSSTRLVPGT-SLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYV
Rv0462|M.tuberculosis_H37Rv ATGSSTRLVPGT-SLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYV
MUL_2214|M.ulcerans_Agy99 ATGSSTRLVPGT-SLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYV
MLBr_02387|M.leprae_Br4923 ATGSKTRLVPGT-LLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYV
MSMEG_2611|M.smegmatis_MC2_155 AAGSRTYIPPAVVDCGVKYHTSDDIMRIPELPTDLVIIGGGFVSAEFAHV
. : . *. * : :* ::: *.. :. **. :
MMAR_3101|M.marinum_M YRRFGAPVTVVERGPRLASREDEDVSATIREILEAEGINVVVGADDVRIT
MAV_2396|M.avium_104 YRRFGAAVTVVERGPRLASREDEDVSAAVQEILRAEGIDIVVNADDVRIA
Mflv_3059|M.gilvum_PYR-GCK YRRFGAEVTVVEKGPRLTAREDEDVSAVIKDILEAEGIRVELGADAISVA
Mvan_3468|M.vanbaalenii_PYR-1 YRRFGAAVTVIERGPRLTAREDEDVSAAIKEILEAEGIDVVVGADAISFA
TH_3945|M.thermoresistible__bu YRRFGARVTVVQRGSRLASHEDADVSAAIHDILAGEGIDIVVDASAIRFA
MAB_3014|M.abscessus_ATCC_1997 YRRFGSQVTVVHRGPRLVEREDPDASAIIQEVLEREGITFRLNASCINLA
Mb0471|M.bovis_AF2122/97 LKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIA
Rv0462|M.tuberculosis_H37Rv LKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIA
MUL_2214|M.ulcerans_Agy99 LKNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESIS
MLBr_02387|M.leprae_Br4923 LKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESIS
MSMEG_2611|M.smegmatis_MC2_155 FSALGVHVTIVVRGDGLLTHCDETICHRFNEIAATK-WDIRTHENVIGSH
* **:: . * . .. . .
MMAR_3101|M.marinum_M KRDSSVGGFELTPCAGAAPIAGSHLLLAVGRRPNTDDLGLEAAGVQTDAR
MAV_2396|M.avium_104 KTGN---GFELTSRDGAPPIRGSHLLLAVGRRPNTDDLDLAVAGVRTDAR
Mflv_3059|M.gilvum_PYR-GCK KRRN---GIAVTPRDGAAPIDASHLLVAVGRVPNTDDLGLEAAGVETDKR
Mvan_3468|M.vanbaalenii_PYR-1 KQAD---GFTVTPRAGAEPIGGSHLLVAVGRRPNTDDLNLEAAGVQTDSR
TH_3945|M.thermoresistible__bu RCDG---GVAVTPADGAEPVVGSHLLIAVGRRPNTDDLALDRAGVAVDER
MAB_3014|M.abscessus_ATCC_1997 RHDEG-VAVGVDCTDGAPKVVGSHVLVAVGRRPNTDDLGLENAGVATDAR
Mb0471|M.bovis_AF2122/97 DGGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDR
Rv0462|M.tuberculosis_H37Rv DGGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDR
MUL_2214|M.ulcerans_Agy99 DDGSA-VTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDR
MLBr_02387|M.leprae_Br4923 DNGSH-VLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTAD
MSMEG_2611|M.smegmatis_MC2_155 QDGDR----IVLELDDGKTVAADTLLVATGRVPNGDLLDAELAGVEVDED
: : .. :* * * ** : .**
MMAR_3101|M.marinum_M GYIVVDDQLKTSVDHIWAMGDCNGKGAFTHTSYNDFEIVAANLL----DD
MAV_2396|M.avium_104 GYILVDDQLKTNVEHIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mflv_3059|M.gilvum_PYR-GCK GYVVVDDQLRTSAENIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mvan_3468|M.vanbaalenii_PYR-1 GYIVVDDQLRTSADNIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
TH_3945|M.thermoresistible__bu GHIVVDDRLRTTAEHIWAMGDCNGRGAFTHTAYNDFEIVAANLL----DA
MAB_3014|M.abscessus_ATCC_1997 GYITVDDQLRTSTPGIWALGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mb0471|M.bovis_AF2122/97 KAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIA----GA
Rv0462|M.tuberculosis_H37Rv KAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIA----GA
MUL_2214|M.ulcerans_Agy99 KAIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIA----GA
MLBr_02387|M.leprae_Br4923 KAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIA----GA
MSMEG_2611|M.smegmatis_MC2_155 GRVIVDQYQRTTARGVFALGDVSSDYQLKHVANHEARVVKENLLRDWDDT
: :.: :*.. ::*:** .. : *.: :. : .
MMAR_3101|M.marinum_M DPRRVSDR-ITTYALYIDPPLGRAGMSVAQAQATGRKLLVGKRPMTRVGR
MAV_2396|M.avium_104 DPRRVSDR-ITTYALYIDPPLGRAGMTVAQVRASGRRALVGKRPMTRVGR
Mflv_3059|M.gilvum_PYR-GCK DPRRVSDR-ITTYALYIDPPLGRAGMTADEVRRTGRKALVGKRPMTRVGR
Mvan_3468|M.vanbaalenii_PYR-1 DPRRVSDR-VTTYALYIDPPLGRAGMTVEEVRRSGRKALVGKRPMTRVGR
TH_3945|M.thermoresistible__bu DPRGVGDR-VRAYAMYIDPPLGRAGMTEDEVRASGRKALLAKRPMSRVGR
MAB_3014|M.abscessus_ATCC_1997 DPRRVTDR-LPCYALYTDPPLGRVGMTEAQARASGRSLLVGRKPMSHVGR
Mb0471|M.bovis_AF2122/97 ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAK
Rv0462|M.tuberculosis_H37Rv ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAK
MUL_2214|M.ulcerans_Agy99 ETLPLGDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGK
MLBr_02387|M.leprae_Br4923 ETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAK
MSMEG_2611|M.smegmatis_MC2_155 ASLVASDHRFVPSAVFTDPQVATVGLTEAEARAAGHDIVVKVQNYGDTAY
. * . * : :* :. *:: :.: * : .
MMAR_3101|M.marinum_M AVEKGETQGFMKVVVDADTDEILGATIFGVGGDEAIHAILDVMSAKAPYT
MAV_2396|M.avium_104 AVEKGETQGFMKVVVDADTREILGAAILGVGGDEAIHGILDVMSAKAPYT
Mflv_3059|M.gilvum_PYR-GCK AVEKGETQGFMKVVVDAETEEILGASILGVGGDEVVHLILDVMTAKLPYT
Mvan_3468|M.vanbaalenii_PYR-1 AVEKGETQGFMKVVVDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYT
TH_3945|M.thermoresistible__bu AVEKGETQGFMKVLVDADTAEILGAAILGVGGDEVVHAIVDVMAARQPYT
MAB_3014|M.abscessus_ATCC_1997 ALEKGETDGYMQVLVDADSDLILGATILGVGGDEVVHCLLDTMQYGIPAR
Mb0471|M.bovis_AF2122/97 AHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTAS
Rv0462|M.tuberculosis_H37Rv AHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTAS
MUL_2214|M.ulcerans_Agy99 AHGLGDPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTAT
MLBr_02387|M.leprae_Br4923 AHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTAT
MSMEG_2611|M.smegmatis_MC2_155 GWAMEDTTGIAKLIGERGTGKLLGAHILGHQASSIIQPLIQAMSLGQTAQ
. :. * ::: : :**. :.* . : : . .
MMAR_3101|M.marinum_M TLSR-TMHIHPTVSELVPTMLQEMAPLV---
MAV_2396|M.avium_104 TLSR-TMHIHPTVSELIPTMLQQMSPLA---
Mflv_3059|M.gilvum_PYR-GCK AISR-TMHIHPTVSELVPTLLQDLHPLT---
Mvan_3468|M.vanbaalenii_PYR-1 AISR-TMHIHPTVSELIPTVLQELKPLA---
TH_3945|M.thermoresistible__bu AISR-TMHIHPTVSELLPTLLQDLQPLR---
MAB_3014|M.abscessus_ATCC_1997 QLQR-TVHIHPTVAEFLPTILGELQPLI---
Mb0471|M.bovis_AF2122/97 ELAR-NVHTHPTMSEALQECFHGLVGHMINF
Rv0462|M.tuberculosis_H37Rv ELAR-NVHTHPTMSEALQECFHGLVGHMINF
MUL_2214|M.ulcerans_Agy99 ELAR-NVHTHPTMSEALQECFHGLAGHMINF
MLBr_02387|M.leprae_Br4923 ELVR-NVHTHPTLSEALQECFHGLIGHMINF
MSMEG_2611|M.smegmatis_MC2_155 EIARGQYWIHPALPEVIENALLGLQE-----
: * **::.* : : :