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M. thermoresistible (build 8) TH_3945 (-)

annotation: pyridine nucleotide-disulphide oxidoreductase dimerisation region
coordinates: 80719 - 82068
length: 450

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3945--100% (450)pyridine nucleotide-disulphide oxidoreductase dimerisation region
M. thermoresistible (build 8)TH_3817-4e-5834.20% (462) PUTATIVE pyridine nucleotide-disulphide oxidoreductase
M. thermoresistible (build 8)TH_4200-6e-5030.60% (451) PUTATIVE dihydrolipoamide dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0471lpd1e-4931.35% (453) dihydrolipoamide dehydrogenase
M. gilvum PYR-GCKMflv_3059-0.075.45% (448) mercuric reductase
M. tuberculosis H37RvRv0462lpd1e-4931.35% (453) dihydrolipoamide dehydrogenase
M. leprae Br4923MLBr_02387lpd5e-4628.26% (453) dihydrolipoamide dehydrogenase
M. abscessus ATCC 19977MAB_3014-1e-15962.08% (451) mercuric reductase
M. marinum MMMAR_3101lpd_10.073.39% (451) dihydrolipoamide dehydrogenase Lpd_1
M. avium 104MAV_2396-0.076.56% (448) mercuric reductase
M. smegmatis MC2 155MSMEG_2611-4e-5231.82% (462) mycothione/glutathione reductase
M. ulcerans Agy99MUL_2214lpd1e-4628.51% (449) dihydrolipoamide dehydrogenase
M. vanbaalenii PYR-1Mvan_3468-0.076.34% (448) mercuric reductase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3101|M.marinum_M               ----MTQHYDAIVVGAGQAGPPLVGRLTAAGERVAIVERKHVGGTCVNSG
MAV_2396|M.avium_104                ----MTKHFDAIIVGAGQAGPPLAGRLTAAGQRVAIIERKLIGGTCVNTG
Mflv_3059|M.gilvum_PYR-GCK          MSETATQKFDAIIIGAGQAGPPLAARLTAAGQTVAVIERKLVGGTCVNYG
Mvan_3468|M.vanbaalenii_PYR-1       ---MSAQHFDAIIVGAGQAGPPLAGRLTAAGQTVAVIERKLVGGTCVNYG
TH_3945|M.thermoresistible__bu      -----------MIIGAGQAGPPLAGRLADAGQRVVLIERRLIGGTCVNYG
MAB_3014|M.abscessus_ATCC_1997      ----MSTHFDAVVVGAGQAGPSLAARLRGAGLTVAIVERHLFGGTCVNTG
Mb0471|M.bovis_AF2122/97            -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
Rv0462|M.tuberculosis_H37Rv         -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVG
MUL_2214|M.ulcerans_Agy99           -----MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVG
MLBr_02387|M.leprae_Br4923          -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVG
MSMEG_2611|M.smegmatis_MC2_155      -----MEHYDLAIIGTGSGNSIVDDR--YAGKKVAICEQGTFGGTCLNVG
                                                ::*:* ..     *    *  ..: *    ** *:* *

MMAR_3101|M.marinum_M               CIPTKTLVASAHAAQLARRGAEYGVGTG-PISVDMAKVKARKDGIMLADR
MAV_2396|M.avium_104                CIPTKTLVASAHAAHLARRGADYGVGTG-AISVDMAKVKARKDEIMLGDR
Mflv_3059|M.gilvum_PYR-GCK          CIPTKTLVASAHAAHLARRGADFGIGTS-EVTVDMAAVKARKDRISGGDR
Mvan_3468|M.vanbaalenii_PYR-1       CIPTKTLVASAHAAHLARRGNDFGVAAA-GVTVDMAAVKARKDRISVGDR
TH_3945|M.thermoresistible__bu      CIPTKTLVASAHAAHLARRAADYGVRTG-PVTVDMARVKARKDAIMLDDR
MAB_3014|M.abscessus_ATCC_1997      CRPTKALVASAHAAHMAREAARWGVVVDGSVSMDMVRVRERKDAVILPSR
Mb0471|M.bovis_AF2122/97            CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
Rv0462|M.tuberculosis_H37Rv         CIPSKALLRNAELVHIFTKDAKAFGISG-EVTFDYGIAYDRSRKVAEGRV
MUL_2214|M.ulcerans_Agy99           CIPSKALLRNAELAHIFTKDAKAFGISG-EATFDYGVAFDRSRKVAEGRV
MLBr_02387|M.leprae_Br4923          CIPSKVLLHNAELAHIFTKEAKTFGISG-DASFDYGIAYDRSRKVSEGRV
MSMEG_2611|M.smegmatis_MC2_155      CIPTKMFVYAAEVAHSVRTSARYGVDAH-IDKVRWPDIVERVFGRIDPIA
                                    * *:* ::  *. .:                ..       *         

MMAR_3101|M.marinum_M               KGVEDWLDGMNGCTVFRGHARFEDPHTLRVGDDLLSADR---IFLN---V
MAV_2396|M.avium_104                KGVEDWLAGMAGCTVVRGHARFRDPHTLQVGEDLLRAER---IFLN---V
Mflv_3059|M.gilvum_PYR-GCK          EGLESWLDGMDGATLIRGHARFESPNTVRVDGTLLGAER---IFLN---V
Mvan_3468|M.vanbaalenii_PYR-1       EGLESWLAGMKGCTLIRGHARFENPHTLRVDDQLLEADR---IFLN---V
TH_3945|M.thermoresistible__bu      RGLESWLQGMDGCTVVRGHARFEDPHTVRVGERLLSADR---IFLN---V
MAB_3014|M.abscessus_ATCC_1997      NGGQTWLKDLG-CAIYHEHASFLSPTELSVGDEIISAER---IFLN---V
Mb0471|M.bovis_AF2122/97            AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
Rv0462|M.tuberculosis_H37Rv         AG-VHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAII
MUL_2214|M.ulcerans_Agy99           AG-VHFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAII
MLBr_02387|M.leprae_Br4923          AG-VHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVII
MSMEG_2611|M.smegmatis_MC2_155      AGGEDYRRSDPNITVYSSHTRFG--PKTDDGRYTLRTESGEEFTSDQVVI
                                     *   :       :    :  *              .:    .  :   :

MMAR_3101|M.marinum_M               GGRAVAPNIPG--LADIDFLTNVSILELDTLPEHLVIVGGSYIALEFAQM
MAV_2396|M.avium_104                GGRAVVPDIPG--LAEVDFLTNVSILELDRLPTHLVIVGGSYIALEFAQM
Mflv_3059|M.gilvum_PYR-GCK          GGRAVVPDIPG--LADVDYLTNVGILDLGVVPEHLVIIGGSYIALEFAQM
Mvan_3468|M.vanbaalenii_PYR-1       GGRAVAPDMPG--LADVDYLTNVGILDLDEVPEHLVVIGGSYIALEFAQM
TH_3945|M.thermoresistible__bu      GGRAVVPDLPG--LADVDHLTNVSMLELDTLPEHLVIVGGGYIALEFAQM
MAB_3014|M.abscessus_ATCC_1997      GGRAVVPDWPG--VDDVPLFTNSSLIEYDGIPEHLVVIGGSYVGLEFAQI
Mb0471|M.bovis_AF2122/97            ATGSSTRLVPGT-SLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYV
Rv0462|M.tuberculosis_H37Rv         ATGSSTRLVPGT-SLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYV
MUL_2214|M.ulcerans_Agy99           ATGSSTRLVPGT-SLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYV
MLBr_02387|M.leprae_Br4923          ATGSKTRLVPGT-LLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYV
MSMEG_2611|M.smegmatis_MC2_155      AAGSRTYIPPAVVDCGVKYHTSDDIMRIPELPTDLVIIGGGFVSAEFAHV
                                    .  : .   *.         *    :    :*  ::: *.. :. **. :

MMAR_3101|M.marinum_M               YRRFGAPVTVVERGPRLASREDEDVSATIREILEAEGINVVVGADDVRIT
MAV_2396|M.avium_104                YRRFGAAVTVVERGPRLASREDEDVSAAVQEILRAEGIDIVVNADDVRIA
Mflv_3059|M.gilvum_PYR-GCK          YRRFGAEVTVVEKGPRLTAREDEDVSAVIKDILEAEGIRVELGADAISVA
Mvan_3468|M.vanbaalenii_PYR-1       YRRFGAAVTVIERGPRLTAREDEDVSAAIKEILEAEGIDVVVGADAISFA
TH_3945|M.thermoresistible__bu      YRRFGARVTVVQRGSRLASHEDADVSAAIHDILAGEGIDIVVDASAIRFA
MAB_3014|M.abscessus_ATCC_1997      YRRFGSQVTVVHRGPRLVEREDPDASAIIQEVLEREGITFRLNASCINLA
Mb0471|M.bovis_AF2122/97            LKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIA
Rv0462|M.tuberculosis_H37Rv         LKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIA
MUL_2214|M.ulcerans_Agy99           LKNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESIS
MLBr_02387|M.leprae_Br4923          LKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESIS
MSMEG_2611|M.smegmatis_MC2_155      FSALGVHVTIVVRGDGLLTHCDETICHRFNEIAATK-WDIRTHENVIGSH
                                        *  **::        . *   .  ..         .    .     

MMAR_3101|M.marinum_M               KRDSSVGGFELTPCAGAAPIAGSHLLLAVGRRPNTDDLGLEAAGVQTDAR
MAV_2396|M.avium_104                KTGN---GFELTSRDGAPPIRGSHLLLAVGRRPNTDDLDLAVAGVRTDAR
Mflv_3059|M.gilvum_PYR-GCK          KRRN---GIAVTPRDGAAPIDASHLLVAVGRVPNTDDLGLEAAGVETDKR
Mvan_3468|M.vanbaalenii_PYR-1       KQAD---GFTVTPRAGAEPIGGSHLLVAVGRRPNTDDLNLEAAGVQTDSR
TH_3945|M.thermoresistible__bu      RCDG---GVAVTPADGAEPVVGSHLLIAVGRRPNTDDLALDRAGVAVDER
MAB_3014|M.abscessus_ATCC_1997      RHDEG-VAVGVDCTDGAPKVVGSHVLVAVGRRPNTDDLGLENAGVATDAR
Mb0471|M.bovis_AF2122/97            DGGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDR
Rv0462|M.tuberculosis_H37Rv         DGGSQ-VTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDR
MUL_2214|M.ulcerans_Agy99           DDGSA-VTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDR
MLBr_02387|M.leprae_Br4923          DNGSH-VLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTAD
MSMEG_2611|M.smegmatis_MC2_155      QDGDR----IVLELDDGKTVAADTLLVATGRVPNGDLLDAELAGVEVDED
                                              :        : .. :* * *  ** :      .**     

MMAR_3101|M.marinum_M               GYIVVDDQLKTSVDHIWAMGDCNGKGAFTHTSYNDFEIVAANLL----DD
MAV_2396|M.avium_104                GYILVDDQLKTNVEHIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mflv_3059|M.gilvum_PYR-GCK          GYVVVDDQLRTSAENIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mvan_3468|M.vanbaalenii_PYR-1       GYIVVDDQLRTSADNIWAMGDCNGRGAFTHTSYNDFEIVAANLL----DD
TH_3945|M.thermoresistible__bu      GHIVVDDRLRTTAEHIWAMGDCNGRGAFTHTAYNDFEIVAANLL----DA
MAB_3014|M.abscessus_ATCC_1997      GYITVDDQLRTSTPGIWALGDCNGRGAFTHTSYNDFEIVAANLL----DD
Mb0471|M.bovis_AF2122/97            KAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIA----GA
Rv0462|M.tuberculosis_H37Rv         KAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIA----GA
MUL_2214|M.ulcerans_Agy99           KAIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIA----GA
MLBr_02387|M.leprae_Br4923          KAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIA----GA
MSMEG_2611|M.smegmatis_MC2_155      GRVIVDQYQRTTARGVFALGDVSSDYQLKHVANHEARVVKENLLRDWDDT
                                      : :.:  :*..  ::*:** ..   : *.:     :.   :     . 

MMAR_3101|M.marinum_M               DPRRVSDR-ITTYALYIDPPLGRAGMSVAQAQATGRKLLVGKRPMTRVGR
MAV_2396|M.avium_104                DPRRVSDR-ITTYALYIDPPLGRAGMTVAQVRASGRRALVGKRPMTRVGR
Mflv_3059|M.gilvum_PYR-GCK          DPRRVSDR-ITTYALYIDPPLGRAGMTADEVRRTGRKALVGKRPMTRVGR
Mvan_3468|M.vanbaalenii_PYR-1       DPRRVSDR-VTTYALYIDPPLGRAGMTVEEVRRSGRKALVGKRPMTRVGR
TH_3945|M.thermoresistible__bu      DPRGVGDR-VRAYAMYIDPPLGRAGMTEDEVRASGRKALLAKRPMSRVGR
MAB_3014|M.abscessus_ATCC_1997      DPRRVTDR-LPCYALYTDPPLGRVGMTEAQARASGRSLLVGRKPMSHVGR
Mb0471|M.bovis_AF2122/97            ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAK
Rv0462|M.tuberculosis_H37Rv         ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAK
MUL_2214|M.ulcerans_Agy99           ETLPLGDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGK
MLBr_02387|M.leprae_Br4923          ETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAK
MSMEG_2611|M.smegmatis_MC2_155      ASLVASDHRFVPSAVFTDPQVATVGLTEAEARAAGHDIVVKVQNYGDTAY
                                     .    *  .   * : :* :.  *::  :.:  *    :        . 

MMAR_3101|M.marinum_M               AVEKGETQGFMKVVVDADTDEILGATIFGVGGDEAIHAILDVMSAKAPYT
MAV_2396|M.avium_104                AVEKGETQGFMKVVVDADTREILGAAILGVGGDEAIHGILDVMSAKAPYT
Mflv_3059|M.gilvum_PYR-GCK          AVEKGETQGFMKVVVDAETEEILGASILGVGGDEVVHLILDVMTAKLPYT
Mvan_3468|M.vanbaalenii_PYR-1       AVEKGETQGFMKVVVDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYT
TH_3945|M.thermoresistible__bu      AVEKGETQGFMKVLVDADTAEILGAAILGVGGDEVVHAIVDVMAARQPYT
MAB_3014|M.abscessus_ATCC_1997      ALEKGETDGYMQVLVDADSDLILGATILGVGGDEVVHCLLDTMQYGIPAR
Mb0471|M.bovis_AF2122/97            AHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTAS
Rv0462|M.tuberculosis_H37Rv         AHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTAS
MUL_2214|M.ulcerans_Agy99           AHGLGDPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTAT
MLBr_02387|M.leprae_Br4923          AHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTAT
MSMEG_2611|M.smegmatis_MC2_155      GWAMEDTTGIAKLIGERGTGKLLGAHILGHQASSIIQPLIQAMSLGQTAQ
                                    .    :. *  ::: :     :**. :.*    . :  :  .     .  

MMAR_3101|M.marinum_M               TLSR-TMHIHPTVSELVPTMLQEMAPLV---
MAV_2396|M.avium_104                TLSR-TMHIHPTVSELIPTMLQQMSPLA---
Mflv_3059|M.gilvum_PYR-GCK          AISR-TMHIHPTVSELVPTLLQDLHPLT---
Mvan_3468|M.vanbaalenii_PYR-1       AISR-TMHIHPTVSELIPTVLQELKPLA---
TH_3945|M.thermoresistible__bu      AISR-TMHIHPTVSELLPTLLQDLQPLR---
MAB_3014|M.abscessus_ATCC_1997      QLQR-TVHIHPTVAEFLPTILGELQPLI---
Mb0471|M.bovis_AF2122/97            ELAR-NVHTHPTMSEALQECFHGLVGHMINF
Rv0462|M.tuberculosis_H37Rv         ELAR-NVHTHPTMSEALQECFHGLVGHMINF
MUL_2214|M.ulcerans_Agy99           ELAR-NVHTHPTMSEALQECFHGLAGHMINF
MLBr_02387|M.leprae_Br4923          ELVR-NVHTHPTLSEALQECFHGLIGHMINF
MSMEG_2611|M.smegmatis_MC2_155      EIARGQYWIHPALPEVIENALLGLQE-----
                                     : *     **::.* :   :  :