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NMGRNFLSSLGIVSPAAVPSTSVRGNRVNGAQAIEYVIRRAGTQIGIPYSWGGGSLAGPSRGVDQGARTV GFDCSGLTRFAFAGVGVLLPRSSGDQYDVGRKVPPSQAKRGDLLFWGPGGSQHEAIYLGGGQMIEAQQTG VPIKVSPARTAGTTPYVVRIIET*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2872 | - | - | 100% (164) | NLP/P60 protein |
| M. gilvum PYR-GCK | Mflv_2843 | - | 2e-86 | 93.29% (164) | NLP/P60 protein |
| M. gilvum PYR-GCK | Mflv_0902 | - | 3e-85 | 91.46% (164) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1514 | - | 7e-59 | 61.76% (170) | invasion protein |
| M. tuberculosis H37Rv | Rv1478 | - | 7e-59 | 61.76% (170) | invasion protein |
| M. leprae Br4923 | MLBr_01812 | - | 6e-56 | 59.76% (169) | putative exported p60 protein homologue |
| M. abscessus ATCC 19977 | MAB_2727c | - | 2e-48 | 56.79% (162) | invasion protein Inv2 |
| M. marinum M | MMAR_2285 | iipB | 2e-57 | 61.90% (168) | invasion and intracellular persistence protein, IipB |
| M. avium 104 | MAV_3301 | - | 1e-55 | 59.52% (168) | invasion protein |
| M. smegmatis MC2 155 | MSMEG_3146 | - | 4e-60 | 65.66% (166) | invasin 1 |
| M. thermoresistible (build 8) | TH_4058 | - | 4e-59 | 64.63% (164) | PUTATIVE NLP/P60 protein |
| M. ulcerans Agy99 | MUL_1487 | inv2 | 1e-57 | 61.90% (168) | invasion protein Inv2 |
| M. vanbaalenii PYR-1 | Mvan_3652 | - | 6e-86 | 91.46% (164) | NLP/P60 protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01812|M.leprae_Br4923 MKRPRRGSVSRPTARFVRPAIPSLVSAALLVSLPVLATADPDGDNLGTLI
MAV_3301|M.avium_104 --------------------MPSVLSVALLICTPGLAQADPAADNLAALI
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3146|M.smegmatis_MC2_155 --------------------------------------------------
TH_4058|M.thermoresistible__bu --------------------------------------------------
Mb1514|M.bovis_AF2122/97 --------------------------------------------------
Rv1478|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2285|M.marinum_M --------------------------------------------------
MUL_1487|M.ulcerans_Agy99 --------------------------------------------------
MAB_2727c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01812|M.leprae_Br4923 ADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAEHDCEVSQQ
MAV_3301|M.avium_104 ANVAKANQRLQNLSAEIQTEQESVNKALVDVETARDNAAAAQHDLEASQQ
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3146|M.smegmatis_MC2_155 --------------------------------------------------
TH_4058|M.thermoresistible__bu --------------------------------------------------
Mb1514|M.bovis_AF2122/97 --------------------------------------------------
Rv1478|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2285|M.marinum_M --------------------------------------------------
MUL_1487|M.ulcerans_Agy99 --------------------------------------------------
MAB_2727c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01812|M.leprae_Br4923 SVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDIIATATAART
MAV_3301|M.avium_104 AVKDANAAIAGAQRRFDTFAAAAYMNGPSNSYLTARNPDDIIATEAAAKT
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3146|M.smegmatis_MC2_155 --------------------------------------------------
TH_4058|M.thermoresistible__bu --------------------------------------------------
Mb1514|M.bovis_AF2122/97 --------------------------------------------------
Rv1478|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2285|M.marinum_M --------------------------------------------------
MUL_1487|M.ulcerans_Agy99 --------------------------------------------------
MAB_2727c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01812|M.leprae_Br4923 LTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKASMDAAVAA
MAV_3301|M.avium_104 LTASSQTVMAKLQQARTEQVNRESAARLAKQNADKAAADAKASQDAAVAA
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 ------------------------------------MESHVRSKGAPTAR
MSMEG_3146|M.smegmatis_MC2_155 --------------------------------------------------
TH_4058|M.thermoresistible__bu --------------------------------------------------
Mb1514|M.bovis_AF2122/97 --------------------------------------------------
Rv1478|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2285|M.marinum_M --------------------------------------------------
MUL_1487|M.ulcerans_Agy99 --------------------------------------------------
MAB_2727c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01812|M.leprae_Br4923 LTASKRKFDEQRDEVNRLAAERDEAQARLEVAQIAAATWVPGMGGHGTPP
MAV_3301|M.avium_104 LTNSRQKFDEQREQMIRLATERDQAQAKLEAAKRQLS----------TPG
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 ADRCDPTILVAAQAVRRLSG------VIAIVVLLFLA-------------
MSMEG_3146|M.smegmatis_MC2_155 -------------MVLRALI------AVVAVAFAAVG-------------
TH_4058|M.thermoresistible__bu ---VVILLRSKTFRLLRPLI------PAILGLGVLIA-------------
Mb1514|M.bovis_AF2122/97 -------MRHTRFHPIKLAW------ITAVVAGLMVG-------------
Rv1478|M.tuberculosis_H37Rv -------MRHTRFHPIKLAW------ITAVVAGLMVG-------------
MMAR_2285|M.marinum_M MSSYRGPMRYKRFRLLGLAW------ITLAVAALLVV-------------
MUL_1487|M.ulcerans_Agy99 -------MRYKRFRLLGLAW------ITLAVAALMVV-------------
MAB_2727c|M.abscessus_ATCC_199 ---------MQGLFLLRSAIA-----VTIAIALVLFMG------------
MLBr_01812|M.leprae_Br4923 FGDRWEPGSPASAGPAGGRKWDG-WDPTLPQVPSANVPG---DP-IAVIN
MAV_3301|M.avium_104 SGDRWETGSAGAPAPSAGRQWDGAWDPTLPMIPSANVPG---DP-IAVIN
Mflv_2872|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3652|M.vanbaalenii_PYR-1 -----------CAPVASAQPAAGPWDPLLPKVASAGAPG---DP-VAIAN
MSMEG_3146|M.smegmatis_MC2_155 -----------LVAPAGAAPEDGQWDPTLPKLISAGAPG---DP-LAIAN
TH_4058|M.thermoresistible__bu -----------AAGPATAAPDDGQWDPTLPKLISAGAPG---DP-LAIAN
Mb1514|M.bovis_AF2122/97 -----------VATPADAEP--GQWDPTLPALVSAGAPG---DP-LAVAN
Rv1478|M.tuberculosis_H37Rv -----------VATPADAEP--GQWDPTLPALVSAGAPG---DP-LAVAN
MMAR_2285|M.marinum_M -----------VSAPADADP--GGWDPTLPATASAGAPG---DA-LAMAN
MUL_1487|M.ulcerans_Agy99 -----------VSAPADADP--GGWDPTLPATASAGAPG---DA-LAMAN
MAB_2727c|M.abscessus_ATCC_199 ----------VPRAAADDNPLGPNVGTAFLNALGLNPTGGQYDPTLPFAG
MLBr_01812|M.leprae_Br4923 QVLGYA-ATSTQVTASMGRNFLQQLGILKPNDTGITNAPIGSTQGRIPRV
MAV_3301|M.avium_104 QVLGIS-ATSTQVTAGLGRNFLQQLGILKPDDTGITNAAPGGVGARIPRV
Mflv_2872|M.gilvum_PYR-GCK --------------MNMGRNFLSSLG--IVS--PAAVPSTSVRGNRVN--
Mvan_3652|M.vanbaalenii_PYR-1 ASLQAT-AMATQTAMSMGRNFLSSLG--LVS--PAADPSTSVRGNRVN--
MSMEG_3146|M.smegmatis_MC2_155 ASLEAT-AQATQVTMGLGRKFLASLG--LVE---DTPAAAGVAPGRVR--
TH_4058|M.thermoresistible__bu ASLAAT-AQATQVTMDLGRKFLASIG--LGG---SQPVSS-VAPGRVR--
Mb1514|M.bovis_AF2122/97 ASLQAT-AQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASRIPRA
Rv1478|M.tuberculosis_H37Rv ASLQAT-AQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASRIPRA
MMAR_2285|M.marinum_M ASLQAT-AQATQTTLDLGRQFLGGLGINLGG--SPAPSAANTGANRIPRV
MUL_1487|M.ulcerans_Agy99 ASLQAT-AQATQTTLDLGRQFLGGLGINLGG--SPAPSAANTGANRIPRV
MAB_2727c|M.abscessus_ATCC_199 PSQGADPAKIMNGVMGVGQTALGALG---------IGGNSASAGAGRPLV
.:*: * :*
MLBr_01812|M.leprae_Br4923 YGRQASEYVIRRGISQIGVPYSWGGGNAAGPSRGIDSGAGITGFDCSGLV
MAV_3301|M.avium_104 YGRQATEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGANIVGFDCSGLV
Mflv_2872|M.gilvum_PYR-GCK -GAQAIEYVIRRAGTQIGIPYSWGGGSLAGPSRGVDQGARTVGFDCSGLT
Mvan_3652|M.vanbaalenii_PYR-1 -GAQAIEYVIRRAGTQIGVPYSWGGGSLTGPSRGVDQGAGTVGFDCSGLT
MSMEG_3146|M.smegmatis_MC2_155 -GPQAIEYVIRRGGTQMGVPYSWGGGKPNGPSRGIDSGANTVGFDCSGFT
TH_4058|M.thermoresistible__bu -GPQAIEYVIRRGASQLGVPYSWGGGKPSGPSTGVGSGANTVGFDCSGFT
Mb1514|M.bovis_AF2122/97 NARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLV
Rv1478|M.tuberculosis_H37Rv NARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLV
MMAR_2285|M.marinum_M YGQQALEYVIRRGGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLM
MUL_1487|M.ulcerans_Agy99 YGRQALEYVIRRGGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLM
MAB_2727c|M.abscessus_ATCC_199 YGRAAVERVIQRGGTQLGVPYSWGGGTVRGPSGGVDYDSGKVGYDCSGFT
. * * **:*. :*:*:*******. *** *:. .: .*:****:
MLBr_01812|M.leprae_Br4923 LYSFAGVGIRLPHYSGSQYNLGRKIPSAQMRRGDVIFYGPGGSQHVTIYL
MAV_3301|M.avium_104 LYSFAGVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPGGSQHVTIYL
Mflv_2872|M.gilvum_PYR-GCK RFAFAGVGVLLPRSSGDQYDVGRKVPPSQAKRGDLLFWGPGGSQHEAIYL
Mvan_3652|M.vanbaalenii_PYR-1 RFAFAGVGVLLPRWSGDQYDAGRKVPPSQAKRGDLLFWGPGGSQHEAIYL
MSMEG_3146|M.smegmatis_MC2_155 QFSFAGVGVLIPKYSGDQYNTGRKVPVNQAKRGDLLFWGPGGSQHVALYL
TH_4058|M.thermoresistible__bu QFAFAGVGVLIPKYSGDQYNTGRKVPVSQAKRGDLLFWGPGGSQHVALYL
Mb1514|M.bovis_AF2122/97 RYAFAGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYL
Rv1478|M.tuberculosis_H37Rv RYAFAGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYL
MMAR_2285|M.marinum_M RYAFAGVGVLIPRYSGDQYNAGRHISPDQARRGDLIFYGPGGSQHVTMYL
MUL_1487|M.ulcerans_Agy99 RYAFAGVGVLIPRYSGDQYNAGRHISPDQARRGDLIFYGPGGSQHVTMYL
MAB_2727c|M.abscessus_ATCC_199 MFSYAAAGVKLPKYSGDQYNAGQKVPVAQAKRGDLLFYGPGGSQHVVIYL
:::*..*: :*: **.**: *:::. : :***::*:****.** .:**
MLBr_01812|M.leprae_Br4923 GHGQMLEAPDIGLRVRVAPVRTSGMTPYVVRYIEY
MAV_3301|M.avium_104 GDGQMLEAPDIGLKVRVAPVRTSGMTPYVVRYIEW
Mflv_2872|M.gilvum_PYR-GCK GGGQMIEAQQTGVPIKVSPARTAGTTPYVVRIIET
Mvan_3652|M.vanbaalenii_PYR-1 GGGQMLEAQQTGVPIKISPVRTSGMTPYVVRIIES
MSMEG_3146|M.smegmatis_MC2_155 GGGKMLEASGSAGKVTVSPVRMSGLQPYAARIIES
TH_4058|M.thermoresistible__bu GNGQMLEASGSAGKVVAGPVRTAGLQPYAARIIET
Mb1514|M.bovis_AF2122/97 GNGQMLEASGSAGKVTVSPVRKAGMTPFVTRIIEY
Rv1478|M.tuberculosis_H37Rv GNGQMLEASGSAGKVTVSPVRKAGMTPFVTRIIEY
MMAR_2285|M.marinum_M GNGQMLEASGSAGKVTVSPVRKAGMTPFVTRIIEY
MUL_1487|M.ulcerans_Agy99 GNGQMLEASGSAGKVTVSPVRKAGMTPFVTRIIEY
MAB_2727c|M.abscessus_ATCC_199 GNGQMLEASGSAGKVTVSPVRTGGMTPYAVRIIAW
* *:*:** . : .*.* .* *:..* *