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WSMEHHPGRSPEQAKGYRALVVDDELPLAEVVASYLERDQFEAVVAGNGVDAIAVARDFDPDVVILDLGL PGIDGLEVCRQLRTFSDAYVVMLTARDTELDTVLGLTVGADDYITKPFSPRELVARVRAMLRRPRVLQSA TATAEREVAPPRRFGALSVDVAAREVGIDDEQILLTRTEFDILEALSGRPGIVLSRRQLLEIVRDGPWVG NEHLVDVHIGHLRRKLGDDAARPRYIATVRGVGYRMGTGQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2838 | - | - | 100% (251) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0893 | - | e-130 | 92.03% (251) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3887 | - | e-120 | 85.20% (250) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3274c | mtrA | 5e-46 | 45.22% (230) | two component sensory transduction transcriptional |
| M. tuberculosis H37Rv | Rv3246c | mtrA | 5e-46 | 45.22% (230) | two component sensory transduction transcriptional |
| M. leprae Br4923 | MLBr_00773 | mtrA | 7e-46 | 44.78% (230) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3339 | - | 1e-91 | 68.67% (233) | putative sensory transduction protein |
| M. marinum M | MMAR_1299 | mtrA | 7e-46 | 45.22% (230) | two-component sensory transduction transcriptional |
| M. avium 104 | MAV_4209 | - | 5e-46 | 45.22% (230) | DNA-binding response regulator MtrA |
| M. smegmatis MC2 155 | MSMEG_0937 | regX3 | 2e-47 | 44.93% (227) | DNA-binding response regulator RegX3 |
| M. thermoresistible (build 8) | TH_4129 | - | 4e-47 | 45.65% (230) | PUTATIVE DNA-binding response regulator MtrA |
| M. ulcerans Agy99 | MUL_4560 | regX3 | 6e-46 | 43.61% (227) | two component sensory transduction protein RegX3 |
| M. vanbaalenii PYR-1 | Mvan_1834 | - | 1e-117 | 83.40% (247) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00773|M.leprae_Br4923 -------------MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGD
MMAR_1299|M.marinum_M ----------------MRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGD
Mb3274c|M.bovis_AF2122/97 -------------MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGD
Rv3246c|M.tuberculosis_H37Rv -------------MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGD
MAV_4209|M.avium_104 -------------MDSMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGD
TH_4129|M.thermoresistible__bu ------LSRFGDNMDTMRQRILVVDDDPSLAEMLTIVLRGEGFDTAVIGD
MSMEG_0937|M.smegmatis_MC2_155 --------------------MLIVEDEESLADPLAFLLRKEGFEATVVGD
MUL_4560|M.ulcerans_Agy99 -----------------MTSVLIVEDEESLADPLAFLLRKEGFEATVVTD
Mflv_2838|M.gilvum_PYR-GCK MWSME-HHPGRSPEQAKGYRALVVDDELPLAEVVASYLERDQFEAVVAGN
Mvan_1834|M.vanbaalenii_PYR-1 ---ME-REKAAPGGRAAGYRALVVDDEVPLAEVIAGYLEREQFETIVAAN
MAB_3339|M.abscessus_ATCC_1997 ---MDGSSRTAAAGPVPDYRALVVDDEVPLAEVVASYLKRESFEVHLAHD
*:*:*: .**: :: *. : *:. : :
MLBr_00773|M.leprae_Br4923 GTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTD
MMAR_1299|M.marinum_M GTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTD
Mb3274c|M.bovis_AF2122/97 GTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTD
Rv3246c|M.tuberculosis_H37Rv GTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTD
MAV_4209|M.avium_104 GTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTD
TH_4129|M.thermoresistible__bu GSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKSD
MSMEG_0937|M.smegmatis_MC2_155 GPSALAEFERSGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDS
MUL_4560|M.ulcerans_Agy99 GPAALAEFDRSGADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDS
Mflv_2838|M.gilvum_PYR-GCK GVDAIAVARDFDPDVVILDLGLPGIDGLEVCRQLRTFSDAYVVMLTARDT
Mvan_1834|M.vanbaalenii_PYR-1 GLDAISVARELDPDVVILDLGLPGIDGLEVCRQIRTFSDAYVVMLTARDT
MAB_3339|M.abscessus_ATCC_1997 GRRALDLAREVDPDVVILDIGLPGVDGIEVCRQLRVFSDAYVVMLTARDT
* *: .*:*:**: ***:.* :**: :*. *.. ::*:**:
MLBr_00773|M.leprae_Br4923 TVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----NDD-----EP
MMAR_1299|M.marinum_M TVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----NDD-----EP
Mb3274c|M.bovis_AF2122/97 TVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----NDD-----EP
Rv3246c|M.tuberculosis_H37Rv TVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----NDD-----EP
MAV_4209|M.avium_104 TVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----NDD-----EP
TH_4129|M.thermoresistible__bu TVDVVLGLESGADDYVVKPFKPKELVARVRARLRR-----NED-----EP
MSMEG_0937|M.smegmatis_MC2_155 EIDKVVGLELGADDYVTKPYSARELIARIRAVLRR-----GADNDDAGAD
MUL_4560|M.ulcerans_Agy99 EIDKVVGLELGADDYVTKPYSARELIARIRAVLRR-----GGD-DDSEVS
Mflv_2838|M.gilvum_PYR-GCK ELDTVLGLTVGADDYITKPFSPRELVARVRAMLRRPRVLQSATATAEREV
Mvan_1834|M.vanbaalenii_PYR-1 EIDTVLGLTVGADDYVTKPFSPRELVARIRAMLRRPRVLHTAGAAAERNV
MAB_3339|M.abscessus_ATCC_1997 EVDTIVGLSVGADDYVTKPFSPREVVARVRAMLRRPRRAPESPAAVTPEL
:* ::** *****: **:..:*::**:** ***
MLBr_00773|M.leprae_Br4923 AEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDV
MMAR_1299|M.marinum_M AEMLSIADVDIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDV
Mb3274c|M.bovis_AF2122/97 AEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDV
Rv3246c|M.tuberculosis_H37Rv AEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDV
MAV_4209|M.avium_104 AEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDV
TH_4129|M.thermoresistible__bu AEMLSIGDIDIDVPAHKVTRNGEQIQLTPLEFDLLVALARKPRQVFTRDV
MSMEG_0937|M.smegmatis_MC2_155 DGVLEAGPVRMDVERHVVSVNGEPITLPLKEFDLLEYLMRNSGRVLTRGQ
MUL_4560|M.ulcerans_Agy99 DGVLESGPVRMDVERHVVSVNGDAITLPLKEFDLLEYLMRNSGRVLTRGQ
Mflv_2838|M.gilvum_PYR-GCK APPRRFGALSVDVAAREVGIDDEQILLTRTEFDILEALSGRPGIVLSRRQ
Mvan_1834|M.vanbaalenii_PYR-1 TPPRQFGPLSIDVAAREVRIDGEPILLTRTEFDILEALSGHPGIVLSRRQ
MAB_3339|M.abscessus_ATCC_1997 SPPRVFGALRINVDGREVHVGERPVTLTRTEFDVLAALSSRPGIVLSRKQ
. : ::* : * . : *. ***:* * .. *::*
MLBr_00773|M.leprae_Br4923 LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGP
MMAR_1299|M.marinum_M LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGP
Mb3274c|M.bovis_AF2122/97 LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGP
Rv3246c|M.tuberculosis_H37Rv LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGP
MAV_4209|M.avium_104 LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGP
TH_4129|M.thermoresistible__bu LLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPQVVLTVRGVGYKAGP
MSMEG_0937|M.smegmatis_MC2_155 LIDRVWGADYVGDTKTLDVHVKRLRSKIEEDPANPVHLVTVRGLGYKLEG
MUL_4560|M.ulcerans_Agy99 LIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTVRGLGYKLEG
Mflv_2838|M.gilvum_PYR-GCK LLEIVRDGPWVGNEHLVDVHIGHLRRKLGDDAARPRYIATVRGVGYRMGT
Mvan_1834|M.vanbaalenii_PYR-1 LIEIVRDGPWVGNEHLVDVHIGHLRRKLGDDAAQPRYIRTVRGVGYRMGT
MAB_3339|M.abscessus_ATCC_1997 LLDTVWGDTWVGNDNIVDVHVGHLRQKLGDSPSQPRYVMTVRGVGYRMGT
*:: * . .: . ::**: :** *: .. .* : ****:**:
MLBr_00773|M.leprae_Br4923 P----
MMAR_1299|M.marinum_M P----
Mb3274c|M.bovis_AF2122/97 P----
Rv3246c|M.tuberculosis_H37Rv P----
MAV_4209|M.avium_104 P----
TH_4129|M.thermoresistible__bu P----
MSMEG_0937|M.smegmatis_MC2_155 -----
MUL_4560|M.ulcerans_Agy99 -----
Mflv_2838|M.gilvum_PYR-GCK GQ---
Mvan_1834|M.vanbaalenii_PYR-1 GSGAD
MAB_3339|M.abscessus_ATCC_1997 GS---