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RPEDVSDVVVIGAGIVGCAIARALAGTHLSVTLVEARDDVGDGTSKANTALLHTGFDATPGTLESRLVAR GYHLLGEYAEQTGIPVERTGAMLVAWTDEEADALPGLMVKAERNGYRDCDLVRSEEVYRRVPDLGLGALG GLGVPGESIICTWTTNLALATDAVARGARLLRGARVTGVQPGPEHTTLHTTAGDVRGRWIINAAGLGADH LDTEFGHRRFTVTPRRGELLVFDKLTRPMVPLIVLAVPSSRGKGVLVSPTIYGNVMVGPTSENLDDRTAT GTSEHGFEFLVSKGRALMPALFEEEVTATYAGLRAAADHDDYLIDLDERLRYVLVGGIRSTGLTSGMAVA EYVSGLLARAGVAVDERDDLPPPPRMPNIGEAGLRPYQDADRVAADPEYGRIVCFCERVTAGEIRDAFGS LIPPADLDGLRRRTRVMNGRCQGFYCGAHTEALLEALLETGALR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2649 | - | - | 100% (465) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3531 | - | 1e-24 | 27.59% (395) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2774 | - | 5e-13 | 27.55% (392) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3330c | glpD2 | 1e-05 | 25.40% (378) | glycerol-3-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv3302c | glpD2 | 1e-05 | 25.40% (378) | glycerol-3-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00713 | glpD | 1e-07 | 26.39% (379) | putative glycerol-3-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3882c | - | 4e-14 | 28.03% (346) | glycerol-3-phosphate dehydrogenase 1 GlpD1 |
| M. marinum M | MMAR_3342 | glpD1 | 5e-12 | 27.96% (397) | glycerol-3-phosphate dehydrogenase GlpD1 |
| M. avium 104 | MAV_2188 | - | 3e-12 | 27.46% (397) | glycerol-3-phosphate dehydrogenase 1 |
| M. smegmatis MC2 155 | MSMEG_1379 | - | 7e-17 | 24.62% (390) | hypothetical protein MSMEG_1379 |
| M. thermoresistible (build 8) | TH_4606 | - | 3e-12 | 27.27% (396) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1300 | glpD1 | 2e-12 | 27.96% (397) | glycerol-3-phosphate dehydrogenase GlpD1 |
| M. vanbaalenii PYR-1 | Mvan_3930 | - | 0.0 | 87.31% (457) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3342|M.marinum_M -----------MPDSTALNAARRSTELTALADGEALDVLVIGGGITGVGI
MUL_1300|M.ulcerans_Agy99 -----------MPDSTALNAARRSTELTALADGEALDVLVIGGGITGVGI
MAV_2188|M.avium_104 ----------MIPDPSALNAARRTADLAALAEGEPLDVLVIGGGITGAGI
TH_4606|M.thermoresistible__bu -------VSAKKGDATALNASRRAAELTALAEQR-LDILVIGGGITGAGI
MAB_3882c|M.abscessus_ATCC_199 -------------MTTQLNSTRRSADLDALSGGAPIDVLVIGGGITGVGV
Mb3330c|M.bovis_AF2122/97 MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGGVVGSGC
Rv3302c|M.tuberculosis_H37Rv MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGGVVGSGC
MLBr_00713|M.leprae_Br4923 MTDLIQAPESEQTWPASALGPQQRAAAWERFGTEQFDVVVIGGGVVGSGC
Mflv_2649|M.gilvum_PYR-GCK -----------------------------MRPEDVSDVVVIGAGIVGCAI
Mvan_3930|M.vanbaalenii_PYR-1 -----------------------------MSRQDISDVVVIGAGIVGCAI
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------MAAPRIGVIGAGIVGLAV
: ***.*:.* .
MMAR_3342|M.marinum_M ALDAASR-GLQVALVEKH-DLAFGTSRWSSKLVHGGLRYLASGNVGIARR
MUL_1300|M.ulcerans_Agy99 ALDAASR-GLQVALVEKH-DLAFGTSRWSSKLVHGGLRYLASGNVGIARR
MAV_2188|M.avium_104 ALDAAAR-GLRVALVEKR-DLAFGTSRWSSKLVHGGLRYLASGNVGIARR
TH_4606|M.thermoresistible__bu ALDAASR-GLTVALVEKH-DLAFGTSRWSSKLVHGGLRYLASGNIGIARR
MAB_3882c|M.abscessus_ATCC_199 ALDAASR-GLRVTLVEKH-DLAFGTSRFSSKLVHGGLRYLASGQVGVARE
Mb3330c|M.bovis_AF2122/97 ALDAATR-GLKVALVEAR-DLASGTSSRSSKMFHGGLRYLEQLEFGLVRE
Rv3302c|M.tuberculosis_H37Rv ALDAATR-GLKVALVEAR-DLASGTSSRSSKMFHGGLRYLEQLEFGLVRE
MLBr_00713|M.leprae_Br4923 ALDAATR-GLKVALVEAR-DLASGTSSRSSKMFHGGLRYLEQLEFGLVRE
Mflv_2649|M.gilvum_PYR-GCK ARALAGT-HLSVTLVEARDDVGDGTSKANTALLHTGFDATPG---TLESR
Mvan_3930|M.vanbaalenii_PYR-1 ARALSGT-GLSVTLLEARGDVGDGTSKANTALLHTGFDATPG---TLESR
MSMEG_1379|M.smegmatis_MC2_155 ARRLQQKLQADVTVLDKENVVAAHQTGHNSNVVHSGVYYPPG---SLKAT
* *:::: . :. : .: :.* *. :
MMAR_3342|M.marinum_M SAIERGILMTRNAPHLVHAMPQLVPLLPSMDHLKRALVRTGFLAGDALRM
MUL_1300|M.ulcerans_Agy99 SAIERGILMTRNAPHLVHAMPQLVPLLPSMDHLKRALVRTGFLAGDALRM
MAV_2188|M.avium_104 SALERGILMTRNAPHLVHAMPQLVPLLPSMSRATRALVRGGFLAGDALRF
TH_4606|M.thermoresistible__bu SAVERGILMTRNAPHLVKAMPQLVPLIPTIGTLERALVRTGFLAGDVLRR
MAB_3882c|M.abscessus_ATCC_199 SAVERHILMTRTAPHLIHPLAQVVPLHPAVSMFSRTLVRVGFIAGDGLRK
Mb3330c|M.bovis_AF2122/97 ALYERELSLTTLAPHLVKPLPFLFPLT--KRWWERPYIAAGIFLYDRLG-
Rv3302c|M.tuberculosis_H37Rv ALYERELSLTTLAPHLVKPLPFLFPLT--KRWWERPYIAAGIFLYDRLG-
MLBr_00713|M.leprae_Br4923 ALYERELSLTTLAPHLVKPLPFLFPLT--KRWWERPYIAAGIFLYDRLG-
Mflv_2649|M.gilvum_PYR-GCK LVARGYHLLGEYAEQTGIPVERTGAMLVAWTDEEADALPGLMVKAERNG-
Mvan_3930|M.vanbaalenii_PYR-1 LVARGYQLLGEYAGQTGIPVERTGAMLVAWTEEEAGALPGLMVKAERNG-
MSMEG_1379|M.smegmatis_MC2_155 LCRRGVGLLRAYCMERGLPYDELGKVIVAVQTDELPRLHDLAKRAVDNG-
. : . . . : :
MMAR_3342|M.marinum_M LAGTPSSTLPRSRRVSAQRVVELAPTVRRDGLAGGLLAYDGQLIDDARLV
MUL_1300|M.ulcerans_Agy99 LAGTPSSTLPRSRRVSAQRVVELAPTVRRDGLAGGLLAYDGQLIDDARLV
MAV_2188|M.avium_104 LAGTPASTLPRSQRVSAQRVVQLAPTVCRDGLDGGLLAYDGQLIDDARLV
TH_4606|M.thermoresistible__bu LAGTPASTLPRSGRVDAGRAAELVPAVRRDRLDGALLAYDGQLIDDARLV
MAB_3882c|M.abscessus_ATCC_199 LAHTSAEVLPRSRAINAGEVIRRAPTVRRNGLRGGLMAFDGQLVDDARLV
Mb3330c|M.bovis_AF2122/97 ----GAKSVPAQRHFTRAGALRLSPGLKRSSLIGGIRYYD-TVVDDARHT
Rv3302c|M.tuberculosis_H37Rv ----GAKSVPAQRHFTRAGALRLSPGLKRSSLIGGIRYYD-TVVDDARHT
MLBr_00713|M.leprae_Br4923 ----GAKSVPAQKHLTRAGALRLSPGLKRSSLIGGIRYYD-TVVDDARHT
Mflv_2649|M.gilvum_PYR-GCK --------YRDCDLVRSEEVYRRVPDLGLGALGG-LGVPGESIICTWTTN
Mvan_3930|M.vanbaalenii_PYR-1 --------YRACGIVGADEVYRRVPDLGPGALAG-LDVPGEAIICTWTTN
MSMEG_1379|M.smegmatis_MC2_155 --------IPDTRVIDRAELREREPHVDG---LAALLIPSTAVVSFPAIA
. . * : . : . ::
MMAR_3342|M.marinum_M AAVARTAAQYG--ARILTYVGASEATGT---SARLTDQRSGESFDVSARA
MUL_1300|M.ulcerans_Agy99 TAVARTAAQHG--ARILTYVGASEATGT---SARLTDQRSGESFDVSARA
MAV_2188|M.avium_104 TAVARTAAQHG--ARILTYVAASRATGT---SVRLTDVRGGGSFDVSAGA
TH_4606|M.thermoresistible__bu TAVARTAAQHG--ARILTRVAADRARGD---GAALTDQLTGESFDVAARA
MAB_3882c|M.abscessus_ATCC_199 VSIARTAAGLG--ARILTRVAAEQVTGD---GAVLRDRLTGNAIRVRAGL
Mb3330c|M.bovis_AF2122/97 MTVARTAAHYGAVVRCSTQVVALLREGDRVIGVGVRDSENGAVAEVRGHV
Rv3302c|M.tuberculosis_H37Rv MTVARTAAHYGAVVRCSTQVVALLREGDRVIGVGVRDSENGAVAEVRGHV
MLBr_00713|M.leprae_Br4923 LTVARTAAHYGAVVRCSTQVVALLREGDRVIGVRVRDSEDGAVTEIRGHV
Mflv_2649|M.gilvum_PYR-GCK LALATDAVARG--ARLLRGARVTGVQPG-----PEHTTLHTTAGDVRGRW
Mvan_3930|M.vanbaalenii_PYR-1 LALATDAVARG--ARLLRGARVTAVETG-----PEHTTLRTTSGEVRARW
MSMEG_1379|M.smegmatis_MC2_155 EEFRADIEAAGGQFRLGSPAVGIASRDG-------GVVITTDTDEFVFDH
. * * . .
MMAR_3342|M.marinum_M VINAAGVWGGQIDPALK------LRPSRGTHLVFDANAFGNPTAALTIPI
MUL_1300|M.ulcerans_Agy99 VINAAGVWGGQIDPALK------LRPSRGTHLVFDANAFGNPTAALTIPI
MAV_2188|M.avium_104 VINAAGVWAGEIDGSLR------LRPSRGTHLVFDAAAFGNPTAALTIPI
TH_4606|M.thermoresistible__bu VINATGVWAGQVDPALR------LRPSRGTHLVFDAAAFGNPVAALTIPI
MAB_3882c|M.abscessus_ATCC_199 VINAAGVWAGQVDREIK------LRPSRGTHLVFRAASFGGLSAALTVPV
Mb3330c|M.bovis_AF2122/97 VVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPRDRIVSDVAMILRTE
Rv3302c|M.tuberculosis_H37Rv VVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPRDRIVSDVAMILRTE
MLBr_00713|M.leprae_Br4923 VVNATGVWTDEIQALSKQRGRFQVRVSKGVHVVVPRDRIVSDVAMILRTK
Mflv_2649|M.gilvum_PYR-GCK IINAAGLGADHLDTEFG-HRRFTVTPRRGELLVFDKLTRP-MVPLIVLAV
Mvan_3930|M.vanbaalenii_PYR-1 VINAAGLGADHLDAEFG-YRRFTVTPRRGELLVFDKLTRP-MVPLIVLAV
MSMEG_1379|M.smegmatis_MC2_155 VVVCAGLQSSMIAEMAG--------APRDPEIIPFRGEYYSLVASRSDLV
:: .:*: . : :. :: .
MMAR_3342|M.marinum_M PGELNRFVFAMPEQLGRVYLGLTDEDAPGPIPDVPEPSSEEIMFLLDTVN
MUL_1300|M.ulcerans_Agy99 PGELNRFVFAMPEQLGRVYLGLTDEDAPGPFLDVPEPSSEEIMFLLDTVN
MAV_2188|M.avium_104 PGELNRFVFAMPEQLGRVYLGLTDEAAPGPIPDVPEPSVEEITFLLDTVN
TH_4606|M.thermoresistible__bu PGELNRFVFAMPEQLGRVYLGLTDEDAPGPIPDVPQPTPQEVSFLLDTVN
MAB_3882c|M.abscessus_ATCC_199 PGTINRFVFALPAIHDRVYLGLTDEPAPGPVPDVAEPSAAEERFLLDTAN
Mb3330c|M.bovis_AF2122/97 KSVMFVIPWGSHWIIG------TTDTDWNLDLAHPAATKADIDYILGTVN
Rv3302c|M.tuberculosis_H37Rv KSVMFVIPWGSHWIIG------TTDTDWNLDLAHPAATKADIDYILGTVN
MLBr_00713|M.leprae_Br4923 KSVMFIIPWGNHWIIG------TTDTDWNLDLAHPAATKADIDYILQTVN
Mflv_2649|M.gilvum_PYR-GCK PSSRGKGVLVSPTIYGNVMVGPTSENLDDRTATG--TSEHGFEFLVSKG-
Mvan_3930|M.vanbaalenii_PYR-1 PSSRGKGVLVSPTIYGNVMVGPTSENLEDRTATG--TSEKGFEFLVSKG-
MSMEG_1379|M.smegmatis_MC2_155 KGLVYPVPDPRYPFLG--------VHFTRGIDGHVHVGPNAVLALAQEGY
. . :
MMAR_3342|M.marinum_M TALGTALQTSDVIGAYAGLRPLIDTGEGRTADVSRDHAVIESPSGVISVV
MUL_1300|M.ulcerans_Agy99 TALGTALQTSDVIGAYAGLRPLIDTGEGRTADVSRDHAVIESPSGVISVV
MAV_2188|M.avium_104 TALGTALAATDVIGAYAGLRPLIDTGEGRTADVSREHAVVESASGVISVI
TH_4606|M.thermoresistible__bu TALATALGPDDVIGAYAGLRPLIDTPGGRTADISRDHAVVESDTGLFSVL
MAB_3882c|M.abscessus_ATCC_199 TVLQTSLSETDVVGRFAGLRPLLDGDDSATADLSRKHAVRVSESGVVSVV
Mb3330c|M.bovis_AF2122/97 AVLATPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIA
Rv3302c|M.tuberculosis_H37Rv AVLATPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIA
MLBr_00713|M.leprae_Br4923 TVLATPLTHADIDGVYAGLRPLLAGESDDTSKLTREHAVAVPVAGLVAIA
Mflv_2649|M.gilvum_PYR-GCK RALMPALFEEEVTATYAGLR----------AAADHDDYLIDLDERLRYVL
Mvan_3930|M.vanbaalenii_PYR-1 RALMPSLFDEEITAGYAGLR----------AATDHDDYLIDVDVQQRYLL
MSMEG_1379|M.smegmatis_MC2_155 RWRDVNVRQLWRSVSYPG------------------------------ML
: :.* :
MMAR_3342|M.marinum_M GGKLTEYRYMAEDVLNRAISLRQLQANQCRTRDLPLIGAPANPGPAAGPG
MUL_1300|M.ulcerans_Agy99 GGKLTEYRYMAEDVLNRAISLRQLQATQCRTRDLPLIGAPATPGPAAGPG
MAV_2188|M.avium_104 GGKLTEYRYMAQDVLDRAVRVRRLRAAKCRTRNLPLIGAPANPGITGAPQ
TH_4606|M.thermoresistible__bu GGKLTEYRHMAEDAVDRAVTSRGLRAGECRTRNLPLVGAPANPVATFRSA
MAB_3882c|M.abscessus_ATCC_199 GGKLTTYRKMAQDALDAGLQRRPLAASECVTQNLAVVDDWP---------
Mb3330c|M.bovis_AF2122/97 GGKYTTYRVMAADAIDAAVQFIPARVAPSITEKVSLLGADGYFALVNQAE
Rv3302c|M.tuberculosis_H37Rv GGKYTTYRVMAADAIDAAVQFIPARVAPSITEKVSLLGADGYFALVNQAE
MLBr_00713|M.leprae_Br4923 GGKYTTYRVMAADAIDAAVAFVPARVAPSITEKVGLLGADGYFALINQVE
Mflv_2649|M.gilvum_PYR-GCK VGGIRSTGLTSGMAVAEYVSGLLARAGVAVDERDDLPPPPRMPN------
Mvan_3930|M.vanbaalenii_PYR-1 VGGIRSTGLTSGMAIAEYVSGLLGEAGVDVTERDDLPPPPRMPN------
MSMEG_1379|M.smegmatis_MC2_155 RLARHHWRMGASEIVGSMSKSVFLRRARAYIPELTAS-------------
: :
MMAR_3342|M.marinum_M ----------GLPESLVARFGAEAANVVATATCE-RPTDPVAEGIDVTRA
MUL_1300|M.ulcerans_Agy99 ----------GLPEFLVARFGAEAANVVVTATCE-RPTDPVAEGIDVTRA
MAV_2188|M.avium_104 V---------ALPESLVSRYGAEAAKVVATAGCE-RPSEPVVDGIDVTRA
TH_4606|M.thermoresistible__bu VDSGAE-LPARLPSSLVARYGAEAPNVIARAACD-RPTDPVAEGIDVIRA
MAB_3882c|M.abscessus_ATCC_199 --------------------GAAGAG--------------LVEGVDITRE
Mb3330c|M.bovis_AF2122/97 HVGALQGLHPYRVRHLLDRYGSLISDVLAMAASDPSLLSPITEAPGYLKV
Rv3302c|M.tuberculosis_H37Rv HVGALQGLHPYRVRHLLDRYGSLISDVLAMAASDPSLLSPITEAPGYLKV
MLBr_00713|M.leprae_Br4923 HVAALQGLHPYRVRHLLDRYGALIGDVLALAAEAPDLLSPIQEAPGYLKV
Mflv_2649|M.gilvum_PYR-GCK ----------------IGEAGLRPYQDADRVAADPEYGRIVCFCERVTAG
Mvan_3930|M.vanbaalenii_PYR-1 ----------------LGEAGVRPYQDTGRVAADPEYGRIVCFCERVSAG
MSMEG_1379|M.smegmatis_MC2_155 ------------------------------------------DIVRAESG
MMAR_3342|M.marinum_M EFEYAVTHEGALDAEDILDRRTRIGLVPHDR-----QRVVGIAEEFLAGV
MUL_1300|M.ulcerans_Agy99 EFEYAVTHEGALDAEDILDRRTRIGLVPHDR-----ERVVGIAEEFLAGV
MAV_2188|M.avium_104 EFEYAITHEGALEVSDIVDRRTRIGLVPRDR-----ERVVAVAEEFLARF
TH_4606|M.thermoresistible__bu EFEYAVTHEGAMTVEDILDRRTRIGLVAADR-----QRAVAAAEEILAAA
MAB_3882c|M.abscessus_ATCC_199 QVEFALTHEGALDADDILDRRTRIGLVPVDK-----NQAIGAVQRLVDSY
Mb3330c|M.bovis_AF2122/97 EAAYAAAAEGALHLEDILARRMRISIEYPHRGVDCAREVAEVVAPVLGWT
Rv3302c|M.tuberculosis_H37Rv EAAYAAAAEGALHLEDILARRMRISIEYPHRGVDCAREVAEVVAPVLGWT
MLBr_00713|M.leprae_Br4923 EARYAVTAEGALHLEDILARRMRVSIEYPHRGVACAREVADVVAPVLGWT
Mflv_2649|M.gilvum_PYR-GCK EIRDAFGSLIPPADLDGLRRRTRVMNGRCQG-----FYCGAHTEALLEAL
Mvan_3930|M.vanbaalenii_PYR-1 EIRDAFDSPIPPADLDGLRRRTRVMNGRCQG-----FYCGAHTQALLRAG
MSMEG_1379|M.smegmatis_MC2_155 VRAQALKPDGNLVDDFVIHRLAGMTFVRNAP-----SPAATASLAIAEHI
* : * : .
MMAR_3342|M.marinum_M G-------------------------------------------------
MUL_1300|M.ulcerans_Agy99 G-------------------------------------------------
MAV_2188|M.avium_104 G-------------------------------------------------
TH_4606|M.thermoresistible__bu E-------------------------------------------------
MAB_3882c|M.abscessus_ATCC_199 FSQVN---------------------------------------------
Mb3330c|M.bovis_AF2122/97 AADIDREVANYMARVEAEVLSQAQPDDVSADMLRASAPEARAEILEPVPL
Rv3302c|M.tuberculosis_H37Rv AADIDREVANYMARVEAEVLSQAQPDDVSADMLRASAPEARAEILEPVPL
MLBr_00713|M.leprae_Br4923 AEDIDREVATYNARVEAEVLSQAQPDDVSADMLRASAPEARTKIIEPVSL
Mflv_2649|M.gilvum_PYR-GCK LETGALR-------------------------------------------
Mvan_3930|M.vanbaalenii_PYR-1 ADR-----------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 VDALA---------------------------------------------
MMAR_3342|M.marinum_M -
MUL_1300|M.ulcerans_Agy99 -
MAV_2188|M.avium_104 -
TH_4606|M.thermoresistible__bu -
MAB_3882c|M.abscessus_ATCC_199 -
Mb3330c|M.bovis_AF2122/97 D
Rv3302c|M.tuberculosis_H37Rv D
MLBr_00713|M.leprae_Br4923 T
Mflv_2649|M.gilvum_PYR-GCK -
Mvan_3930|M.vanbaalenii_PYR-1 -
MSMEG_1379|M.smegmatis_MC2_155 -