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MVERVAVVGGGILGVAVARELTRRSPEAAVTVFEKEDRLASHQTGCNSGVVHAGLYYEPGSAKAVLCRRG VGLLEQYCAEHAIERIACGKVLVARDEHERARLTGIEDRARANGVPGVRVIGPAELREIEPHVRGVAGLH SPSTSIVDFAAVTRSLADDARAAGAEILLGREVTGMRLHATEVVVRTQTPDGVAERPFDRVVACGGLQSD RLAEMAGDGPEPVIMPFRGEYYALRPERRGLVNGLVYPVPDPRYPFLGVHLTPRVDGEVLIGPNAVLALA REGYTWRDVSASDLAGVARTPAFWRFARRHWRTGITEMYGSLSRRRFVAAARAYVPELGDDDVVPARAGV RAQALDPDGGLVDDFRISVRDRIVVLRNAPSPAATSALAIAEHVVTAVLGEDDQRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3531 | - | - | 100% (406) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2649 | - | 8e-25 | 27.59% (395) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3080 | - | 2e-06 | 26.52% (230) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2273c | glpD1 | 7e-05 | 29.08% (196) | glycerol-3-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv2249c | glpD1 | 7e-05 | 29.08% (196) | glycerol-3-phosphate dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2681 | - | 5e-12 | 27.56% (439) | malate:quinone oxidoreductase |
| M. marinum M | MMAR_4420 | gcvT_2 | 3e-07 | 28.70% (223) | aminomethyltransferase GcvT_2 |
| M. avium 104 | MAV_4746 | thiO | 5e-05 | 27.24% (279) | glycine oxidase ThiO |
| M. smegmatis MC2 155 | MSMEG_1379 | - | 1e-112 | 54.18% (395) | hypothetical protein MSMEG_1379 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1300 | glpD1 | 2e-05 | 28.57% (196) | glycerol-3-phosphate dehydrogenase GlpD1 |
| M. vanbaalenii PYR-1 | Mvan_0204 | - | 1e-119 | 56.31% (396) | hypothetical protein Mvan_0204 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3531|M.gilvum_PYR-GCK ------------------------MVERVAVVGGGILGVAVARELTRRSP
MSMEG_1379|M.smegmatis_MC2_155 -----------------------MAAPRIGVIGAGIVGLAVARRLQQK-L
Mvan_0204|M.vanbaalenii_PYR-1 -----------------------MAALRVAVVGGGIVGLAVARELLHSID
Mb2273c|M.bovis_AF2122/97 MLMPHSAALNAARRSADLTALADGGALDVIVIGGGITGVGIALDAATR--
Rv2249c|M.tuberculosis_H37Rv MLMPHSAALNAARRSADLTALADGGALDVIVIGGGITGVGIALDAATR--
MUL_1300|M.ulcerans_Agy99 --MPDSTALNAARRSTELTALADGEALDVLVIGGGITGVGIALDAASR--
MMAR_4420|M.marinum_M ------------------------MGPKIVIVGAGIVGASLADELTAR-G
MAV_4746|M.avium_104 ---------------------MPSDCGSLAVVGGGVIGLAVARRAAQA--
MAB_2681|M.abscessus_ATCC_1997 ------------MSRIPRASQAHPIDADVVLIGGGIMSATLGSMLSILAP
: ::*.*: . :.
Mflv_3531|M.gilvum_PYR-GCK EAAVTVFEKEDRLASHQTG-----CNSGVVHAGLYYEPGSAKAVLCRRGV
MSMEG_1379|M.smegmatis_MC2_155 QADVTVLDKENVVAAHQTG-----HNSNVVHSGVYYPPGSLKATLCRRGV
Mvan_0204|M.vanbaalenii_PYR-1 GARVTVFEKESGVARHQTG-----HNSGVVHAGLYYAPGSLKARLCRRGV
Mb2273c|M.bovis_AF2122/97 GLTVALVEKHD-LAFGTSR-----WSSKLVHGGLRYLASGNVGIARRSAV
Rv2249c|M.tuberculosis_H37Rv GLTVALVEKHD-LAFGTSR-----WSSKLVHGGLRYLASGNVGIARRSAV
MUL_1300|M.ulcerans_Agy99 GLQVALVEKHD-LAFGTSR-----WSSKLVHGGLRYLASGNVGIARRSAI
MMAR_4420|M.marinum_M VIDVTVVDRGP--LFTTGG-----STSHAPGLVFATNPSKTMSAFARYTV
MAV_4746|M.avium_104 GWSVRVHRSGE---RGASW-----VAGGMLAPHSEGWPG--EERLLRLGL
MAB_2681|M.abscessus_ATCC_1997 EWRIVLLERSDALATESSGPWNNAGTGHTGFCELNYMPDPGDGAQAAAIA
: : . ..
Mflv_3531|M.gilvum_PYR-GCK G---LLEQYCAEHAIERIACGKVLVARDEHERARLTG---------IEDR
MSMEG_1379|M.smegmatis_MC2_155 G---LLRAYCMERGLPYDELGKVIVAVQTDELPRLHD---------LAKR
Mvan_0204|M.vanbaalenii_PYR-1 H---LLREYLAQKDIRYSECGKIVVAHTAGDAARLAG---------IHER
Mb2273c|M.bovis_AF2122/97 ERGILMTRNAPHLVHAMPQLVPLLPSMGHTKRALVRAGFLAGDALRVLAG
Rv2249c|M.tuberculosis_H37Rv ERGILMTRNAPHLVHAMPQLVPLLPSMGHTKRALVRAGFLAGDALRVLAG
MUL_1300|M.ulcerans_Agy99 ERGILMTRNAPHLVHAMPQLVPLLPSMDHLKRALVRTGFLAGDALRMLAG
MMAR_4420|M.marinum_M D---KFSGLHHRDGAVFNRVGGLEVATTAERWADLHR---------KAGW
MAV_4746|M.avium_104 ESLRLWREGGFLDGLPGRLVTARESLVVAVDRADVAD---------LRTV
MAB_2681|M.abscessus_ATCC_1997 RQFHLSRQWWSYLADHALLRPDTFIHSAAHMDVVFGHRDANYLRQRYETL
.
Mflv_3531|M.gilvum_PYR-GCK ARANGVPGVRVIGPAELRE-IEPHVRG-------VAGLHSPSTSIVDFAA
MSMEG_1379|M.smegmatis_MC2_155 AVDNGIPDTRVIDRAELRE-REPHVDG-------LAALLIPSTAVVSFPA
Mvan_0204|M.vanbaalenii_PYR-1 ALANGVPGVRLVDAGEITD-IEPHARG-------ISALHSPSTAIVDYPA
Mb2273c|M.bovis_AF2122/97 TPAATLPRSRRIPASRVVE-IAPTVRRD----GLDGGLLAYDGQLIDDAR
Rv2249c|M.tuberculosis_H37Rv TPAATLPRSRRIPASRVVE-IAPTVRRD----GLDGGLLAYDGQLIDDAR
MUL_1300|M.ulcerans_Agy99 TPSSTLPRSRRVSAQRVVE-LAPTVRRD----GLAGGLLAYDGQLIDDAR
MMAR_4420|M.marinum_M AQAWGVPG-RLVGPDQCVE-LHPLLDRA----GILGGFHTPSDGLASAVR
MAV_4746|M.avium_104 ADWLSAQGHPVVWESAARD-VEPLLAQG-----IRHGFTAPTELAVDNRA
MAB_2681|M.abscessus_ATCC_1997 AADPMFSGMRFSDDPATIERWAPLVMRGRTPGGPIAATLHPEGTDVDFGA
: : * . .
Mflv_3531|M.gilvum_PYR-GCK VTRSLADDARAAGAEILLGREVTGMRLH---------------ATEVVVR
MSMEG_1379|M.smegmatis_MC2_155 IAEEFRADIEAAGGQFRLGSPAVGIASR---------------DGGVVIT
Mvan_0204|M.vanbaalenii_PYR-1 VAEALAVDIADAGGEVLCDHGVIGMRRH---------------GTEVVVT
Mb2273c|M.bovis_AF2122/97 LVMAVARTAAQHGARILTYVGASNVTGTSVELTDRRTRQSFALSARAVIN
Rv2249c|M.tuberculosis_H37Rv LVMAVARTAAQHGARILTYVGASNVTGTSVELTDRRTRQSFALSARAVIN
MUL_1300|M.ulcerans_Agy99 LVTAVARTAAQHGARILTYVGASEATGTSARLTDQRSGESFDVSARAVIN
MMAR_4420|M.marinum_M AVEAQARRAIARGAVFLAETEVQRVADHNGLVTGVHTSRG-VIEADIVVC
MAV_4746|M.avium_104 VLEALDAACERLGVRWAPPLHDLAEADA-----------------DAVVI
MAB_2681|M.abscessus_ATCC_1997 LTAALTRIVTDRGGQLRLGHEVRALRQS--------------IDGSWMVT
* ::
Mflv_3531|M.gilvum_PYR-GCK TQTPDGVAERPFDRVVA----------CGGLQSDRLAEMAGDGPEPV---
MSMEG_1379|M.smegmatis_MC2_155 TDT----DEFVFDHVVV----------CAGLQSSMIAEMAGAPRDPE---
Mvan_0204|M.vanbaalenii_PYR-1 TAA----TSGAFDVVVT----------CAGLQSDRVARMFGDSSSPR---
Mb2273c|M.bovis_AF2122/97 AAGVWAGEIDPSLRLRP----------SRGTHLVFDAKSFANPTAAL---
Rv2249c|M.tuberculosis_H37Rv AAGVWAGEIDPSLRLRP----------SRGTHLVFDAKSFANPTAAL---
MUL_1300|M.ulcerans_Agy99 AAGVWGGQIDPALKLRP----------SRGTHLVFDANAFGNPTAAL---
MMAR_4420|M.marinum_M AAGFWGAQLAKQVGLVLPLVPMAHQYAKTGQVAPLVGRNTEDAPASLPIL
MAV_4746|M.avium_104 ANGIDAPALWPGLPVRP---------------------------------
MAB_2681|M.abscessus_ATCC_1997 GRNAEGGFAVRTHKVFVG---------AGGHALRLLQRAHLAEVRGY---
:
Mflv_3531|M.gilvum_PYR-GCK ----------------------IMPFRGEYYALR-PERRGLVNGLVYPVP
MSMEG_1379|M.smegmatis_MC2_155 ----------------------IIPFRGEYYSLV-ASRSDLVKGLVYPVP
Mvan_0204|M.vanbaalenii_PYR-1 ----------------------IVPFFGDYFLLH-EAKSDMVNGLIYPVP
Mb2273c|M.bovis_AF2122/97 ----------------------TIPIPGELNRFV-FAMPEQLGRIYLGLT
Rv2249c|M.tuberculosis_H37Rv ----------------------TIPIPGELNRFV-FAMPEQLGRIYLGLT
MUL_1300|M.ulcerans_Agy99 ----------------------TIPIPGELNRFV-FAMPEQLGRVYLGLT
MMAR_4420|M.marinum_M RHQDGDLYFREHVDRLGIGSYGHQPMPVDMSTLL-ADTAGEPMPSMLPFT
MAV_4746|M.avium_104 -------------------------VKGEVLRLR-WRKG------CMPVP
MAB_2681|M.abscessus_ATCC_1997 ---------------------AVLPVGAAFLRSANAAVADAHTTKVYGQA
. .
Mflv_3531|M.gilvum_PYR-GCK DPRYP----------------------------------FLGVHLTPR--
MSMEG_1379|M.smegmatis_MC2_155 DPRYP----------------------------------FLGVHFTRG--
Mvan_0204|M.vanbaalenii_PYR-1 DPRYP----------------------------------FLGVHLTKH--
Mb2273c|M.bovis_AF2122/97 DEDAPGPIPDVPQPSSEE-----------ITFLLDTVNTALGTAVGTK--
Rv2249c|M.tuberculosis_H37Rv DEDAPGPIPDVPQPSSEE-----------ITFLLDTVNTALGTAVGTK--
MUL_1300|M.ulcerans_Agy99 DEDAPGPFLDVPEPSSEE-----------IMFLLDTVNTALGTALQTS--
MMAR_4420|M.marinum_M EEDFEPAWRECVRLLPALGDTKVDEGFNGIFSFTPDGYSLLGEHRELGGF
MAV_4746|M.avium_104 QRVIR---------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 PVGAPP---------------------------------MSVPHLDKR--
Mflv_3531|M.gilvum_PYR-GCK -VDGEVLIGPNAVLALAREGYTWRDVSASDLAGVARTP-AFWRFARRHWR
MSMEG_1379|M.smegmatis_MC2_155 -IDGHVHVGPNAVLALAQEGYRWRDVNVRQLWRSVSYP-GMLRLARHHWR
Mvan_0204|M.vanbaalenii_PYR-1 -VDGRVSLGPNAFLAPGREAYTRGGWSARDVAAAVGFP-GFWRFAVRNTA
Mb2273c|M.bovis_AF2122/97 -DVIGAYAGLRPLIDTGGAGVQGRTADVSRDHAVFESPSGVISVVGGKLT
Rv2249c|M.tuberculosis_H37Rv -DVIGAYAGLRPLIDTGGAGVQGRTADVSRDHAVFESPSGVISVVGGKLT
MUL_1300|M.ulcerans_Agy99 -DVIGAYAGLRPLIDTG----EGRTADVSRDHAVIESPSGVISVVGGKLT
MMAR_4420|M.marinum_M WVAEAVWVTHSAGVAKAVAEWIVDGTPSIDVHECDLYRFEDFARSPRFID
MAV_4746|M.avium_104 -------------------------ARVHGRQVYLVPRADGVVVGATQYE
MAB_2681|M.abscessus_ATCC_1997 IVDGRPYVMFGPYATFSTKLLKHGRWTDFFSTVRWHNLHVIAAALLQNLA
Mflv_3531|M.gilvum_PYR-GCK TGITEMYGSLS-RRRFVAAARAYVPELGDDDVVPARAGVRAQALDPDGGL
MSMEG_1379|M.smegmatis_MC2_155 MGASEIVGSMS-KSVFLRRARAYIPELTASDIVRAESGVRAQALKPDGNL
Mvan_0204|M.vanbaalenii_PYR-1 AAVREARTVMS-RAAFVREAQKYVPDVSVDDVVRGPRGIRAQAMNADGTL
Mb2273c|M.bovis_AF2122/97 EYRYMAEDVLN-RAITLRHLRAAKCRTRNLPLIGAPANPGPAPGSGAGLP
Rv2249c|M.tuberculosis_H37Rv EYRYMAEDVLN-RAITLRHLRAAKCRTRNLPLIGAPANPGPAPGSGAGLP
MUL_1300|M.ulcerans_Agy99 EYRYMAEDVLN-RAISLRQLQATQCRTRDLPLIGAPATPGPAAGPG-GLP
MMAR_4420|M.marinum_M ETCAQAFVEVY-DIVHPHQYRSALRGLRTSPFHHRQRELGAYFYEGGGWE
MAV_4746|M.avium_104 HGRDTAPVVSG-VRDLLDDACAVLPALGEYELAECGAGLRPMTPDNLPLV
MAB_2681|M.abscessus_ATCC_1997 LIRYLIGQVVAGPRQRMGQLRRYYPTAAPDDWELVPAGQRAQLITPDPRQ
.
Mflv_3531|M.gilvum_PYR-GCK VDDFRISVRDRIVVLRN-----------APSPAATSALAIAEHVVTAVLG
MSMEG_1379|M.smegmatis_MC2_155 VDDFVIHRLAGMTFVRN-----------APSPAATASLAIAEHIVDALA-
Mvan_0204|M.vanbaalenii_PYR-1 EDDFVITGTDKVIHLRN-----------APSPGATSSLAIAEYIVGTVVP
Mb2273c|M.bovis_AF2122/97 ESLVARYGAEAANVAAA-----------ATCERPTEPVADGIDVTRAEFE
Rv2249c|M.tuberculosis_H37Rv ESLVARYGAEAANVAAA-----------ATCERPTEPVADGIDVTRAEFE
MUL_1300|M.ulcerans_Agy99 EFLVARFGAEAANVVVT-----------ATCERPTDPVAEGIDVTRAEFE
MMAR_4420|M.marinum_M RPAWFQANAELVRELAGRNVAFPERDDWAARYWSPIAIAEAQWTRERVAL
MAV_4746|M.avium_104 GRLDARTLVAAGHGRSG----------FLLAPWTAEQIVSELAPVGAHR-
MAB_2681|M.abscessus_ATCC_1997 VGVLRHGTELVVSADHSIAG------LLGASPGASTAVPIMLDALRRCFP
.. :
Mflv_3531|M.gilvum_PYR-GCK EDDQRR--------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 ARLGA---------------------------------------------
Mb2273c|M.bovis_AF2122/97 YAVTHEGALDVDDILDRRTRIGLVPRDRERVVAVAKEFLSR---------
Rv2249c|M.tuberculosis_H37Rv YAVTHEGALDVDDILDRRTRIGLVPRDRERVVAVAKEFLSR---------
MUL_1300|M.ulcerans_Agy99 YAVTHEGALDAEDILDRRTRIGLVPHDRERVVGIAEEFLAGVG-------
MMAR_4420|M.marinum_M YDMTPLTRYEVSGAGAVDLLQRLTTNDIDKGVGSVTYTLMLDETGGIRSD
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 EQWRTTWQRTLTAAMPGAGDITWDEAAVTRSARSTARSLRLDQARPSN--
Mflv_3531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2273c|M.bovis_AF2122/97 --------------------------------------------------
Rv2249c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1300|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4420|M.marinum_M LTVARLGTARFQVGANGPQDFDWLSRHLPQDGSVTLRDITGATCCIGVWG
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2273c|M.bovis_AF2122/97 --------------------------------------------------
Rv2249c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1300|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4420|M.marinum_M PAARDLVQPLCRDDLSHQAFPYFRLLQTYLEAIPVTMLRVSYVGELGWEI
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2273c|M.bovis_AF2122/97 --------------------------------------------------
Rv2249c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1300|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4420|M.marinum_M YTEASYGGALWDLLWAAGAGHQAIAAGRIAFNSLRMEKGYRAWGTDMTAE
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2273c|M.bovis_AF2122/97 --------------------------------------------------
Rv2249c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1300|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4420|M.marinum_M HRPDEAGLGFAVRMSKDFIGKAALVDAAARKVLQCLVFDDPAAAALGKEP
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1379|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0204|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2273c|M.bovis_AF2122/97 --------------------------------------------------
Rv2249c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1300|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4420|M.marinum_M VLAGDVCIGFVTSAGYSPTIGRTIAYAWLPAESSIGDTVTVDHRGRRYPA
MAV_4746|M.avium_104 --------------------------------------------------
MAB_2681|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3531|M.gilvum_PYR-GCK -----------------
MSMEG_1379|M.smegmatis_MC2_155 -----------------
Mvan_0204|M.vanbaalenii_PYR-1 -----------------
Mb2273c|M.bovis_AF2122/97 -----------------
Rv2249c|M.tuberculosis_H37Rv -----------------
MUL_1300|M.ulcerans_Agy99 -----------------
MMAR_4420|M.marinum_M SVHQQPVVDPESTRIRR
MAV_4746|M.avium_104 -----------------
MAB_2681|M.abscessus_ATCC_1997 -----------------