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NGVLLVLIVLVVAAIGIAVYASSKASGNRAAASLADAKADARRVIERLGGQVFALTGSDDASKQALADAS ERYTAASSQIDQATTARQAELAKESAMEGLYYVRAARTAMGMDPGPELESLTGQKSAGTVTEDRRVNFEG REIEASPAPSPRTPNYYPGGRVAGRPVPAGWYSEPWWKPALVAGAWGLGSALLFSTMFSGMAGVGYDAQA FENGYGDGFQDGLDQGQLDGGGDWGGDAGGGDWDSGGDWGGGDFGGGDFGGFDF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2584 | - | - | 100% (265) | hypothetical protein Mflv_2584 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0856 | PE_PGRS13 | 4e-06 | 32.38% (105) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv0279c | PE_PGRS4 | 3e-06 | 37.35% (83) | PE-PGRS family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1577c | - | 4e-98 | 65.11% (278) | hypothetical protein MAB_1577c |
| M. marinum M | MMAR_3729 | - | 9e-07 | 42.68% (82) | PE-PGRS family protein, PE_PGRS25 |
| M. avium 104 | MAV_3950 | - | 3e-12 | 35.83% (120) | hypothetical protein MAV_3950 |
| M. smegmatis MC2 155 | MSMEG_4681 | - | 1e-121 | 79.93% (274) | hypothetical protein MSMEG_4681 |
| M. thermoresistible (build 8) | TH_0349 | - | 1e-103 | 71.59% (264) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3672 | - | 2e-06 | 43.75% (80) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_4049 | - | 1e-133 | 87.08% (271) | hypothetical protein Mvan_4049 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 --------------------------------------------------
Rv0279c|M.tuberculosis_H37Rv -----------------------MSFVIAAPEVIAAAATDLASLESSIAA
MMAR_3729|M.marinum_M --------------------------------------------------
MUL_3672|M.ulcerans_Agy99 --------------------------------------------------
MAV_3950|M.avium_104 MTSRFAGLALAPVAIALAMLFAPFAGADDYTDQLVARFDSQTHVVADPGA
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 --------------------------------------------------
Rv0279c|M.tuberculosis_H37Rv ANAAAAANTTALLAAGADEVSTAVAALFGAHGQAYQALSAQAQAFHAQFV
MMAR_3729|M.marinum_M --------------------------------------------------
MUL_3672|M.ulcerans_Agy99 --------------------------------------------------
MAV_3950|M.avium_104 RPPLQNPDGLNRQILAGPWRWSSGPPIWVAAVAPAQSGVTTADSIHEAML
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 ----------------------------MIGNG-----GAGGSGAPGAIG
Rv0279c|M.tuberculosis_H37Rv QALTSGGGAYAAAEAAATSPLLAPINEFFLANTGRPLIGNGTNGAPGTGA
MMAR_3729|M.marinum_M -------------------------MAYVIADL--------EAMAAAAAD
MUL_3672|M.ulcerans_Agy99 -------------------------MAYVIADL--------EAMAAAAAD
MAV_3950|M.avium_104 RRDAQFSGVILVIDSRGYHVRAYHVPKVVADNVDEFMNQSAQDHRNDPYG
Mflv_2584|M.gilvum_PYR-GCK -----------------------------MNGVLLVLIVLVVAAIGIAVY
Mvan_4049|M.vanbaalenii_PYR-1 -----------------------------MDGALLVLIVLVVAAIGLAVY
MSMEG_4681|M.smegmatis_MC2_155 -----------------------------MNGVLLLLIVLVIGAIAFAVY
TH_0349|M.thermoresistible__bu ------------------LGRRVVGRLVGMNGVLLLLVVLVLAAIVFAVY
MAB_1577c|M.abscessus_ATCC_199 --------------------------------MEIILGLLLLGVIVGGAI
Mb0856|M.bovis_AF2122/97 GAGGPAGLIGVGGAGGAGGDSAVAGVIGGAGGAGGAALLFGAGGAGGAGG
Rv0279c|M.tuberculosis_H37Rv NGGDGGWLIGNGGAGGSG----AAGVNGGAGGNGGAGGLIGNGGAGGAGG
MMAR_3729|M.marinum_M LAGVNSAIAAANGIAAVP----TTAVQACAG--DQVSAAVAALFAAHAQG
MUL_3672|M.ulcerans_Agy99 LAGVNSAIAAANGIAAVP----TTAVQACAG--DQVSAAVAALFAAHAQG
MAV_3950|M.avium_104 AASEFVGKLSGVSVPTRAPVSTSPLVQHQRDDWAWLKAAFVIAGITLATA
. .
Mflv_2584|M.gilvum_PYR-GCK ---------ASSKASGNRAAASLADAKADARRVIERLGGQVFALTGSDDA
Mvan_4049|M.vanbaalenii_PYR-1 ---------ATSKSSQKRNAASLADAKADARRTIERLGGQVFALTGIDDA
MSMEG_4681|M.smegmatis_MC2_155 ---------SSSRATGRRTAESLADAKADARRVIERLGGQVLNLSGTDDA
TH_0349|M.thermoresistible__bu ---------TASKSAGERNAMALADAKAEARRLIERLGGQVLNLTGTDDA
MAB_1577c|M.abscessus_ATCC_199 ---------IYTQGSTRRRGEQLEDAKAEARRLTERLGGQVLGLSGTDDA
Mb0856|M.bovis_AF2122/97 ---------SGGSGAAGGAGGAGGAGGLFASGGSGGFGGFASTG--TGGA
Rv0279c|M.tuberculosis_H37Rv ---------RASTGTGGAGGAGGAAGMLFGAAGVGGPGGFAAAFGATGGA
MMAR_3729|M.marinum_M ---------YQSISAQMSAMHDQLVQTLSASSAS--YAGAEASN--AAQA
MUL_3672|M.ulcerans_Agy99 ---------YQSISTQMSAMHDQLVQTLSASSAS--YAGAEASN--AAQA
MAV_3950|M.avium_104 GLIWFAVSRNRKHRKDIENREQIKQELITAASNVGDLDNEVLTDGNTDVS
. . :
Mflv_2584|M.gilvum_PYR-GCK SKQALADASERYTAASSQIDQATTARQAELAKESAMEGLYYVRAARTAMG
Mvan_4049|M.vanbaalenii_PYR-1 SKQALADASERYTAASSQIDQATTARQAELAKESAMEGLYYVRAARLALG
MSMEG_4681|M.smegmatis_MC2_155 SKQALADASERYTAAASQIDQATTVKQAALAKESAIEGLYYVRAARTAMG
TH_0349|M.thermoresistible__bu SRQALADASERYTAAASQIEQATSVKQAMLAKESALEGLYYVRAARLAMG
MAB_1577c|M.abscessus_ATCC_199 SRQALADASERYTAASSAIEQARTPSQAALAKESAIEGLYYVRAARLAMG
Mb0856|M.bovis_AF2122/97 GGTGGAGGLFASGGVGGTGGGAGSGGTGGVGGTGGAGGLFASGGAGGAGG
Rv0279c|M.tuberculosis_H37Rv GGAGGNGGLFADGGVGGAGG-ATDAGTGGAGGSGGNGGLFGAGGTGGPGG
MMAR_3729|M.marinum_M FLDLINAPTQALLGRPLIGNGADGATVGGIGTPGGAGGLLYGN--GGRGG
MUL_3672|M.ulcerans_Agy99 SLDLINAPTQALLGRPLIGNGADGATVGRIGTPGGAGGLLYGN--GGRGG
MAV_3950|M.avium_104 AESLKANASLHDARKAYEKGDYGAARAHLRVVESTVAKANRKLHPGQREP
.
Mflv_2584|M.gilvum_PYR-GCK -------MDPGPELESLTGQKSAGTVTEDRRVNFEGRE-IEASPAPSPRT
Mvan_4049|M.vanbaalenii_PYR-1 -------MDPGPELETLAGQRTAGTVTEDRRVQFEGRE-IEASPTPSQRT
MSMEG_4681|M.smegmatis_MC2_155 -------MDPGPELETLAGQKSAGAVTEDRRINFEGRE-IEASPAPSPRT
TH_0349|M.thermoresistible__bu -------MDPGPELEPLAGQRVAGAVTEERRIEFEGRE-IAASPTPSERT
MAB_1577c|M.abscessus_ATCC_199 -------MDPGPELPSTAGQSRAGAVSEERRINFEGRE-IEASPQPSGRT
Mb0856|M.bovis_AF2122/97 SGGTGG-AGGTGGAGGLFGAGGAGGLGGQ-GNHTGGHGGAGGSAGLLALG
Rv0279c|M.tuberculosis_H37Rv FGIFGGGAGGDGGSGGLFGAGGTGGSGGTSIINVGGNGGAGGDAGMLSLG
MMAR_3729|M.marinum_M DSTLAGVSGGGGGDAGLIGNGGAGGTGGN-----GGSGGLGGNAWLLGSG
MUL_3672|M.ulcerans_Agy99 DSTLAGVSGGGGGYAGLIGNGGAGGTGGN-----GGSGGLGGNAWLLGSG
MAV_3950|M.avium_104 EG-----AAADSSVPAPERKQASVRTTDPETGQTVTISNADYRTTAQPGY
: .
Mflv_2584|M.gilvum_PYR-GCK PNYYPGGRVAGRPVPAGWYSEPWWKPALVAGAWGLGS-------------
Mvan_4049|M.vanbaalenii_PYR-1 PNYYPGGRVAGRPVPAGWYSEPWWKPALVAGAWGLGS-------------
MSMEG_4681|M.smegmatis_MC2_155 PNYYPGGRVAGRPVPAGWYSEPWWKPALVAGAWGLGS-------------
TH_0349|M.thermoresistible__bu PNYFPGGQVAGRPVPAGWYSEPWWKPALVAGAWGLGS-------------
MAB_1577c|M.abscessus_ATCC_199 PNYYPGGTVAGRPVPAGWYSEPWWKPALVAGAWGVGS-------------
Mb0856|M.bovis_AF2122/97 D-GGAGGAGGAATTGTGGAGGAGGKAGLLFGSGGAGGSGGAAGTFGDTGN
Rv0279c|M.tuberculosis_H37Rv AAGGAGGSGGSNPDGGGGAGGIGGDGGTLFGSGGAGGVCGLG------FD
MMAR_3729|M.marinum_M GTGGTGGAG--VSSGFGGTGGNGGLGGLLYGSGGAGG-------------
MUL_3672|M.ulcerans_Agy99 GTGGTGGAG--VSSGFGGTGGNGGLGGLLYGSGGAGG-------------
MAV_3950|M.avium_104 PHYFGGGYHNGIFFQPGFYPYPFWGP---GWGWALGD-------------
** * . . *.
Mflv_2584|M.gilvum_PYR-GCK -------------------------------------------ALLFSTM
Mvan_4049|M.vanbaalenii_PYR-1 -------------------------------------------ALLFSSL
MSMEG_4681|M.smegmatis_MC2_155 -------------------------------------------VLLFDAL
TH_0349|M.thermoresistible__bu -------------------------------------------MMLFNMM
MAB_1577c|M.abscessus_ATCC_199 -------------------------------------------ALLFNSL
Mb0856|M.bovis_AF2122/97 SGGAGGAGGKAGLLFGSGGAGGSGGAGGFANGSTGGAGGAGGGAGLIGNG
Rv0279c|M.tuberculosis_H37Rv AGGAGGAGGKAGLLIGAGGAGGAGG-GSFAG--AGGTGGAGGAPGLVGNA
MMAR_3729|M.marinum_M TGGAGAAGAVLG-----------------------GMGGLGGDARLFGTG
MUL_3672|M.ulcerans_Agy99 TGGAGAAGAVLG-----------------------GMGGLGGDARLFGTG
MAV_3950|M.avium_104 -------------------------------------------VLLMDAL
*..
Mflv_2584|M.gilvum_PYR-GCK FSGMAG--------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 FSGMAG--------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 FSGMHG--------------------------------------------
TH_0349|M.thermoresistible__bu FAGMAG--------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 FSGMHG--------------------------------------------
Mb0856|M.bovis_AF2122/97 GNGGSGGTSVATGGAGNGGAGGAGGGAGLIGNGGNGGSGGMGDAPGGTGV
Rv0279c|M.tuberculosis_H37Rv GNGGNGGASAN----GAGAAGGAGGSGVLIGNGGNGGSGGTGAPAGTAGA
MMAR_3729|M.marinum_M GAGGTG---------GDNSLG-------LTGQGGQGGDGGYGGALFGSGG
MUL_3672|M.ulcerans_Agy99 GAGGTG---------GDNSLG-------LTGQGGQGGD------------
MAV_3950|M.avium_104 LDDHWG--------------------------------------------
. *
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 GGIGGLLLGLDGANAPASTNPLHTAQQQALAAVNAPIQAVTGRPLIGNGA
Rv0279c|M.tuberculosis_H37Rv GGLGGQLLGRDGFNAPAST-PLHTLQQQILNAINEPTQALTGRPLIGNGA
MMAR_3729|M.marinum_M SGGG------------------------------------------GGAG
MUL_3672|M.ulcerans_Agy99 --------------------------------------------------
MAV_3950|M.avium_104 --------------------------------------------------
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------VGYDAQ
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------VGYDAQ
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------VDYGAQ
TH_0349|M.thermoresistible__bu --------------------------------------------TAY-EQ
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------VGYGAQ
Mb0856|M.bovis_AF2122/97 NGAPGSGAPGGHGGWLFGGGGTGGSGVS---GGAGGDGGAGGILFGAGGA
Rv0279c|M.tuberculosis_H37Rv NGTPGTGADGGAGGWLFGNGGNGGHGATGADGGDGGSGGAGGILSGIGGT
MMAR_3729|M.marinum_M SSAGGDGGAGGASGYGIGNGGAGG--------AAGDGGGAG--SLGTGGN
MUL_3672|M.ulcerans_Agy99 ------AGAGGASGYGIGNGGAGG--------AAGDGGGAG--SLGTGGN
MAV_3950|M.avium_104 ---------------------------------------------GGFER
Mflv_2584|M.gilvum_PYR-GCK AFENG--------------------YGDGFQDGLDQGQ--------LDGG
Mvan_4049|M.vanbaalenii_PYR-1 AFESG--------------------YGDGFQDGLDQGQ--------LEGG
MSMEG_4681|M.smegmatis_MC2_155 GFEAG--------------------YGDGYADGLAAGQD-----GGFDGG
TH_0349|M.thermoresistible__bu GFDAG--------------------LAQGMAG---------------DTG
MAB_1577c|M.abscessus_ATCC_199 GFESG--------------------FGQGYSDGYDAGLN-----AGQDSG
Mb0856|M.bovis_AF2122/97 GGAGGAVTGTGATGGSGGAGGGALLFGAGGAGGAGGSSGIGGFAAGGAGG
Rv0279c|M.tuberculosis_H37Rv GGSGG--IGTTGQGGTGGTGGAALLIGSGGTGGSGG----FGLDTGGAGG
MMAR_3729|M.marinum_M GGSGG---------------RAALLYGVGGDGGAGG-----------AGG
MUL_3672|M.ulcerans_Agy99 GGSGG---------------RAALLYGVGRDGGAGG-----------AGG
MAV_3950|M.avium_104 GFEAG----------------RDAAFADAGSHNAAAN---------YEAA
. * . . .
Mflv_2584|M.gilvum_PYR-GCK --------------------------GDWGG-DAGGGDWDSGGDWGGG--
Mvan_4049|M.vanbaalenii_PYR-1 DAGG----------------------GDWGGGDAGGGDWGGGWDSGGGG-
MSMEG_4681|M.smegmatis_MC2_155 ADAG----------------------GDWGG-DTAG-DWG-GMDTGGGWG
TH_0349|M.thermoresistible__bu --------------------------GDFGGSDFGG---------DGGGL
MAB_1577c|M.abscessus_ATCC_199 ADQGGWDQGS--------GADQGGGWDQGGGWDSGGSGWD-GGGWDGGGG
Mb0856|M.bovis_AF2122/97 PGGAGGLFNGGGAGGAGGSGVSG---GAGGEGGAGGAGGLFAGGGIGGAG
Rv0279c|M.tuberculosis_H37Rv RGGDAGLFLG-AAGTGGQAALSQNFIGAGGTAGAGGTGGLFANGGAGGAG
MMAR_3729|M.marinum_M DVVGS----------------------AGGSGGFGGAAGLVGVGGDGGAG
MUL_3672|M.ulcerans_Agy99 DGVGS----------------------AGGSGGLGGAAGLVDVGGDGGAG
MAV_3950|M.avium_104 NYDGG---------------------YDAGGDIGFDGGWDSGAGWDSGGS
* . .*
Mflv_2584|M.gilvum_PYR-GCK DFGG---------------------------------GDFGGFDF-----
Mvan_4049|M.vanbaalenii_PYR-1 DWGG---------------------------------GDFGGFEF-----
MSMEG_4681|M.smegmatis_MC2_155 DFGGD-------------------------------FGDFGGF-------
TH_0349|M.thermoresistible__bu DFGG--------------------------------FGDFGGF-------
MAB_1577c|M.abscessus_ATCC_199 DFGG----------------------------------DFGDF-------
Mb0856|M.bovis_AF2122/97 GFGGFRGGEGGAGGAGGLFAGGGAGGAGGSGNNVGGAGGAGGVGGLFGAG
Rv0279c|M.tuberculosis_H37Rv GFG----ANGGTGGNGLLFGAGGTGGAG----TLGADGGAGGHGGLFGAG
MMAR_3729|M.marinum_M GAG------------------GGAGG----------DGGAGAY--LIGDG
MUL_3672|M.ulcerans_Agy99 GAG------------------GGAGG----------DGGAGAY--LIGDG
MAV_3950|M.avium_104 DSGG----------------------------------DIGF--------
. * . *
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 GAGGSGG--GGSVAGDGGAGGNAGLLAPGLAGGAGGGGGQGFDTGGAGGP
Rv0279c|M.tuberculosis_H37Rv GTGGAGGSSGGTFGGNGGSGGNAGLLALGASGGAGGSGGSALNVG-----
MMAR_3729|M.marinum_M GDGGAG--------------------------------------------
MUL_3672|M.ulcerans_Agy99 GDGGAGG-----HGGDGGAG------------------------------
MAV_3950|M.avium_104 --------------------------------------------------
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 GGDAGLLVGSGGVGGAGGFGLTTGGPGAAGGDAGLLFGSGGAGGAGGS-G
Rv0279c|M.tuberculosis_H37Rv --------GTGGVGGNG-------------GSGGSLFGFGGAGGTGGSSG
MMAR_3729|M.marinum_M -------------------------------------GDGNAG-------
MUL_3672|M.ulcerans_Agy99 -------------------------------------GDGNAG-------
MAV_3950|M.avium_104 --------------------------------------------------
Mflv_2584|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4681|M.smegmatis_MC2_155 --------------------------------------------------
TH_0349|M.thermoresistible__bu --------------------------------------------------
MAB_1577c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0856|M.bovis_AF2122/97 RTDLGGAGGAGGKAGLIGNGGNGGAGGAGGAGGPGGAAFG----LGNGGN
Rv0279c|M.tuberculosis_H37Rv IGSSGGTGGDGGTAGVFGNGGDGGAGGFGADTGGNSSSVPNAVLIGNGGN
MMAR_3729|M.marinum_M -SLAGGTGGNGGDAKLIGNGGNGGDGGVGFGGGAN----------GSGGT
MUL_3672|M.ulcerans_Agy99 -SLAGGTGGNGGDAKVIGNGGNGGDGGVRFGGGAN----------GSGGT
MAV_3950|M.avium_104 --------------------------------------------------
Mflv_2584|M.gilvum_PYR-GCK ---------------------------------
Mvan_4049|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_4681|M.smegmatis_MC2_155 ---------------------------------
TH_0349|M.thermoresistible__bu ---------------------------------
MAB_1577c|M.abscessus_ATCC_199 ---------------------------------
Mb0856|M.bovis_AF2122/97 GGNGGTGTSAGSPGAGGAGGSLIGAEGLPGLLP
Rv0279c|M.tuberculosis_H37Rv GGNGGK--AGGTPGAGGTSGLIIGENGLNGL--
MMAR_3729|M.marinum_M GG------AAGLLGSPGSDGTTV----------
MUL_3672|M.ulcerans_Agy99 GG------AAGLLGSPGSDGTTV----------
MAV_3950|M.avium_104 ---------------------------------