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M. gilvum PYR-GCK Mflv_2538 (-)

annotation: peptidase S15
coordinates: 2646131 - 2648794
length: 887

MNAASVIGRVGGLAVAFGVGTAVLGGNAVASAKPAADGSDTRASVSQASETSGAADTSEPTTAADTDTRD
SDIPADDAPDSDDDAADPDGAAEPDREDADGDIGLPAANEDAGDAESDDRPATSSRKPDTSDGDASTQVT
SPASATSPTSDDDAPAETPDDAGAAAPTTSPVRQEQAITWLSSPAAVAGRTGAAPTPAVTASASVASPLL
TLVENLFSPFAGYSPDGLPSGSPLSWAMAAAARREALVAGGPISVDPTLDFLDGVIYGSVGATDTNGRPL
IYTLLDGPDQGGKITLNDDGTFSFLPDLSVVDSRGVENFTVMVSQTSVLMALLEQIPIIGDFVQPLVIGL
QQVPVLGALLQPIIGYRVITTIGVDVDELVPVGAPVAFTTMVTSFDGTQISTNFFPASGLQFGETAPTVL
NGPGLGSAGDIDPTSETTVFDLVPGLVPLRDGGYNVVTWDPRGEFASGGVLQLDNPFFEGRDVQAIISWV
AGRPETELDAPGDPTMGMVGGSYGGGIQLVTAGIDDRVDAIVPVIAWNSLTRALYPTKAFKTGWATLLGL
DLLEAGARINSQIYPAIILGDLLGFITETQEAILESSGPTVLVSSITAPTLLIQGTADGLFTLAQAVANA
MLLDANGVPVEMIWACGGHGVCLDPLNPIQTPLLVNTTLDWLDRYVRGNELIPTGPRFEWFDQTGAYHSS
DLLPTEPDFYGDPIVTDSDGGFLPIIPILGGSGPQTQSPTPLIVSPALASEASLALNLEIAAPAGTQIVG
APEITLTYSGLGTATHIYGQLVDDATGLVLGNLVTPIPVTLNGRTQTVTIDLEQIAYTAVPGGTLTLQLA
GFATPYLDLFQVGFIDVESVSLSLPTVAVGAGAGAAQAGVAVGSAAA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2538--100% (887)peptidase S15
M. gilvum PYR-GCKMflv_5229-e-14538.64% (898) peptidase S15
M. gilvum PYR-GCKMflv_5192-e-13137.89% (797) peptidase S15

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3469c-5e-0627.89% (190) hypothetical protein Mb3469c
M. tuberculosis H37RvRv3439c-6e-0627.89% (190) hypothetical protein Rv3439c
M. leprae Br4923MLBr_01022rpoT7e-0629.50% (139) RNA polymerase sigma factor
M. abscessus ATCC 19977MAB_4508-5e-0528.24% (170) putative membrane protein, MmpL
M. marinum MMMAR_2416lgt5e-0825.77% (194) prolipoprotein diacylglyceryl transferases Lgt
M. avium 104MAV_4382-8e-0729.17% (168) hypothetical protein MAV_4382
M. smegmatis MC2 155MSMEG_4365-2e-0925.45% (279) hypothetical protein MSMEG_4365
M. thermoresistible (build 8)TH_2316-2e-1130.29% (208) conserved hypothetical protein
M. ulcerans Agy99MUL_3715rne9e-0727.97% (143) ribonuclease E Rne
M. vanbaalenii PYR-1Mvan_4077-1e-16441.77% (905) peptidase S15

CLUSTAL 2.0.9 multiple sequence alignment


Mb3469c|M.bovis_AF2122/97           ----------------------------------------------MADR
Rv3439c|M.tuberculosis_H37Rv        ----------------------------------------------MADR
MAV_4382|M.avium_104                ----------------------------------------------MADR
Mflv_2538|M.gilvum_PYR-GCK          ----------------------------------MNAASVIGRVGGLAVA
Mvan_4077|M.vanbaalenii_PYR-1       ----------------------------------MGAAKYVGRVGGLAVA
MSMEG_4365|M.smegmatis_MC2_155      ----------------------------------------MGRIGALAVA
TH_2316|M.thermoresistible__bu      ----------------------------------------VGRVGALAVA
MAB_4508|M.abscessus_ATCC_1997      --------------------------------MFAWWGRMVYRYRFIVVA
MMAR_2416|M.marinum_M               -----------------------------------MTATVLAYFPSPPRG
MUL_3715|M.ulcerans_Agy99           MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTSSRRVLDALSALDGR
MLBr_01022|M.leprae_Br4923          ----------------------------------MEQSRRVPPLQWLSAV
                                                                                      

Mb3469c|M.bovis_AF2122/97           LNVAERLAEG------------RPAAEHTQSYVR----------------
Rv3439c|M.tuberculosis_H37Rv        LNVAERLAEG------------RPAAEHTQSYVR----------------
MAV_4382|M.avium_104                LDVAGRLAEG------------RAGVEHTQTYVQ----------------
Mflv_2538|M.gilvum_PYR-GCK          FGVGTAVLGG-NAVASAKPAADGSDTRASVSQASETSGAADTSEPTTAAD
Mvan_4077|M.vanbaalenii_PYR-1       LGVGVAILTG-QGVA----YADDTGTASSETTATENSSAEGPARQGAASD
MSMEG_4365|M.smegmatis_MC2_155      LGIGAALTTG-TGVAWADDSGASGGSTSSSSSASDS------SSSSAGGS
TH_2316|M.thermoresistible__bu      LGVGVAVATGGTAVAWAD-SGSTASSSSSQDSSSKSNPAQTRSSAKSGIG
MAB_4508|M.abscessus_ATCC_1997      AFVTVCLGSGLFGITLGDHVTQSGFFADNSESVKASVMADDALGRDRTTH
MMAR_2416|M.marinum_M               VWHLGPLPIRAYAFFIIIGIVMGLMIGDRRFAARGGERGVIYDIALWMVP
MUL_3715|M.ulcerans_Agy99           IRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEDQQAPDAVAAEVPDAPGE
MLBr_01022|M.leprae_Br4923          ARPIARVLTLISTPTFDIADTFGYACPNPPEVSPTEGVYVVATKTSPATG
                                                                                      

Mb3469c|M.bovis_AF2122/97           --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4382|M.avium_104                --------------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          TDTRDSDIPADDAPDSDDDAADPDGAAEPDREDADGDIGLPAANEDAGDA
Mvan_4077|M.vanbaalenii_PYR-1       SDVGTG---------ADDEASDVGTVADDEASDVG-----TVADDEASDV
MSMEG_4365|M.smegmatis_MC2_155      SGSASG-----------------GADAAKPRKPGV-----TKP-------
TH_2316|M.thermoresistible__bu      SGAGSGPGSRLDRPASRAPLGGSGADSSATEQTGA-----VSSGTSAWRS
MAB_4508|M.abscessus_ATCC_1997      VVAVIAAPEGKTVDDPAFQKKVIDHFDQLQKDNPD-----EVYGWAGWLR
MMAR_2416|M.marinum_M               FGLIGG--------------------------------------------
MUL_3715|M.ulcerans_Agy99           PAEPESRLMLETQETVQVVETWVERPHYMPLFVAPQPISEPVAGDDADDE
MLBr_01022|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ------------ACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHALDADC
Rv3439c|M.tuberculosis_H37Rv        ------------ACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHALDADC
MAV_4382|M.avium_104                ------------ACHALGYQHPDLTAHPAQVREWYAGEDGLDLRALDRDC
Mflv_2538|M.gilvum_PYR-GCK          ESDDRPATSSRKPDTSDGDASTQVTSPASATSPTSDDDAPAETPDDAGAA
Mvan_4077|M.vanbaalenii_PYR-1       GTVADDGAS--DVETAEDDEASDVEEQQSGGGTGEDSTTPAEPVDTADDT
MSMEG_4365|M.smegmatis_MC2_155      -----RIQPTGKIAESLKKTAKAVEGAVADAHKRAQQSAAQQAEKRAERR
TH_2316|M.thermoresistible__bu      AGMPAGTSLTGRLADSVRDAVKPWRPATTRSTDPTPVETPAEANPEAQPD
MAB_4508|M.abscessus_ATCC_1997      APTTTDPTVKRMVTEDRKHTFVSVSLKGDDDDTILNNYKALSNPDKDDDP
MMAR_2416|M.marinum_M               -------RLYHLSTDWQTYFGEGGAGLGAALRIWDGGLGIWGAVTLGTVG
MUL_3715|M.ulcerans_Agy99           SGDEGDDDEEQADRPGNRRRRRGRRGRGRGRGEQGANDGQDQPGDDGDEA
MLBr_01022|M.leprae_Br4923          -----------QPVKRTATKTPATPAKRSTTKAANGSAPTKRATSTASRA
                                                                                      

Mb3469c|M.bovis_AF2122/97           AQLR----------------------------------------------
Rv3439c|M.tuberculosis_H37Rv        AQLR----------------------------------------------
MAV_4382|M.avium_104                AELR----------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          APTTSPVRQEQAITWLSSPAAVAGRTGAAPTPAVTASASVASPLLTLVEN
Mvan_4077|M.vanbaalenii_PYR-1       ASLSAPVVS---TTVVSPPASAD----LALDPIADDSG------------
MSMEG_4365|M.smegmatis_MC2_155      AKLRAQIRP-GKDTDKQAPEKQ---------AGNEAKN------------
TH_2316|M.thermoresistible__bu      AHAGSPGES-TAPETQPAPSSRGIRSMTAVLPDTESTN------------
MAB_4508|M.abscessus_ATCC_1997      AKNKFLMDGVDIQLAGLQPVASELTGTIGKDQQRMEVLS-----------
MMAR_2416|M.marinum_M               AWIGCRRRG-----------------------------------------
MUL_3715|M.ulcerans_Agy99           PQKAGGNSTSSDDSEAQDGADSEESDNGDDDNGSADGASR--------RR
MLBr_01022|M.leprae_Br4923          TKSTTP--------------------------------------------
                                    .                                                 

Mb3469c|M.bovis_AF2122/97           -----------------------AAASVLMEALRMERSQVAVLAAAWTG-
Rv3439c|M.tuberculosis_H37Rv        -----------------------AAASVLMEALRMERSQVAVLAAAWTG-
MAV_4382|M.avium_104                -----------------------AAGVVAAEALRLQRAQVAELAVAWTG-
Mflv_2538|M.gilvum_PYR-GCK          LFSPFAGYSPDGLPSGSPLSWAMAAAARREALVAGGPISVDPTLDFLDGV
Mvan_4077|M.vanbaalenii_PYR-1       -TAPIGGSAADLLLLAGTR---RELQAQQEAALEIPPYSVGVTAGVIGGC
MSMEG_4365|M.smegmatis_MC2_155      -AAQPATKTQRQLP--------AAPAVKVPDVITSVRARSDEVAREITTG
TH_2316|M.thermoresistible__bu      -TESTNTESTVQHDDSERRSSLRSTAASVPELSTPVRLADATAVRALAER
MAB_4508|M.abscessus_ATCC_1997      LPVMAVVLFFVFGGVIAAGLPLMVGGLTIAGALGIMRLVTLFAPVHFFAQ
MMAR_2416|M.marinum_M               --------------------IPLPAFLDAVAPGVVMGQAIGRLGNYFNQE
MUL_3715|M.ulcerans_Agy99           RRRRRRKSGAGDDGDEGPAPDDPPNTVVHERAPRSGDKSGNSDSGDDSGG
MLBr_01022|M.leprae_Br4923          -----------------------PKASGASDAAKKARTSVKSVDTKAPS-
                                                                                      

Mb3469c|M.bovis_AF2122/97           --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4382|M.avium_104                --------------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          IYGSVGATDTNGRPLIYTLLDGPDQGGKITLN-DDGTFSFLPDLSVVDS-
Mvan_4077|M.vanbaalenii_PYR-1       VVGPTCTTADGS---TFTLIKDPDKGGKLALDPTTGAFRFLPFASEKNPD
MSMEG_4365|M.smegmatis_MC2_155      VTGIRTAIENAAPRIALPDLRPTTNL-------ARPVTPVALKAAQPVQ-
TH_2316|M.thermoresistible__bu      LTERRSVTLESVR--AFTDVAATTALTSAASVAAATVEPVALITAAPEAT
MAB_4508|M.abscessus_ATCC_1997      PVVTLIGLGIAIDYSLFIVSRFREEIAEGYDTETAVRRTVITSGRTVMFS
MMAR_2416|M.marinum_M               LYGRETTVPWGLEIFYRRDPSGFVDVHSLDGVSTGQVAVVVQPTFLYELI
MUL_3715|M.ulcerans_Agy99           NEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMV
MLBr_01022|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ------------------SGADAAVHFVQRHCETGNSVVTEVRAAAQRCE
Rv3439c|M.tuberculosis_H37Rv        ------------------SGADAAVHFVQRHCETGNSVVTEVRAAAQRCE
MAV_4382|M.avium_104                ------------------AGGEAAVQLLQRHCDTAEALATELRAAAQRCE
Mflv_2538|M.gilvum_PYR-GCK          --------RGVENFTVMVSQTSVLMALLEQIPIIG-DFVQPLVIGLQQVP
Mvan_4077|M.vanbaalenii_PYR-1       GSQNADGPSGQETFSVLVAQNTQFTTFLIGLPIVGSSILAPVIMTLQQIP
MSMEG_4365|M.smegmatis_MC2_155      -----------------VSPPRPTITGLVRGLLTAAAGFSPRAATAPVAP
TH_2316|M.thermoresistible__bu      ---------------PAVDAEQPAAPRLVTGLL-AAVGLAPFTANSPLAP
MAB_4508|M.abscessus_ATCC_1997      -----------ATLIAAALMPMLIVPQQFLRSLTYAGIASVLLAAILAVT
MMAR_2416|M.marinum_M               WN----------------LLVFAALIYLDRRFTIGHGRLFASYVALYCVG
MUL_3715|M.ulcerans_Agy99           VR-----------DRVRTEPPHPGSRYTQIAVLEDGIVVEHFVTSAASAS
MLBr_01022|M.leprae_Br4923          ------------------AQDHTTKASAAKDTLNDPEATLNTLDSDATAD
                                                                                      

Mb3469c|M.bovis_AF2122/97           SLRDNLWQLVDSKVATAIAIDERALA-----------------QRPAWLA
Rv3439c|M.tuberculosis_H37Rv        SLRDNLWQLVDSKVATAIAIDERALA-----------------QRPAWLA
MAV_4382|M.avium_104                SLRDNLWYLIDAKAATAIAVDDRTRA-----------------QRPEWLA
Mflv_2538|M.gilvum_PYR-GCK          VLGALLQPIIGYRVITTIGVDVDEL------------------VPVGAPV
Mvan_4077|M.vanbaalenii_PYR-1       VISTVLAPLIGTATRQDILVDIDFLR-----------------TPAETPV
MSMEG_4365|M.smegmatis_MC2_155      APSPAAWALLAFARREFERAFTPGAA-----------------TALAAPA
TH_2316|M.thermoresistible__bu      TQSTPLLALLGWARRETDRAYTQQAR-----------------SLVTA--
MAB_4508|M.abscessus_ATCC_1997      VLPACLGVLGRHVDALSIKRFSRTKSREELENGFWGRTVVYVMQRPLVFA
MMAR_2416|M.marinum_M               RFCVELLRDDTATHIAGIRINSFTST-----------------FVFIGAV
MUL_3715|M.ulcerans_Agy99           LVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYAGEVNWDAAGLGGADRK
MLBr_01022|M.leprae_Br4923          DLDAEPDLDVEPSEDIDIDIEAADLG----------------LDDLEDDD
                                                                                      

Mb3469c|M.bovis_AF2122/97           AAEALTT-------------------------------------------
Rv3439c|M.tuberculosis_H37Rv        AAEALTT-------------------------------------------
MAV_4382|M.avium_104                AAAAVTA-------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          AFTTMVTSFDGTQISTNFFPASGLQFGETAP----TVLNGPGLGSAGDID
Mvan_4077|M.vanbaalenii_PYR-1       AYTTMVTSWDGTQISTNFFPAIADGNPDDGNPGYETILYGPGLAQAGATD
MSMEG_4365|M.smegmatis_MC2_155      ITTSAVT----SAAVVNPLPGRLD--SVPVG-----WVTGVSNPSGNWPQ
TH_2316|M.thermoresistible__bu      -RPAVVS----TAAVVDPLPADLIGETERIG-----RITGPG-------I
MAB_4508|M.abscessus_ATCC_1997      VPIVIVMLLLIIPLGNLKLGGFSEKYLPPTNSVRQAQENFDSLFPGFRTE
MMAR_2416|M.marinum_M               VYIILAPKGREDPASVRGTAAAAEEVPEPEP-------------------
MUL_3715|M.ulcerans_Agy99           IEQALKPGDYIVVQVSKDPVGHKGARLTTQVSLAGRYLVYVAGASSTGIS
MLBr_01022|M.leprae_Br4923          VVTDIEP-------------------------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ---------------------------EGADRPTAVEVVRQQIQPYVDDD
Rv3439c|M.tuberculosis_H37Rv        ---------------------------EGADRPTAVEVVRQQIQPYVDDD
MAV_4382|M.avium_104                ---------------------------GQPDRDDAHNVIRQKVIPYVDND
Mflv_2538|M.gilvum_PYR-GCK          PTSETTVFDLVPGLVPLRDGGYNVVTWDPRGEFASGGVLQLDNPFFEGRD
Mvan_4077|M.vanbaalenii_PYR-1       PE--------NPFVSTFRLGGYNVVTWDPRGEFASGGVLQLDSPQYEGQD
MSMEG_4365|M.smegmatis_MC2_155      TNNT---------AGFDIWGTDLGIMWDGGEWNGQRFVHTAFGDTFSGPN
TH_2316|M.thermoresistible__bu      TDGP---------NRLNIYGTDLGIMWDMGEWRGQRAVHVVFGDTFSGPN
MAB_4508|M.abscessus_ATCC_1997      TITIVTKGATDSQLNQIRADAMKVPGFVEPGGDKTQMWQRRQAVKTDGDT
MMAR_2416|M.marinum_M               ---------------AGEVATAAAPAGDTEGDEPTGLAETAKAAEVAEPE
MUL_3715|M.ulcerans_Agy99           RKLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVTRLQERW
MLBr_01022|M.leprae_Br4923          ----------------------------GETEDGEATAATKTDEASTDDD
                                                                                      

Mb3469c|M.bovis_AF2122/97           VRN--DWLTTMRSTTAGVAAS------YDAVTDQLASAPRAHFEIPDDLG
Rv3439c|M.tuberculosis_H37Rv        VRN--DWLTTMRSTTAGVAAS------YDAVTDQLASAPRAHFEIPDDLG
MAV_4382|M.avium_104                IRN--EWLTAMRSATDGVQTS------YAMVVDRMAAAPAARFELPGDLG
Mflv_2538|M.gilvum_PYR-GCK          VQAIISWVAGRPETELDAPGDPTMGMVGGSYGGGIQLVTAGIDDRVDAIV
Mvan_4077|M.vanbaalenii_PYR-1       VSQLISWAAGLDGVELDGVGDPTLGMVGVSYGGGIQFVTAAGDNRVDAIA
MSMEG_4365|M.smegmatis_MC2_155      MSG--WWRSNVLLISTDNVLSDGLG--LVQTGTAYQFIPASGRNLFGLFG
TH_2316|M.thermoresistible__bu      MSG--DWISNAIMISTSRTLYENPAGFLEQTGPAFQFIP--GGQLLSWFF
MAB_4508|M.abscessus_ATCC_1997      SVKVIQNALVDRNTAGAKVKQLREIPVPKGVTMYVGGTPALEQDSIDTVF
MMAR_2416|M.marinum_M               TVG--SAVAGDESTADTEASDAVESEVGEAAEAEAPEAEAEEAEVGEVEV
MUL_3715|M.ulcerans_Agy99           NQIEAKAVEIKQKAAGAAVALYEEPDVLVKVIRDLFNEDFAGLVVSGDDA
MLBr_01022|M.leprae_Br4923          EEIVEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIG
                                                                                      

Mb3469c|M.bovis_AF2122/97           PGRQPSPAS--------------------VPAQPSATAAITP--------
Rv3439c|M.tuberculosis_H37Rv        PGRQPSPAS--------------------VPAQPSATAAITP--------
MAV_4382|M.avium_104                SGLVPVPATRPLVAAPMPPLDAAPTLPDAAPTLPAAVSEPAA--------
Mflv_2538|M.gilvum_PYR-GCK          PVIAWNSLTRALYPTKAFKTGWATLLGLDLLEAGARINSQIYP-----AI
Mvan_4077|M.vanbaalenii_PYR-1       PGWAWNTLPDSLYPDRSFKTAYSSLLLLGLVTTGARINPQIYG-----GI
MSMEG_4365|M.smegmatis_MC2_155      GSEVTVIPTAGVQIDG---TQYVNYMSVRSWDTPGRWTTNFS--------
TH_2316|M.thermoresistible__bu      PAEVTVIPTAGVHANG---TQYVNYMSVRQWGVPGSWTTNFS--------
MAB_4508|M.abscessus_ATCC_1997      DKLPFVIVVLISVTTILMFLAFGSLVLPIKAAVMSALGLGSTMGILTWIF
MMAR_2416|M.marinum_M               AEAVEGEVEEAEEAEPGEVEVAEAVEGEVEAAAEAEEAEEAEEA------
MUL_3715|M.ulcerans_Agy99           WDTINEYVSSVAPDLVSKLSKYEPAVGSEGQVGPDVFAVHRIDEH---LA
MLBr_01022|M.leprae_Br4923          KVALLNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRR-------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ----AAALPPPDPVPAVTSRPVTP--SDFGSAPG-DGSATPAG-VGSAGG
Rv3439c|M.tuberculosis_H37Rv        ----AAALPPPDPVPAVTSRPVTP--SDFGSAPG-DGSATPAG-VGSAGG
MAV_4382|M.avium_104                ----AATLPAAAPTPAAVPPAAAAPAADWGAALG-DVAGMPAGDLGGLAE
Mflv_2538|M.gilvum_PYR-GCK          ILGDLLGFITETQEAILESSGPTVLVSSITAPTL-LIQGTADGLFTLAQA
Mvan_4077|M.vanbaalenii_PYR-1       ITGAILGVLTPGQIQLLQTSGPGQTVRGISAPTL-IIQGTVDVLFPLQQS
MSMEG_4365|M.smegmatis_MC2_155      ----AISVYDPSTDTWVLAPSTIRSAGWFRSSTL-YVPGSQN---FQQAA
TH_2316|M.thermoresistible__bu      ----AISRYDQATDTWVTVPSSVRSAGWLRSSTP-YRAGDQN---FQQMA
MAB_4508|M.abscessus_ATCC_1997      VDGHFSKWLNFTPTPLTAPVIVLIIVVIYGLSSDYEVFLMSRMIEARHQG
MMAR_2416|M.marinum_M               --EEAEEAEEAEPGEIEVAEAVEGEVEAAAEAEEAEVGEVEAVDEAAEAE
MUL_3715|M.ulcerans_Agy99           KAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSGGNLEQTVTKNNLE
MLBr_01022|M.leprae_Br4923          ----DMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGN
                                                                                      

Mb3469c|M.bovis_AF2122/97           FGDAGGTG-GLGGFAGLAGLAN----------------------------
Rv3439c|M.tuberculosis_H37Rv        FGDAGGTG-GLGGFAGLAGLAN----------------------------
MAV_4382|M.avium_104                SGMGSGLGSGLGGGGGLLGLAG----------------------------
Mflv_2538|M.gilvum_PYR-GCK          VANAMLLDANGVPVEMIWACGGHGVCLDP---------------------
Mvan_4077|M.vanbaalenii_PYR-1       IVNEGLLALN-EDVKMLWFCGGHGSCLPG---------------------
MSMEG_4365|M.smegmatis_MC2_155      YVLQPEDQVGEDGIRYLYAFG-----------------------------
TH_2316|M.thermoresistible__bu      YVLQPVDQVGEDGVRYVYAFG-----------------------------
MAB_4508|M.abscessus_ATCC_1997      LSTTEAVRVGTANTGRIITAAALILIVVAGGFAFSDLVMMKYLAFGLIAA
MMAR_2416|M.marinum_M               APEVGEIEAAEAVEGEVEVAAEAEEAEAG---------------------
MUL_3715|M.ulcerans_Agy99           AAEEIVRQLRLRDIGGIVVIDFIDMVLESN-------------------R
MLBr_01022|M.leprae_Br4923          LGLIRAVEKFDYTKGYKFSTYAT---------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ----------RIVDAVDSLLG-------------SVAEQLG--DPLAADN
Rv3439c|M.tuberculosis_H37Rv        ----------RIVDAVDSLLG-------------SVAEQLG--DPLAADN
MAV_4382|M.avium_104                ----------KIVDAMGGLLG-------------SVGDGLDGSDPFGDQD
Mflv_2538|M.gilvum_PYR-GCK          -LN--PIQTPLLVNTTLDWLDR----YVRGNELIPTGPRFEWFDQTGAYH
Mvan_4077|M.vanbaalenii_PYR-1       -QGNGEADSAWVMRETLAWMYR----YVK-DDGSQDDVVFEWTDQYGDRW
MSMEG_4365|M.smegmatis_MC2_155      ------TPSGRAGSAYLSRVP---------EDAVTDLSKYEYWD--GNRW
TH_2316|M.thermoresistible__bu      ------TPSGRQGSVHLSRVP---------EEHITDVSKYEYWD--GNAW
MAB_4508|M.abscessus_ATCC_1997      LILDATVVRMLLIPAVMKLLGDDCWWAPAWMKRIQVKLGLGEVTLPDERK
MMAR_2416|M.marinum_M               ------EDEPKEAEEVAEAEGS------------EAEDKTVQAIDGGQTG
MUL_3715|M.ulcerans_Agy99           DLVLRRLTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPH
MLBr_01022|M.leprae_Br4923          ---------WWIRQAITRAMAD--------------QARTIRIPVHMVEV
                                                                                      

Mb3469c|M.bovis_AF2122/97           PPG----AVDPF-AEDAADN------------------ADDGDDAHPEEA
Rv3439c|M.tuberculosis_H37Rv        PPG----AVDPF-AEDAADN------------------ADDGDDAHPEEA
MAV_4382|M.avium_104                PLDDNAFHGDPFHADDPADA------------------KDAGDDADETAA
Mflv_2538|M.gilvum_PYR-GCK          SSDLLPTEPDFYGDPIVTDS----DGGFLPIIPILGGSGPQTQSPTPLIV
Mvan_4077|M.vanbaalenii_PYR-1       TSEVSPTEAGFYDPPGVIPTTVWDTGKVLPIIPLIGGSGPNPEVPLPYSL
MSMEG_4365|M.smegmatis_MC2_155      VTGNAAVAAPVIGDSTRSTG-------------LFGFIVDWANDPNVLGG
TH_2316|M.thermoresistible__bu      VS-SAAHAAPIIGESTRSAG-------------LFGFIIDWANDPNVFGG
MAB_4508|M.abscessus_ATCC_1997      RPTGREQAIAAASSPVGSNARTTKLPIASERTRLPSTPTPRQHDPSAPAR
MMAR_2416|M.marinum_M               VDDAGEADAEPDDDSTAAEP------------------EVVVEQADIEEI
MUL_3715|M.ulcerans_Agy99           CSGRGILLHADPVDSAPTTGRKADSGGRRNRRSKKNRAEEPSEKEAVAKV
MLBr_01022|M.leprae_Br4923          INKLGRIQRELLQDLGREPTP-----------------EELAKEMDITPE
                                                                              .       

Mb3469c|M.bovis_AF2122/97           DEAAEPKEATEPDEADEVDDADESVP------AERAQDVAEEATLPPVAE
Rv3439c|M.tuberculosis_H37Rv        DEAAEPKEATEPDEADEVDDADESVP------AERAQDVAEEATLPPVAE
MAV_4382|M.avium_104                DEPGAPD---RPAPAGEAEPSGEPAP------SGEAAPTGEPAQP---VE
Mflv_2538|M.gilvum_PYR-GCK          SPALASEASLALNLEIAAPAGTQIVGAPEITLTYSGLGTATHIYGQLVDD
Mvan_4077|M.vanbaalenii_PYR-1       GDGSIASNAVTIALENPV-AEANVVGSPSVVIHYSGFGTSRHIYAQVVDR
MSMEG_4365|M.smegmatis_MC2_155      YLGGLVGAKTGGNVSELSVQYNEYLG---KYVVLYGDG-NNNIQMRIADR
TH_2316|M.thermoresistible__bu      YLGGLFGAKTGGNVGEMSVQYNEYLG---KYVILYGNGRTNNIEMRIADS
MAB_4508|M.abscessus_ATCC_1997      PTPPPPAPPTAPVNLAGNDSGDASATTRMAVPGKNVAPTDAPTTRVPGGN
MMAR_2416|M.marinum_M               EPQEPEAEAVAAAEATDADEGDGEPAEPASDDLDAVAAEDADVDVDATAT
MUL_3715|M.ulcerans_Agy99           PTYAPGEHPMFKAMAASSSSEAEHGDGEVEESGEELTAAVDDQTAVQVAL
MLBr_01022|M.leprae_Br4923          KVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQD
                                                                                      

Mb3469c|M.bovis_AF2122/97           PPPPAAPPVAE---------------------------------------
Rv3439c|M.tuberculosis_H37Rv        PPPPAAPPVAE---------------------------------------
MAV_4382|M.avium_104                ATPPAAPPPAA---------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          ATGLVLGNLVT---------------------------------------
Mvan_4077|M.vanbaalenii_PYR-1       STGLVVGNIVT---------------------------------------
MSMEG_4365|M.smegmatis_MC2_155      PEGPWSDPIEL---------------------------------------
TH_2316|M.thermoresistible__bu      PEGPWSDPIIL---------------------------------------
MAB_4508|M.abscessus_ATCC_1997      PAGPDAPTTRSSVAGTHRPDRRNADREIESWLGELRGPKQPGAAAGTEAG
MMAR_2416|M.marinum_M               EAEESGDESPE---------------------------------------
MUL_3715|M.ulcerans_Agy99           DLGETEESEETDG-------------------------------TDETDD
MLBr_01022|M.leprae_Br4923          QLQSVLETLSERE-------------------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ---PPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP---
Rv3439c|M.tuberculosis_H37Rv        ---PPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP---
MAV_4382|M.avium_104                ---PPP-GAPPADPGPAPAAAQPTPEP---GSTPCQIAADQLPQAGQ---
Mflv_2538|M.gilvum_PYR-GCK          ---PIPVTLNGRTQTVTIDLEQIAYTAVPGGTLTLQLAGFATPYLDLFQV
Mvan_4077|M.vanbaalenii_PYR-1       ---PVPVTLNGRDQVVTVDLNDIAYTVGPDSELELQIFTTATSYFNATQF
MSMEG_4365|M.smegmatis_MC2_155      ---ASSADYPGLYAPMIHPWSGTGMLEDDNGDPDVNNLYWNMSLWGDYNV
TH_2316|M.thermoresistible__bu      ---ATPQQYPGLYAPMIHPWSGTGYLLDENGDPDPESLYWNMSMWGPYNV
MAB_4508|M.abscessus_ATCC_1997      DATTAIPVSKPQSTPRPAQPNRASGTPGEDATTAMPIAKPEVQRQGPPRA
MMAR_2416|M.marinum_M               ----PAADSEEPEADESAPEDSAEDTSSGESDTQSELEQSQTIEQGSDQT
MUL_3715|M.ulcerans_Agy99           FDDDSDDSDDSDEDDDTDETNDTDVDADEDEDTDDDSDEDEDTEDDDELD
MLBr_01022|M.leprae_Br4923          --AGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSR
                                                                                      

Mb3469c|M.bovis_AF2122/97           --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4382|M.avium_104                --------------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK          GFIDVESVSLSLPTVAVGAGAGAAQAGVAVGSAAA---------------
Mvan_4077|M.vanbaalenii_PYR-1       GFINVESVEVTMPTTTKGTNQGPNPSLPEMPEVLVAV-------------
MSMEG_4365|M.smegmatis_MC2_155      VLMQTDLSGLKTVAV-----------------------------------
TH_2316|M.thermoresistible__bu      YLMQTDLSSLVEV-------------------------------------
MAB_4508|M.abscessus_ATCC_1997      QRPQPEQQQPAKPSTDATEALPAPGQNRTPQQQEVDEATRRSRGGSVSAQ
MMAR_2416|M.marinum_M               SAGDGEGPPPSAAVDGDTGPTRQGWRGRLRNRMRRSGR------------
MUL_3715|M.ulcerans_Agy99           DDLDDELDDDDSDSDDEDSESELTEPAAGRPAALEVTTIAERPRRRRAAG
MLBr_01022|M.leprae_Br4923          SQVLRDYLD-----------------------------------------
                                                                                      

Mb3469c|M.bovis_AF2122/97           ----------
Rv3439c|M.tuberculosis_H37Rv        ----------
MAV_4382|M.avium_104                ----------
Mflv_2538|M.gilvum_PYR-GCK          ----------
Mvan_4077|M.vanbaalenii_PYR-1       ----------
MSMEG_4365|M.smegmatis_MC2_155      ----------
TH_2316|M.thermoresistible__bu      ----------
MAB_4508|M.abscessus_ATCC_1997      DLLRREGRRI
MMAR_2416|M.marinum_M               ----------
MUL_3715|M.ulcerans_Agy99           RPAGPPIHLG
MLBr_01022|M.leprae_Br4923          ----------