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GAAKYVGRVGGLAVALGVGVAILTGQGVAYADDTGTASSETTATENSSAEGPARQGAASDSDVGTGADDE ASDVGTVADDEASDVGTVADDEASDVGTVADDGASDVETAEDDEASDVEEQQSGGGTGEDSTTPAEPVDT ADDTASLSAPVVSTTVVSPPASADLALDPIADDSGTAPIGGSAADLLLLAGTRRELQAQQEAALEIPPYS VGVTAGVIGGCVVGPTCTTADGSTFTLIKDPDKGGKLALDPTTGAFRFLPFASEKNPDGSQNADGPSGQE TFSVLVAQNTQFTTFLIGLPIVGSSILAPVIMTLQQIPVISTVLAPLIGTATRQDILVDIDFLRTPAETP VAYTTMVTSWDGTQISTNFFPAIADGNPDDGNPGYETILYGPGLAQAGATDPENPFVSTFRLGGYNVVTW DPRGEFASGGVLQLDSPQYEGQDVSQLISWAAGLDGVELDGVGDPTLGMVGVSYGGGIQFVTAAGDNRVD AIAPGWAWNTLPDSLYPDRSFKTAYSSLLLLGLVTTGARINPQIYGGIITGAILGVLTPGQIQLLQTSGP GQTVRGISAPTLIIQGTVDVLFPLQQSIVNEGLLALNEDVKMLWFCGGHGSCLPGQGNGEADSAWVMRET LAWMYRYVKDDGSQDDVVFEWTDQYGDRWTSEVSPTEAGFYDPPGVIPTTVWDTGKVLPIIPLIGGSGPN PEVPLPYSLGDGSIASNAVTIALENPVAEANVVGSPSVVIHYSGFGTSRHIYAQVVDRSTGLVVGNIVTP VPVTLNGRDQVVTVDLNDIAYTVGPDSELELQIFTTATSYFNATQFGFINVESVEVTMPTTTKGTNQGPN PSLPEMPEVLVAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4077 | - | - | 100% (854) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_1067 | - | e-123 | 35.02% (848) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_1041 | - | e-115 | 35.23% (843) | peptidase S15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2538 | - | 1e-164 | 41.77% (905) | peptidase S15 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2458 | - | 4e-05 | 27.85% (158) | PE-PGRS family protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_4365 | - | 4e-11 | 27.88% (165) | hypothetical protein MSMEG_4365 |
| M. thermoresistible (build 8) | TH_2316 | - | 8e-12 | 32.02% (178) | conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4077|M.vanbaalenii_PYR-1 MGAAKYVGRVGGLAVALGVGVAILTG-QGVA----YADDTGTASSETTAT
Mflv_2538|M.gilvum_PYR-GCK MNAASVIGRVGGLAVAFGVGTAVLGG-NAVASAKPAADGSDTRASVSQAS
MSMEG_4365|M.smegmatis_MC2_155 ------MGRIGALAVALGIGAALTTG-TGVAWADDSGASGGSTSSSSSAS
TH_2316|M.thermoresistible__bu ------VGRVGALAVALGVGVAVATGGTAVAWAD-SGSTASSSSSQDSSS
MMAR_2458|M.marinum_M ------MSFVNVVPNTVAAAAGDLAS-------IRSALSEATAAAAGPTT
:. :. :. :.. ... . . : :: ::
Mvan_4077|M.vanbaalenii_PYR-1 ENSSAEGPARQGAASDSDVGTG---------ADDEASDVGTVADDEASDV
Mflv_2538|M.gilvum_PYR-GCK ETSGAADTSEPTTAADTDTRDSDIPADDAPDSDDDAADPDGAAEPDREDA
MSMEG_4365|M.smegmatis_MC2_155 DS------SSSSAGGSSGSASG-----------------GADAAKPRKPG
TH_2316|M.thermoresistible__bu KSNPAQTRSSAKSGIGSGAGSGPGSRLDRPASRAPLGGSGADSSATEQTG
MMAR_2458|M.marinum_M DVLAAGGDEVSTAISQLFGAHG----------------------------
. : .
Mvan_4077|M.vanbaalenii_PYR-1 G-----TVADDEASDVGTVADDGAS--DVETAEDDEASDVEEQQSGGGTG
Mflv_2538|M.gilvum_PYR-GCK DGDIGLPAANEDAGDAESDDRPATSSRKPDTSDGDASTQVTSPASATSPT
MSMEG_4365|M.smegmatis_MC2_155 V-----TKP------------RIQPTGKIAESLKKTAKAVEGAVADAHKR
TH_2316|M.thermoresistible__bu A-----VSSGTSAWRSAGMPAGTSLTGRLADSVRDAVKPWRPATTRSTDP
MMAR_2458|M.marinum_M -------------------QEFQVVSAQLRGFHDQLVRLMRAGAAAYASV
. :
Mvan_4077|M.vanbaalenii_PYR-1 EDSTTPAEPVDTADDTASLSAPVVS---TTVVSPPASAD----LALDPIA
Mflv_2538|M.gilvum_PYR-GCK SDDDAPAETPDDAGAAAPTTSPVRQEQAITWLSSPAAVAGRTGAAPTPAV
MSMEG_4365|M.smegmatis_MC2_155 AQQSAAQQAEKRAERRAKLRAQIRP-GKDTDKQAPEKQ---------AGN
TH_2316|M.thermoresistible__bu TPVETPAEANPEAQPDAHAGSPGES-TAPETQPAPSSRGIRSMTAVLPDT
MMAR_2458|M.marinum_M EATAQQDLSMAEQGLVNAVNAPAQALLGHPIIGTGGSGS---------QS
. : .
Mvan_4077|M.vanbaalenii_PYR-1 DDSG-------------TAPIGGSAADLLLLAGTR---RELQAQQEAALE
Mflv_2538|M.gilvum_PYR-GCK TASASVASPLLTLVENLFSPFAGYSPDGLPSGSPLSWAMAAAARREALVA
MSMEG_4365|M.smegmatis_MC2_155 EAKN-------------AAQPATKTQRQLP--------AAPAVKVPDVIT
TH_2316|M.thermoresistible__bu ESTN-------------TESTNTESTVQHDDSERRSSLRSTAASVPELST
MMAR_2458|M.marinum_M ATTG--------------TSTSGVTSGSVASG-------SAAGSVSSGAT
. :
Mvan_4077|M.vanbaalenii_PYR-1 IPPYSVGVTAGVIGGCVVGPTCTTADGS---TFTLIKDPDKGGKLALDPT
Mflv_2538|M.gilvum_PYR-GCK GGPISVDPTLDFLDGVIYGSVGATDTNGRPLIYTLLDGPDQGGKITLN-D
MSMEG_4365|M.smegmatis_MC2_155 SVRARSDEVAREITTGVTGIRTAIENAAPRIALPDLRPTTNL-------A
TH_2316|M.thermoresistible__bu PVRLADATAVRALAERLTERRSVTLESVR--AFTDVAATTALTSAASVAA
MMAR_2458|M.marinum_M AGTVSTGATTGSVSSGATAGTVSAGATDGAVTSGTTASSSDGTTVSAGGV
. : .
Mvan_4077|M.vanbaalenii_PYR-1 TGAFRFLPFASEKNPDGSQNADGPSGQETFSVLVAQNTQFTTFLIGLPIV
Mflv_2538|M.gilvum_PYR-GCK DGTFSFLPDLSVVDS---------RGVENFTVMVSQTSVLMALLEQIPII
MSMEG_4365|M.smegmatis_MC2_155 RPVTPVALKAAQPVQ------------------VSPPRPTITGLVRGLLT
TH_2316|M.thermoresistible__bu ATVEPVALITAAPEAT---------------PAVDAEQPAAPRLVTGLL-
MMAR_2458|M.marinum_M AATDPGSDGGVAVSDP------------------GSDGGVAVSGSGSGSG
.
Mvan_4077|M.vanbaalenii_PYR-1 GSSILAPVIMTLQQIPVISTVLAPLIGTATRQDILVDIDFLRTPAETPVA
Mflv_2538|M.gilvum_PYR-GCK G-DFVQPLVIGLQQVPVLGALLQPIIGYRVITTIGVDVDEL-VPVGAPVA
MSMEG_4365|M.smegmatis_MC2_155 AAAGFSPRAATAPVAPAPSPAAWALLAFARREFERAFTPGAATALAAPAI
TH_2316|M.thermoresistible__bu AAVGLAPFTANSPLAPTQSTPLLALLGWARRETDRAYTQQARSLVTA---
MMAR_2458|M.marinum_M VAVGGTDTPGTSAPAPVTPNTFGDVVAAPYQTLISNTVTNLQSLDGAWAA
*. ::. :
Mvan_4077|M.vanbaalenii_PYR-1 YTTMVTSWDGTQISTNFFPAIADGNPDDGNPGYETILYGPGLAQAGATDP
Mflv_2538|M.gilvum_PYR-GCK FTTMVTSFDGTQISTNFFPASGLQFGETAP----TVLNGPGLGSAGDIDP
MSMEG_4365|M.smegmatis_MC2_155 TTSAVT----SAAVVNPLPGRLD--SVPVG-----WVTGVSNPSGNWPQT
TH_2316|M.thermoresistible__bu RPAVVS----TAAVVDPLPADLIGETERIG-----RITGPG-------IT
MMAR_2458|M.marinum_M NPAPFL----HQLIANQMG-------------------------------
.: . .: :
Mvan_4077|M.vanbaalenii_PYR-1 E--------NPFVSTFRLGGYNVVTWDPRGEFASGGVLQLDS-PQYEGQD
Mflv_2538|M.gilvum_PYR-GCK TSETTVFDLVPGLVPLRDGGYNVVTWDPRGEFASGGVLQLDN-PFFEGRD
MSMEG_4365|M.smegmatis_MC2_155 NNT----------AGFDIWGTDLGIMWDGGEWNGQRFVHTAFGDTFSGPN
TH_2316|M.thermoresistible__bu DGP----------NRLNIYGTDLGIMWDMGEWRGQRAVHVVFGDTFSGPN
MMAR_2458|M.marinum_M -------------------------------YAQTAATALQS----SVSN
: . :
Mvan_4077|M.vanbaalenii_PYR-1 VSQLISWAAGLDGVELDGVGDPTLGMVGVSYGGGIQFVTAAGDNRVDAIA
Mflv_2538|M.gilvum_PYR-GCK VQAIISWVAGRPETELDAPGDPTMGMVGGSYGGGIQLVTAGIDDRVDAIV
MSMEG_4365|M.smegmatis_MC2_155 MSG--WWRSNVLLISTDNVLSDGLG--LVQTGTAYQFIPASGRNLFGLFG
TH_2316|M.thermoresistible__bu MSG--DWISNAIMISTSRTLYENPAGFLEQTGPAFQFIP--GGQLLSWFF
MMAR_2458|M.marinum_M LPAALAHLPADIQLGTHSLMAADPG----AFLHSLVTNQLGYAQTISTAL
: . . . : ..
Mvan_4077|M.vanbaalenii_PYR-1 PGWAWNTLPDSLYPDRSFKTAYSSLLLLGLVTTGARINPQIYGGIITGAI
Mflv_2538|M.gilvum_PYR-GCK PVIAWNSLTRALYPTKAFKTGWATLLGLDLLEAGARINSQIYPAIILGDL
MSMEG_4365|M.smegmatis_MC2_155 GSEVTVIPTAGVQIDG---TQYVNYMSVRSWDTPGRWTTNFS-------A
TH_2316|M.thermoresistible__bu PAEVTVIPTAGVHANG---TQYVNYMSVRQWGVPGSWTTNFS-------A
MMAR_2458|M.marinum_M QSAAHDFGTGAAALPAAYQAAFQDFMAGNVSGAADHVESGLAN-------
. . . : : : . . :
Mvan_4077|M.vanbaalenii_PYR-1 LGVLTPGQIQLLQTSGPGQTVRGISAPTLIIQGTVDVLFPLQQSIVNEGL
Mflv_2538|M.gilvum_PYR-GCK LGFITETQEAILESSGPTVLVSSITAPTLLIQGTADGLFTLAQAVANAML
MSMEG_4365|M.smegmatis_MC2_155 ISVYDPSTDTWVLAPSTIRSAGWFRSSTLYVPGSQN---FQQAAYVLQPE
TH_2316|M.thermoresistible__bu ISRYDQATDTWVTVPSSVRSAGWLRSSTPYRAGDQN---FQQMAYVLQPV
MMAR_2458|M.marinum_M -----------LFITGFDVTPGSDAVLSITPTGTVG--------------
: .. : * .
Mvan_4077|M.vanbaalenii_PYR-1 LALN-EDVKMLWFCGGHGSCLPGQGNGEADSAWVMRETLAWMYRYVK-DD
Mflv_2538|M.gilvum_PYR-GCK LDANGVPVEMIWACGGHGVCLDPLN--PIQTPLLVNTTLDWLDRYVRGNE
MSMEG_4365|M.smegmatis_MC2_155 DQVGEDGIRYLYAFG-------------TPSGRAGSAYLSRVP-----ED
TH_2316|M.thermoresistible__bu DQVGEDGVRYVYAFG-------------TPSGRQGSVHLSRVP-----EE
MMAR_2458|M.marinum_M --------DLLPILG--------------IPGQMAQNFTNLLP-----AG
: * . :
Mvan_4077|M.vanbaalenii_PYR-1 GSQDDVVFEWTDQYGDRWTSEVSPTEAGFYDPPGVIPTTVWDTGKVLPII
Mflv_2538|M.gilvum_PYR-GCK LIPTGPRFEWFDQTGAYHSSDLLPTEPDFYGDPIVTDS----DGGFLPII
MSMEG_4365|M.smegmatis_MC2_155 AVTDLSKYEYWD--GNRWVTGNAAVAAPVIGDSTRSTG------------
TH_2316|M.thermoresistible__bu HITDVSKYEYWD--GNAWVS-SAAHAAPIIGESTRSAG------------
MMAR_2458|M.marinum_M SVPELVSQNFTNIVNAATNTAVTSTLTLVVDPSSPTG-------------
:: : . : . . . . .
Mvan_4077|M.vanbaalenii_PYR-1 PLIGGSGPNPEVPLPYSLGDGSIASNAVTIALENPV-AEANVVGSPSVVI
Mflv_2538|M.gilvum_PYR-GCK PILGGSGPQTQSPTPLIVSPALASEASLALNLEIAAPAGTQIVGAPEITL
MSMEG_4365|M.smegmatis_MC2_155 -LFGFIVDWANDPNVLGGYLGGLVGAKTGGNVSELSVQYNEYLG---KYV
TH_2316|M.thermoresistible__bu -LFGFIIDWANDPNVFGGYLGGLFGAKTGGNVGEMSVQYNEYLG---KYV
MMAR_2458|M.marinum_M -----VGVAIDATMGLPLALGVEALGGPVDAIDAFGTSATAFVTAAQSGN
: . . : :
Mvan_4077|M.vanbaalenii_PYR-1 HYSGFGTSRHIYAQVVDRSTGLVVGNIVTPVPVTLNGRDQVVTVDLNDIA
Mflv_2538|M.gilvum_PYR-GCK TYSGLGTATHIYGQLVDDATGLVLGNLVTPIPVTLNGRTQTVTIDLEQIA
MSMEG_4365|M.smegmatis_MC2_155 VLYGDG-NNNIQMRIADRPEGPWSDPIELASSADYPGLYAPMIHPWSGTG
TH_2316|M.thermoresistible__bu ILYGNGRTNNIEMRIADSPEGPWSDPIILATPQQYPGLYAPMIHPWSGTG
MMAR_2458|M.marinum_M VLAATAAVLDAPAVVAN---GLFNGQSTFPLTIDALGIPTTLNLPMDGIL
. . . :.: * . . . * : .
Mvan_4077|M.vanbaalenii_PYR-1 YTVGPDSELELQIFTTATSYFNATQFGFINVESVEVTMPTTTKGTNQGPN
Mflv_2538|M.gilvum_PYR-GCK YTAVPGGTLTLQLAGFATPYLDLFQVGFIDVESVSLSLPTVAVGAGAGAA
MSMEG_4365|M.smegmatis_MC2_155 MLEDDNGDPDVNNLYWNMSLWGDYNVVLMQTDLSGLKTVAV---------
TH_2316|M.thermoresistible__bu YLLDENGDPDPESLYWNMSMWGPYNVYLMQTDLSSLVEV-----------
MMAR_2458|M.marinum_M VPAGPYTATIPDLG--VTATVNGTPLGGVAPGLLTLLPEQLAEAIGASPV
: . . . : :
Mvan_4077|M.vanbaalenii_PYR-1 PSLPEMPEVLVAV
Mflv_2538|M.gilvum_PYR-GCK QAGVAVGSAAA--
MSMEG_4365|M.smegmatis_MC2_155 -------------
TH_2316|M.thermoresistible__bu -------------
MMAR_2458|M.marinum_M TD-----------