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SCRLSTASARLPEEPIAESLGISRNTLVTAEQHLDPEPVHPARRYHRTPTASDRNPVSMISMRAGTYVGR VGGLAVALGIGAAVLVGAGAAAADDDTGSSQSQSSQSANPATQESDPTSAANAAGDSSNESTDADSATAS SDDDTETEETAATDTVVEDTVVEDTAVDDSDGDLANEESEAEEVATERHPAKVATAQLTRDIAVVVDDTQ APETPAAPAITSLMTSVAAAGREATQEPAADRATTAEAPQYDLPTDVVVTEWTPPLEWLQTIPLFGRFVM TPLVGLLHNIPLIGDILHPVFGFPIDHNAPPGTPRARSFRVTSFDGTRIFVNFMPAKGLQAGESAPTILN GPGVSLPGSTTLELDVDSLLPDDVIGIGALRKAGYNVVTWDPRGEWRSEGRMQLQSPDFEGRDVSHIISY LATLDEVQTVNGDPKIGMVGASYGGGIQLSTATIDHRIDAIVPTIAWNSLAHSLFPNGAVRNGWGTILST ALILTLARPNERVLPATITGVLTGKVAQSDLDLFESLNFADRLANITAPTLLVQGTVDTLLPLSQADLNA KALIEAGTTTKVVWYCGGHGACLSSVNNGDLVVDRTLDWLDRHVKGEDIDTGAQFEWVDQNGDWYSSDTY PAAQDLTPITAQRTEDQSMLFFPFVGGAGPNPLIITRGLIATLLGLPSGAPAVNAVNLTVTAPSDGAGTT HVVGAPEVTLTYSGTGTATHVWAQIVDDETGLVLGNHTTPIPVQLDGNSHTVTVPLEQVAHTLMPGQSVT VQIVTSSFAFLNFYSGGAITIDELSVRLPTLAAGQAAQTVAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5192 | - | - | 100% (813) | peptidase S15 |
| M. gilvum PYR-GCK | Mflv_5229 | - | 0.0 | 56.75% (800) | peptidase S15 |
| M. gilvum PYR-GCK | Mflv_2538 | - | e-131 | 38.31% (804) | peptidase S15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2416 | lgt | 4e-06 | 24.73% (182) | prolipoprotein diacylglyceryl transferases Lgt |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_4365 | - | 1e-10 | 31.96% (194) | hypothetical protein MSMEG_4365 |
| M. thermoresistible (build 8) | TH_2316 | - | 5e-08 | 38.14% (97) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3715 | rne | 1e-05 | 27.74% (155) | ribonuclease E Rne |
| M. vanbaalenii PYR-1 | Mvan_1067 | - | 0.0 | 61.00% (777) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5192|M.gilvum_PYR-GCK ------------MSCRLSTASARLPEEPIAESLGISRNTLVTAEQHLDPE
Mvan_1067|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4365|M.smegmatis_MC2_155 --------------------MGRIGALAVALGIGAALTTG-TGVAWADDS
TH_2316|M.thermoresistible__bu --------------------VGRVGALAVALGVGVAVATGGTAVAWAD-S
MMAR_2416|M.marinum_M ----------------------------MTATVLAYFPSPPRGVWHLGPL
MUL_3715|M.ulcerans_Agy99 MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTSSRRVLDALSALDGR
Mflv_5192|M.gilvum_PYR-GCK PVHPARRYHRTPTASDRNPVSMISMRAGTYVGRVGGLAVALG--------
Mvan_1067|M.vanbaalenii_PYR-1 --MLLRRVARHG--------KYIAVTAGTYVGRVGGLAVALG--------
MSMEG_4365|M.smegmatis_MC2_155 GASGGSTSSSSSASDS------SSSSAGGSSGSASG--------------
TH_2316|M.thermoresistible__bu GSTASSSSSQDSSSKSNPAQTRSSAKSGIGSGAGSGPGSRLDRP------
MMAR_2416|M.marinum_M PIRAYAFFIIIG------------IVMGLMIGDR----------------
MUL_3715|M.ulcerans_Agy99 IRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEDQQAPDAVAAEVPDAPGE
*
Mflv_5192|M.gilvum_PYR-GCK ------------------------------------------------IG
Mvan_1067|M.vanbaalenii_PYR-1 ------------------------------------------------IG
MSMEG_4365|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu ------------------------------------------------AS
MMAR_2416|M.marinum_M --------------------------------------------------
MUL_3715|M.ulcerans_Agy99 PAEPESRLMLETQETVQVVETWVERPHYMPLFVAPQPISEPVAGDDADDE
Mflv_5192|M.gilvum_PYR-GCK AAVLVGAGAAAADD----DTGSSQSQSSQSANPATQESDPTSAANAAGDS
Mvan_1067|M.vanbaalenii_PYR-1 AAILAGTGVALADDGAASDTATSTSQTSEAAPAKDMPDDSTSEADTADGA
MSMEG_4365|M.smegmatis_MC2_155 -------GADAAKP----RKPGVTKP------------RIQPTGKIAESL
TH_2316|M.thermoresistible__bu RAPLGGSGADSSAT----EQTGAVSSGTSAWRSAGMPAGTSLTGRLADSV
MMAR_2416|M.marinum_M ---------------------RFAARGGERGVIYDIALWMVPFGLIGGRL
MUL_3715|M.ulcerans_Agy99 SGDEGDDDEEQADRPGNRRRRRGRRGRGRGRGEQGANDGQDQPGDDGDEA
. .
Mflv_5192|M.gilvum_PYR-GCK SNESTDADSATASSDDDTETEETAATDTVVEDTVVEDTAVDDSDGDLANE
Mvan_1067|M.vanbaalenii_PYR-1 EPNGDVEDESVAEADPDSAEPEEDAEDEVVEPEAADESAP-VVEPELAED
MSMEG_4365|M.smegmatis_MC2_155 KKTAKAVEGAVADAHKRAQQSAAQQAEKRAERRAKLRAQIRPGKDTDKQA
TH_2316|M.thermoresistible__bu RDAVKPWRPATTRSTDPTPVETPAEANPEAQPDAHAGSPGESTAPETQPA
MMAR_2416|M.marinum_M YHLSTDWQTYFGEGGAGLGAALRIWDGGLGIWGAVTLGTVGAWIGCRRRG
MUL_3715|M.ulcerans_Agy99 PQKAGGNSTSSDDSEAQDGADSEESDNGDDDNGSADGASRRRRRRRRRKS
.
Mflv_5192|M.gilvum_PYR-GCK -----ESEAEEVATERHPAKVATAQLTRDIAVVVDDTQAPETPAAPAITS
Mvan_1067|M.vanbaalenii_PYR-1 PTPVVEGPVDAEAAEEDDEPEFVSTPISNVGHTDFEADKDEEPAAPAESA
MSMEG_4365|M.smegmatis_MC2_155 PEKQ---------AGNEAKNAAQPATKTQRQLP--------AAPAVKVPD
TH_2316|M.thermoresistible__bu PSSRGIRSMTAVLPDTESTNTESTNTESTVQHDDSERRSSLRSTAASVPE
MMAR_2416|M.marinum_M IPLP-------AFLDAVAPGVVMGQAIGRLGNYFNQELYGRETTVPWGLE
MUL_3715|M.ulcerans_Agy99 GAGD---DGDEGPAPDDPPNTVVHERAPRSGDKSGNSDSGDDSGGNEIKG
.
Mflv_5192|M.gilvum_PYR-GCK LMTSVAAAGREATQEPAADRATTAEAP-----QYDLPTDVVVTEWTP---
Mvan_1067|M.vanbaalenii_PYR-1 LALSVLATAREKADEPTIDTVGAQAALSLVDDEYPIPTDVEVTELKP---
MSMEG_4365|M.smegmatis_MC2_155 VITSVRARSDEVAREITTGVTGIRTAIENAAPRIALPDLRPTTNL-----
TH_2316|M.thermoresistible__bu LSTPVRLADATAVRALAERLTERRSVTLESVR--AFTDVAATTALTSA--
MMAR_2416|M.marinum_M IFYRRDPSGFVDVHSLDGVSTG----------------QVAVVVQPTF--
MUL_3715|M.ulcerans_Agy99 IDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRV
: .
Mflv_5192|M.gilvum_PYR-GCK ------------PLEWLQTIPLFGRFVMTPLVG--LLHNIPLIGDILHPV
Mvan_1067|M.vanbaalenii_PYR-1 ------------AFEWLQQIPVLGRFVVTPIVH--LIHAIPFVSEILHPL
MSMEG_4365|M.smegmatis_MC2_155 ----------------ARPVTPVALKAAQPVQ---VSPPRPTITGLVRGL
TH_2316|M.thermoresistible__bu ------------ASVAAATVEPVALITAAPEATPAVDAEQPAAPRLVTGL
MMAR_2416|M.marinum_M ------------LYELIWNLLVFAALIYLDRRFTIGHGRLFASYVALYCV
MUL_3715|M.ulcerans_Agy99 RTEPPHPGSRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPS
. :
Mflv_5192|M.gilvum_PYR-GCK FGFPIDHNAPPGTPRARSFRVTSFDGTRIFVNFMPAKGLQAGESAPTILN
Mvan_1067|M.vanbaalenii_PYR-1 IGFPIDHDAPPGTPRARTVRLKSFDGTEIYVNFMPAKGLQAGESAPTVLS
MSMEG_4365|M.smegmatis_MC2_155 LTAAAGFSPRAATAPVAPAPSPAAWALLAFARREFERAFTPGAATALAAP
TH_2316|M.thermoresistible__bu L-AAVGLAPFTANSPLAPTQSTPLLALLGWARRETDRAYTQQARSLVTA-
MMAR_2416|M.marinum_M GRFCVELLRDDTATHIAGIRINSFTSTFVFIGAVVYIILAPKGRE-----
MUL_3715|M.ulcerans_Agy99 MEAAFVDIGRGRNGVLYAGEVNWDAAGLGGADRKIEQALKPGDYIVVQVS
.
Mflv_5192|M.gilvum_PYR-GCK GPGVSLPGS---------------------TTLELDVDSLLPDDVIGIGA
Mvan_1067|M.vanbaalenii_PYR-1 GPGVGLPGS---------------------TTLGLDIDSFLPHDVVGIGM
MSMEG_4365|M.smegmatis_MC2_155 AITTSAVTS---------------------AAVVNPLPGRLD--SVPVGW
TH_2316|M.thermoresistible__bu --RPAVVST---------------------AAVVDPLPADLIGETERIGR
MMAR_2416|M.marinum_M -DPASVRGT---------------------AAAAEEVPEPEPAGEVATAA
MUL_3715|M.ulcerans_Agy99 KDPVGHKGARLTTQVSLAGRYLVYVAGASSTGISRKLPDTERQRLKEILR
. : : :
Mflv_5192|M.gilvum_PYR-GCK LRKAGYNVVTWDPRGEWRSEGRMQLQSP----------------------
Mvan_1067|M.vanbaalenii_PYR-1 LRKAGYNVVTWDPRGEWHSGGRMQLQSP----------------------
MSMEG_4365|M.smegmatis_MC2_155 VTGVSNPSGNWP---QTNNTAGFDIWGT----------------------
TH_2316|M.thermoresistible__bu ITGPG----------ITDGPNRLNIYGT----------------------
MMAR_2416|M.marinum_M APAGDTEGDEPTGLAETAKAAEVAEPET----------------------
MUL_3715|M.ulcerans_Agy99 EVVPSDAGVIIRTASEGVKEDDIRADVTRLQERWNQIEAKAVEIKQKAAG
. . .
Mflv_5192|M.gilvum_PYR-GCK ----------------------DFEGRDVSHIISYLATLDEVQTVNGDPK
Mvan_1067|M.vanbaalenii_PYR-1 ----------------------DFEGRDISHIISWLSTLGEVDSVDGDPK
MSMEG_4365|M.smegmatis_MC2_155 ----------------------DLG---IMWDGGEWNGQRFVHTAFGDTF
TH_2316|M.thermoresistible__bu ----------------------DLG---IMWDMGEWRGQRAVHVVFGDTF
MMAR_2416|M.marinum_M ----------------------VGSAVAGDESTADTEASDAVESEVGEAA
MUL_3715|M.ulcerans_Agy99 AAVALYEEPDVLVKVIRDLFNEDFAGLVVSGDDAWDTINEYVSSVAPDLV
. * :
Mflv_5192|M.gilvum_PYR-GCK IGMVGASYGGGIQLSTATIDHRIDAIVPTIAWNSLAHSLFPN-GAVRNGW
Mvan_1067|M.vanbaalenii_PYR-1 VGMVGVSYGGGIQLSAASVDHRIDAIVPTIAWNSLVDAIFPR-QAVSSVW
MSMEG_4365|M.smegmatis_MC2_155 SGPNMSGWWRSNVLLISTDNVLSDGLG--LVQTGTAYQFIPASGRNLFGL
TH_2316|M.thermoresistible__bu SGPNMSGDWISNAIMISTSRTLYENPAGFLEQTGPAFQFIP--GGQLLSW
MMAR_2416|M.marinum_M EAEAPEAEAEEAEVGEVEVAEAVEGEVEEAEEAEPGEVEVAEAVEGEVEA
MUL_3715|M.ulcerans_Agy99 SKLSKYEPAVGSEGQVGPDVFAVHRIDEHLAKAMDRKVWLPSGGTLVIDR
. ..
Mflv_5192|M.gilvum_PYR-GCK GTILSTALILTLARPNERVLPATITGVLTGKVAQSDLDLFESLNFADRLA
Mvan_1067|M.vanbaalenii_PYR-1 GTFLSALLVGVGARPNERVLPAVIEAVLTGEAAQSDIDLFNSLNFADQLA
MSMEG_4365|M.smegmatis_MC2_155 FGGSEVTVIPTAGVQIDGTQYVNYMSVRSWDTPGRWTTNFSAISVYDPST
TH_2316|M.thermoresistible__bu FFPAEVTVIPTAGVHANGTQYVNYMSVRQWGVPGSWTTNFSAISRYDQAT
MMAR_2416|M.marinum_M AAEAEEAEEAEEAEEAEEAEEAEPGEIEVAEAVEGEVEAAAEAEEAEVGE
MUL_3715|M.ulcerans_Agy99 TEAMTVVDVNTGKFTGSGGNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVV
. . .
Mflv_5192|M.gilvum_PYR-GCK NITAPTLLVQGTVDTLLPLSQADLNAKALIEAGTTTKV--VWYCGGHGAC
Mvan_1067|M.vanbaalenii_PYR-1 NITAPTLLIQGTVDTLTTLAQADANAKALIAAGTTTKV--VWFCGGHGAC
MSMEG_4365|M.smegmatis_MC2_155 DTWVLAPSTIRSAGWFRSSTLYVPGSQNFQQAAYVLQP--EDQVGEDGIR
TH_2316|M.thermoresistible__bu DTWVTVPSSVRSAGWLRSSTPYRAGDQNFQQMAYVLQP--VDQVGEDGVR
MMAR_2416|M.marinum_M VEAVDEAAEAEAPEVGEIEAAEAVEGEVEVAAEAEEAE--AGEDEPKEAE
MUL_3715|M.ulcerans_Agy99 IDFIDMVLESNRDLVLRRLTEALARDRTRHQVSEVTSLGLVQLTRKRLGT
: .
Mflv_5192|M.gilvum_PYR-GCK LSSVNNGDLVVDRTLDWLDRHVKG-EDIDTGAQFEWVDQNGDWYSSDTYP
Mvan_1067|M.vanbaalenii_PYR-1 LSSFNDGEVVWRETMEWLDRHVKGDESIDPGPQFEWVDQHGDWYSSEVYP
MSMEG_4365|M.smegmatis_MC2_155 Y-LYAFGTPSGRAGSAYLSR--VPEDAVTDLSKYEYWDGNR-WVTGNAAV
TH_2316|M.thermoresistible__bu Y-VYAFGTPSGRQGSVHLSR--VPEEHITDVSKYEYWDGNA-WVS-SAAH
MMAR_2416|M.marinum_M EVAEAEGSEAEDKTVQAIDG---GQTGVDDAGEADAEPDDDSTAAEPEVV
MUL_3715|M.ulcerans_Agy99 GLIEAFSTSCPHCSGRGILLHADPVDSAPTTGRKADSGGRRNRRSKKNRA
. : . :
Mflv_5192|M.gilvum_PYR-GCK AAQDL--TPITAQRTEDQSMLFFPFVGGAGPNPLIITRGLIAT-----LL
Mvan_1067|M.vanbaalenii_PYR-1 VASGE--SVTATLANGGKTLPFVPFIGGSGPNPAILTRGVIRA-----VM
MSMEG_4365|M.smegmatis_MC2_155 AAP--------VIGDSTRSTGLFGFIVDWANDPNVLG-GYLGG-----LV
TH_2316|M.thermoresistible__bu AAP--------IIGESTRSAGLFGFIIDWANDPNVFG-GYLGG-----LF
MMAR_2416|M.marinum_M VEQ-------ADIEEIEPQEPEAEAVAAAEATDADEGDGEPAE-----PA
MUL_3715|M.ulcerans_Agy99 EEPSEKEAVAKVPTYAPGEHPMFKAMAASSSSEAEHGDGEVEESGEELTA
: *
Mflv_5192|M.gilvum_PYR-GCK GLPSGAPAVNAVNLTVTAPSDGAGTTHVVGAPEVTLTYSGTGTATHVWAQ
Mvan_1067|M.vanbaalenii_PYR-1 GLPSGAPALNAVNLRVP---DATEPTHLLGAPQLTLTYSGTGNAKHVYAQ
MSMEG_4365|M.smegmatis_MC2_155 GAKTGG-NVSELSVQYN---------EYLGK---YVVLYGDG-NNNIQMR
TH_2316|M.thermoresistible__bu GAKTGG-NVGEMSVQYN---------EYLGK---YVILYGNGRTNNIEMR
MMAR_2416|M.marinum_M SDDLDAVAAEDADVDVD-----------------ATATEAEESGDESPEP
MUL_3715|M.ulcerans_Agy99 AVDDQTAVQVALDLGETEESEETDGTDETDDFDDDSDDSDDSDEDDDTDE
. .: .
Mflv_5192|M.gilvum_PYR-GCK IVDDETGLVLGNHTTPIPVQLDGNSHTVTVPLEQVAHTLMPGQSVTVQIV
Mvan_1067|M.vanbaalenii_PYR-1 LVDDETGLVLGNQVTPIPVVLDGESHTVTFSMEQIAHTLKPGESVTLQVL
MSMEG_4365|M.smegmatis_MC2_155 IADRPEGPWSDPIELASSADYPGLYAPMIHPWSGTGMLEDDNGDPDVNNL
TH_2316|M.thermoresistible__bu IADSPEGPWSDPIILATPQQYPGLYAPMIHPWSGTGYLLDENGDPDPESL
MMAR_2416|M.marinum_M AADSEEPEADESAPEDSAEDTSSGESDTQSELEQSQTIEQGSDQTSAGDG
MUL_3715|M.ulcerans_Agy99 TNDTDVDADEDEDTDDDSDEDEDTEDDDELDDDLDDELDDDDSDSDDEDS
* . . . . .
Mflv_5192|M.gilvum_PYR-GCK TSSFAFLNFYSGGAITIDELSVRLPTLAAGQAAQTVAA---
Mvan_1067|M.vanbaalenii_PYR-1 TSSFSFLNFYSYGAITVEGMSVKLPTMAAAQVVAVAA----
MSMEG_4365|M.smegmatis_MC2_155 YWNMSLWGDYN-----VVLMQTDLSGLKTVAV---------
TH_2316|M.thermoresistible__bu YWNMSMWGPYN-----VYLMQTDLSSLVEV-----------
MMAR_2416|M.marinum_M EGPPPSAAVDGDTGPTRQGWRGRLRNRMRRSGR--------
MUL_3715|M.ulcerans_Agy99 ESELTEPAAGRPAALEVTTIAERPRRRRAAGRPAGPPIHLG
.