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MSESRRLVDKLWSYCNVLRDDGVGVIEYTEQLTYLLFLKMAHERATRKLNPQKIVPDEYSWQKLLDAEGT DLEVEYTKILVGLAQQPGTLGTIYRKAQNRVQDPAKLKRLIIDLIDKENWSASGTDLKGDAYEELLAKGA SDKGSGAGQYFTPRDLIRAIVDVINPSVSDTIVDPACGTGGFLLVAHEHVAEGAGKLTPTQRSHLRDKFV TGYELVDGTARLAAMNLLLHGIGTADGESLIEVRDALISDPGQRWSVVLSNPPFGRKSSLTMVGADGREA RDDVEIERQDFVVTTSNKQLNFLQHIMTILDINGRAAVVLPDNVLFEGGAGETLRRKLLDDFDLHTMLRL PTGIFYAQGVKANVLFFDRKPAAEQPWTKKLWVYDLRTNQHFTLKQNPLRRHHLDEFADSYLSGKPREER VESERWKAYDYDDLVARDKVNLDITWLRDESLEDADNLPAPEVIAREIVEDLTAALAEFEAVAAALEAAA ADRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2413 | - | - | 100% (494) | N-6 DNA methylase |
| M. gilvum PYR-GCK | Mflv_0805 | - | 4e-43 | 28.99% (507) | N-6 DNA methylase |
| M. gilvum PYR-GCK | Mflv_1345 | - | 1e-06 | 25.64% (195) | N-6 DNA methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2777c | hsdM | 6e-25 | 29.01% (293) | type I restriction/modification system DNA methylase HsdM |
| M. tuberculosis H37Rv | Rv2756c | hsdM | 9e-24 | 28.67% (293) | type I restriction/modification system DNA methylase HsdM |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1959 | hsdM | 2e-26 | 28.50% (386) | type I restriction/modification system DNA methylase HsdM |
| M. avium 104 | MAV_5027 | - | 9e-41 | 29.24% (489) | type I restriction-modification system, M subunit |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0034 | - | 8e-24 | 29.19% (298) | N-6 DNA methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2777c|M.bovis_AF2122/97 MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Rv2756c|M.tuberculosis_H37Rv MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Mvan_0034|M.vanbaalenii_PYR-1 MPPRRGTKKAEPLLPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
MMAR_1959|M.marinum_M ------------MAPSTMKELKDTLWKGAEKLRG---SIPASQYKDVILG
Mflv_2413|M.gilvum_PYR-GCK --------------MSESRRLVDKLWSYCNVLRDD--GVGVIEYTEQLTY
MAV_5027|M.avium_104 --MAAKAKKQAPMATSPQAKLAAVIKSARDYMRKDAGLNGDLDRIPQLAW
* .* : . : :* : :
Mb2777c|M.bovis_AF2122/97 LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Rv2756c|M.tuberculosis_H37Rv LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Mvan_0034|M.vanbaalenii_PYR-1 LVFLKYVSDAYDERREAIRTELEADGLDAEQIEDLIEDPEEYQGYGVFVV
MMAR_1959|M.marinum_M LVFLKFVSDARDGRK-------------------------------PFVV
Mflv_2413|M.gilvum_PYR-GCK LLFLKMAHERATRKLNP-----------------------------QKIV
MAV_5027|M.avium_104 LLFLKAFDGLEENREITEEN-------------------------FRPAI
*:*** : :
Mb2777c|M.bovis_AF2122/97 PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Rv2756c|M.tuberculosis_H37Rv PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Mvan_0034|M.vanbaalenii_PYR-1 PPGARWKFLAENAKGLP-AAGGEPAKNIGQLIDEAMDAVMKANP--TLQG
MMAR_1959|M.marinum_M PPEARWEALAGNAK----------SPDIGQLIDTAMLSVMTANP--SLAA
Mflv_2413|M.gilvum_PYR-GCK PDEYSWQKLLDAEG-----------TDLEVEYTKILVGLAQQPG--TLGT
MAV_5027|M.avium_104 EAPYRWRDWAADPNGRTGDALLTFVNNELLPYLRGLSGTGSHDPRDVLAA
*. : : . *
Mb2777c|M.bovis_AF2122/97 TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Rv2756c|M.tuberculosis_H37Rv TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Mvan_0034|M.vanbaalenii_PYR-1 TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGDGRARDLMGEVYEYFLGN
MMAR_1959|M.marinum_M TLPQLYHK--VDQRRLGELVEVLGAARFSGRPSHRARDLMGEVYEYFLGN
Mflv_2413|M.gilvum_PYR-GCK IYRKAQNRVQDPAKLKRLIIDLIDKENWSASG----TDLKGDAYEELLAK
MAV_5027|M.avium_104 VFKETYNR-MLSGYLLRDVVNKVNEINFASSDD---IHTMAHLYESMLRE
. :: ::: .. .:: . .. ** :* :
Mb2777c|M.bovis_AF2122/97 FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Rv2756c|M.tuberculosis_H37Rv FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Mvan_0034|M.vanbaalenii_PYR-1 FARAEGKRGGEFFTPPSVVKVIVEVLEPSR-GRVYDPCCGSGGMFVQTEK
MMAR_1959|M.marinum_M FARAEGRRGGEFFTPPSVVRVIVEILEPSS-GRIYDPCCGSGGMFVQTER
Mflv_2413|M.gilvum_PYR-GCK GASDKGSGAGQYFTPRDLIRAIVDVINPSVSDTIVDPACGTGGFLLVAHE
MAV_5027|M.avium_104 MRDAAGD-SGEFYTPRPIIRFIVQQVDPRLGEVILDPACGTGGFLVEALE
* .*:::** ::: **: ::* : **.**:**::: : .
Mb2777c|M.bovis_AF2122/97 FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Rv2756c|M.tuberculosis_H37Rv FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Mvan_0034|M.vanbaalenii_PYR-1 FIYEHDGDPK--------EIAVYGQESIEETWRMAKMNLAIHGIDNKGLG
MMAR_1959|M.marinum_M FICAHDGDPA--------QISIYGQESVEQTWRMAKMNLAVHGIDDAGLG
Mflv_2413|M.gilvum_PYR-GCK HVAEGAGKLTPTQRSHLRDKFVTGYELVDGTARLAAMNLLLHGIGTADGE
MAV_5027|M.avium_104 HLSPKVTTTAQLR---ALHENLRGIEKKPLPFLLGMMNLVLHGVGQPNIT
.: . : * * . :. *** :**:. .
Mb2777c|M.bovis_AF2122/97 ARWSDTFARDQHPDVQ-MDYVMANPPFNIKD----------WARNEEDPR
Rv2756c|M.tuberculosis_H37Rv ARWSDTFARDQHPDVQ-MDYVMANLPFNIKD----------WARNEEDPR
Mvan_0034|M.vanbaalenii_PYR-1 ARWGDTFARDQHPDVQ-MDYVLANPPFNIKD----------WARNEEDAR
MMAR_1959|M.marinum_M ARWGDTFATDQHDGVP-MDYVMANPPFNIKD----------WARDEQDPR
Mflv_2413|M.gilvum_PYR-GCK SLIEVRDALISDPGQR-WSVVLSNPPFGRKSSLTMVGADGREARDDVEIE
MAV_5027|M.avium_104 RGNALAESITQISKARRVDVILTNPPFGGEE-------------EKSIQA
: . . :::* **. :. :.
Mb2777c|M.bovis_AF2122/97 WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Rv2756c|M.tuberculosis_H37Rv WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Mvan_0034|M.vanbaalenii_PYR-1 WRFGVPPANNANYAWIQHILYKLASGGKAGVVMANGSMSSNSNGEGDIRA
MMAR_1959|M.marinum_M WRFGTPPAANANFAWIQHILSKLAPTGQAGVVMANGSMSSKTNGEDRIRA
Mflv_2413|M.gilvum_PYR-GCK RQDFVVTTSNKQLNFLQHIMTILDINGRAAVVLPDNVLFEGGAGET-LRR
MAV_5027|M.avium_104 NFPADKQTAETAWLFLQLVIRMLKDGGRCGIVVPNGLLFGGGVGAR-IKK
: : ::* :: * *:..:*:.:. : * ::
Mb2777c|M.bovis_AF2122/97 QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Rv2756c|M.tuberculosis_H37Rv QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Mvan_0034|M.vanbaalenii_PYR-1 QIVEADLVSCMIALPTQLFR-STGIPVCVWFFAKD--KTAGKQGSVDRSG
MMAR_1959|M.marinum_M GIIDADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KKA-------RSG
Mflv_2413|M.gilvum_PYR-GCK KLLDDFDLHTMLRLPTGIFY-AQGVKANVLFFDRK--PAAEQP-----WT
MAV_5027|M.avium_104 QLLTECNLHTIVRLPDGAFAPYTDIPSNLLFFDKTGRT------------
:: : :: ** * .: : ** :
Mb2777c|M.bovis_AF2122/97 QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Rv2756c|M.tuberculosis_H37Rv QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Mvan_0034|M.vanbaalenii_PYR-1 QVLFIDAREMGYMVDRAERALSDDDIVKIGDTFHAWRGSASAAAKGVVYQ
MMAR_1959|M.marinum_M QVLFIDARGLGSMVDRCERTLTDDDVARIGDTYHGWFGSASSVAKGTVYQ
Mflv_2413|M.gilvum_PYR-GCK KKLWVYDLRTNQHFTLKQNPLRRHHLDEFADSYLSGKPREERVES-----
MAV_5027|M.avium_104 KEIWYYEISPPEGRKKYSKSKP-MRFEEFADCQVWWSNRVE---------
: :: ... . .:.* .
Mb2777c|M.bovis_AF2122/97 DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Rv2756c|M.tuberculosis_H37Rv DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Mvan_0034|M.vanbaalenii_PYR-1 DVPGFCKSATLAEIKAADYALTPGRYVGAAAVED-DGEPIDEKIAR-LKT
MMAR_1959|M.marinum_M DIPGFCRSASLDEIRAEGYVLTPGRYVGTGASCA-DGEPIGDKLAR-LTT
Mflv_2413|M.gilvum_PYR-GCK ---ERWKAYDYDDLVARDKVNLDITWLRDESLEDADNLPAPEVIAREIVE
MAV_5027|M.avium_104 --NERAWRVPIADIEANDMYNLDLRNPNRG--DDLAHRPPAELLAE-LID
:: * . * : :*. :
Mb2777c|M.bovis_AF2122/97 ALLEAFDESARLERVVREQLGRLR--
Rv2756c|M.tuberculosis_H37Rv ALLEAFDESARLERVVREQLGRLR--
Mvan_0034|M.vanbaalenii_PYR-1 ELLAAFDESARLEKVVREQLERIDA-
MMAR_1959|M.marinum_M QLLAALDESTKLDEAVRAQLGRVRWR
Mflv_2413|M.gilvum_PYR-GCK DLTAALAEFEAVAAALEAAAADRS--
MAV_5027|M.avium_104 TERSILALLDGLQREVTGEGP-----
: : :