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ITGELKSKVDRVWDAFWSGGISNPLEVIEQITYLLFIRRLDDLETLEERKARLGAAGELRFGSDQQEFRW SRFKNEEPAVMFATVGEKVFPFLRTLGGDGSTYGEHMKDARFTIPTAQLLSRVVDLLDEIPMNDRDTNGD LYEYLLSKIASAGVNGQFRTPRHIIKLMVDMTAPTPADEICDPAAGTAGFLVAASEYIREQHPSVLTDGA KRKHFHASMFHGYDFDNTMLRIASMNMLMHGIESPDIRYRDSLSEGASDDAEKYTLILANPPFAGSLDYE STSKDLQRVVKTKKTELLFVALFLKLLKPGGRAAVIVPDGVLFGSSKAHKDLRRMLVEDQKLDGIVKLPS GVFRPYAGVSTAILLFTKTNSGGTDQVWFYDVTADGFSLDDKRNPVEANDLPDLLSRWGSRTGSELERTR TEQSFCVPKDDIVAQGYDLSLNRYKEVVHDDVKHRPPLEIIAEIDKLECEIAAGLAELKAMLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0805 | - | - | 100% (484) | N-6 DNA methylase |
| M. gilvum PYR-GCK | Mflv_2413 | - | 4e-43 | 28.99% (507) | N-6 DNA methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2777c | hsdM | 3e-20 | 25.88% (340) | type I restriction/modification system DNA methylase HsdM |
| M. tuberculosis H37Rv | Rv2756c | hsdM | 4e-19 | 25.59% (340) | type I restriction/modification system DNA methylase HsdM |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1959 | hsdM | 4e-18 | 24.23% (326) | type I restriction/modification system DNA methylase HsdM |
| M. avium 104 | MAV_5027 | - | 5e-49 | 30.19% (477) | type I restriction-modification system, M subunit |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0034 | - | 1e-20 | 24.86% (366) | N-6 DNA methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2777c|M.bovis_AF2122/97 -MPPR---KKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLV
Rv2756c|M.tuberculosis_H37Rv -MPPR---KKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLV
Mvan_0034|M.vanbaalenii_PYR-1 -MPPRRGTKKAEPLLPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLV
MMAR_1959|M.marinum_M -------------MAPSTMKELKDTLWKGAEKLRGSIPASQYKDVILGLV
Mflv_0805|M.gilvum_PYR-GCK -------------MITGELKSKVDRVWDAFWSG-GISNPLEVIEQITYLL
MAV_5027|M.avium_104 MAAKAKKQAPMATSPQAKLAAVIKSARDYMRKDAGLNGDLDRIPQLAWLL
. : . . . * : : *:
Mb2777c|M.bovis_AF2122/97 FLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVVPV
Rv2756c|M.tuberculosis_H37Rv FLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVVPV
Mvan_0034|M.vanbaalenii_PYR-1 FLKYVSDAYDERREAIRTELEADGLDAEQIEDLIEDPEEYQGYGVFVVPP
MMAR_1959|M.marinum_M FLKFVSDARDGRK-------------------------------PFVVPP
Mflv_0805|M.gilvum_PYR-GCK FIRRLDDLETLEER--------------------------------KARL
MAV_5027|M.avium_104 FLKAFDGLEENRE----------------------------------ITE
*:: ... ..
Mb2777c|M.bovis_AF2122/97 SARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPR-
Rv2756c|M.tuberculosis_H37Rv SARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPR-
Mvan_0034|M.vanbaalenii_PYR-1 GARWKFLAENAKGLPAAGGEPAKNIGQLIDEAMDAVMKANPTLQGTLPR-
MMAR_1959|M.marinum_M EARWEALAGNAK---------SPDIGQLIDTAMLSVMTANPSLAATLPQ-
Mflv_0805|M.gilvum_PYR-GCK GAAGELRFGSDQQEFRWSRFKNEEPAVMFATVGEKVFPFLRTLGGDGST-
MAV_5027|M.avium_104 ENFRPAIEAPYRWRDWAADPNGRTGDALLTFVNNELLPYLRGLSGTGSHD
: :: . :: * . .
Mb2777c|M.bovis_AF2122/97 ----LYNKDNIDQRRLGELIDLFNSARFSRQGEHRARD---LMGEVYEYF
Rv2756c|M.tuberculosis_H37Rv ----LYNKDNIDQRRLGELIDLFNSARFSRQGEHRARD---LMGEVYEYF
Mvan_0034|M.vanbaalenii_PYR-1 ----LYNKDNIDQRRLGELIDLFNSARFSRQGDGRARD---LMGEVYEYF
MMAR_1959|M.marinum_M ----LYHK--VDQRRLGELVEVLGAARFSGRPSHRARD---LMGEVYEYF
Mflv_0805|M.gilvum_PYR-GCK ----YGEHMKDARFTIPTAQLLSRVVDLLDEIPMNDRD---TNGDLYEYL
MAV_5027|M.avium_104 PRDVLAAVFKETYNRMLSGYLLRDVVNKVNEINFASSDDIHTMAHLYESM
: : . . * ..:** :
Mb2777c|M.bovis_AF2122/97 LGNFARAEGKRGGEFFTPPSVVKVIVEVLEPS-SGRVYDPCCGSGGMFVQ
Rv2756c|M.tuberculosis_H37Rv LGNFARAEGKRGGEFFTPPSVVKVIVEVLEPS-SGRVYDPCCGSGGMFVQ
Mvan_0034|M.vanbaalenii_PYR-1 LGNFARAEGKRGGEFFTPPSVVKVIVEVLEPS-RGRVYDPCCGSGGMFVQ
MMAR_1959|M.marinum_M LGNFARAEGRRGGEFFTPPSVVRVIVEILEPS-SGRIYDPCCGSGGMFVQ
Mflv_0805|M.gilvum_PYR-GCK LSKIASAG--VNGQFRTPRHIIKLMVDMTAPTPADEICDPAAGTAGFLVA
MAV_5027|M.avium_104 LREMRDAAG-DSGEFYTPRPIIRFIVQQVDPRLGEVILDPACGTGGFLVE
* :: * .*:* ** :::.:*: * : **..*:.*::*
Mb2777c|M.bovis_AF2122/97 TEKFIYEHD----------GDPKDVSIYGQESIEETWRMAKMNLAIHGID
Rv2756c|M.tuberculosis_H37Rv TEKFIYEHD----------GDPKDVSIYGQESIEETWRMAKMNLAIHGID
Mvan_0034|M.vanbaalenii_PYR-1 TEKFIYEHD----------GDPKEIAVYGQESIEETWRMAKMNLAIHGID
MMAR_1959|M.marinum_M TERFICAHD----------GDPAQISIYGQESVEQTWRMAKMNLAVHGID
Mflv_0805|M.gilvum_PYR-GCK ASEYIREQHPSVLTDGAKRKHFHASMFHGYDFDNTMLRIASMNMLMHGIE
MAV_5027|M.avium_104 ALEHLSPKVTT-----TAQLRALHENLRGIEKKPLPFLLGMMNLVLHGVG
: ..: : . * : :. **: :**:
Mb2777c|M.bovis_AF2122/97 NKGLGARWSDTFAR-DQHPDVQMDYVMANPPFN-IKDWARNEEDPRWRFG
Rv2756c|M.tuberculosis_H37Rv NKGLGARWSDTFAR-DQHPDVQMDYVMANLPFN-IKDWARNEEDPRWRFG
Mvan_0034|M.vanbaalenii_PYR-1 NKGLGARWGDTFAR-DQHPDVQMDYVLANPPFN-IKDWARNEEDARWRFG
MMAR_1959|M.marinum_M DAGLGARWGDTFAT-DQHDGVPMDYVMANPPFN-IKDWARDEQDPRWRFG
Mflv_0805|M.gilvum_PYR-GCK SP--DIRYRDSLSEGASDDAEKYTLILANPPFAGSLDYESTSKDLQR---
MAV_5027|M.avium_104 QPNITRGNALAESITQISKARRVDVILTNPPFG----GEEEKSIQANFPA
. : : :::* ** ..
Mb2777c|M.bovis_AF2122/97 VPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVE
Rv2756c|M.tuberculosis_H37Rv VPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVE
Mvan_0034|M.vanbaalenii_PYR-1 VPPANNANYAWIQHILYKLASGGKAGVVMANGSMSSNSNGEGDIRAQIVE
MMAR_1959|M.marinum_M TPPAANANFAWIQHILSKLAPTGQAGVVMANGSMSSKTNGEDRIRAGIID
Mflv_0805|M.gilvum_PYR-GCK VVKTKKTELLFVALFLKLLKPGGRAAVIVPDGVLFGSSKAHKDLRRMLVE
MAV_5027|M.avium_104 DKQTAETAWLFLQLVIRMLKDGGRCGIVVPNGLLFGGGVG-ARIKKQLLT
: :: :: .: * *:..:::.:* : . . :: ::
Mb2777c|M.bovis_AF2122/97 ADLVSCMVALPTQLFR-STGIPVCLWFFAKDKAAGKQGSIDRCGQVLFID
Rv2756c|M.tuberculosis_H37Rv ADLVSCMVALPTQLFR-STGIPVCLWFFAKDKAAGKQGSIDRCGQVLFID
Mvan_0034|M.vanbaalenii_PYR-1 ADLVSCMIALPTQLFR-STGIPVCVWFFAKDKTAGKQGSVDRSGQVLFID
MMAR_1959|M.marinum_M ADLVSCMVALPTQLFR-STGIPVCLWFFAKDKKA-------RSGQVLFID
Mflv_0805|M.gilvum_PYR-GCK DQKLDGIVKLPSGVFRPYAGVSTAILLFTKTNSGG-------TDQVWFYD
MAV_5027|M.avium_104 ECNLHTIVRLPDGAFAPYTDIPSNLLFFDKTGRT---------KEIWYYE
: :: ** * :.:. : :* * :: : :
Mb2777c|M.bovis_AF2122/97 AR-ELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGF
Rv2756c|M.tuberculosis_H37Rv AR-ELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGF
Mvan_0034|M.vanbaalenii_PYR-1 AR-EMGYMVDRAERALSDDDIVKIGDTFHAWRGSASAAAKGVVYQDVPGF
MMAR_1959|M.marinum_M AR-GLGSMVDRCERTLTDDDVARIGDTYHGWFGSASSVAKGTVYQDIPGF
Mflv_0805|M.gilvum_PYR-GCK VT-ADGFSLDDKRNPVEANDLPDLLSRWGSRTGSELERTR-----TEQSF
MAV_5027|M.avium_104 ISPPEGRKKYSKSKPMRFEEFADCQVWWSNRVENE-------------RA
* ..: ::. : .
Mb2777c|M.bovis_AF2122/97 CKSATLAEIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFD
Rv2756c|M.tuberculosis_H37Rv CKSATLAEIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFD
Mvan_0034|M.vanbaalenii_PYR-1 CKSATLAEIKAADYALTPGRYVGAAAVEDDGEPIDEKIARLKTELLAAFD
MMAR_1959|M.marinum_M CRSASLDEIRAEGYVLTPGRYVGTGASCADGEPIGDKLARLTTQLLAALD
Mflv_0805|M.gilvum_PYR-GCK CVPK--DDIVAQGYDLSLNRYKEVVHDDVKHRPPLEIIAEIDKLECEIAA
MAV_5027|M.avium_104 WRVPIADIEANDMYNLDLR--NPNRGDDLAHRPPAELLAELIDTERSILA
* * .* : :*.:
Mb2777c|M.bovis_AF2122/97 ESARLERVVREQLGRLR--
Rv2756c|M.tuberculosis_H37Rv ESARLERVVREQLGRLR--
Mvan_0034|M.vanbaalenii_PYR-1 ESARLEKVVREQLERIDA-
MMAR_1959|M.marinum_M ESTKLDEAVRAQLGRVRWR
Mflv_0805|M.gilvum_PYR-GCK GLAELKAMLS---------
MAV_5027|M.avium_104 LLDGLQREVTGEGP-----
*. :