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M. tuberculosis H37Rv Rv2756c (hsdM)

annotation: POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM DNA METHYLASE HSDM (M PROTEIN) (DNA METHYLTRANSFERASE)
coordinates: 3068461 - 3070083
length: 540

PPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLVFLKYVSDAYDERREAIRAELAAEGM
EESQIEDLIDDPEQYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGG
TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVK
VIVEVLEPSSGRVYDPCCGSGGMFVQTEKFIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNKGL
GARWSDTFARDQHPDVQMDYVMANLPFNIKDWARNEEDPRWRFGVPPANNANYAWIQHILYKLAPGGRAG
VVMANGSMSSNSNGEGDIRAQIVEADLVSCMVALPTQLFRSTGIPVCLWFFAKDKAAGKQGSIDRCGQVL
FIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGFCKSATLAEIKATDYALTP
GRYVGTPAVEDDGEPIDEKMARLSKALLEAFDESARLERVVREQLGRLR*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv2756c hsdM - 100% (540) POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM DNA METHYLASE HSDM (M PROTEIN) (DNA METHYLTRANSFERASE)
M. tuberculosis H37Rv Rv3263 - 8e-05 23.43% (175) DNA methylase (modification methylase) (methyltransferase)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2777c hsdM 0.0 99.81% (540) type I restriction/modification system DNA methylase HsdM
M. gilvum PYR-GCK Mflv_2413 - 1e-23 28.67% (293) N-6 DNA methylase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 - - - - -
M. marinum M MMAR_1959 hsdM 0.0 67.55% (530) type I restriction/modification system DNA methylase HsdM
M. avium 104 MAV_5027 - 3e-16 24.23% (421) type I restriction-modification system, M subunit
M. smegmatis MC2 155 - - - - -
M. thermoresistible (build 8) - - - - -
M. ulcerans Agy99 - - - - -
M. vanbaalenii PYR-1 Mvan_0034 - 0.0 88.19% (542) N-6 DNA methylase

CLUSTAL 2.0.9 multiple sequence alignment


Rv2756c|M.tuberculosis_H37Rv       MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Mb2777c|M.bovis_AF2122/97          MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Mvan_0034|M.vanbaalenii_PYR-1      MPPRRGTKKAEPLLPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
MMAR_1959|M.marinum_M              ------------MAPSTMKELKDTLWKGAEKLRG---SIPASQYKDVILG
Mflv_2413|M.gilvum_PYR-GCK         --------------MSESRRLVDKLWSYCNVLRDD--GVGVIEYTEQLTY
MAV_5027|M.avium_104               --MAAKAKKQAPMATSPQAKLAAVIKSARDYMRKDAGLNGDLDRIPQLAW
                                                  *   .*   : .  : :*         :    :  

Rv2756c|M.tuberculosis_H37Rv       LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Mb2777c|M.bovis_AF2122/97          LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Mvan_0034|M.vanbaalenii_PYR-1      LVFLKYVSDAYDERREAIRTELEADGLDAEQIEDLIEDPEEYQGYGVFVV
MMAR_1959|M.marinum_M              LVFLKFVSDARDGRK-------------------------------PFVV
Mflv_2413|M.gilvum_PYR-GCK         LLFLKMAHERATRKLNP-----------------------------QKIV
MAV_5027|M.avium_104               LLFLKAFDGLEENREITEEN-------------------------FRPAI
                                   *:***        :                                   :

Rv2756c|M.tuberculosis_H37Rv       PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Mb2777c|M.bovis_AF2122/97          PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Mvan_0034|M.vanbaalenii_PYR-1      PPGARWKFLAENAKGLP-AAGGEPAKNIGQLIDEAMDAVMKANP--TLQG
MMAR_1959|M.marinum_M              PPEARWEALAGNAK----------SPDIGQLIDTAMLSVMTANP--SLAA
Mflv_2413|M.gilvum_PYR-GCK         PDEYSWQKLLDAEG-----------TDLEVEYTKILVGLAQQPG--TLGT
MAV_5027|M.avium_104               EAPYRWRDWAADPNGRTGDALLTFVNNELLPYLRGLSGTGSHDPRDVLAA
                                        *.                   :        : .         *  

Rv2756c|M.tuberculosis_H37Rv       TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Mb2777c|M.bovis_AF2122/97          TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Mvan_0034|M.vanbaalenii_PYR-1      TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGDGRARDLMGEVYEYFLGN
MMAR_1959|M.marinum_M              TLPQLYHK--VDQRRLGELVEVLGAARFSGRPSHRARDLMGEVYEYFLGN
Mflv_2413|M.gilvum_PYR-GCK         IYRKAQNRVQDPAKLKRLIIDLIDKENWSASG----TDLKGDAYEELLAK
MAV_5027|M.avium_104               VFKETYNR-MLSGYLLRDVVNKVNEINFASSDD---IHTMAHLYESMLRE
                                      .  ::          ::: ..  .::        .  .. ** :* :

Rv2756c|M.tuberculosis_H37Rv       FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Mb2777c|M.bovis_AF2122/97          FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Mvan_0034|M.vanbaalenii_PYR-1      FARAEGKRGGEFFTPPSVVKVIVEVLEPSR-GRVYDPCCGSGGMFVQTEK
MMAR_1959|M.marinum_M              FARAEGRRGGEFFTPPSVVRVIVEILEPSS-GRIYDPCCGSGGMFVQTER
Mflv_2413|M.gilvum_PYR-GCK         GASDKGSGAGQYFTPRDLIRAIVDVINPSVSDTIVDPACGTGGFLLVAHE
MAV_5027|M.avium_104               MRDAAGD-SGEFYTPRPIIRFIVQQVDPRLGEVILDPACGTGGFLVEALE
                                        *  .*:::**  ::: **: ::*     : **.**:**::: : .

Rv2756c|M.tuberculosis_H37Rv       FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Mb2777c|M.bovis_AF2122/97          FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Mvan_0034|M.vanbaalenii_PYR-1      FIYEHDGDPK--------EIAVYGQESIEETWRMAKMNLAIHGIDNKGLG
MMAR_1959|M.marinum_M              FICAHDGDPA--------QISIYGQESVEQTWRMAKMNLAVHGIDDAGLG
Mflv_2413|M.gilvum_PYR-GCK         HVAEGAGKLTPTQRSHLRDKFVTGYELVDGTARLAAMNLLLHGIGTADGE
MAV_5027|M.avium_104               HLSPKVTTTAQLR---ALHENLRGIEKKPLPFLLGMMNLVLHGVGQPNIT
                                   .:                .  : * *    .  :. *** :**:.  .  

Rv2756c|M.tuberculosis_H37Rv       ARWSDTFARDQHPDVQ-MDYVMANLPFNIKD----------WARNEEDPR
Mb2777c|M.bovis_AF2122/97          ARWSDTFARDQHPDVQ-MDYVMANPPFNIKD----------WARNEEDPR
Mvan_0034|M.vanbaalenii_PYR-1      ARWGDTFARDQHPDVQ-MDYVLANPPFNIKD----------WARNEEDAR
MMAR_1959|M.marinum_M              ARWGDTFATDQHDGVP-MDYVMANPPFNIKD----------WARDEQDPR
Mflv_2413|M.gilvum_PYR-GCK         SLIEVRDALISDPGQR-WSVVLSNPPFGRKSSLTMVGADGREARDDVEIE
MAV_5027|M.avium_104               RGNALAESITQISKARRVDVILTNPPFGGEE-------------EKSIQA
                                          :  .       . :::* **. :.             :.    

Rv2756c|M.tuberculosis_H37Rv       WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Mb2777c|M.bovis_AF2122/97          WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Mvan_0034|M.vanbaalenii_PYR-1      WRFGVPPANNANYAWIQHILYKLASGGKAGVVMANGSMSSNSNGEGDIRA
MMAR_1959|M.marinum_M              WRFGTPPAANANFAWIQHILSKLAPTGQAGVVMANGSMSSKTNGEDRIRA
Mflv_2413|M.gilvum_PYR-GCK         RQDFVVTTSNKQLNFLQHIMTILDINGRAAVVLPDNVLFEGGAGET-LRR
MAV_5027|M.avium_104               NFPADKQTAETAWLFLQLVIRMLKDGGRCGIVVPNGLLFGGGVGAR-IKK
                                          : :    ::* ::  *   *:..:*:.:. :     *   :: 

Rv2756c|M.tuberculosis_H37Rv       QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Mb2777c|M.bovis_AF2122/97          QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Mvan_0034|M.vanbaalenii_PYR-1      QIVEADLVSCMIALPTQLFR-STGIPVCVWFFAKD--KTAGKQGSVDRSG
MMAR_1959|M.marinum_M              GIIDADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KKA-------RSG
Mflv_2413|M.gilvum_PYR-GCK         KLLDDFDLHTMLRLPTGIFY-AQGVKANVLFFDRK--PAAEQP-----WT
MAV_5027|M.avium_104               QLLTECNLHTIVRLPDGAFAPYTDIPSNLLFFDKTGRT------------
                                    ::    :  :: **   *    .:   : ** :                

Rv2756c|M.tuberculosis_H37Rv       QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Mb2777c|M.bovis_AF2122/97          QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Mvan_0034|M.vanbaalenii_PYR-1      QVLFIDAREMGYMVDRAERALSDDDIVKIGDTFHAWRGSASAAAKGVVYQ
MMAR_1959|M.marinum_M              QVLFIDARGLGSMVDRCERTLTDDDVARIGDTYHGWFGSASSVAKGTVYQ
Mflv_2413|M.gilvum_PYR-GCK         KKLWVYDLRTNQHFTLKQNPLRRHHLDEFADSYLSGKPREERVES-----
MAV_5027|M.avium_104               KEIWYYEISPPEGRKKYSKSKP-MRFEEFADCQVWWSNRVE---------
                                   : ::             ...     . .:.*         .         

Rv2756c|M.tuberculosis_H37Rv       DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Mb2777c|M.bovis_AF2122/97          DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Mvan_0034|M.vanbaalenii_PYR-1      DVPGFCKSATLAEIKAADYALTPGRYVGAAAVED-DGEPIDEKIAR-LKT
MMAR_1959|M.marinum_M              DIPGFCRSASLDEIRAEGYVLTPGRYVGTGASCA-DGEPIGDKLAR-LTT
Mflv_2413|M.gilvum_PYR-GCK         ---ERWKAYDYDDLVARDKVNLDITWLRDESLEDADNLPAPEVIAREIVE
MAV_5027|M.avium_104               --NERAWRVPIADIEANDMYNLDLRNPNRG--DDLAHRPPAELLAE-LID
                                               :: * .                    *  : :*. :  

Rv2756c|M.tuberculosis_H37Rv       ALLEAFDESARLERVVREQLGRLR--
Mb2777c|M.bovis_AF2122/97          ALLEAFDESARLERVVREQLGRLR--
Mvan_0034|M.vanbaalenii_PYR-1      ELLAAFDESARLEKVVREQLERIDA-
MMAR_1959|M.marinum_M              QLLAALDESTKLDEAVRAQLGRVRWR
Mflv_2413|M.gilvum_PYR-GCK         DLTAALAEFEAVAAALEAAAADRS--
MAV_5027|M.avium_104               TERSILALLDGLQREVTGEGP-----
                                        :     :   :

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv2756c	hsdM	-	100% (540)	POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM DNA METHYLASE HSDM (M PROTEIN) (DNA METHYLTRANSFERASE)
M. tuberculosis H37Rv	Rv3263	-	8e-05	23.43% (175)	DNA methylase (modification methylase) (methyltransferase)