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MAPSTMKELKDTLWKGAEKLRGSIPASQYKDVILGLVFLKFVSDARDGRKPFVVPPEARWEALAGNAKSP DIGQLIDTAMLSVMTANPSLAATLPQLYHKVDQRRLGELVEVLGAARFSGRPSHRARDLMGEVYEYFLGN FARAEGRRGGEFFTPPSVVRVIVEILEPSSGRIYDPCCGSGGMFVQTERFICAHDGDPAQISIYGQESVE QTWRMAKMNLAVHGIDDAGLGARWGDTFATDQHDGVPMDYVMANPPFNIKDWARDEQDPRWRFGTPPAAN ANFAWIQHILSKLAPTGQAGVVMANGSMSSKTNGEDRIRAGIIDADLVSCMVALPTQLFRSTGIPVCLWF FAKDKKARSGQVLFIDARGLGSMVDRCERTLTDDDVARIGDTYHGWFGSASSVAKGTVYQDIPGFCRSAS LDEIRAEGYVLTPGRYVGTGASCADGEPIGDKLARLTTQLLAALDESTKLDEAVRAQLGRVRWR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1959 | hsdM | - | 100% (484) | type I restriction/modification system DNA methylase HsdM |
| M. marinum M | MMAR_1279 | - | 2e-05 | 24.00% (175) | DNA methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2777c | hsdM | 0.0 | 67.74% (530) | type I restriction/modification system DNA methylase HsdM |
| M. gilvum PYR-GCK | Mflv_2413 | - | 2e-26 | 28.50% (386) | N-6 DNA methylase |
| M. tuberculosis H37Rv | Rv2756c | hsdM | 0.0 | 67.55% (530) | type I restriction/modification system DNA methylase HsdM |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_5027 | - | 1e-14 | 27.02% (248) | type I restriction-modification system, M subunit |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2608 | - | 3e-06 | 24.57% (175) | DNA methylase |
| M. vanbaalenii PYR-1 | Mvan_0034 | - | 0.0 | 67.55% (530) | N-6 DNA methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2777c|M.bovis_AF2122/97 MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Rv2756c|M.tuberculosis_H37Rv MPPR---KKQAPQAPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
Mvan_0034|M.vanbaalenii_PYR-1 MPPRRGTKKAEPLLPSTMKELKDTLWKAADKLRG---SLSASQYKDVILG
MMAR_1959|M.marinum_M ------------MAPSTMKELKDTLWKGAEKLRG---SIPASQYKDVILG
Mflv_2413|M.gilvum_PYR-GCK --------------MSESRRLVDKLWSYCNVLRDD--GVGVIEYTEQLTY
MAV_5027|M.avium_104 --MAAKAKKQAPMATSPQAKLAAVIKSARDYMRKDAGLNGDLDRIPQLAW
MUL_2608|M.ulcerans_Agy99 ------MKTFAGKTAASADKVRGGYYTPAPVVRFLARWVGRAGTKILEPS
: .: . :*
Mb2777c|M.bovis_AF2122/97 LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Rv2756c|M.tuberculosis_H37Rv LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVV
Mvan_0034|M.vanbaalenii_PYR-1 LVFLKYVSDAYDERREAIRTELEADGLDAEQIEDLIEDPEEYQGYGVFVV
MMAR_1959|M.marinum_M LVFLKFVSDARDGRK-------------------------------PFVV
Mflv_2413|M.gilvum_PYR-GCK LLFLKMAHERATRKLNP-----------------------------QKIV
MAV_5027|M.avium_104 LLFLKAFDGLEENREITEEN-------------------------FRPAI
MUL_2608|M.ulcerans_Agy99 CGDGRILAELAAASGSARGVELIADEAAKAR---------------RFAP
:
Mb2777c|M.bovis_AF2122/97 PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Rv2756c|M.tuberculosis_H37Rv PVSARWKFLAENTKGKP-AVGGEPAKNIGQLIDEAMDAVMKANP--TLGG
Mvan_0034|M.vanbaalenii_PYR-1 PPGARWKFLAENAKGLP-AAGGEPAKNIGQLIDEAMDAVMKANP--TLQG
MMAR_1959|M.marinum_M PPEARWEALAGNAK----------SPDIGQLIDTAMLSVMTANP--SLAA
Mflv_2413|M.gilvum_PYR-GCK PDEYSWQKLLDAEG-----------TDLEVEYTKILVGLAQQPG--TLGT
MAV_5027|M.avium_104 EAPYRWRDWAADPNGRTGDALLTFVNNELLPYLRGLSGTGSHDPRDVLAA
MUL_2608|M.ulcerans_Agy99 VDNTNLFTWLDESATGRWDGVAGNPPYIRFGNWPADQRDPALELMRQVGL
:
Mb2777c|M.bovis_AF2122/97 TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Rv2756c|M.tuberculosis_H37Rv TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDLMGEVYEYFLGN
Mvan_0034|M.vanbaalenii_PYR-1 TLPRLYNKDNIDQRRLGELIDLFNSARFSRQGDGRARDLMGEVYEYFLGN
MMAR_1959|M.marinum_M TLPQLYHK--VDQRRLGELVEVLGAARFSGRPSHRARDLMGEVYEYFLGN
Mflv_2413|M.gilvum_PYR-GCK IYRKAQNRVQDPAKLKRLIIDLIDKENWSASG----TDLKGDAYEELLAK
MAV_5027|M.avium_104 VFKETYNR-MLSGYLLRDVVNKVNEINFASSDD---IHTMAHLYESMLRE
MUL_2608|M.ulcerans_Agy99 NPTRLTNAWVPFVVASTIVVRDGGRVGLVLPAELLQVGYAGQLREFLLNR
. : :: . .. * :* .
Mb2777c|M.bovis_AF2122/97 FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Rv2756c|M.tuberculosis_H37Rv FARAEGKRGGEFFTPPSVVKVIVEVLEPSS-GRVYDPCCGSGGMFVQTEK
Mvan_0034|M.vanbaalenii_PYR-1 FARAEGKRGGEFFTPPSVVKVIVEVLEPSR-GRVYDPCCGSGGMFVQTEK
MMAR_1959|M.marinum_M FARAEGRRGGEFFTPPSVVRVIVEILEPSS-GRIYDPCCGSGGMFVQTER
Mflv_2413|M.gilvum_PYR-GCK GASDKGSGAGQYFTPRDLIRAIVDVINPSVSDTIVDPACGTGGFLLVAHE
MAV_5027|M.avium_104 MRDAAGD-SGEFYTPRPIIRFIVQQVDPRLGEVILDPACGTGGFLVEALE
MUL_2608|M.ulcerans_Agy99 FREITLVTFDRLVFDGVLQEVVLFCSDVGSDAAQIRTVNLGDADALATAD
.. : . :: : . .. : :
Mb2777c|M.bovis_AF2122/97 FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Rv2756c|M.tuberculosis_H37Rv FIYEHDGDPK--------DVSIYGQESIEETWRMAKMNLAIHGIDNKGLG
Mvan_0034|M.vanbaalenii_PYR-1 FIYEHDGDPK--------EIAVYGQESIEETWRMAKMNLAIHGIDNKGLG
MMAR_1959|M.marinum_M FICAHDGDPA--------QISIYGQESVEQTWRMAKMNLAVHGIDDAGLG
Mflv_2413|M.gilvum_PYR-GCK HVAEGAGKLTPTQRSHLRDKFVTGYELVDGTARLAAMNLLLHGIGTADGE
MAV_5027|M.avium_104 HLSPKVTTTAQLR---ALHENLRGIEKKPLPFLLGMMNLVLHGVGQPNIT
MUL_2608|M.ulcerans_Agy99 LEVEPAAALR--------HENEKWTKYFLDPRQIQTMRALKQCDAMIRLG
. : . : *. :
Mb2777c|M.bovis_AF2122/97 ARWSDTFARDQHPDVQ-MDYVMANPPFNIKD----------WARNEEDPR
Rv2756c|M.tuberculosis_H37Rv ARWSDTFARDQHPDVQ-MDYVMANLPFNIKD----------WARNEEDPR
Mvan_0034|M.vanbaalenii_PYR-1 ARWGDTFARDQHPDVQ-MDYVLANPPFNIKD----------WARNEEDAR
MMAR_1959|M.marinum_M ARWGDTFATDQHDGVP-MDYVMANPPFNIKD----------WARDEQDPR
Mflv_2413|M.gilvum_PYR-GCK SLIEVRDALISDPGQR-WSVVLSNPPFGRKSSLTMVGADGREARDDVEIE
MAV_5027|M.avium_104 RGNALAESITQISKARRVDVILTNPPFGGEE-------------EKSIQA
MUL_2608|M.ulcerans_Agy99 AVADVNVGIVTGRNSFFTFTDTVARQLGLAAHCVP------LVSRSAQLR
. :. .
Mb2777c|M.bovis_AF2122/97 WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Rv2756c|M.tuberculosis_H37Rv WRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRA
Mvan_0034|M.vanbaalenii_PYR-1 WRFGVPPANNANYAWIQHILYKLASGGKAGVVMANGSMSSNSNGEGDIRA
MMAR_1959|M.marinum_M WRFGTPPAANANFAWIQHILSKLAPTGQAGVVMANGSMSSKTNGEDRIRA
Mflv_2413|M.gilvum_PYR-GCK RQDFVVTTSNKQLNFLQHIMTILDINGRAAVVLPDNVLFEGGAGET-LRR
MAV_5027|M.avium_104 NFPADKQTAETAWLFLQLVIRMLKDGGRCGIVVPNGLLFGGGVGAR-IKK
MUL_2608|M.ulcerans_Agy99 GLVYDPDCRASDIAADHRTWLLDAPADPADPALIAHIDAGEAAGVHLGYK
: . . .: *
Mb2777c|M.bovis_AF2122/97 QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Rv2756c|M.tuberculosis_H37Rv QIVEADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KAAGKQGSIDRCG
Mvan_0034|M.vanbaalenii_PYR-1 QIVEADLVSCMIALPTQLFR-STGIPVCVWFFAKD--KTAGKQGSVDRSG
MMAR_1959|M.marinum_M GIIDADLVSCMVALPTQLFR-STGIPVCLWFFAKD--KKA-------RSG
Mflv_2413|M.gilvum_PYR-GCK KLLDDFDLHTMLRLPTGIFY-AQGVKANVLFFDRK--PAAEQP-----WT
MAV_5027|M.avium_104 QLLTECNLHTIVRLPDGAFAPYTDIPSNLLFFDKTGRT------------
MUL_2608|M.ulcerans_Agy99 CSIRKPWWSTPSLWVPDLFMLRQIHRTPRLSVNSAAATST---------D
: * .
Mb2777c|M.bovis_AF2122/97 QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Rv2756c|M.tuberculosis_H37Rv QVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYE
Mvan_0034|M.vanbaalenii_PYR-1 QVLFIDAREMGYMVDRAERALSDDDIVKIGDTFHAWRGSASAAAKGVVYQ
MMAR_1959|M.marinum_M QVLFIDARGLGSMVDRCERTLTDDDVARIGDTYHGWFGSASSVAKGTVYQ
Mflv_2413|M.gilvum_PYR-GCK KKLWVYDLRTNQHFTLKQNPLRRHHLDEFADSYLSGKPREERVES-----
MAV_5027|M.avium_104 KEIWYYEISPPEGRKKYSKSKP-MRFEEFADCQVWWSNRVE---------
MUL_2608|M.ulcerans_Agy99 TVHRVRIKTAGPRVDPTALAVAFHNSVTFAFAEIMDRSYGGGILELE---
. :.
Mb2777c|M.bovis_AF2122/97 DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Rv2756c|M.tuberculosis_H37Rv DVPGFCKSATLAEIKATDYALTPGRYVGTPAVED-DGEPIDEKMAR-LSK
Mvan_0034|M.vanbaalenii_PYR-1 DVPGFCKSATLAEIKAADYALTPGRYVGAAAVED-DGEPIDEKIAR-LKT
MMAR_1959|M.marinum_M DIPGFCRSASLDEIRAEGYVLTPGRYVGTGASCA-DGEPIGDKLAR-LTT
Mflv_2413|M.gilvum_PYR-GCK ---ERWKAYDYDDLVARDKVNLDITWLRDESLEDADNLPAPEVIAREIVE
MAV_5027|M.avium_104 --NERAWRVPIADIEANDMYNLDLRNPNRG--DDLAHRPPAELLAE-LID
MUL_2608|M.ulcerans_Agy99 -PREAELLPIPPPTRAGAELATDVDLLLKADEIDKALDLVDRHVLIGELG
* :
Mb2777c|M.bovis_AF2122/97 ALLEAFDESARLERVVREQLGRLR--
Rv2756c|M.tuberculosis_H37Rv ALLEAFDESARLERVVREQLGRLR--
Mvan_0034|M.vanbaalenii_PYR-1 ELLAAFDESARLEKVVREQLERIDA-
MMAR_1959|M.marinum_M QLLAALDESTKLDEAVRAQLGRVRWR
Mflv_2413|M.gilvum_PYR-GCK DLTAALAEFEAVAAALEAAAADRS--
MAV_5027|M.avium_104 TERSILALLDGLQREVTGEGP-----
MUL_2608|M.ulcerans_Agy99 MAPDAVARCRSAWMTLRDRRIKRGSR
. :