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MSDSDDDARLPAEARARKLIDSQLTQAGWVVQDKKDLNLFAAQGVAVREVVMKPGHGRVDYLLYVDKAVV GVIEAKPVGTPLSGVEWQSAMYADGLPADVRIAAKTRDGRLPFVFEASGVETHFTNGFDPEPRARLIFNV PRPETMARHLREAETNPDSPTWRAKVRKLPALDTEALRPAQIEAINGVEQSLADQRYDRSLVQMATGAGK TFTAVTQSYRLLKHGGVDRVLFLVDRNNLADQTLGEFQNYRTPDDGRRFTELYNVNKLSSAGLLGSTKVT ISTIQRVFRFIKAGEVSDTDDPDIDDYIPDAPVTVSYSDALPPETFDLVIVDEAHRSIYGVWRGVLEYFD AHVVGLTATPGKQTFAFFRQNLVSDYTYPESVADGVNVDFDVYRIRTKISDQGSHIEAGTIVPKVDRRTR EQRLETLDDDLDYVPGQLDRAVTATDQIRTVLESFRDRLFTEIFPGRSTVPKTLIFAKDDNHAEEIVKQV REVFGKGNDFAAKITYNARNAKEQLKAFRTSPSLRIAVTVDMIATGTDVKPLECVFFMRDVRSAQYFEQM KGRGARTVPDADFQAVTPDATSKTRFVIVDAIGVTEHEFVEPPLNRQRSVPLKKLLEKAANLTITEDEAA TLASRLAKLELDLTDAERVELDEVAGQPVRDVIRSLVDAVEPSTTTPEAIEAALVPIASNPELRSRVLEL RAAHDRIIDEVSADELIEAGGVVDTGKARHIVESWTAYLDEHRDEITALQLGYEAGERRIDFAFIEGLAT RIARPPHNWTPDVIWNAYAAIDGEKVHRSATHAVTDLVSLVRYATGVDDELVPYGDRVREKYAAWLTQQE QAGVTFTDTERWWLDRMVSVIASSAGIRVEDLDDAPFIERGGTDGAIRDLGDRAAELIDELNAELTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2408 | - | - | 100% (907) | type III restriction enzyme, res subunit |
| M. gilvum PYR-GCK | Mflv_0803 | - | 1e-32 | 27.14% (608) | type III restriction enzyme, res subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2049c | - | 3e-12 | 25.90% (444) | hypothetical protein Mb2049c |
| M. tuberculosis H37Rv | Rv2024c | - | 7e-07 | 31.71% (164) | hypothetical protein Rv2024c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_5024 | - | 2e-25 | 25.57% (751) | type I restriction-modification system, R subunit |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4094 | - | 2e-12 | 24.05% (449) | PUTATIVE - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2049c|M.bovis_AF2122/97 ----MGSVHDVIEAFRKAPSNAERGTKFEQL-MVRYFELDPTMAQQYDAV
Rv2024c|M.tuberculosis_H37Rv ----MGSVHDVIEAFRKAPSNAERGTKFEQL-MVRYFELDPTMAQQYDAV
Mflv_2408|M.gilvum_PYR-GCK ----MSDSDDDARLPAEARARKLIDSQLTQAGWVVQDKKDLNLFAAQGVA
MAV_5024|M.avium_104 ------------------MLPKLKDAGWTEEQIIEQYRITDGRIVKVGSK
TH_4094|M.thermoresistible__bu VDAGLYESVITQRLQRQLETLRERSAQLTPQLTEVDEAEEALTLARHLMP
.:
Mb2049c|M.bovis_AF2122/97 WRWIDWPERRGRTD-------TGIDLVARERDTGNYTAIQCKFYEPTHTL
Rv2024c|M.tuberculosis_H37Rv WWWIDWPERRGRTD-------TGIDLVARERDTGNYTAIQCKFYEPTHTL
Mflv_2408|M.gilvum_PYR-GCK VREVVMKPGHGRVDYLLYVDKAVVGVIEAKPVGTPLSGVEWQSAMYADGL
MAV_5024|M.avium_104 HRRTAPLRADYVLEYEPG---MPIGVVEAKREYS----TPGKGMQQAKNY
TH_4094|M.thermoresistible__bu VIERSLRCARGAEDRARLIEKLLAALGDPDALAEAVHQLDPGKIHRLDAV
: : . .
Mb2049c|M.bovis_AF2122/97 AKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMA
Rv2024c|M.tuberculosis_H37Rv AKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMA
Mflv_2408|M.gilvum_PYR-GCK PADVRIAAKTRDGRLPFVFEASGVETHFTNGFDPEPRARLIFNVPRPETM
MAV_5024|M.avium_104 AQLLDVPFAYSTNGVSIVEDDRNTGIERAN-LSTFPSPEMLWARYR-EWK
TH_4094|M.thermoresistible__bu TPVALGTTHIPRPTTPLSDAALMTNARDEPTLAAELRAELASADHVDLLC
. . : .
Mb2049c|M.bovis_AF2122/97 EIAESPIDWDIAWPAGDLQVN--LTPAKR-HELRPHQQQAIDAVFRGFAV
Rv2024c|M.tuberculosis_H37Rv EIAESPIDWDIAWPADDLQVN--LTPAKR-HELRPHQQQAIDAVFRGFAV
Mflv_2408|M.gilvum_PYR-GCK ARHLREAETNPDSPTWRAKVR--KLPALDTEALRPAQIEAINGVEQSLAD
MAV_5024|M.avium_104 GIKDDSAADGLLLPFNRSLRN--ADGTVK--EPRYYQRTAINRTVEAILA
TH_4094|M.thermoresistible__bu AFVKWHGLRLLERELTELKERGIPLRVITTTYMGATDARALDALVNEFGA
. . : *:: . :
Mb2049c|M.bovis_AF2122/97 G------NDRGKLIMACGTGKTFTALKIAER----IAAD---NGGSARIL
Rv2024c|M.tuberculosis_H37Rv G------NDRGKLIMACGTGKTFTALKIAER----IAAD---NGGSARIL
Mflv_2408|M.gilvum_PYR-GCK QR-----YDRSLVQMATGAGKTFTAVTQSYR----LLK----HGGVDRVL
MAV_5024|M.avium_104 G------DKRLLLTMATGTGKTFVSMQIVWK----LWNSQWVHGRHPRIL
TH_4094|M.thermoresistible__bu EVRVNYETDRTRLHAKAWLLRRNTGFHTAYVGSSNLSHAALVDGLEWNVR
.* : : ... : .* .:
Mb2049c|M.bovis_AF2122/97 LLVPSISLLSQTLR-EWT-AQSELDVRAFAVCSDTKVSRSAEDYHVHDVP
Rv2024c|M.tuberculosis_H37Rv LLVPSISLLSQTLR-EWT-AQSELDVRAFAVCSDTKVSRSAEDYHVHDVP
Mflv_2408|M.gilvum_PYR-GCK FLVDRNNLADQTLG-EFQNYRTPDDGRRFTELYNVNKLSSAGLLGSTKVT
MAV_5024|M.avium_104 YLADRNVLVDQPIEREFKPAFGAGEGSPIWKLKGTAKSGREIYFGLYQQL
TH_4094|M.thermoresistible__bu LSAVSTPHLLEKFRATFDSYWENREFESYRPCEDGDKLRNALDVASGKKP
. : : : : . .
Mb2049c|M.bovis_AF2122/97 IP------------------------------------------------
Rv2024c|M.tuberculosis_H37Rv IP------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK IS------------------------------------------------
MAV_5024|M.avium_104 AD------------------------------------------------
TH_4094|M.thermoresistible__bu RDPLRVTLSGLEVTAKPYQAELLEQLEAERVLHDRHRNLLVAATGTGKTV
Mb2049c|M.bovis_AF2122/97 -VTTDARVLLHEMAHRRCAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVM
Rv2024c|M.tuberculosis_H37Rv -VTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVM
Mflv_2408|M.gilvum_PYR-GCK -TIQRVFRFIKAGEVSDTDD-PDIDDYIPDAPVTVSYSDALPPETFDLVI
MAV_5024|M.avium_104 -GGDEPTGMFRQFAR----------------------------DFFDLVI
TH_4094|M.thermoresistible__bu IAALDYRRLVREVHGRDLSLLFVAHRKEILQQARRMYQEVLTDPTFGELL
:.: *. ::
Mb2049c|M.bovis_AF2122/97 CDEAHR---TTGVTLAGDDESNVVRVHDGQYLKAARRLYMTATPRIFTES
Rv2024c|M.tuberculosis_H37Rv CDEAHR---TTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTES
Mflv_2408|M.gilvum_PYR-GCK VDEAHR---SIYGVWRG-----VLEYFDAHVVGLTATPGKQTFAFFRQNL
MAV_5024|M.avium_104 VDECHRGSARAESSWRKILDHFSPATQLGMTATPKRDETADTYAYFGGAP
TH_4094|M.thermoresistible__bu VDGEQPARWRHVFASIQSLNSERLSTIDPEHFDVVVVDEFHHAQAASYRR
* :
Mb2049c|M.bovis_AF2122/97 IKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVD
Rv2024c|M.tuberculosis_H37Rv IKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVD
Mflv_2408|M.gilvum_PYR-GCK VSDYTYPESVADGVNVDFDVYRIRTKISDQGSHIEAGTIVP-KVDRRTRE
MAV_5024|M.avium_104 LFEYTLAQGIEDGFLAPYRVRRVVLSPDAHGWAPEQGQLDLFGKEIPPGL
TH_4094|M.thermoresistible__bu LLDHIRPIELLGLTATPERGDGVDVRQFFGGRVAAELRLWDALEQNLLCP
: : * :
Mb2049c|M.bovis_AF2122/97 QGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMR
Rv2024c|M.tuberculosis_H37Rv QGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMR
Mflv_2408|M.gilvum_PYR-GCK QRLETLDDDLDYVPGQLDRAVTATDQIRTVLESFRDRLFTEIFPGRSTVP
MAV_5024|M.avium_104 YTTPDFERVVSLLSRTEAAAKHLTNYLHATDRFAKTIVFCANQEHADQMR
TH_4094|M.thermoresistible__bu FHYFGIYDGTDLEALQWKRGRYDLDELDRVYTGNDARTRIILKEVRDKIA
. . : :
Mb2049c|M.bovis_AF2122/97 -----RAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACSVRHVDG
Rv2024c|M.tuberculosis_H37Rv -----RAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLAC-------
Mflv_2408|M.gilvum_PYR-GCK -----KTLIFAKDDNHAEEIVKQVREVFGKGNDFAAKITYNARN------
MAV_5024|M.avium_104 -----RALHNANSDLTPQHRDYVVRIVSDEQEIGQGHLSRFCDT------
TH_4094|M.thermoresistible__bu DVGAMRALGFCVSVEHARYMAKRFVEAGIPARSVVGLDDSRERR------
::: . . .. . . .
Mb2049c|M.bovis_AF2122/97 TFNALVRNEQLAWLKGVVAEDECRILSNARCLSEGVDVPALDAVLFLNPR
Rv2024c|M.tuberculosis_H37Rv -------------------------LNSSRRIQA----------------
Mflv_2408|M.gilvum_PYR-GCK ---------AKEQLKAFRTSPSLRIAVTVDMIATGTDVKPLECVFFMRDV
MAV_5024|M.avium_104 ------------------EAQFPVIATTSEMLSTGVDAPTVRNIVLFRPV
TH_4094|M.thermoresistible__bu ------------EALAALQSREINALFTVDLFNEGLDIPMVDTVLFLRPT
. :
Mb2049c|M.bovis_AF2122/97 NSIVDVVQSVGRVMRKSPGKDYGYVILPVAVPEGVEPSAALADNKRFKVV
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK RSAQYFEQMKGRGARTVPDADFQAVTP----------------DATSKTR
MAV_5024|M.avium_104 GSMALFKQMIGRGTRLFPDED--------------------------KLS
TH_4094|M.thermoresistible__bu ESATVFLQQLGRGLRLAPGKTVLTALDFVGHHRREFRFDQRFRALTGLSR
Mb2049c|M.bovis_AF2122/97 WQVLNALRSHDERFDAMVNSIALNVKPTKTGEGSDKLLGGHIGPTSDEAG
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK FVIVDAIGVTEHEFVEPPLNRQRSVPLKKLLEKAANLT------ITEDEA
MAV_5024|M.avium_104 FEIIDYSG-ASALFSDPEFDGPPEHVIEEAIND-----------------
TH_4094|M.thermoresistible__bu KRLEKQVQEGFPFLPSGSQIVLDEVAQKIVLENVRQQVSPKKSVLVSEIR
Mb2049c|M.bovis_AF2122/97 PAVAEQLAMFSLSQWQEAIYARIVDKVGTRTYWEQWAADVADIAATLTTR
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK ATLASRLAKLELDLTDAER--VELDEVAGQPVRDVIRSLVDAVEPSTTTP
MAV_5024|M.avium_104 ----------------------EGDVVEDVVVEEPEPSFEPTPRPADVDV
TH_4094|M.thermoresistible__bu SHPDDRLASYLEESGRGLDDILRPNRSWTTLCRDAG-KLAEQPGPREAEL
Mb2049c|M.bovis_AF2122/97 IHALLGGADATAAAAFEQFLAGLRDNLND-SITPDDAISMLSQHLITKPV
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK EAIEAALVPIASNPELRSRVLELRAAHDR-IIDEVSADELIEAGGVVDTG
MAV_5024|M.avium_104 DLDPEDLPAPRAKFYVDDVEVIVTAEAVY-ELDPQTQQLRLVEYRDLVTE
TH_4094|M.thermoresistible__bu VKRLKALAHVDDRKRADAYRRLLASDVRSDSLAERRLADMLFYSLYPDGG
Mb2049c|M.bovis_AF2122/97 FDALFAGHDFASHNPVSRAMQKMVDTVGGAGLEAETARLEGFYESVRRRA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK KARHIVESWTAYLDEHRDEITALQLGYEAGERRIDFAFIEGLATRIARPP
MAV_5024|M.avium_104 TVRSLFPSANELRAKWASRVSRREVLDALAEHGIDADELADRAGLPDADP
TH_4094|M.thermoresistible__bu GFEAAADGFDEVRREIVVAEMRQIIDIAFDAAHRRTSELGEVIPELRDVP
Mb2049c|M.bovis_AF2122/97 GEVTSAEGKQQVIAELYEKFFRIGFKKQAEALGIVYTPVEVVDFIVRAAD
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK HNWTPDVIWNAYAAIDGEKVHRSATHAVTDLVSLVRYATGVDDELVPYGD
MAV_5024|M.avium_104 IDVLVHLAWNQPLATRTDRVRRVRKEYSDFFEAFQPAAREVLEYLLDK--
TH_4094|M.thermoresistible__bu LALHATYSREEILAALG--WVSPGRKPSTMREGVAWCPEVNADAFLITLK
Mb2049c|M.bovis_AF2122/97 FVSRKHFGRGLTDEGVHILDGFAGTGTFITRLLQSDLITAADLTRKYSQE
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK RVREKYAAWLTQQE-------------------------QAGVTFTDTER
MAV_5024|M.avium_104 ---------------------------------------YAEYGISELES
TH_4094|M.thermoresistible__bu KSDTEYSPTTMYRDFALSPDLFHWESQSTTTASSPTGQRYIHHRERGSHV
Mb2049c|M.bovis_AF2122/97 LHANEIMLLAYYIAAVNIESTYHALAGKTADADAYEPFPGMALADTFQIS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK WWLDRMVSVIASSAGIRVEDLDDAPFIERGGTDG-------------AIR
MAV_5024|M.avium_104 PGVLQVPPLSSLGTPVEIARRFGSPE---------------------EWR
TH_4094|M.thermoresistible__bu LLFVREAKKGAFGDGAPYIFLGPADYVSHEGDRP----------MAITWR
Mb2049c|M.bovis_AF2122/97 EAGDSMDAIMFPYNNARILRQLATPISVIIGNPPYSVGQSSANDLNANVK
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK DLGDRAAELIDELNAELTA-------------------------------
MAV_5024|M.avium_104 AAQTRLGELVYVA-------------------------------------
TH_4094|M.thermoresistible__bu LRRPMPTEVYLGARAAVA--------------------------------
Mb2049c|M.bovis_AF2122/97 YPTLDGRIEQTYAKRSTAQLKNSLYDSYIRAFRWATDRIGDNGVVGFVSN
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 GGYIDGNTADGMRLSLADDYAAVYVYNLRGNQRTAGELSRQEGGKVFGGG
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 SRNTVAIFLGIKDPKHSGPCDVLYRDIGDYLSREEKLRIVGDGYLDTVEW
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 QTVTPNLHGDWVNQRDDAFSAWPVIGDKKAALDVTRVFANYSAGLKTSRD
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 AWCYNFSRGALEANIGRTIDFYNSEVDRINEIRGRDAKTPPVDALITVDS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 AKFSWDRINKRQVAQGIRIEFAPAGMRLGTYRPFTKEHAYLDPNQQLNNC
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 TYQLPSMFPTPEHGNVGYYVVGMGSDKPFSCLMLNAIPDLAFWGSSNGQF
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 FPRWTYEKTEPRDGELDFESTTNAEVDDHGYRRVDNITGVILKLYRDTIG
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 DQVTKDDIFYYVYGLLHDPAYRTKYAADLKKMLPHIPTPETRERFDQLAS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 AGRKLADLHVGYESVKPYPLDVQLKPGADPEDRETWRVEKMKWKSKQDHS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 TIIYNSRVTIAGIPDEAERYLLGSRSALGWIIDRYRVTTDKASGIVNDPN
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 DWCDEHANPTYIVDLIKKVTTVSVETMKIVDSIVALASAGSDST
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------
MAV_5024|M.avium_104 --------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------