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VLPKLKDAGWTEEQIIEQYRITDGRIVKVGSKHRRTAPLRADYVLEYEPGMPIGVVEAKREYSTPGKGMQ QAKNYAQLLDVPFAYSTNGVSIVEDDRNTGIERANLSTFPSPEMLWARYREWKGIKDDSAADGLLLPFNR SLRNADGTVKEPRYYQRTAINRTVEAILAGDKRLLLTMATGTGKTFVSMQIVWKLWNSQWVHGRHPRILY LADRNVLVDQPIEREFKPAFGAGEGSPIWKLKGTAKSGREIYFGLYQQLADGGDEPTGMFRQFARDFFDL VIVDECHRGSARAESSWRKILDHFSPATQLGMTATPKRDETADTYAYFGGAPLFEYTLAQGIEDGFLAPY RVRRVVLSPDAHGWAPEQGQLDLFGKEIPPGLYTTPDFERVVSLLSRTEAAAKHLTNYLHATDRFAKTIV FCANQEHADQMRRALHNANSDLTPQHRDYVVRIVSDEQEIGQGHLSRFCDTEAQFPVIATTSEMLSTGVD APTVRNIVLFRPVGSMALFKQMIGRGTRLFPDEDKLSFEIIDYSGASALFSDPEFDGPPEHVIEEAINDE GDVVEDVVVEEPEPSFEPTPRPADVDVDLDPEDLPAPRAKFYVDDVEVIVTAEAVYELDPQTQQLRLVEY RDLVTETVRSLFPSANELRAKWASRVSRREVLDALAEHGIDADELADRAGLPDADPIDVLVHLAWNQPLA TRTDRVRRVRKEYSDFFEAFQPAAREVLEYLLDKYAEYGISELESPGVLQVPPLSSLGTPVEIARRFGSP EEWRAAQTRLGELVYVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5024 | - | - | 100% (787) | type I restriction-modification system, R subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0803 | - | 9e-47 | 30.73% (537) | type III restriction enzyme, res subunit |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4094 | - | 5e-22 | 26.84% (380) | PUTATIVE - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0037 | - | 2e-06 | 22.65% (574) | HsdR family type I site-specific deoxyribonuclease |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5024|M.avium_104 --------------------------------------------------
Mflv_0803|M.gilvum_PYR-GCK --MSNFAFLQAIGWPEMHADCRRAESYATSDPRSACFYSRRTVELLVDYL
TH_4094|M.thermoresistible__bu --VDAGLYESVITQRLQRQLETLRERSAQLTPQLTEVDEAEEALTLARHL
Mvan_0037|M.vanbaalenii_PYR-1 MTDFSEAEWESLALETLAQQEWLPLNGSAIAPGTENGRASWDELVLPDRM
MAV_5024|M.avium_104 ------------------------------------MLPKLKDAGWTEEQ
Mflv_0803|M.gilvum_PYR-GCK YGVLALPIPYKNDLAAKINDPKFKSKVGVGIATKLNLIRKLGNTAVHDTQ
TH_4094|M.thermoresistible__bu MPVIERSLRCARGAEDRARLIEKLLAALGDPDALAEAVHQLDPGKIHRLD
Mvan_0037|M.vanbaalenii_PYR-1 LAKLRELNAHVPGEYLEQARAAILQPSSQDAIAENYRLHQYLVGGYRGIS
: : .
MAV_5024|M.avium_104 IIEQYRITDGR-----IVKVGSKHRRTAPLRADYVLEYEPGMPIGVVEAK
Mflv_0803|M.gilvum_PYR-GCK QIPQRAALDALRELHHVMLWAAFRYSTKPQAVPMKVLFDPKIAAKAAPLS
TH_4094|M.thermoresistible__bu AVTPVALGTTHIPRPTTPLSDAALMTNARDEPTLAAELRAELASADHVDL
Mvan_0037|M.vanbaalenii_PYR-1 YVDSDGIEQNPTIRLISHRPEENELLAVQQVTIRDAEHDRRFDIVLYLNG
: :
MAV_5024|M.avium_104 R------------------------------------------------E
Mflv_0803|M.gilvum_PYR-GCK RQEVAELAAKFAAQDEAHVKTLADKDELAAQKDTEIAALREAVKQAQAAN
TH_4094|M.thermoresistible__bu LCAFVKWHG---------------------LRLLERELTELKERGIPLRV
Mvan_0037|M.vanbaalenii_PYR-1 MPIAFFELKQAG---------------------------SKYADLPGAHA
MAV_5024|M.avium_104 YSTPGKGMQQAKNYAQLLDVPFAYSTNGVSIVEDD---------RNTGIE
Mflv_0803|M.gilvum_PYR-GCK QQTDDRDYNEADTRDRFVDVMLAEAGWGLTETKDREYPVTGMP-NGDGKG
TH_4094|M.thermoresistible__bu ITTTYMGATDARALDALVNEFGAEVRVNYETDRTRLHAKAWLLRRNTGFH
Mvan_0037|M.vanbaalenii_PYR-1 QFATYLREFPMAFRFAVLNVISDGLTARYGTPFTPLEHFAPWNVDDDGKP
: .:: . *
MAV_5024|M.avium_104 RANLSTFPSPEMLWARYREWKGIKDDSAADGLLLPFNRSLRNADG-----
Mflv_0803|M.gilvum_PYR-GCK FVDYVLWGEDGLPLAIVEAKRTTKSPQVGQQQAKLYADCLEKMTGRRPVI
TH_4094|M.thermoresistible__bu TAYVGSSNLSHAALVDGLEWNVRLSAVSTPHLLEKFRATFDSYWENREFE
Mvan_0037|M.vanbaalenii_PYR-1 VAFGDPVDDVHLGTELEYLIDGLFNPERFLQLVRNFTAFDAGADG-----
. . :
MAV_5024|M.avium_104 --------------------------------------------------
Mflv_0803|M.gilvum_PYR-GCK FYTNGFEHWIWDDTGGYPPREIQGFYTRDQLELLIQRRGTRKPLTDMPID
TH_4094|M.thermoresistible__bu SYRPCED----------------GDKLRNALDVASGKKPRDPLRVTLSGL
Mvan_0037|M.vanbaalenii_PYR-1 ---------------------------------------------LIKRI
MAV_5024|M.avium_104 TVKEPRYYQRTAINRTVEAILAGDKRLLLTMATGTGKTFVSMQIVWKLWN
Mflv_0803|M.gilvum_PYR-GCK SAIVERHYQHRAIRAIDDAFTAKEREALLVMATGSGKTRTVIALVKQLME
TH_4094|M.thermoresistible__bu EVTAKPYQAELLEQLEAERVLHDRHRNLLVAATGTGKTVIAALDYRRLVR
Mvan_0037|M.vanbaalenii_PYR-1 AKPHQYFAVTKAVGSTVTAAESNGKAGVVWHTQGSGKSMEMELYTHLVAQ
. : :: : *:**: : .
MAV_5024|M.avium_104 SQWVHGRHPRILYLADRNVLVDQPIEREFKPAFGAG-----EGSPIWKLK
Mflv_0803|M.gilvum_PYR-GCK ANWVK----RVLFLADRTALVTQAAN-AFKAHLPDA-----TTVNLVTEK
TH_4094|M.thermoresistible__bu --EVHGRDLSLLFVAHRKEILQQARR-----MYQEV-----LTDPTFGEL
Mvan_0037|M.vanbaalenii_PYR-1 QPKLKN--PTVVVVTDRKDLDGQLYATFDRSKLLGESPVKVTTRSQLRDE
:: :: ::.*. : *
MAV_5024|M.avium_104 GTAKSGREIYFGLYQQLAD--GGDEPTGMFRQFARDFFDLVIVDECHRGS
Mflv_0803|M.gilvum_PYR-GCK ITDG---RVYVCTYPTMMN--LINDTDSGIRKFGPGYFDLVVIDEAHR--
TH_4094|M.thermoresistible__bu LVDGEQPARWRHVFASIQS--LNSE---RLSTIDPEHFDVVVVDEFHH--
Mvan_0037|M.vanbaalenii_PYR-1 LSNRTTGGIYFTTLQKFGLSKAERESGADHPLLTDRRNIIVVVDEAHRSH
: : : : :*::** *:
MAV_5024|M.avium_104 ARAESSWR-KILDHFSPATQLGMTATPKRDETADTYAYFG---GAPLFEY
Mflv_0803|M.gilvum_PYR-GCK -SVYQKYR-AIFDWYD-SLLVCLTATPKDEVDHNTYRLFHLEDGVPTDAY
TH_4094|M.thermoresistible__bu -AQAASYR-RLLDHIRPIELLGLTATPERGDGVDVRQFFG---GRVAAEL
Mvan_0037|M.vanbaalenii_PYR-1 YDDLDGYARHIRDALPNAVYIAFTGTPISEADRDTRDVFG----PDIDVY
: : * : :*.** :. *
MAV_5024|M.avium_104 TLAQGIEDGFLAPYR--------VRRVVLSPDAHGWAPEQGQLDLFGKEI
Mflv_0803|M.gilvum_PYR-GCK SLDDAVKEGFLVPAVGISVGTKFLRQGIRYADLSEEEKDDWDALDWGDDD
TH_4094|M.thermoresistible__bu RLWDALEQNLLCPFH----------------YFGIYDGTDLEALQWKR--
Mvan_0037|M.vanbaalenii_PYR-1 DLTRAVNDKATVPVFFEP-------RLIKVALAQGVTEDDLDKAADEVTA
* .::: * : :
MAV_5024|M.avium_104 PPGLYTTPDFERVVS-------LLSRTEAAAKHLTNYLHATDRFAKTIVF
Mflv_0803|M.gilvum_PYR-GCK PPDEVSSEEINRFLFNE----DTVDKVLAELMSKGHRVAEGDRLGKTIIF
TH_4094|M.thermoresistible__bu --GRYDLDELDRVYTG------NDARTRIILKEVRDKIADVG-AMRALGF
Mvan_0037|M.vanbaalenii_PYR-1 GLDDVERDQIEKSVAVINAVYGAPDRLAALARDIVDHWEVRSQEMRKFIS
. :::: : . . : :
MAV_5024|M.avium_104 CANQEHADQMRRALHNANSDLTPQHR---------DYVVRIVSDEQEIGQ
Mflv_0803|M.gilvum_PYR-GCK AKNQAHAEFIARRFDVQ----YPQYA---------GTFARVITHSTAYAQ
TH_4094|M.thermoresistible__bu CVSVEHARYMAKRFVEAG-------------------IPARSVVGLDDSR
Mvan_0037|M.vanbaalenii_PYR-1 CPGKAFIVGATREICAELYEEIVKLKPEWHDDAVDKGVIKVVYSGSAKDQ
. . . : : . :
MAV_5024|M.avium_104 GHLSRFCDTEAQF-------------PVIATTSEMLSTGVDAPTVRNIVL
Mflv_0803|M.gilvum_PYR-GCK SLIDNFS-VTDKA-------------PHIAISVDMLDTGIDVPDVVNLVF
TH_4094|M.thermoresistible__bu ERREALAALQSRE-------------INALFTVDLFNEGLDIPMVDTVLF
Mvan_0037|M.vanbaalenii_PYR-1 GLVAKHVRRDGQNKTIQQRLRDPDDELQIVLVKDMLLTGFDAPPLHTLYL
: ::: *.* * : .: :
MAV_5024|M.avium_104 FRPVGSMALFKQMIGRGTRLFPD-----EDKLSFEIIDYSGASALFSD--
Mflv_0803|M.gilvum_PYR-GCK FKLVRSKTKFWQMIGRGTRLRPDLLGPGKDKQNFYVFDFCGNLEFFSQDL
TH_4094|M.thermoresistible__bu LRPTESATVFLQQLGRGLRLAPG----KTVLTALDFVGHHRREFRFDQRF
Mvan_0037|M.vanbaalenii_PYR-1 DRPLKG-ALLMQTLARVNRTFREKPNGLLVAYAPLVENLNKALAEYTQT-
: . : : * :.* * . . : :
MAV_5024|M.avium_104 PEFDGPPEHVIEEAINDE-----GDVVEDVVVEEPEP-------------
Mflv_0803|M.gilvum_PYR-GCK PGSEGSFQKSLNQRLFEARLGLITAIDHAWPPSEPEPEEGQGTETERGLR
TH_4094|M.thermoresistible__bu RALTGLSRKRLEKQVQEG-FPFLPSGSQIVLDEVAQKIVLENVRQQVSPK
Mvan_0037|M.vanbaalenii_PYR-1 DRTEKPVGKNIDEAVALT-ETLIAQLDALCAGYDWRAKVAQPHGWMKAAV
: ::: : .
MAV_5024|M.avium_104 ---SFEPTPRPADVDVD---------------------------------
Mflv_0803|M.gilvum_PYR-GCK VDVAWSLHRSVAGMNLDNFLVRPHRRLVEQYSQWPAWTSLTPEVAGDVAE
TH_4094|M.thermoresistible__bu KSVLVSEIRSHPDDRLASYLEESGRGLDDILRPNRSWTTLCRDAG-----
Mvan_0037|M.vanbaalenii_PYR-1 GLTNYLRSPATAGNQVAEGEATVSDRFRALANQLSRAWSLCAG-------
.. :
MAV_5024|M.avium_104 ------------------------------LDPEDLPAPRAKFYVDDVEV
Mflv_0803|M.gilvum_PYR-GCK HLAGLPSLHKDDDEDAKRFDMLVLRRQLAQLEGDAVAAERLREQIQNIAT
TH_4094|M.thermoresistible__bu ----------------------KLAEQPGPREAELVKRLKALAHVDDRKR
Mvan_0037|M.vanbaalenii_PYR-1 ------------------------NQALDALRPTAKFYEEVRVWMAKFDA
. : .
MAV_5024|M.avium_104 -IVTAEAVYELDPQTQQLRLVEYRDLVTETVRSLFPSAN-ELR--AKWAS
Mflv_0803|M.gilvum_PYR-GCK GLLSQTAIPSVKAQEALLDEVGGDEWWIDVTLPMLESVRRKLRGLLRFLE
TH_4094|M.thermoresistible__bu ----ADAYRRLLASDVRSDSLAERRLADMLFYSLYPDGG-GFEAAADGFD
Mvan_0037|M.vanbaalenii_PYR-1 NDRQASGKPVPEAIRRMLESLVYDSTASDGIVDIYDAAGLPKPSLSDLTP
. . : :
MAV_5024|M.avium_104 RVSRREVLDALAEHGIDADELADR------AGLPDADPIDVLVHLAWNQP
Mflv_0803|M.gilvum_PYR-GCK KAKRNQVYTDFADELSEASLVDLP------GITPGTNWERFQAKARAYLR
TH_4094|M.thermoresistible__bu EVRREIVVAEMRQIIDIAFDAAHRRTSELGEVIPELRDVPLALHATYSRE
Mvan_0037|M.vanbaalenii_PYR-1 EFEAKAASASNPHLAIEALRAVIT-----EEAVRATKSNVVRQRAFSERL
. . . . * . :
MAV_5024|M.avium_104 LATRTDRVRRVRKEYSDFFEAFQPAAREVLEYLLDKYAEYGISELESPGV
Mflv_0803|M.gilvum_PYR-GCK RHQDHVALQRLRRNKPLTPDDLASLEQMLIESGTGEQADIELAKEQSHGL
TH_4094|M.thermoresistible__bu EILAALGWVSPGRKPSTMREGVAWCPEVNADAFLITLKKSDTEYSPTTMY
Mvan_0037|M.vanbaalenii_PYR-1 TDLMRRYTNQQLTSAEVIAELIEMAKEVAAESNRGAHFSPPLSHDELAFY
. : . . : .
MAV_5024|M.avium_104 -LQVPPLSSLG--TPVEIARRFGSPEEWRAAQTRLGELVYVA--------
Mflv_0803|M.gilvum_PYR-GCK GLFVRSLVGLDREAAAEAFGAYLDGTKFNADQIRFVNLIITELTANGFME
TH_4094|M.thermoresistible__bu RDFALSPDLFHWESQSTTTASSPTGQRYIHHRERGSHVLLFVREAK---K
Mvan_0037|M.vanbaalenii_PYR-1 DAVAQNESAVELQGEDVLAQIARELVGVMQRDTKTDWTVRDDVRAK----
. . : :
MAV_5024|M.avium_104 -------------------------------------------------
Mflv_0803|M.gilvum_PYR-GCK PVRLYESPYIDHAPTGPDDVFGDADVDTIVAILNSVRDNAAPKDGAA--
TH_4094|M.thermoresistible__bu GAFGDGAPYIFLGPADYVSHEGDRPMAITWRLRRPMPTEVYLGARAAVA
Mvan_0037|M.vanbaalenii_PYR-1 ---LRSSIKRLLVKYKYPPDKQPEAIKLVIEQMEALAPGYADAARAG--