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MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWRWIDWPERRGRTDTGIDLVARERD TGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEI AESPIDWDIAWPAGDLQVNLTPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAER IAADNGGSARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVL LHEMAHRRCAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNVVRVHDGQYL KAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQG VIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKV VEAYRELVDDGPGLACSVRHVDGTFNALVRNEQLAWLKGVVAEDECRILSNARCLSEGVDVPALDAVLFL NPRNSIVDVVQSVGRVMRKSPGKDYGYVILPVAVPEGVEPSAALADNKRFKVVWQVLNALRSHDERFDAM VNSIALNVKPTKTGEGSDKLLGGHIGPTSDEAGPAVAEQLAMFSLSQWQEAIYARIVDKVGTRTYWEQWA ADVADIAATLTTRIHALLGGADATAAAAFEQFLAGLRDNLNDSITPDDAISMLSQHLITKPVFDALFAGH DFASHNPVSRAMQKMVDTVGGAGLEAETARLEGFYESVRRRAGEVTSAEGKQQVIAELYEKFFRIGFKKQ AEALGIVYTPVEVVDFIVRAADFVSRKHFGRGLTDEGVHILDGFAGTGTFITRLLQSDLITAADLTRKYS QELHANEIMLLAYYIAAVNIESTYHALAGKTADADAYEPFPGMALADTFQISEAGDSMDAIMFPYNNARI LRQLATPISVIIGNPPYSVGQSSANDLNANVKYPTLDGRIEQTYAKRSTAQLKNSLYDSYIRAFRWATDR IGDNGVVGFVSNGGYIDGNTADGMRLSLADDYAAVYVYNLRGNQRTAGELSRQEGGKVFGGGSRNTVAIF LGIKDPKHSGPCDVLYRDIGDYLSREEKLRIVGDGYLDTVEWQTVTPNLHGDWVNQRDDAFSAWPVIGDK KAALDVTRVFANYSAGLKTSRDAWCYNFSRGALEANIGRTIDFYNSEVDRINEIRGRDAKTPPVDALITV DSAKFSWDRINKRQVAQGIRIEFAPAGMRLGTYRPFTKEHAYLDPNQQLNNCTYQLPSMFPTPEHGNVGY YVVGMGSDKPFSCLMLNAIPDLAFWGSSNGQFFPRWTYEKTEPRDGELDFESTTNAEVDDHGYRRVDNIT GVILKLYRDTIGDQVTKDDIFYYVYGLLHDPAYRTKYAADLKKMLPHIPTPETRERFDQLASAGRKLADL HVGYESVKPYPLDVQLKPGADPEDRETWRVEKMKWKSKQDHSTIIYNSRVTIAGIPDEAERYLLGSRSAL GWIIDRYRVTTDKASGIVNDPNDWCDEHANPTYIVDLIKKVTTVSVETMKIVDSIVALASAGSDST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2049c | - | - | 100% (1606) | hypothetical protein Mb2049c |
| M. bovis AF2122 / 97 | Mb2043c | - | 8e-29 | 67.01% (97) | hypothetical protein Mb2043c |
| M. bovis AF2122 / 97 | Mb1212c | - | 4e-05 | 31.18% (93) | hypothetical protein Mb1212c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2408 | - | 7e-12 | 25.90% (444) | type III restriction enzyme, res subunit |
| M. tuberculosis H37Rv | Rv2024c | - | 0.0 | 99.21% (506) | hypothetical protein Rv2024c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4094 | - | 4e-06 | 25.00% (296) | PUTATIVE - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2049c|M.bovis_AF2122/97 ----MGSVHDVIEAFRKAPSNAERGTKFEQL-MVRYFELDPTMAQQYDAV
Rv2024c|M.tuberculosis_H37Rv ----MGSVHDVIEAFRKAPSNAERGTKFEQL-MVRYFELDPTMAQQYDAV
Mflv_2408|M.gilvum_PYR-GCK ----MSDSDDDARLPAEARARKLIDSQLTQAGWVVQDKKDLNLFAAQGVA
TH_4094|M.thermoresistible__bu VDAGLYESVITQRLQRQLETLRERSAQLTPQLTEVDEAEEALTLARHLMP
: . . : : .::: :
Mb2049c|M.bovis_AF2122/97 WRWIDWPERRGRTD-------TGIDLVARERDTGNYTAIQCKFYEPTHTL
Rv2024c|M.tuberculosis_H37Rv WWWIDWPERRGRTD-------TGIDLVARERDTGNYTAIQCKFYEPTHTL
Mflv_2408|M.gilvum_PYR-GCK VREVVMKPGHGRVDYLLYVDKAVVGVIEAKPVGTPLSGVEWQSAMYADGL
TH_4094|M.thermoresistible__bu VIERSLRCARGAEDRARLIEKLLAALGDPDALAEAVHQLDPGKIHRLDAV
:* * : . :: . :
Mb2049c|M.bovis_AF2122/97 AKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMA
Rv2024c|M.tuberculosis_H37Rv AKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMA
Mflv_2408|M.gilvum_PYR-GCK PADVRIAAKTRDGRLPFVFEASGVETHFTNGFDPEPRARLIFNVPRPETM
TH_4094|M.thermoresistible__bu TPVALGTTHIPRPTTPLSDAALMTNARDEPTLAAELRAELASADHVDLLC
. : : . : : *
Mb2049c|M.bovis_AF2122/97 EIAESPIDWDIAWPAGDLQVNLTPAKR---HELRPHQQQAIDAVFRGFAV
Rv2024c|M.tuberculosis_H37Rv EIAESPIDWDIAWPADDLQVNLTPAKR---HELRPHQQQAIDAVFRGFAV
Mflv_2408|M.gilvum_PYR-GCK ARHLREAETNPDSPTWRAKVRKLPALDT--EALRPAQIEAINGVEQSLAD
TH_4094|M.thermoresistible__bu AFVKWHGLRLLERELTELKERGIPLRVITTTYMGATDARALDALVNEFGA
: . * : . : .*::.: . :.
Mb2049c|M.bovis_AF2122/97 G------NDRGKLIMACGTGKTFTALKIAER--------IAADNGGSARI
Rv2024c|M.tuberculosis_H37Rv G------NDRGKLIMACGTGKTFTALKIAER--------IAADNGGSARI
Mflv_2408|M.gilvum_PYR-GCK QR-----YDRSLVQMATGAGKTFTAVTQSYR--------LLK-HGGVDRV
TH_4094|M.thermoresistible__bu EVRVNYETDRTRLHAKAWLLRRNTGFHTAYVGSSNLSHAALVDGLEWNVR
** : : *.. :
Mb2049c|M.bovis_AF2122/97 LLLVPSISLLSQTLREWT-AQSELDVRAFAVCSDTKVSRSAEDYHVHDVP
Rv2024c|M.tuberculosis_H37Rv LLLVPSISLLSQTLREWT-AQSELDVRAFAVCSDTKVSRSAEDYHVHDVP
Mflv_2408|M.gilvum_PYR-GCK LFLVDRNNLADQTLGEFQNYRTPDDGRRFTELYNVNKLSSAGLLGSTKVT
TH_4094|M.thermoresistible__bu LSAVSTPHLLEKFRATFDSYWENREFESYRPCEDGDKLRNALDVASGKKP
* * * .: : : . : : . .* . .
Mb2049c|M.bovis_AF2122/97 IPVTTDARVLLHEMAHRRCAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLV
Rv2024c|M.tuberculosis_H37Rv IPVTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLV
Mflv_2408|M.gilvum_PYR-GCK ISTIQRVFRFIKAGEVSDTDD-PDIDDYIPDAPVTVSYSDALPPETFDLV
TH_4094|M.thermoresistible__bu RDPLRVTLSGLEVTAKPYQAELLEQLEAERVLHDRHRNLLVAATGTGKTV
. :. : . *
Mb2049c|M.bovis_AF2122/97 MCDEAHRTTGVTLAGDDESNVVRVHDGQYLKAARRLYMTATPRIFTESIK
Rv2024c|M.tuberculosis_H37Rv MCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIK
Mflv_2408|M.gilvum_PYR-GCK IVDEAHRSIYGVWRG-----VLEYFDAHVVGLTATPGKQTFAFFRQNLVS
TH_4094|M.thermoresistible__bu IAALDYRRLVREVHGRDLSLLFVAHRKEILQQARRMYQEVLTDPTFGELL
: :* * .. . . : : . . :
Mb2049c|M.bovis_AF2122/97 DRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQG
Rv2024c|M.tuberculosis_H37Rv DRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQG
Mflv_2408|M.gilvum_PYR-GCK DYTYPESVADGVNVDFDVYRIRTKISDQGSHIEAGTIVP-KVDRRTREQR
TH_4094|M.thermoresistible__bu VDGEQPARWRHVFASIQSLNSERLSTIDPEHFDVVVVDEFHHAQAASYRR
: . . . .: : : : :
Mb2049c|M.bovis_AF2122/97 VIAPRLQQELSGVSGELMLDDASKIVGCWNG----------------LAK
Rv2024c|M.tuberculosis_H37Rv VIAPRLQQELSGVSGELMLDDASKIVGCWNG----------------LAK
Mflv_2408|M.gilvum_PYR-GCK LETLDDDLDYVPGQLDRAVTATDQIRTVLES----------------FRD
TH_4094|M.thermoresistible__bu LLDHIRPIELLGLTATPERGDGVDVRQFFGGRVAAELRLWDALEQNLLCP
: : .: . :
Mb2049c|M.bovis_AF2122/97 RSGTGIVAGE------------PPMRRAVAFAKDIKTSKQVAELFPKVVE
Rv2024c|M.tuberculosis_H37Rv RSGTGIVAGE------------PPMRRAVAFAKDIKTSKQVAELFPKVVE
Mflv_2408|M.gilvum_PYR-GCK RLFTEIFPGR------------STVPKTLIFAKDDNHAEEIVKQVREVFG
TH_4094|M.thermoresistible__bu FHYFGIYDGTDLEALQWKRGRYDLDELDRVYTGNDARTRIILKEVRDKIA
* * :: : :. : : . . .
Mb2049c|M.bovis_AF2122/97 AYRELVDDGPGLACSVRHVDGTFNALV-----------RNEQLAWLKGVV
Rv2024c|M.tuberculosis_H37Rv AYRELVDDGPGLAC------------------------------------
Mflv_2408|M.gilvum_PYR-GCK KGNDFAAKITYNARN--------------------------AKEQLKAFR
TH_4094|M.thermoresistible__bu DVGAMRALGFCVSVEHARYMAKRFVEAGIPARSVVGLDDSRERREALAAL
: :
Mb2049c|M.bovis_AF2122/97 AEDECRILSNARCLSEGVDVPALDAVLFLNPRNSIVDVVQSVGRVMRKSP
Rv2024c|M.tuberculosis_H37Rv -------LNSSRRIQA----------------------------------
Mflv_2408|M.gilvum_PYR-GCK TSPSLRIAVTVDMIATGTDVKPLECVFFMRDVRSAQYFEQMKGRGARTVP
TH_4094|M.thermoresistible__bu QSREINALFTVDLFNEGLDIPMVDTVLFLRPTESATVFLQQLGRGLRLAP
. :
Mb2049c|M.bovis_AF2122/97 GKDYGYVILPVAVPEGVEPSAALADNKRFKVVWQVLNALRSHDERFDAMV
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK DADFQAVTP----------------DATSKTRFVIVDAIGVTEHEFVEPP
TH_4094|M.thermoresistible__bu G----------------------------KTVLTALDFVGHHRREFRFDQ
Mb2049c|M.bovis_AF2122/97 NSIALNVKPTKTGEGSDKLLGGHIGPTSDEAGPAVAEQLAMFSLSQWQEA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK LNRQRSVPLKKLLEKAANLT------ITEDEAATLASRLAKLELDLTDAE
TH_4094|M.thermoresistible__bu RFRALTGLSRKRLEKQVQEGFPFLPSGSQIVLDEVAQKIVLENVRQQVSP
Mb2049c|M.bovis_AF2122/97 IYARIVDKVGTRT-------YWEQWAADVADIAA----TLTTRIHALLGG
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK R--VELDEVAGQP-------VRDVIRSLVDAVEP----STTTPEAIEAAL
TH_4094|M.thermoresistible__bu KKSVLVSEIRSHPDDRLASYLEESGRGLDDILRPNRSWTTLCRDAGKLAE
Mb2049c|M.bovis_AF2122/97 ADATAAAAFEQFLAGLRDNLNDSITPDDAISMLSQHLITKPVFDALFAGH
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK VPIASNPELRSRVLELRAAHDRIIDEVSADELIEAGGVVDTGKARHIVES
TH_4094|M.thermoresistible__bu QPGPREAELVKRLKALAHVDDRKR-ADAYRRLLASDVRSDSLAERRLADM
Mb2049c|M.bovis_AF2122/97 DFASHNPVSRAMQKMVDTVGGAGLEAETARLEGFYESVRRRAGEVTSAE-
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK WTAYLDEHRDEITALQLGYEAGERRIDFAFIEGLATRIARPPHNWTPDV-
TH_4094|M.thermoresistible__bu LFYSLYPDGGGFEAAADGFDEVRREIVVAEMRQIIDIAFDAAHRRTSELG
Mb2049c|M.bovis_AF2122/97 ----GKQQVIAELYEKFFRIGFKKQAEALGIVYTPVEVVDFIVRAADFVS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK ----IWNAYAAIDGEKVHRSATHAVTDLVSLVRYATGVDDELVPYGDRVR
TH_4094|M.thermoresistible__bu EVIPELRDVPLALHATYSREEILAALGWVSPGRKPSTMREGVAWCPEVNA
Mb2049c|M.bovis_AF2122/97 RKHFGRGLTDEGVHILDGFAGTGTFITRLLQSDLITAADLTRKYSQELHA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK EKYAAWLTQQE-------------------------QAGVTFTDTERWWL
TH_4094|M.thermoresistible__bu DAFLITLKKSDTEYSPTTMYRDFALSPDLFHWESQSTTTASSPTGQRYIH
Mb2049c|M.bovis_AF2122/97 N--EIMLLAYYIAAVNIESTYHALAGKTADADAYEPFPGMALADTFQISE
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK D--RMVSVIASSAGIRVEDLDDAPFIERGGTDGAIRDLGDRAAELIDELN
TH_4094|M.thermoresistible__bu HRERGSHVLLFVREAKKGAFGDGAPYIFLGPADYVSHEGDRPMAITWRLR
Mb2049c|M.bovis_AF2122/97 AGDSMDAIMFPYNNARILRQLATPISVIIGNPPYSVGQSSANDLNANVKY
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK AELTA---------------------------------------------
TH_4094|M.thermoresistible__bu RPMPTEVYLGARAAVA----------------------------------
Mb2049c|M.bovis_AF2122/97 PTLDGRIEQTYAKRSTAQLKNSLYDSYIRAFRWATDRIGDNGVVGFVSNG
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 GYIDGNTADGMRLSLADDYAAVYVYNLRGNQRTAGELSRQEGGKVFGGGS
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 RNTVAIFLGIKDPKHSGPCDVLYRDIGDYLSREEKLRIVGDGYLDTVEWQ
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 TVTPNLHGDWVNQRDDAFSAWPVIGDKKAALDVTRVFANYSAGLKTSRDA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 WCYNFSRGALEANIGRTIDFYNSEVDRINEIRGRDAKTPPVDALITVDSA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 KFSWDRINKRQVAQGIRIEFAPAGMRLGTYRPFTKEHAYLDPNQQLNNCT
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 YQLPSMFPTPEHGNVGYYVVGMGSDKPFSCLMLNAIPDLAFWGSSNGQFF
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 PRWTYEKTEPRDGELDFESTTNAEVDDHGYRRVDNITGVILKLYRDTIGD
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 QVTKDDIFYYVYGLLHDPAYRTKYAADLKKMLPHIPTPETRERFDQLASA
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 GRKLADLHVGYESVKPYPLDVQLKPGADPEDRETWRVEKMKWKSKQDHST
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 IIYNSRVTIAGIPDEAERYLLGSRSALGWIIDRYRVTTDKASGIVNDPND
Rv2024c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK --------------------------------------------------
TH_4094|M.thermoresistible__bu --------------------------------------------------
Mb2049c|M.bovis_AF2122/97 WCDEHANPTYIVDLIKKVTTVSVETMKIVDSIVALASAGSDST
Rv2024c|M.tuberculosis_H37Rv -------------------------------------------
Mflv_2408|M.gilvum_PYR-GCK -------------------------------------------
TH_4094|M.thermoresistible__bu -------------------------------------------