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MDFQFSEEQVLLRDTTRDMLSRKYDPETRLKAIDSELGWSRDVWKQLAEVGVLGLGFDEDAGGQLEVLVV LTEIGRRLAPEPVLHAALGPGALIAEVGTEAQRGLLDEVAGGERLLAFAHLEPGMRLPTAKVSTTAVREG DSWTLSGRKNPVLAGDCADTLVVSAALPDGGTGLFLVDATSSNPVQRTPYRTFDGQRGAQIDFDSVAAEP LGEAADASDAISRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRAADMYVSLEL ARSMAFYANMSVADGNLDPTIAARAKLQIGRSGRHIAQESIQLHGGIGVTAEYPISHYAARLTAIDNTLG STQDQLHVLIGQLGDYEIVTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4380 | - | - | 100% (371) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1964 | - | 7e-51 | 32.70% (367) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0393 | - | 2e-34 | 32.78% (360) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 1e-26 | 30.00% (370) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_2286 | - | 0.0 | 90.03% (371) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 1e-26 | 30.00% (370) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-18 | 24.79% (363) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2496 | - | 3e-49 | 33.79% (367) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3738 | fadE18_2 | 1e-157 | 74.05% (370) | acyl-CoA dehydrogenase FadE18_2 |
| M. avium 104 | MAV_1765 | - | 1e-163 | 77.24% (369) | pimeloyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6512 | - | 1e-155 | 75.20% (371) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3980 | - | 1e-137 | 66.40% (372) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3682 | fadE18_2 | 1e-156 | 73.78% (370) | acyl-CoA dehydrogenase FadE18_2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 ----------MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSD----
Rv1933c|M.tuberculosis_H37Rv ----------MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSD----
Mvan_4380|M.vanbaalenii_PYR-1 ----------MDFQFSEEQVLLRDTTRDMLSRKYDPETRLKAIDSELGWS
Mflv_2286|M.gilvum_PYR-GCK ----------MDFQFSEEQVLLRDTTREMLSRKYDPETRLKTIDSELGWS
MMAR_3738|M.marinum_M ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MUL_3682|M.ulcerans_Agy99 ----------MDFQYSDEQTLLRDTTRDLLSRSYDAESRNKIIDTDLGWS
MAV_1765|M.avium_104 ----------MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWS
MSMEG_6512|M.smegmatis_MC2_155 ----------MDFQLTEEQTLLADTTRDLLS-SYDTETRNKVIASDPGHK
TH_3980|M.thermoresistible__bu ----------MDFDLTDEQELLRDTTRDLLAGVYDVETRNRTVDTDPGWS
MAB_2496|M.abscessus_ATCC_1997 ----------MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQ
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP--HAADVDQRARFP
* . *: : : :
Mb1968c|M.bovis_AF2122/97 RRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAA
Rv1933c|M.tuberculosis_H37Rv RRLWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAA
Mvan_4380|M.vanbaalenii_PYR-1 RDVWKQLAEVG-VLGLGFDEDAGGQ----LEVLVVLTEIGRRLAPEPVLH
Mflv_2286|M.gilvum_PYR-GCK RDVWKQLAEVG-VLGLGFDEDAGGQ----IEVLAVLTEVGRRLAPEPVLH
MMAR_3738|M.marinum_M RDVWSQLADTG-ILGLGFEPAEAGQ----IEIMLVMTEVGRRLAPEPIVH
MUL_3682|M.ulcerans_Agy99 RDVWSQLADTG-ILGLGFEPAEAGQ----IEIMLVMTEVGRRLAPEPIVH
MAV_1765|M.avium_104 REVWSQLADTG-ILGLGFDPDESGQ----IEIMVVLTEIGRRLAPEPVLH
MSMEG_6512|M.smegmatis_MC2_155 PEVWNQLAEIG-ILGLGFDEDSGGQ----LEIMVVLNEIGRRLAPEPVLH
TH_3980|M.thermoresistible__bu REVWKQLADIG-ILSLGFDPAESGQ----IEVMVVMTEIGRRLAPEPVAA
MAB_2496|M.abscessus_ATCC_1997 PQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLGRHLVVEPFIG
MLBr_00737|M.leprae_Br4923 EEALAALNASG-FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIP
: . . . .* :.* . ..
Mb1968c|M.bovis_AF2122/97 TVFAIE--AILRMGDDEQRKRLLAGLLTGARIGTIAVSG---HDVASATT
Rv1933c|M.tuberculosis_H37Rv TVFAIE--AILRMGDDEQRKRLLAGLLTGARIGTIAVSG---HDVASATT
Mvan_4380|M.vanbaalenii_PYR-1 AALGPG--ALIAEVGTEAQRGLLDEVAGGERLLAFAHLEPGMRLPTAKVS
Mflv_2286|M.gilvum_PYR-GCK AALGPG--ALVAEVGSEQQRGLLDEVAAGERLLAFAHLEPGMRLPTAAVS
MMAR_3738|M.marinum_M AALAPG--AIIAELGNDAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MUL_3682|M.ulcerans_Agy99 AALAPG--AIIAELGNDAQLQLLDEVAAGGRLLAFAHLEPGQRSPAATVS
MAV_1765|M.avium_104 AALGPG--ALIAELGSAAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVG
MSMEG_6512|M.smegmatis_MC2_155 GALAPG--AIIAERGTDAQRALLDEVASGQRILAFAHLEPGVRDAAATPT
TH_3980|M.thermoresistible__bu AALVPG--TLIAELGSDDQ--LLEQVGSGDMLLALAHREPGTRGVFGSVT
MAB_2496|M.abscessus_ATCC_1997 TVVLGG--GLLRRSNAEVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQ
MLBr_00737|M.leprae_Br4923 AVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
. :: . :: : : *
Mb1968c|M.bovis_AF2122/97 VRAVRRDGRPALTGECTPVLHGHVADLFVVPA-----VAD-GSIVLHVV-
Rv1933c|M.tuberculosis_H37Rv VRAVRRDGRPALTGECTPVLHGHVADLFVVPA-----VAD-GSIVLHVV-
Mvan_4380|M.vanbaalenii_PYR-1 TTAVREGDSWTLSGRKNPVLAGDCADTLVVSA----ALPD-GGTGLFLV-
Mflv_2286|M.gilvum_PYR-GCK TKAVREGDSWTLSGSKNPVLAGGSADTLIVSA----QLPD-GGTGLFLV-
MMAR_3738|M.marinum_M TRAVQQGDSWLLSGTKNPVLAGDCADTLVVSA----ALPD-GGVGLFLV-
MUL_3682|M.ulcerans_Agy99 TRAVRQGDSWLLIGTKNPVLAGDCADTLVVSA----ALPD-GGVGLFLV-
MAV_1765|M.avium_104 TKAARQGDPWTLSGQKNPVLAGDCADTLVVSA----ALPD-GGTGLFLV-
MSMEG_6512|M.smegmatis_MC2_155 VTATRDGDAWTLNGTKNPVLAGDAANTLVVSA----ALPD-GGAGLFLV-
TH_3980|M.thermoresistible__bu STAAQQGNSWTITGRKHPVLAGDVADTLIVSA----ALPDSGGTGLFLV-
MAB_2496|M.abscessus_ATCC_1997 TTARRDGPDWVLDGEKIVVSDAPLATHVIVSARTSGEVADTSGLTLFVVP
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTD---PDKGANGISAFI
* . : * : . : * * .* .. : .
Mb1968c|M.bovis_AF2122/97 ---AADAPGVTVTPLPSFDITRPVATLRLAG---SPAEPLTAG--TPDDM
Rv1933c|M.tuberculosis_H37Rv ---AADAPGVTVTPLPSFDITRPVATLRLAG---SPAEPLTAG--TPDDM
Mvan_4380|M.vanbaalenii_PYR-1 -DATSSN-PVQRTPYRTFDGQR-GAQIDFD---SVAAEPLGEAADASDAI
Mflv_2286|M.gilvum_PYR-GCK -DGAAA----QRTPYRTFDGQR-AAQIDFD---SVAAEPLGEAADASEAI
MMAR_3738|M.marinum_M -DAGPEGGGVDKHPYPTFDSQR-GAQIDLD---QAPAAPLGDAVDASAAI
MUL_3682|M.ulcerans_Agy99 -NAGPEGGGVDKHPYPTFDSQR-GAQINLD---QAPAAPLGDAVDASAAI
MAV_1765|M.avium_104 -DAG----AVTRHPYRTFDGQR-GAQIDLD---ATPAEPLGEATDASGGI
MSMEG_6512|M.smegmatis_MC2_155 -DAGASG--VSRKPFRTFDGAR-GAQIELS---AAPAEPLGDATDASETI
TH_3980|M.thermoresistible__bu -DAAAAE----RQPFRTFDGQR-AAQIDFD---ATPARPLGSGGDATEHL
MAB_2496|M.abscessus_ATCC_1997 FDPAAPAQGIEAHHYRTIDDHH-ASDLVISGLRVPDSARISEVDQAWPLI
MLBr_00737|M.leprae_Br4923 VHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTA
: : : :
Mb1968c|M.bovis_AF2122/97 ERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHAC
Rv1933c|M.tuberculosis_H37Rv ERVLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHAC
Mvan_4380|M.vanbaalenii_PYR-1 SRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRA
Mflv_2286|M.gilvum_PYR-GCK TRALVRISSGLCAEALGAMEEALRLTSEYLTQRKQFGVTLSKFQTLTQRA
MMAR_3738|M.marinum_M RNAITRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLNKFQALTQRA
MUL_3682|M.ulcerans_Agy99 RNAIIRIQSAMCAEAVGAMEEALRLTTDYLKTRKQFGVTLSKFQALTQRA
MAV_1765|M.avium_104 EAAIIRIQSALCSEALGAMEESLRLTTDYLKTRKQFGVTLNKFQALTQRA
MSMEG_6512|M.smegmatis_MC2_155 SRALVRISAGLAAEALGAMEEALRLTTDYLKSRKQFGVTLSKFQTLTQRA
TH_3980|M.thermoresistible__bu QRALIRHQSALCAEAVGAMAEALRLTTEYLPSRKQFGVPLSSFQTLTQRA
MAB_2496|M.abscessus_ATCC_1997 EAALDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRM
MLBr_00737|M.leprae_Br4923 LATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFML
.: :: :* * : * * **. .:..**::
Mb1968c|M.bovis_AF2122/97 ADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGSA
Rv1933c|M.tuberculosis_H37Rv ADMMIEIDATRATVMFAAMSAANGDELQ-TVAPLAKAQTAETFVLCAGSA
Mvan_4380|M.vanbaalenii_PYR-1 ADMYVSLELARSMAFYANMSVADGNLDP-TIAARAKLQIGRSGRHIAQES
Mflv_2286|M.gilvum_PYR-GCK ADMYVSLELARSMTFYAAMSVADENLDP-TIAARAKLQIGRSGRHIAQES
MMAR_3738|M.marinum_M ADMYVSLELARSMNFYAAMSIADGNLDP-LIASRSKLQIGRSGRHIAQES
MUL_3682|M.ulcerans_Agy99 ADMYVSLELARSMNFYAAMSIADGNLDP-LIASRSKLQIGRSGRHIAQES
MAV_1765|M.avium_104 ADMYVSLELARSMSLYAAMSIADGNIDP-VIASRAKLQIGRSGRHIAQES
MSMEG_6512|M.smegmatis_MC2_155 ADMYVSLELARSMAFYASMSIADGEFDP-VKAARAKLQIGRSGRHIAQES
TH_3980|M.thermoresistible__bu ADMYVSLELARSMNFWAAMSIADGRFDP-AVAARAKLQICRSGRHIGQEA
MAB_2496|M.abscessus_ATCC_1997 VDMHIEVEQSVAASYLASLNLDGPRRAR-AVS-AAKATIARAARLVGQEA
MLBr_00737|M.leprae_Br4923 ADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDA
.** :.:: : * : :* .:
Mb1968c|M.bovis_AF2122/97 LQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA--
Rv1933c|M.tuberculosis_H37Rv LQIHGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA--
Mvan_4380|M.vanbaalenii_PYR-1 IQLHGGIGVTAEYPISHYAARLTAIDNTLGSTQDQLHVLIGQLGDYEIVT
Mflv_2286|M.gilvum_PYR-GCK IQLHGGIGVTAEYPISHYAARLTAIDHTLGSASDQLHVLTGQLDDYEVVS
MMAR_3738|M.marinum_M IQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLVR
MUL_3682|M.ulcerans_Agy99 IQLHGGIGVTAEYPVGHYAARLTAIDHTLGSTQDQLRVLIDHIADYDLVR
MAV_1765|M.avium_104 IQMHGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLVR
MSMEG_6512|M.smegmatis_MC2_155 IQLHGGIGITAEYPVGHYAARLTAIEHTLGSAQDQLRTLAGQLDSYEIVS
TH_3980|M.thermoresistible__bu IQLHGGIGMTAEYPVGHYAARLTAIEQTLGSAHDQLQVLIDGLTGYDTVS
MAB_2496|M.abscessus_ATCC_1997 VQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG---
MLBr_00737|M.leprae_Br4923 VQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-----
:*:.*. . * : : : . : *. :
Mb1968c|M.bovis_AF2122/97 -
Rv1933c|M.tuberculosis_H37Rv -
Mvan_4380|M.vanbaalenii_PYR-1 V
Mflv_2286|M.gilvum_PYR-GCK L
MMAR_3738|M.marinum_M L
MUL_3682|M.ulcerans_Agy99 L
MAV_1765|M.avium_104 L
MSMEG_6512|M.smegmatis_MC2_155 L
TH_3980|M.thermoresistible__bu L
MAB_2496|M.abscessus_ATCC_1997 -
MLBr_00737|M.leprae_Br4923 -