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MVFALGVLADAPDRVDAVEKRGELDRSSQRPVGALPTVELGQNGVHLFVSQYSHAFDGIPSSPMSNLIVV AGALIEHGALLVAQRARPPELAGLWELPGGKVTPPESDESALARELNEELGIDVTVGPRIGADVALSATT TLRAYVVTRTRGAVTAHDHRALRWVRADEIPSLPWVPADRAWLPDLVGLLAGNNLTQSGSGTDTDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2154 | - | - | 100% (206) | NUDIX hydrolase |
| M. gilvum PYR-GCK | Mflv_3031 | - | 1e-07 | 30.37% (135) | NUDIX hydrolase |
| M. gilvum PYR-GCK | Mflv_0199 | - | 2e-06 | 33.65% (104) | NUDIX hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1192 | mutT2 | 8e-37 | 57.89% (133) | 7,8-dihydro-8-oxoguanine-triphosphatase |
| M. tuberculosis H37Rv | Rv1160 | mutT2 | 9e-37 | 57.89% (133) | 7,8-dihydro-8-oxoguanine-triphosphatase |
| M. leprae Br4923 | MLBr_00451 | - | 3e-05 | 30.64% (173) | hypothetical protein MLBr_00451 |
| M. abscessus ATCC 19977 | MAB_1308 | - | 1e-29 | 52.76% (127) | mutator protein MutT2/NUDIX hydrolase |
| M. marinum M | MMAR_4290 | mutT2 | 3e-38 | 61.83% (131) | mutator protein MutT2 |
| M. avium 104 | MAV_1301 | - | 5e-41 | 61.31% (137) | hydrolase, NUDIX family protein |
| M. smegmatis MC2 155 | MSMEG_5148 | - | 2e-47 | 72.09% (129) | CTP pyrophosphohydrolase |
| M. thermoresistible (build 8) | TH_0645 | mutT2 | 6e-40 | 62.90% (124) | PROBABLE MUTATOR PROTEIN MUTT |
| M. ulcerans Agy99 | MUL_1008 | mutT2 | 6e-36 | 59.54% (131) | mutator protein MutT2 |
| M. vanbaalenii PYR-1 | Mvan_4548 | - | 7e-56 | 79.84% (129) | NUDIX hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2154|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4548|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5148|M.smegmatis_MC2_155 --------------------------------------------------
TH_0645|M.thermoresistible__bu --------------------------------------------------
Mb1192|M.bovis_AF2122/97 --------------------------------------------------
Rv1160|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1301|M.avium_104 --------------------------------------------------
MMAR_4290|M.marinum_M --------------------------------------------------
MUL_1008|M.ulcerans_Agy99 --------------------------------------------------
MAB_1308|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00451|M.leprae_Br4923 MLTLLVLLVALATLAGGWGYQTANRLNRLHVRYDLSWQALDGALARRAVV
Mflv_2154|M.gilvum_PYR-GCK -------------------------------------MVFALGVLADAPD
Mvan_4548|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5148|M.smegmatis_MC2_155 --------------------------------------------------
TH_0645|M.thermoresistible__bu --------------------------------------------------
Mb1192|M.bovis_AF2122/97 --------------------------------------------------
Rv1160|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1301|M.avium_104 --------------------------------------------------
MMAR_4290|M.marinum_M --------------------------------------------MRAIMF
MUL_1008|M.ulcerans_Agy99 --------------------------------------------------
MAB_1308|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00451|M.leprae_Br4923 ARAVAIDAYSGTSPGRRLAALADAAECAPRHTRENAENELSAALAMVDPA
Mflv_2154|M.gilvum_PYR-GCK RVDAVEKRGELDRSSQRPVGALPTVELGQNGVHLFVSQYSHAFDGIPSSP
Mvan_4548|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5148|M.smegmatis_MC2_155 --------------------------------------------------
TH_0645|M.thermoresistible__bu ----------------------------------------------MTQI
Mb1192|M.bovis_AF2122/97 --------------------------------------------------
Rv1160|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1301|M.avium_104 ----------------------------------------MRADGIPSLA
MMAR_4290|M.marinum_M GLSKPAWRAVKAAVAQGWGVLGQHGFGRIAVRRIWEVALPGRLGEIPSLA
MUL_1008|M.ulcerans_Agy99 --------------------------------------------------
MAB_1308|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00451|M.leprae_Br4923 SLPTALIAELADAEARVLLARRFHNDAVRDTLALGEQRLVRTLRLRGTAS
Mflv_2154|M.gilvum_PYR-GCK MSN---LIVVAGALIEHGALLVAQRARP------------------PELA
Mvan_4548|M.vanbaalenii_PYR-1 MSK---LIVVAGALIEGGALLVAQRDRP------------------PELA
MSMEG_5148|M.smegmatis_MC2_155 MTK---QIVVAGALISRGTLLVAQRDRP------------------AELA
TH_0645|M.thermoresistible__bu PQP---QIVVAGALIADAALLVAQRNRP------------------PELA
Mb1192|M.bovis_AF2122/97 MLN---QIVVAGAIVRGCTVLVAQRVRP------------------PELA
Rv1160|M.tuberculosis_H37Rv MLN---QIVVAGAIVRGCTVLVAQRVRP------------------PELA
MAV_1301|M.avium_104 MPT---QIVVAGALIRGSRLLVAQRARP------------------PELA
MMAR_4290|M.marinum_M MPNQPNQIVVAGAIIRGATVLVAQRARP------------------PELA
MUL_1008|M.ulcerans_Agy99 MPNQPNQIVVAGAFICGATVLVAQRVRP------------------PELA
MAB_1308|M.abscessus_ATCC_1997 --------MVAGAVIDGDKLLIAQRAKP------------------AELA
MLBr_00451|M.leprae_Br4923 VPTYFEIVERPHALTHGDHGVPNQRTSARVVLLDETGAVLLLCGSDPAIT
. *. : ** . . ::
Mflv_2154|M.gilvum_PYR-GCK G-----LWELPGGKVTPPESDESALARELNEELGIDV---TVGPRIG---
Mvan_4548|M.vanbaalenii_PYR-1 G-----LWELPGGKVAPGESDEAALVRELNEELGVDV---TVGARVG---
MSMEG_5148|M.smegmatis_MC2_155 G-----LWELPGGKVTPGESDADALARELREELGVDV---AVGERLG---
TH_0645|M.thermoresistible__bu G-----RWELPGGKVAPGETEAEALVRELKEELGVDV---EVGARLG---
Mb1192|M.bovis_AF2122/97 G-----RWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVG---
Rv1160|M.tuberculosis_H37Rv G-----RWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVG---
MAV_1301|M.avium_104 G-----RWELPGGKVAPGETERDALARELAEELGLRVGDIAVGDRLG---
MMAR_4290|M.marinum_M G-----RWELPGGKVAGGETEPAALARELVEELGLGVDDVAVGERLG---
MUL_1008|M.ulcerans_Agy99 G-----RWELPGGKVAGGETEPAALARELVEELGLGVDDVAVGERLG---
MAB_1308|M.abscessus_ATCC_1997 G-----QWELPGGKVADGESEPQALVRELREELGIEV---EVGARLG---
MLBr_00451|M.leprae_Br4923 NGHAPRWWITVGGEVRPGERLAAAAARELAEETGLRVIPTHMVGPIWRRD
. * **:* * * .*** ** *: * : :
Mflv_2154|M.gilvum_PYR-GCK -----ADVALSATTTLRAYVVTRTR---GAVTAHDHRALR---WVRADEI
Mvan_4548|M.vanbaalenii_PYR-1 -----ADIALSAAMCLRAYAVTRTR---GVVAPHDHRALR---WIRTEEI
MSMEG_5148|M.smegmatis_MC2_155 -----ADVALNDAMTLRAYRVTLRS---GSPHPHDHRALR---WVGADEI
TH_0645|M.thermoresistible__bu -----VEVALTESMVLRAFRVHHRG---GSPSPNDHRALR---WVTAAEL
Mb1192|M.bovis_AF2122/97 -----DDIALNGTTTLRAYRVHLLG---GEPRARDHRALC---WVTAAEL
Rv1160|M.tuberculosis_H37Rv -----DDIALNGTTTLRAYRVHLLG---GEPRARDHRALC---WVTAAEL
MAV_1301|M.avium_104 -----GDIAVDGGMTLRAYRVRLLR---GRPDARDHRALR---WITAAQL
MMAR_4290|M.marinum_M -----ADVVLDEKTVLRAYRVRLLR---GHPCARDHRALR---WVTADQL
MUL_1008|M.ulcerans_Agy99 -----ADVVPDEKTVLRAYRVRLLR---GHPCARDHRALR---WVTVDQL
MAB_1308|M.abscessus_ATCC_1997 -----EDVVVG-NLVLRAYSARLHPQHPGSPHPHEHLALR---WVTAGEL
MLBr_00451|M.leprae_Br4923 AIFEFNGSVIDSEEFYLVYRTRRFEPSTVGWTELEHLCLHGSRWCDANDI
. .: . :* .* * . ::
Mflv_2154|M.gilvum_PYR-GCK PSLPWVPADRAWLPDLVGLLAGNNLTQSGSGTDTDG--------------
Mvan_4548|M.vanbaalenii_PYR-1 ETLPWVPADRAWLPDLTRLLAGADHARASGAAARRGNQPPA---------
MSMEG_5148|M.smegmatis_MC2_155 DGLAWVPADRAWVPDLVAALSGR---------------------------
TH_0645|M.thermoresistible__bu HDLDWVPADRAWIPELTALLSAR---------------------------
Mb1192|M.bovis_AF2122/97 HDVDWVPADRGWIADLARTLNGSAADVHRRC-------------------
Rv1160|M.tuberculosis_H37Rv HDVDWVPADRGWIADLARTLNGSAADVHRRC-------------------
MAV_1301|M.avium_104 HDLDWVPADRGWLGDLARVL------------------------------
MMAR_4290|M.marinum_M DDVDWVPADRCWLADLDRALRPAPPPG-----------------------
MUL_1008|M.ulcerans_Agy99 DDVDWVPADRCWLADLDRALRPAPPTG-----------------------
MAB_1308|M.abscessus_ATCC_1997 DAVEWVAADGGWIPALKQALVGTRPV------------------------
MLBr_00451|M.leprae_Br4923 AELVAS-GEQVYPRQLGELLPVANQLADASTGTARGTAAARNTYVLLSIC
: .: : * *