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MDEVFRALADPSRRRLLDNLNARNGQSLRELCAGLDMARQSVSKHLKVLEDANLVSIVWQGREKLHYLNA EPINAIADRWINHYDRMRAQTLADLKTALERNPMADNTHSAAADFVYTTYIRTTPERLWQAVTDPAFSER YMGHGLVSDWQVGSTFAWRDGDLSITSPEQVILECEPYRRLAFTFHTFTKDLTTVGLSEDVIERAAAEPR SQVVFDIESVEDGRVKLTVTHTGFPSESIVRELVSGGWPSKLSDLKTHLELDRVAVGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2031 | - | - | 100% (268) | activator of Hsp90 ATPase 1 family protein |
| M. gilvum PYR-GCK | Mflv_3162 | - | 2e-19 | 51.76% (85) | regulatory protein, ArsR |
| M. gilvum PYR-GCK | Mflv_3234 | - | 1e-08 | 33.67% (98) | regulatory protein, ArsR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0591 | - | 2e-07 | 24.46% (184) | ArsR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0576 | - | 2e-07 | 24.46% (184) | ArsR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0986 | - | 1e-50 | 44.62% (260) | ArsR family transcriptional regulator |
| M. marinum M | MMAR_5343 | - | 7e-18 | 51.19% (84) | transcriptional regulator |
| M. avium 104 | MAV_2783 | - | 3e-12 | 38.83% (103) | ArsR family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3497 | - | 6e-54 | 45.59% (261) | transcriptional regulator, ArsR family protein |
| M. thermoresistible (build 8) | TH_0041 | - | 1e-08 | 37.62% (101) | transcriptional regulator, ArsR family protein |
| M. ulcerans Agy99 | MUL_0086 | - | 3e-17 | 50.00% (84) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4686 | - | 1e-129 | 84.33% (268) | regulatory protein, ArsR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2031|M.gilvum_PYR-GCK -----------MDEVFRALADPSRRRLLDNLNARNGQSLRELCA------
Mvan_4686|M.vanbaalenii_PYR-1 -----------MDEVFRALADPSRRRLLDSLNARNGQSLRELCA------
MSMEG_3497|M.smegmatis_MC2_155 -----------MEAVLKALSDANRRTLLARLGDRDGQTLKELCA------
MMAR_5343|M.marinum_M MHIVREVGD-----VFKALADPTRRVILDELTDRNGQTLFEICARLTTKH
MUL_0086|M.ulcerans_Agy99 ---MREVGD-----VFKALADPTRRVILGELTDRNGQTLFEICARLTTKH
MAB_0986|M.abscessus_ATCC_1997 --MQSAPGHSHWDVVFKALADPTRRELLDRLHERNGQTLSQLCE------
MAV_2783|M.avium_104 -----MVVVTGVDRVFLALANPVRRELLQLL-ARHPLSAGELSER-----
Mb0591|M.bovis_AF2122/97 --------------MLEVAAEPTRRRLLQLLAPGER-TVTQLASQFT---
Rv0576|M.tuberculosis_H37Rv --------------MLEVAAEPTRRRLLQLLAPGER-TVTQLASQFT---
TH_0041|M.thermoresistible__bu ------------VDVFEAIAEPNRRALLDALTEGER-TAGELAATLPG--
:: . ::. ** :* * . : ::.
Mflv_2031|M.gilvum_PYR-GCK GLDMARQSVSKHLKVLEDANLVSIVWQGREKLHYLNAEPINAIADRWINH
Mvan_4686|M.vanbaalenii_PYR-1 GLDMARQSVSKHLKVLEDANLVSTVWRGREKLHYLNAEPINAIADRWINH
MSMEG_3497|M.smegmatis_MC2_155 DLAMARQSVAKHLEVLEAAGLVTVQWEGRQKLHHLDTGPITELAGELTAR
MMAR_5343|M.marinum_M GICSTRQAISQHLDVLEAAELIETQRGGRQKFHYLNTAPLGQIAKRWR--
MUL_0086|M.ulcerans_Agy99 GICSTRQAISQHLDVLEAAGLIETQRGGRQKFHYLNTAPLGQIAKRWR--
MAB_0986|M.abscessus_ATCC_1997 GVAMARQSATQHLGVLESANLISTVRHGREKLHYLNPVPLHEIQERWIDK
MAV_2783|M.avium_104 -FELSRPAVAEHLKVLREAALVADERRGRQRIYHLTAEPLAELGEWLHP-
Mb0591|M.bovis_AF2122/97 ---VTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVLRLRALMESF
Rv0576|M.tuberculosis_H37Rv ---VTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVLRLRALMESF
TH_0041|M.thermoresistible__bu ---LTQPTVSRHLRVLREVGLVEVRPDAQRRIYALRADGLIAIDTWIDRY
:: : :.** :* . *: .:.: : * : :
Mflv_2031|M.gilvum_PYR-GCK YDRMRAQTLADLKTALERNPMADNTHSAAADFVYTTYIRTTPERLWQAVT
Mvan_4686|M.vanbaalenii_PYR-1 YDRLRAQTLADLKTALEQDTMEHDN-----DFVYTTYIRTTPERLWQAVT
MSMEG_3497|M.smegmatis_MC2_155 WGAPRRHG-----ARLEAGAGNDGD-----VFVYVIYIRTTPERLWHAIT
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 FERPRLRALSAIKQRAEERDMSQPT------FVYTTYINSTPEKVWQAIT
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 WSDELDRLVADAAHYPPSQGDCAMP------FEKAVVVPLDPTSTFALIT
Rv0576|M.tuberculosis_H37Rv WSDELDRLVADAAHYPPSQGDCAMP------FEKAVVVPLDPTSTFALIT
TH_0041|M.thermoresistible__bu RRYWAGRLDALERHLHETHRDETNR------EDR----------------
Mflv_2031|M.gilvum_PYR-GCK DPAFSERYMGHGLVSDWQVGSTFAWR-DGDLSITSPEQVILECEPYRRLA
Mvan_4686|M.vanbaalenii_PYR-1 DPAFSERYMGHGLVTDWKVGSTFDWR-DGDLNISNPEQVVLEADPYRRLA
MSMEG_3497|M.smegmatis_MC2_155 NPGTSLGYLGHAIESDWLKGSTYVWI-ERGIRFERPQQVVLESDPYQRLA
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 DPELSGQYWGHANVSDWQEGSRWEHRRTDGSGIADVVGTVVESDPPRKLV
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 QPDRLRRWMAVAARIELRTGGAYRWT---VTPGHSAAGTVIDVDPGKRVV
Rv0576|M.tuberculosis_H37Rv QPDRLRRWMAVAARIELRTGGAYRWT---VTPGHSAAGTVIDVDPGKRVV
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK FTFHTFTKDL-----TTVGLSEDVIERAAAEPRSQVVFDIESVEDGRVKL
Mvan_4686|M.vanbaalenii_PYR-1 FTFHTFTRQL-----TTVGLSEDVIDRAAAEPRSKVSFDIEQVDGGRVKL
MSMEG_3497|M.smegmatis_MC2_155 FTYP-------------MPRTPDLDDPGAEHDTTRVSFDIEPGE-HQVKL
MMAR_5343|M.marinum_M ------------------------IDTADS-GRGTT--------------
MUL_0086|M.ulcerans_Agy99 ------------------------IDTADS-GRGTT--------------
MAB_0986|M.abscessus_ATCC_1997 TTWA------------------DPADGADA-AVSTVTFLIQPYQ-NIVRL
MAV_2783|M.avium_104 ------------------------FEKFWRTRLRRLAEVAEELE------
Mb0591|M.bovis_AF2122/97 FTWGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGW
Rv0576|M.tuberculosis_H37Rv FTWGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGW
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK TVTHTGFPSESIVRELVSGGWPSKLSDLKTHLELDRVAVGA---------
Mvan_4686|M.vanbaalenii_PYR-1 TVIHTGFPSGSIVRELVSGGWPSKLSDLKSNLELASVTADA---------
MSMEG_3497|M.smegmatis_MC2_155 TLVHDGLRPDSITHTLVSGEWPLKLSDLKSGLEQLTAP------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 TVSHADL-ADPAEYAQASGGWAAVLSNLKSFLETGAPLPTEPWTQPG---
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 NHFLDRLVVAGQHGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGA
Rv0576|M.tuberculosis_H37Rv NHFLDRLVVAGQRGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGA
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 SDLTRQTPCTEYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVA
Rv0576|M.tuberculosis_H37Rv SDLTRQTPCTEYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVA
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 DAAQAVMEAWRRRGLAGTVELNSNQVPATVPVGILCLEFLVHAWDFAIAT
Rv0576|M.tuberculosis_H37Rv DAAQAVMEAWRRRGLAGTVELNSNQVPATVPVGILCLEFLVHAWDFAIAT
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 GSQVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIA
Rv0576|M.tuberculosis_H37Rv GSQVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIA
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mflv_2031|M.gilvum_PYR-GCK --------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------
MSMEG_3497|M.smegmatis_MC2_155 --------------
MMAR_5343|M.marinum_M --------------
MUL_0086|M.ulcerans_Agy99 --------------
MAB_0986|M.abscessus_ATCC_1997 --------------
MAV_2783|M.avium_104 --------------
Mb0591|M.bovis_AF2122/97 FTGRQPTAGHVSAT
Rv0576|M.tuberculosis_H37Rv FTGRQPTAGHVSAT
TH_0041|M.thermoresistible__bu --------------